Leisure time television watching, computer use and risks of breast, colorectal and prostate cancer: A Mendelian randomisation analysis.

BACKGROUND: Sedentary behaviours have been associated with increased risks of some common cancers in epidemiological studies; however, it is unclear if these associations are causal. METHODS: We used univariable and multivariable two-sample Mendelian randomisation (MR) to examine potential causal relationships between sedentary behaviours and risks of breast, colorectal and prostate cancer. Genetic variants associated with self-reported leisure television watching and computer use were identified from a recent genome-wide association study (GWAS). Data related to cancer risk were obtained from cancer GWAS consortia. A series of sensitivity analyses were applied to examine the robustness of the results to the presence of confounding. RESULTS: A 1-standard deviation (SD: 1.5 h/day) increment in hours of television watching increased risk of breast cancer (OR per 1-SD: 1.15, 95% confidence interval [CI]: 1.05-1.26) and colorectal cancer (OR per 1-SD: 1.32, 95% CI: 1.16-1.49) while there was little evidence of an association for prostate cancer risk (OR per 1-SD: 0.94, 95% CI: 0.84-1.06). After adjusting for years of education, the effect estimates for television watching were attenuated (breast cancer, OR per 1-SD: 1.08, 95% CI: 0.92-1.27; colorectal cancer, OR per 1-SD: 1.08, 95% CI: 0.90-1.31). Post hoc analyses showed that years of education might have a possible confounding and mediating role in the association between television watching with breast and colorectal cancer. Consistent results were observed for each cancer site according to sex (colorectal cancer), anatomical subsites and cancer subtypes. There was little evidence of associations between genetically predicted computer use and cancer risk. CONCLUSIONS: Our univariable analysis identified some positive associations between hours of television watching and risks of breast and colorectal cancer. However, further adjustment for additional lifestyle factors especially years of education attenuated these results. Future studies using objective measures of exposure can provide new insights into the possible role of sedentary behaviour in cancer development.

Accelerometer-derived physical activity and sedentary behaviors in individuals with newly diagnosed type 2 diabetes: A cross-sectional study from the Danish nationwide DD2 cohort.

Introduction: Habitual physical activity behaviors of individuals with new-onset type 2 diabetes are largely unknown. We aimed to investigate accelerometer-derived physical activity behaviors in individuals with newly diagnosed type 2 diabetes. We also examined sociodemographic and health-related correlates of a high-risk physical activity profile. Methods: This cross-sectional study used data from 768 participants enrolled in an intervention study nested within the Danish Centre for Strategic Research in Type 2 diabetes (DD2) cohort. Physical activity was assessed by 24-h dual monitor accelerometry. Prevalence ratios of having a high-risk physical activity profile were estimated using Poisson regression adjusted for age and sex. Results: Study participants spent on average 9.7 (25th and 75th percentiles, 8.3; 11.1) hours/day sitting, walked for 1.1 (0.8; 1.6) hours/day and accumulated 4,000 (2,521; 5,864) steps/day. Still, 62% met the recommendations for physical activity. Characteristics associated with a high-risk physical activity profile (observed in 24.5% of participants) included older age, higher body mass index (BMI), unemployment, retirement, comorbidities, and current smoking. Hence, participants aged 60-69, 70-79 and 80+ years had prevalence ratios of 2.12 (95% CI 1.31; 3.42), 1.99 (1.18; 3.34) and 3.09 (1.42; 6.75) for a high-risk activity profile, respectively, versus participants <50 years. BMI values of 30-39 and 40+ were associated with 1.83 (1.06; 3.15) and 3.38 (1.88; 6.05) higher prevalence ratios compared to normal-weight. Unemployment or retirement was associated with 1.62 (1.09; 2.41) and 2.15 (1.37; 3.39) times higher prevalence ratios, compared to individuals in the working force. Having a Charlson Comorbidity Index score of 1-2 or 3+ was associated with 1.36 (1.03-1.79) and 1.90 (1.27-1.84) higher prevalence ratios, while current smoking was associated with a prevalence ratio of 1.72 (1.25; 2.35) compared to never smokers. Conclusion: This study shows that 62% of individuals with newly diagnosed type 2 diabetes met the recommendations for physical activity. Still, the majority of participants were also highly sedentary and accumulated very few daily steps, emphasizing the need for focusing on both increasing physical activity and reducing sedentary behaviors in the prevention of diabetes-related complications. Individuals with a high-risk physical activity profile were characterized by more obesity, socioeconomic inequalities, advanced age and comorbidities.Trial registration number: NCT02015130.

