ABSTRACT
BACKGROUND: The order of clinical symptoms of POEMS syndrome is different, and the first diagnosis department is different accordingly, which is easy to cause misdiagnosis by clinicians. METHODS: A retrospective study was conducted between 2019 and 2023 in West China Hospital. Demographic, clinical and laboratory test indicators data were collected. RESULTS: Out of a total of 48 patients, 32 patients were from outpatient clinics and 16 were inpatients. The median age was 51 years old, and 30 were male. The most prevalent initial symptom is polyneuropathy (77.1%). 22 out of the 48 patients had an elevated VEGF. The most prevalent serum M protein was lgA λ(54.2%), and one patient had no M protein which could be regarded as the atypical POEMS syndrome. CONCLUSIONS: At present, the diagnosis of POEMS syndrome is based on the combination of clinical manifestations and laboratory tests. Emphasizing pluralism is of great significance for the diagnosis of this disease.