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1.
Sci Rep ; 14(1): 15302, 2024 Jul 03.
Article in English | MEDLINE | ID: mdl-38961244

ABSTRACT

Extractive document summary is usually seen as a sequence labeling task, which the summary is formulated by sentences from the original document. However, the selected sentences usually are high redundancy in semantic space, so that the composed summary are high semantic redundancy. To alleviate this problem, we propose a model to reduce the semantic redundancy of summary by introducing the cluster algorithm to select difference sentences in semantic space and we improve the base BERT to score sentences. We evaluate our model and perform significance testing using ROUGE on the CNN/DailyMail datasets compare with six baselines, which include two traditional methods and four state-of-art deep learning model. The results validate the effectiveness of our approach, which leverages K-means algorithm to produce more accurate and less repeat sentences in semantic summaries.

2.
Memory ; : 1-15, 2024 Jul 05.
Article in English | MEDLINE | ID: mdl-38968421

ABSTRACT

Accumulating world knowledge is a major task of development and education. The productive process of self-derivation through memory integration seemingly is a valid model of the process. To test the model, we examined relations between generation and retention of new factual knowledge via self-derivation through integration and world knowledge as measured by standardised assessments. We also tested whether the productive process of self-derivation predicted world knowledge even when a measure of learning through direct instruction also was considered. Participants were 162 children ages 8-12 years (53% female; 15% Black, 6% Asian, 1% Arab, 66% White, 5% mixed race, 7% unreported; 1% Latinx). Age accounted for a maximum of 4% of variance in self-derivation and retention. In contrast, substantial individual variability related to general knowledge and content knowledge in several domains, explaining 20-40% variance. In each domain for which self-derivation performance was a unique predictor, it explained a nominally greater share of the variance than the measure of learning through direct instruction. The findings imply that individual variability in self-derivation has functional consequences for accumulation of semantic knowledge across the elementary-school years.

3.
Neurocase ; : 1-9, 2024 Jul 04.
Article in English | MEDLINE | ID: mdl-38965869

ABSTRACT

OBJECTIVE: To describe a case of Post-Treatment Lyme Disease Syndrome (PTLDS) with an atypical cognitive profile. METHOD: A 41-year-old PTLDS patient underwent comprehensive neuropsychological testing and psychological assessment. RESULTS: The patient exhibited impaired intensive attention but preserved selective attention. Executive functions were normal. Short-term and anterograde memory were intact, while retrograde and semantic memory were significantly impaired. The patient also experienced identity loss, specific phobias, dissociative symptoms, and depressed mood. CONCLUSIONS: Severe episodic-autobiographical and retrograde semantic amnesia was consistent with some reports of dissociative amnesia. Loss of identity and phobias were also highly suggestive of a psychogenic mechanism underlying amnesia.

4.
Hum Brain Mapp ; 45(10): e26770, 2024 Jul 15.
Article in English | MEDLINE | ID: mdl-38970217

ABSTRACT

Alpha oscillations are known to play a central role in several higher-order cognitive functions, especially selective attention, working memory, semantic memory, and creative thinking. Nonetheless, we still know very little about the role of alpha in the generation of more remote semantic associations, which is key to creative and semantic cognition. Furthermore, it remains unclear how these oscillations are shaped by the intention to "be creative," which is the case in most creativity tasks. We aimed to address these gaps in two experiments. In Experiment 1, we compared alpha oscillatory activity (using a method which distinguishes genuine oscillatory activity from transient events) during the generation of free associations which were more vs. less distant from a given concept. In Experiment 2, we replicated these findings and also compared alpha oscillatory activity when people were generating free associations versus associations with the instruction to be creative (i.e. goal-directed). We found that alpha was consistently higher during the generation of more distant semantic associations, in both experiments. This effect was widespread, involving areas in both left and right hemispheres. Importantly, the instruction to be creative seems to increase alpha phase synchronisation from left to right temporal brain areas, suggesting that intention to be creative changed the flux of information in the brain, likely reflecting an increase in top-down control of semantic search processes. We conclude that goal-directed generation of remote associations relies on top-down mechanisms compared to when associations are freely generated.