NAFLD and Physical Exercise: Ready, Steady, Go!

Along with the increase in obesity and type 2 diabetes, the non-alcoholic fatty liver disease (NAFLD) incidence is escalating, thus becoming a leading cause of liver cirrhosis and a significant burden of liver-related outcomes. Since there is no pharmacotherapy available to address the NAFLD, the most effective solutions seem to be lifestyle changes centered on physical activity. Exercise could mediate its beneficial effects directly on the liver and indirectly via extrahepatic pathways, forming a dose-response relationship with NAFLD in terms of prevalence and disease severity. Health-enhancing physical activity (HEPA) levels are mainly needed to exert beneficial effects in obese subjects, while even a small amount of exercise can be beneficial for lean individuals to prevent NAFLD. This mini-review addresses three major points regarding physical activity and NAFLD: prevention, treatment, and extrahepatic benefits, offering recommendations on type and intensity of exercise in liver disease.

Does aerobic fitness impact prolonged sitting-induced popliteal artery endothelial dysfunction?

PURPOSE: Acute prolonged bouts of sitting reduce popliteal artery blood flow and flow-mediated dilation (FMD). Individuals with higher aerobic fitness have enhanced popliteal FMD. Conflicting evidence regarding whether more aerobically fit individuals are protected from the negative impacts of sitting on popliteal endothelial function in male-dominated studies have been reported. We further explored the relationship between aerobic fitness and sitting-induced impairments in popliteal blood flow and FMD in a more sex-balanced cohort. METHODS: Relative peak oxygen consumption (V̇O2peak) was assessed using a cycling-based incremental test in 21 healthy adults (eight males; 23 ± 2 years; 23.9 ± 2.9 kg/m2). Popliteal blood flow and relative FMD (%) were measured via duplex ultrasonography before and after 3 h of uninterrupted sitting. Pearson correlations were performed separately between V̇O2peak versus pre-sitting and sitting-induced reductions in popliteal outcomes. RESULTS: Aerobic fitness (41.0 ± 9.7 ml/kg/min) was positively correlated with pre-sitting popliteal blood flow (65 ± 23 mL/min; R = 0.59, P = 0.005) and relative FMD (4.2 ± 1.5%; R = 0.49, P = 0.03). As expected, sitting reduced resting blood flow (19 ± 11 mL/min) and FMD (1.9 ± 0.7%) (both, P < 0.001). V̇O2peak was inversely related to sitting-induced declines in blood flow (Δ-46 ± 23 mL/min; R = - 0.71, P < 0.001) and FMD (Δ-2.4 ± 1.5%; R = - 0.51, P = 0.02). CONCLUSIONS: Although higher aerobic fitness was associated with more favorable popliteal endothelial-dependent vasodilator responses, it also corresponded with larger sitting-induced impairments in FMD. This suggests that being more aerobically fit does not protect against sitting-induced vascular endothelial dysfunction. As such, all young adults should minimize habitual prolonged sedentary bouts, regardless of their aerobic fitness level.

Relation among Perceived Weight Change, Sedentary Activities and Sleep Quality during COVID-19 Lockdown: A Study in an Academic Community in Northern Italy.

In Italy, COVID-19 lockdown was imposed from 8 March until 3 May 2020 with negative consequences on the lifestyles and health of people. Within this context, the paper aims: (i) to analyse the impact of COVID-19 lockdown on perceived weight changes; (ii) to evaluate factors associated with the perception of weight changes (Body Mass Index (BMI), sleep quality, time spent in sedentary activities), in an Italian academic community of students and workers. A total of 3666 participants took part in this cross-sectional study (2838 students and 828 workers, of whom 73.0% were female). T-test, Chi-square test and the two-way ANOVA were used. Results showed that 43.3% of participants perceived a weight gain. Workers experienced a more substantial increase in body weight (0.7 kg) compared to students (0.3 kg; p = 0.013). A significant difference between preobese/obese workers (0.9 kg) and students (-0.3 kg; p < 0.001) was found. Overall, 57.0% of the sample was characterized by high levels of sedentary activities. Sedentary people noticed a higher weight gain (0.4 kg) compared to less sedentary people (0.3 kg; p = 0.048). More than 45% of participants reported a worsening of sleep quality and showed a perceived increase in body weight (0.5 kg) in comparison to those who improved their sleep quality (no weight change; p = 0.001). Designing tailored interventions to promote health-related behaviours during lockdown periods is essential.

