ABSTRACT
As a common disorder that accounts for over 70% of all breast disease cases, mammary gland hyperplasia (MGH) causes a severe problem for the quality of patients' life, and confers an increased risk of breast carcinoma. However, the etiology and pathogenesis of MGH remain unclear, and the safety and efficacy of current western drug therapy for MGH still need to be improved. Therefore, a meta-analysis was conducted by our team to determine whether a TCM formula named Ru-Pi-Xiao in combination with tamoxifen or Ru-Pi-Xiao treated alone can show more prominent therapeutic effects against MGH with fewer adverse reactions than that of tamoxifen. Studies published before June 2017 were searched based on standardized searching rules in several mainstream medical databases. A total of 27 articles with 4,368 patients were enrolled in this meta-analysis. The results showed that the combination of Ru-Pi-Xiao and tamoxifen could exhibit better therapeutic effects against MGH than that of tamoxifen (OR: 3.79; 95% CI: 3.09-4.65; P < 0.00001) with a lower incidence of adverse reactions (OR: 0.35; 95% CI: 0.28-0.43; P < 0.00001). The results also suggested that this combination could improve the level of progesterone (MD: 2.22; 95% CI: 1.72-2.71; P < 0.00001) and decrease the size of breast lump (MD: -0.67; 95% CI: -0.86 to -0.49; P < 0.00001) to a greater extent, which might provide a possible explanation for the pharmacodynamic mechanism of Ru-Pi-Xiao plus tamoxifen. In conclusion, Ru-Pi-Xiao and related preparations could be recommended as auxiliary therapy combined tamoxifen for the treatment of MGH.
ABSTRACT
La enfermedad fibroquística constituye la afección más frecuente de la mama durante la etapa de la madurez sexual. Más del 30 % de las mujeres en Cuba la padece. En la Medicina Tradicional China esta se corresponde mayoritariamente con la categoría Ru-Pi. Con el objetivo de identificar las características de esta afección desde la perspectiva de la Medicina Tradicional China, se desarrolló una búsqueda a través de la Biblioteca Virtual de la Salud de Infomed, en varias bases de datos internacionales, y en la Biblioteca del Servicio de Referencia Provincial de Medicina Natural y Tradicional de Matanzas. Fueron revisados 32 artículos y 17 libros sin limitación de año y país, seleccionándose 27 de ellos con calidad, los que se ajustaban a los objetivos de la investigación. Ru-Pi se define ampliamente como un nódulo (o nódulos) de apariencia duradera en las mamas, los que no son supurativos. Se diferencian según el diagnóstico sindrómico tradicional en estancamiento de Qi de hígado, estancamiento de Qi de hígado transformado en fuego, estancamiento de Qi de hígado que concomita con Xu (deficiencia) de Yin y estancamiento de Qi que concomita con desarmonía de los canales Chong y Ren, fundamentalmente. Se expusieron los principios de tratamiento de esta enfermedad y los esquemas terapéuticos definidos según el modelo de la Medicina Tradicional China.
The fibrocystic disease is the most frequent mamma disorder during the stage of sexual maturity. More than 30 % of the women in Cuba suffer from that disease. In Traditional Chinese Medicine, it corresponds mainly with Ru-Pi category. With the aim of identifying the characteristics of this disease from the perspective of the Traditional Chinese Medicine, a search was carried out in the Health Virtual Library Infomed, in several international databases and in the Library of the Provincial Reference Service of Traditional and Natural Medicine of Matanzas. 32 articles and 17 books were reviewed without limitation of edition year and country, choosing 27 of them qualitatively adjusted to the research aims. Ru-Pi is widely defined as a long-lasting appearance nodule (or nodules) in the mamma; these nodules are not suppurative. They are differenced according to the traditional syndrome diagnosis mainly as liver Qi stagnation, liver Qi stagnation transformed in fire, liver Qi stagnation concomitant with Xu (deficiency) of Yin, and Qi stagnation concomitant with Chon and Ren canals disharmony. There it were exposed the treatment principles of this disease and the therapeutic schemes defined according to the models of the Traditional Chinese Medicine.
ABSTRACT
La enfermedad fibroquística constituye la afección más frecuente de la mama durante la etapa de la madurez sexual. Más del 30 % de las mujeres en Cuba la padece. En la Medicina Tradicional China esta se corresponde mayoritariamente con la categoría Ru-Pi. Con el objetivo de identificar las características de esta afección desde la perspectiva de la Medicina Tradicional China, se desarrolló una búsqueda a través de la Biblioteca Virtual de la Salud de Infomed, en varias bases de datos internacionales, y en la Biblioteca del Servicio de Referencia Provincial de Medicina Natural y Tradicional de Matanzas. Fueron revisados 32 artículos y 17 libros sin limitación de año y país, seleccionándose 27 de ellos con calidad, los que se ajustaban a los objetivos de la investigación. Ru-Pi se define ampliamente como un nódulo (o nódulos) de apariencia duradera en las mamas, los que no son supurativos. Se diferencian según el diagnóstico sindrómico tradicional en estancamiento de Qi de hígado, estancamiento de Qi de hígado transformado en fuego, estancamiento de Qi de hígado que concomita con Xu (deficiencia) de Yin y estancamiento de Qi que concomita con desarmonía de los canales Chong y Ren, fundamentalmente. Se expusieron los principios de tratamiento de esta enfermedad y los esquemas terapéuticos definidos según el modelo de la Medicina Tradicional China(AU)
The fibrocystic disease is the most frequent mamma disorder during the stage of sexual maturity. More than 30 % of the women in Cuba suffer from that disease. In Traditional Chinese Medicine, it corresponds mainly with Ru-Pi category. With the aim of identifying the characteristics of this disease from the perspective of the Traditional Chinese Medicine, a search was carried out in the Health Virtual Library Infomed, in several international databases and in the Library of the Provincial Reference Service of Traditional and Natural Medicine of Matanzas. 32 articles and 17 books were reviewed without limitation of edition year and country, choosing 27 of them qualitatively adjusted to the research aims. Ru-Pi is widely defined as a long-lasting appearance nodule (or nodules) in the mamma; these nodules are not suppurative. They are differenced according to the traditional syndrome diagnosis mainly as liver Qi stagnation, liver Qi stagnation transformed in fire, liver Qi stagnation concomitant with Xu (deficiency) of Yin, and Qi stagnation concomitant with Chon and Ren canals disharmony. There it were exposed the treatment principles of this disease and the therapeutic schemes defined according to the models of the Traditional Chinese Medicine(AU)