Subject(s)
Alpha Rhythm , Creativity , Goals , Semantics , Humans , Alpha Rhythm/physiology , Male , Female , Young Adult , Adult , Brain/physiology , Brain/diagnostic imaging , Brain Mapping , Association , Electroencephalography , Adolescent
5.
Elife ; 122024 Jul 05.
Article in English | MEDLINE | ID: mdl-38968325

ABSTRACT

Humans can read and comprehend text rapidly, implying that readers might process multiple words per fixation. However, the extent to which parafoveal words are previewed and integrated into the evolving sentence context remains disputed. We investigated parafoveal processing during natural reading by recording brain activity and eye movements using MEG and an eye tracker while participants silently read one-line sentences. The sentences contained an unpredictable target word that was either congruent or incongruent with the sentence context. To measure parafoveal processing, we flickered the target words at 60 Hz and measured the resulting brain responses (i.e. Rapid Invisible Frequency Tagging, RIFT) during fixations on the pre-target words. Our results revealed a significantly weaker tagging response for target words that were incongruent with the previous context compared to congruent ones, even within 100ms of fixating the word immediately preceding the target. This reduction in the RIFT response was also found to be predictive of individual reading speed. We conclude that semantic information is not only extracted from the parafovea but can also be integrated with the previous context before the word is fixated. This early and extensive parafoveal processing supports the rapid word processing required for natural reading. Our study suggests that theoretical frameworks of natural reading should incorporate the concept of deep parafoveal processing.


Subject(s)
Eye Movements , Reading , Semantics , Humans , Female , Male , Adult , Young Adult , Eye Movements/physiology , Fovea Centralis/physiology , Fixation, Ocular/physiology , Magnetoencephalography , Brain/physiology , Comprehension/physiology
6.
Trop Anim Health Prod ; 56(6): 192, 2024 Jul 02.
Article in English | MEDLINE | ID: mdl-38954103

ABSTRACT

Accurate breed identification in dairy cattle is essential for optimizing herd management and improving genetic standards. A smart method for correctly identifying phenotypically similar breeds can empower farmers to enhance herd productivity. A convolutional neural network (CNN) based model was developed for the identification of Sahiwal and Red Sindhi cows. To increase the classification accuracy, first, cows's pixels were segmented from the background using CNN model. Using this segmented image, a masked image was produced by retaining cows' pixels from the original image while eliminating the background. To improve the classification accuracy, models were trained on four different images of each cow: front view, side view, grayscale front view, and grayscale side view. The masked images of these views were fed to the multi-input CNN model which predicts the class of input images. The segmentation model achieved intersection-over-union (IoU) and F1-score values of 81.75% and 85.26%, respectively with an inference time of 296 ms. For the classification task, multiple variants of MobileNet and EfficientNet models were used as the backbone along with pre-trained weights. The MobileNet model achieved 80.0% accuracy for both breeds, while MobileNetV2 and MobileNetV3 reached 82.0% accuracy. CNN models with EfficientNet as backbones outperformed MobileNet models, with accuracy ranging from 84.0% to 86.0%. The F1-scores for these models were found to be above 83.0%, indicating effective breed classification with fewer false positives and negatives. Thus, the present study demonstrates that deep learning models can be used effectively to identify phenotypically similar-looking cattle breeds. To accurately identify zebu breeds, this study will reduce the dependence of farmers on experts.


Subject(s)
Deep Learning , Phenotype , Animals , Cattle , Breeding , Neural Networks, Computer , Female , Dairying/methods
7.
PeerJ Comput Sci ; 10: e2080, 2024.
Article in English | MEDLINE | ID: mdl-38983194

ABSTRACT

Poultry farming is an indispensable part of global agriculture, playing a crucial role in food safety and economic development. Managing and preventing diseases is a vital task in the poultry industry, where semantic segmentation technology can significantly enhance the efficiency of traditional manual monitoring methods. Furthermore, traditional semantic segmentation has achieved excellent results on extensively manually annotated datasets, facilitating real-time monitoring of poultry. Nonetheless, the model encounters limitations when exposed to new environments, diverse breeding varieties, or varying growth stages within the same species, necessitating extensive data retraining. Overreliance on large datasets results in higher costs for manual annotations and deployment delays, thus hindering practical applicability. To address this issue, our study introduces HSDNet, an innovative semantic segmentation model based on few-shot learning, for monitoring poultry farms. The HSDNet model adeptly adjusts to new settings or species with a single image input while maintaining substantial accuracy. In the specific context of poultry breeding, characterized by small congregating animals and the inherent complexities of agricultural environments, issues of non-smooth losses arise, potentially compromising accuracy. HSDNet incorporates a Sharpness-Aware Minimization (SAM) strategy to counteract these challenges. Furthermore, by considering the effects of imbalanced loss on convergence, HSDNet mitigates the overfitting issue induced by few-shot learning. Empirical findings underscore HSDNet's proficiency in poultry breeding settings, exhibiting a significant 72.89% semantic segmentation accuracy on single images, which is higher than SOTA's 68.85%.