Exploring Feelings of Pleasure and Purpose Associated With Older People's Activities Using Ecological Momentary Analysis: An Observational Study.

Momentary feelings of pleasure and purpose can be sources of intrinsic motivation, but momentary purpose is rarely studied. Activities, contexts, and feelings of retired/semiretired adults (n = 67, aged 50-78 years) were captured using ecological momentary assessment. Participants provided 2,065 valid responses to six daily smartphone surveys for 7 days. Physical activity was measured by waist-worn ActiGraph accelerometer. Pleasure (measured by affective happiness) and purpose outcomes were regressed on activities, context, and potential confounding variables. Interactions between activities and contexts were explored. Participants were highly active: 98.5% met physical activity guidelines. Sedentary activities were negatively associated with sense of purpose, especially when indoors. However, social sedentary activities were positively associated with feelings of happiness. Active, social outdoor activities were positively associated with both outcomes. Less sedentary participants experienced greater happiness and purpose during all their activities. Context matters: active, social, and outdoor activities seem to be more appealing to older adults.

Association of the Dietary Approaches to Stop Hypertension, Physical Activity, and Their Combination with Semen Quality: A Cross-Sectional Study.

The influence of individual lifestyle factors is widely described in studies on semen quality. However, their synergistic effect is often neglected. The aim of the study was to examine the association between semen quality and dietary approaches to stop hypertension (DASH) diet, physical activity (PA), and the two separately and in combination. A cross-sectional study was carried out among 207 men aged 20-55. Dietary data were collected by a food frequency questionnaire (FFQ) and analysed according to the DASH scoring index. Physical activity was evaluated by the International Physical Activity Questionnaire. Semen parameters were assessed via the computer-aided semen analysis (CASA). Adherence to the DASH diet was associated with higher sperm count (ΔT3-T1 = 82.1 mln/ej) and concentration (ΔT3-T1 = 24.6 mln/mL). Higher PA was related to higher sperm count (ΔT3-T1 = 69.4 mln/ej), total (ΔT3-T1 = 11.9%), and progressive motility (ΔT3-T1 = 8.5%) and morphology (ΔT3-T1 = 2.8%) in the crude model and remained significant after adjustment. The combination of the DASH diet and PA, was significantly positively associated with sperm count (ΔT3-T1 = 98.1 mln/ej), sperm concentration (ΔT3-T1 = 17.5 mln/mL), total (ΔT3-T1 = 11.8%), and progressive motility (ΔT3-T1 = 10.0%) and morphology (ΔT3-T1 = 3.3%) in both models. Adherence to the DASH diet was related to higher sperm count and concentration, whereas after its combination with physical activity it was also positively correlated with sperm motility and morphology.

Physical Activity, Sedentary Behaviours and Duration of Sleep as Factors Affecting the Well-Being of Young People against the Background of Environmental Moderators.

Mental health problems during adolescence are becoming increasingly frequent. The purpose of this study was to evaluate the total impact of selected behavioural and environmental factors on the variability of mental well-being indexes of young people aged 15 to 17 years. The survey, conducted as part of the last round of the Health Behaviour in School-Aged Children (HBSC) 2017/18 study, covered 3693 secondary school students in Poland at the average age of 16.53 years (SD = 1.09). Dependent variables: depression (CES-DC), stress (Cohen scale), satisfaction with life (Cantril's Ladder), and self-efficacy in social relations (Smith and Betz scale). Independent variables included: physical activity; sedentary behaviours; length of sleep; and perception of the environment in which the respondent was raised. The analyses were adjusted by gender, age, and occurrence of chronic disease. It was demonstrated that gender, duration of sleep, and perception of the surrounding environment proved to be significant predictors of all four mental health indicators. The protective influence of physical activity appeared to be a particular advantage in a less-supportive environment. The intervention programmes aimed at improving the mental well-being of young people should include promoting physical activity and sufficient sleep; furthermore, environmental moderators should be taken into consideration.

Why Do Children Engage in Sedentary Behavior? Child- and Parent-Perceived Determinants.

Todays children spend a large amount of their time sedentary. There is limited evidence on the determinants of sedentary behavior in children, and qualitative studies are especially lacking. Therefore, this study aimed to explore determinants of children's sedentary behavior from the child- and parent perspective. Qualitative data were collected during concept mapping sessions with four groups of 11-13 years old children (n = 38) and two online sessions with parents (n = 21). Children and parents generated sedentary behavior motives, sorted related motives, and rated their importance in influencing children's sedentary time. Next, multidimensional scaling and hierarchical cluster analysis was performed to create clusters of motives resulting in a concept map. Finally, the researchers named the clusters in the concept map. Concept maps of children yielded eight to ten perceived determinants, and concept maps of parents six to seven. Children and parents identified six similar potential determinants, and both rated as important: Sitting because… "it is the norm (I have to)", and "I can work/play better that way". In addition, children rated "there is nobody to play with" as an important potential determinant for engaging in sedentary behavior. The most important child- and parent perceived determinants were related to the social/cultural and physical environment, indicating that these are promising targets for future interventions.

Prevalence and lifestyle determinants of central obesity in children.

PURPOSE: Central obesity is a strong risk factor for metabolic disorders and cardiometabolic diseases in children and adolescents. The aim of the present study was to evaluate the prevalence of central obesity and to determine its cross-sectional association with lifestyle habits in a sample of school-aged children in Greece. METHODS: The study sample consisted of 124,113 children (9.9 ± 1.1 years old, 51 % boys) attending the third and fifth grade of primary school. Anthropometric measurements were performed by trained physical education teachers, and central obesity was defined as waist-to-height ratio ≥0.5. Children's lifestyle habits were assessed through 7-day recall questionnaires. RESULTS: Of the participating children, 33.4 % were classified as centrally obese. Central obesity was significantly more prevalent in boys than in girls (36.0 vs. 30.7 %, P < 0.001) and was present in 95 % of obese children, as well as in a significant percentage of overweight (69.5 %) and normal-weight ones (12.0 %). Children with central obesity, compared to their non-centrally obese counterparts, reported poorer dietary habits and were less physically active. According to multiple logistic regression analysis, frequent breakfast (OR 0.72, 95 % CI 0.69-0.75) and snack consumption (OR 0.70, 95 % CI 0.67-0.74), as well as frequent participation in sedentary activities (OR 1.10, 95 % CI 1.07-1.14), were the strongest lifestyle determinants of central obesity. CONCLUSION: Strategies for the prevention of central obesity and associated comorbidities are urgently needed, for both obese and non-obese children. Our results suggest the need for a shift towards a healthier environment for our children, with emphasis on specific lifestyle habits, such as regular meal consumption and low sedentariness.

[Food consumption in children and youth: effect of sedentary activities]. / Impact des activités sédentaires sur la prise alimentaire des jeunes.

Sedentary behavior has progressed with modern society, generating very low levels of energy expenditure and subsequent body weight disorders (obesity). There is also evidence that the absence of physical activity associated with short sleep time and watching television or playing video games leads to poor eating habits and favors high-energy intake. These findings have generally been reported in adults, with a few studies including data on children and adolescents. This brief review summarizes the current literature regarding the impact of such activities on food consumption and eating behavior in children and adolescents. There appears to be an uncoupling effect dissociating these activities from the sensation of hunger and thus energy intake. Children and adolescents seem to increase their energy intake during and after such activities without any alteration of their subjective appetite. In addition to considering the impact of sedentary behavior and physical activity level, future public health recommendations should also focus on associated nutritional adaptations (energy balance).

Prevalência e fatores associado à dor musculoesquelética em profissionais de atividades sedentárias / Prevalence and factors associated with musculoskeletal pain in professionals of sedentary activities