8.
PeerJ Comput Sci ; 10: e2146, 2024.
Article in English | MEDLINE | ID: mdl-38983210

ABSTRACT

In recent years, the growing importance of accurate semantic segmentation in ultrasound images has led to numerous advances in deep learning-based techniques. In this article, we introduce a novel hybrid network that synergistically combines convolutional neural networks (CNN) and Vision Transformers (ViT) for ultrasound image semantic segmentation. Our primary contribution is the incorporation of multi-scale CNN in both the encoder and decoder stages, enhancing feature learning capabilities across multiple scales. Further, the bottleneck of the network leverages the ViT to capture long-range high-dimension spatial dependencies, a critical factor often overlooked in conventional CNN-based approaches. We conducted extensive experiments using a public benchmark ultrasound nerve segmentation dataset. Our proposed method was benchmarked against 17 existing baseline methods, and the results underscored its superiority, as it outperformed all competing methods including a 4.6% improvement of Dice compared against TransUNet, 13.0% improvement of Dice against Attention UNet, 10.5% improvement of precision compared against UNet. This research offers significant potential for real-world applications in medical imaging, demonstrating the power of blending CNN and ViT in a unified framework.

9.
Aging Clin Exp Res ; 36(1): 154, 2024 Jul 30.
Article in English | MEDLINE | ID: mdl-39078432

ABSTRACT

Mild cognitive impairment (MCI) is recognized as the prodromal phase of dementia, a condition that can be either maintained or reversed through timely medical interventions to prevent cognitive decline. Considerable studies using functional magnetic resonance imaging (fMRI) have indicated that altered activity in the medial prefrontal cortex (mPFC) serves as an indicator of various cognitive stages of aging. However, the impacts of intrinsic functional connectivity in the mPFC as a mediator on cognitive performance in individuals with and without MCI have not been fully understood. In this study, we recruited 42 MCI patients and 57 healthy controls, assessing their cognitive abilities and functional brain connectivity patterns through neuropsychological evaluations and resting-state fMRI, respectively. The MCI patients exhibited poorer performance on multiple neuropsychological tests compared to the healthy controls. At the neural level, functional connectivity between the mPFC and the anterior cingulate cortex (ACC) was significantly weaker in the MCI group and correlated with multiple neuropsychological test scores. The result of the mediation analysis further demonstrated that functional connectivity between the mPFC and ACC notably mediated the relationship between the MCI and semantic fluency performance. These findings suggest that altered mPFC-ACC connectivity may have a plausible causal influence on cognitive decline and provide implications for early identifications of neurodegenerative diseases and precise monitoring of disease progression.


Subject(s)
Cognitive Dysfunction , Gyrus Cinguli , Magnetic Resonance Imaging , Prefrontal Cortex , Humans , Cognitive Dysfunction/physiopathology , Cognitive Dysfunction/diagnostic imaging , Prefrontal Cortex/physiopathology , Prefrontal Cortex/diagnostic imaging , Gyrus Cinguli/physiopathology , Gyrus Cinguli/diagnostic imaging , Male , Female , Aged , Magnetic Resonance Imaging/methods , Middle Aged , Neuropsychological Tests , Case-Control Studies
10.
J Gen Psychol ; : 1-41, 2024 Jul 29.
Article in English | MEDLINE | ID: mdl-39074043