Objetivos: Verificar a prevalência dos sintomas musculoesqueléticos e investigar fatores associados, em funcionários de uma empresa de prestação de serviço de fornecimento de água e tratamento de esgoto da cidade de Bauru, São Paulo. Materiais e métodos: Trata-se de um estudo transversal, com 176 profissionais que exerciam atividades sedentárias e que responderam a questionários para coleta de dados das variáveis demográficas, ocupacionais e hábitos de vida, o Índice de Capacidade para o Trabalho e o Questionário Nórdico de Sintomas Osteomusculares. Foram realizadas análises descritiva, bivariada e multivariada por regressão logística binária. Resultados: Os trabalhadores relataram algum tipo de sintoma osteomuscular nos últimos 12 meses, principalmente na região lombar (40,3%), na coluna cervical (27,2%) e nos ombros (23,8%).Observou-se associação entre os sintomas osteomusculares e as seguintes variáveis: tipo de movimento, postura no trabalho e problemas de saúde. Conclusão: Conclui-se que a prevalência de sintomas osteomuscularesnos trabalhadores é alta e que houve uma associação significativa com os movimentos repetitivos, postura sentada e problemas de saúde, sendo, portanto, necessária uma atuação interdisciplinar, multiprofissional e intersetorial, de forma a interferir positivamente no processo de trabalho e na saúde do trabalhador

OBJECTIVES: To determine the prevalence of musculoskeletal symptoms and to investigate factors associated with employees of a company that provides service of water supply and sewage treatment in the city of Bauru, São Paulo.MATERIALS AND METHODS: This is a cross-sectional study with 176 professionals who perform sedentary activities and answered questionnaires for data collection of demographic, occupational and lifestyle variables, the Index of the Work Ability and the Nordic Musculoskeletal Questionnaire. Descriptive analysis, bivariate and multivariate binary logistic regression were made. RESULTS: The workers reported some type of musculoskeletal symptoms in the last 12 months, mainly in the lumbar region (40.3%), cervical spine (27.2%) and shoulders (23.8%). There was an association between musculoskeletal symptoms and the variables type of movement, posture at work and health problems.CONCLUSION: The prevalence of musculoskeletal symptoms in workers is high and there was a significant association with repetitive movements, sitting posture and health problems, being therefore, needed an interdisciplinary, intersectoral and multidisciplinary presence, in order to positively affect the process of work and occupational health.

Nível de capacidade para o trabalho e fatores associados em profissionais de atividades sedentárias / Level of abiity to work and associated factor in professional sedentary activities

Introdução: Configurando um problema de saúde no Brasil e no mundo, a saúde do trabalhador vem apresentando uma modificação no seu perfil, influenciando a capacidade de trabalho. O objetivo foi identificar o nível de capacidade para o trabalho, e analisar os fatores associados em funcionários de uma empresa de prestação de serviço de fornecimento de água e tratamento de esgoto da cidade de Bauru. Metodologia: Realizou-se um estudo transversal, com 176 funcionários que exerciam atividades sedentárias de uma empresa de uma cidade do Estado de São Paulo, com a utilização de questionário multidimensional, o Índice de Capacidade para o Trabalho, o Job Content Questionnaire e o Questionário Nórdico de Sintomas Osteomusculares. Realizaram-se análises descritiva, bivariada e multivariada por regressão logística. Resultados: Encontrou-se que quanto à capacidade para o trabalho, 68,2 por cento apresentaram índice baixo e 31,8 por cento bom. Na análise ajustada evidenciaram que a faixa etária acima de 35 anos (p=0,01), dor musculoesquelética em mais de duas regiões corporais (p=0,05) e tempo trabalhado acima de 10 anos (p= 0,01) mostraram associação de forma independente com a capacidade de trabalho. Conclusão: Os fatores relacionados à capacidade para o trabalho são múltiplos e, ações para a prevenção e recuperação devem ser discutidas, implementadas e conciliadas entre os empregados e empregadores.

Introduction: Setting up a health problem in Brazil and worldwide, the health worker has been showing a change in your profile, influencing the ability to work. The objective was to identify the level of work ability, and analyze the associated factors in employees of a company providing service water supply and sewage treatment in the city of Bauru. Methodology: A cross-sectional study, with 176 employees who performed sedentary activities of an enterprise of a city of São Paulo, with the use of multidimensional questionnaire, the Index of the Work Ability, Job Content Questionnaire and the Nordic Questionnaire Musculoskeletal. Analyses Descriptive, bivariate and multivariate logistic regression. Results: We found that the capacity for work, 68.2 per cent had a low rate and 31.8 per cent good. In the adjusted analysis showed that age above 35 years (p = 0.01), musculoskeletal pain in more than two body regions (p = 0.05) and time worked over 10 years (p = 0.01 ) were associated independently with the ability to work. Conclusion: The factors related to the ability to work are many and actions for the prevention and recovery should be discussed, implemented and reconciled between employees and employers.