ABSTRACT

Extensive attention has been dedicated to studying the influence of others on genuine or false memory during ongoing and post-collaboration. These studies have revealed both detrimental and beneficial effects on episodic memory. Although ongoing effects such as collaborative inhibition have been examined in the semantic situation, the post-collaboration effects have not received the same level of scrutiny To address this gap, the current study instructed participants to either generate or remember idioms during the study phase, which encompassed semantic and episodic encoding. There were three recall sessions, during which four groups were designated: individual (III), preceding collaboration (CII), following collaboration (ICI), and multiple collaboration (CCI). The main results and implications of the study are outlined below. (a) The detrimental effect of collaborative inhibition was found to be sensitive to collaborative frequency, indicating that the contribution of retrieval strategy disruption proposed by the Retrieval Strategy Disruption Hypothesis (RSDH) is conditional. (b) We observed a reliable beneficial effect of error pruning, as evidenced by smaller errors in collaborators compared to individual participants. Furthermore, this beneficial effect was consistently evident in both ongoing and post-collaboration scenarios for the two encoding tasks. (c) The post-collaborative memory benefit was observed in both Recall 2 and Recall 3. This suggests that mechanisms such as relearning, cross-cueing, re-exposure, and pruning errors may have contributed to this effect. (d) The observation of the beneficial effects of picked-up and shared memory indicates the contribution of similar mechanisms as to post-collaborative memory benefit. (e) These effects were observed regardless of the encoding task, but they were influenced by both collaborative frequency and collaborative order. The results are discussed in terms of the RSDH and other relevant theories. Additionally, future research directions are provided.

11.
Front Neurosci ; 18: 1448294, 2024.
Article in English | MEDLINE | ID: mdl-39077427

ABSTRACT

In bronchial ultrasound elastography, accurately segmenting mediastinal lymph nodes is of great significance for diagnosing whether lung cancer has metastasized. However, due to the ill-defined margin of ultrasound images and the complexity of lymph node structure, accurate segmentation of fine contours is still challenging. Therefore, we propose a dual-stream feature-fusion attention U-Net (DFA-UNet). Firstly, a dual-stream encoder (DSE) is designed by combining ConvNext with a lightweight vision transformer (ViT) to extract the local information and global information of images; Secondly, we propose a hybrid attention module (HAM) at the bottleneck, which incorporates spatial and channel attention to optimize the features transmission process by optimizing high-dimensional features at the bottom of the network. Finally, the feature-enhanced residual decoder (FRD) is developed to improve the fusion of features obtained from the encoder and decoder, ensuring a more comprehensive integration. Extensive experiments on the ultrasound elasticity image dataset show the superiority of our DFA-UNet over 9 state-of-the-art image segmentation models. Additionally, visual analysis, ablation studies, and generalization assessments highlight the significant enhancement effects of DFA-UNet. Comprehensive experiments confirm the excellent segmentation effectiveness of the DFA-UNet combined attention mechanism for ultrasound images, underscoring its important significance for future research on medical images.

12.
Foods ; 13(14)2024 Jul 13.
Article in English | MEDLINE | ID: mdl-39063292

ABSTRACT

The lack of spatial pose information and the low positioning accuracy of the picking target are the key factors affecting the picking function of citrus-picking robots. In this paper, a new method for automatic citrus fruit harvest is proposed, which uses semantic segmentation and rotating target detection to estimate the pose of a single culture. First, Faster R-CNN is used for grab detection to identify candidate grab frames. At the same time, the semantic segmentation network extracts the contour information of the citrus fruit to be harvested. Then, the capture frame with the highest confidence is selected for each target fruit using the semantic segmentation results, and the rough angle is estimated. The network uses image-processing technology and a camera-imaging model to further segment the mask image of the fruit and its epiphyllous branches and realize the fitting of contour, fruit centroid, and fruit minimum outer rectangular frame and three-dimensional boundary frame. The positional relationship of the citrus fruit to its epiphytic branches was used to estimate the three-dimensional pose of the citrus fruit. The effectiveness of the method was verified through citrus-planting experiments, and then field picking experiments were carried out in the natural environment of orchards. The results showed that the success rate of citrus fruit recognition and positioning was 93.6%, the average attitude estimation angle error was 7.9°, and the success rate of picking was 85.1%. The average picking time is 5.6 s, indicating that the robot can effectively perform intelligent picking operations.

13.
J Pers Med ; 14(7)2024 Jun 24.
Article in English | MEDLINE | ID: mdl-39063930

ABSTRACT

Communication and cooperation are fundamental for the correct deployment of P5 medicine, and this can be achieved only by correct comprehension of semantics so that it can aspire to medical knowledge sharing. There is a hierarchy in the operations that need to be performed to achieve this goal that brings to the forefront the complete understanding of the real-world business system by domain experts using Domain Ontologies, and only in the last instance acknowledges the specific transformation at the pure information and communication technology level. A specific feature that should be maintained during such types of transformations is versioning that aims to record the evolution of meanings in time as well as the management of their historical evolution. The main tool used to represent ontology in computing environments is the Ontology Web Language (OWL), but it was not created for managing the evolution of meanings in time. Therefore, we tried, in this paper, to find a way to use the specific features of Common Terminology Service-Release 2 (CTS2) to perform consistent and validated transformations of ontologies written in OWL. The specific use case managed in the paper is the Alzheimer's Disease Ontology (ADO). We were able to consider all of the elements of ADO and map them with CTS2 terminological resources, except for a subset of elements such as the equivalent class derived from restrictions on other classes.

14.
Front Psychol ; 15: 1373541, 2024.
Article in English | MEDLINE | ID: mdl-38988382

ABSTRACT

Introduction: Timely and accurate diagnosis of the earliest manifestations of Alzheimer's disease (AD) is critically important. Cognitive challenge tests such as the Loewenstein Acevedo Scales for Semantic Interference and Learning (LASSI-L) have shown favorable diagnostic properties in a number of previous investigations using amyloid or FDG PET. However, no studies have examined LASSI-L performance against cerebrospinal fluid biomarkers of AD, which can be affected before the distribution of fibrillar amyloid and other changes that can be observed in brain neuroimaging. Therefore, we aimed to evaluate the relationship between LASSI-L scores and CSF biomarkers and the capacity of the cognitive challenge test to detect the presence of amyloid and tau deposition in patients with subjective cognitive decline and amnestic mild cognitive impairment (MCI). Methods: One hundred and seventy-nine patients consulting for memory loss without functional impairment were enrolled. Patients were examined using comprehensive neuropsychological assessment, the LASSI-L, and cerebrospinal fluid (CSF) biomarkers (Aß1-42/Aß1-40 and ptau181). Means comparisons, correlations, effect sizes, and ROC curves were calculated. Results: LASSI-L scores were significantly associated with CSF biomarkers Aß1-42/Aß1-40 in patients diagnosed with MCI and subjective cognitive decline, especially those scores evaluating the capacity to recover from proactive semantic interference effects and delayed recall. A logistic regression model for the entire sample including LASSI-L and age showed an accuracy of 0.749 and an area under the curve of 0.785 to detect abnormal amyloid deposition. Conclusion: Our study supports the biological validity of the LASSI-L and its semantic interference paradigm in the context of the early stages of AD. These findings emphasize the utility and the convenience of including sensitive cognitive challenge tests in the assessment of patients with suspicion of early stages of AD.

15.
Neuroimage Clin ; 43: 103639, 2024 Jul 04.
Article in English | MEDLINE | ID: mdl-38991435

ABSTRACT

Primary progressive aphasia (PPA) variants present with distinct disruptions in speech-language functions with little known about the interplay between affected and spared regions within the speech-language network and their interaction with other functional networks. The Neurodegenerative Research Group, Mayo Clinic, recruited 123 patients with PPA (55 logopenic (lvPPA), 44 non-fluent (nfvPPA) and 24 semantic (svPPA)) who were matched to 60 healthy controls. We investigated functional connectivity disruptions between regions within the left-speech-language network (Broca, Wernicke, anterior middle temporal gyrus (aMTG), supplementary motor area (SMA), planum temporale (PT) and parietal operculum (PO)), and disruptions to other networks (visual association, dorsal-attention, frontoparietal and default mode networks (DMN)). Within the speech-language network, multivariate linear regression models showed reduced aMTG-Broca connectivity in all variants, with lvPPA and nfvPPA findings remaining significant after Bonferroni correction. Additional loss in Wernicke-Broca connectivity in nfvPPA, Wernicke-PT connectivity in lvPPA and greater aMTG-PT connectivity in svPPA were also noted. Between-network connectivity findings in all variants showed reduced aMTG-DMN and increased aMTG-dorsal-attention connectivity, with additional disruptions between aMTG-visual association in both lvPPA and svPPA, aMTG-frontoparietal in lvPPA, and Wernicke-DMN breakdown in svPPA. These findings suggest that aMTG connectivity breakdown is a shared feature in all PPA variants, with lvPPA showing more extensive connectivity disruptions with other networks.

16.
J Exp Child Psychol ; 246: 105998, 2024 Jul 08.
Article in English | MEDLINE | ID: mdl-38981331

ABSTRACT

Across word reading development, there are important and evolving relationships between oral and written semantic knowledge. Recent research has focused on these relationships, with accumulating evidence supporting the role of word knowledge and related word characteristics as important factors influencing polysyllabic word reading abilities. The purpose of this study was to investigate how semantic-related effects across child-level skills (e.g., general vocabulary knowledge), word-level properties (e.g., age of acquisition), child-by-word-level familiarity (e.g., item-level familiarity), and interactions between key child attributes and word characteristics (e.g., word reading skill by age of acquisition) contribute to polysyllabic word reading. Specifically, we emphasize the semantic contributions of word-level features to word reading development, which have been relatively underexplored in the literature. A sample of elementary school students oversampled for word reading difficulty (N = 92) in Grades 3 to 5 read a set of polysyllabic words (J = 45) and completed a battery of reading and language-related measures. Using cross-classified random-effects models and accounting for various control variables, semantic-related variables representing item-level familiarity; child-level set for variability; and word-level age of acquisition and number of morphemes were significant predictors in the main-effects model. A significant interaction between sight word efficiency and age of acquisition indicated higher probabilities of correctly reading polysyllabic words at lower levels of acquisition for better readers. Results indicate important semantic-related influences on polysyllabic word reading at the child, word, and child-by-word levels, suggesting meaningful relationships between knowledge of the orthographic form of a word and semantic knowledge in developing readers.

17.
Alzheimers Dement ; 2024 Jul 10.
Article in English | MEDLINE | ID: mdl-38982845

ABSTRACT

INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. RESULTS: Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. HIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.

18.
Front Hum Neurosci ; 18: 1356483, 2024.
Article in English | MEDLINE | ID: mdl-38974479

ABSTRACT

Reading is vital for acquiring knowledge and studies have demonstrated that phonology-focused interventions generally yield greater improvements than meaning-focused interventions in English among children with reading disabilities. However, the effectiveness of reading instruction can vary among individuals. Among the various factors that impact reading skills like reading exposure and oral language skills, reading instruction is critical in facilitating children's development into skilled readers; it can significantly influence reading strategies, and contribute to individual differences in reading. To investigate this assumption, we developed a computational model of reading with an optimised MikeNet simulator. In keeping with educational practices, the model underwent training with three different instructional methods: phonology-focused training, meaning-focused training, and phonology-meaning balanced training. We used semantic reliance (SR), a measure of the relative reliance on print-to-sound and print-to-meaning mappings under the different training conditions in the model, as an indicator of individual differences in reading. The simulation results demonstrated a direct link between SR levels and the type of reading instruction. Additionally, the SR scores were able to predict model performance in reading-aloud tasks: higher SR scores were correlated with increased phonological errors and reduced phonological activation. These findings are consistent with data from both behavioral and neuroimaging studies and offer insights into the impact of instructional methods on reading behaviors, while revealing individual differences in reading and the importance of integrating OP and OS instruction approaches for beginning readers.

19.
Front Immunol ; 15: 1393839, 2024.
Article in English | MEDLINE | ID: mdl-38975336

ABSTRACT

Introduction: Therapeutic monoclonal antibodies (mAbs) have demonstrated promising outcomes in diverse clinical indications, including but not limited to graft rejection, cancer, and autoimmune diseases lately.Recognizing the crucial need for the scientific community to quickly and easily access dependable information on monoclonal antibodies (mAbs), IMGT®, the international ImMunoGeneTics information system®, provides a unique and invaluable resource: IMGT/mAb-DB, a comprehensive database of therapeutic mAbs, accessible via a user-friendly web interface. However, this approach restricts more sophisticated queries and segregates information from other databases. Methods: To connect IMGT/mAb-DB with the rest of the IMGT databases, we created IMGT/mAb-KG, a knowledge graph for therapeutic monoclonal antibodies connected to IMGT structures and genomics databases. IMGT/mAb-KG is developed using the most effective methodologies and standards of semantic web and acquires data from IMGT/mAb-DB. Concerning interoperability, IMGT/mAb-KG reuses terms from biomedical resources and is connected to related resources. Results and discussion: In February 2024, IMGT/mAb-KG, encompassing a total of 139,629 triplets, provides access to 1,489 mAbs, approximately 500 targets, and over 500 clinical indications. It offers detailed insights into the mechanisms of action of mAbs, their construction, and their various products and associated studies. Linked to other resources such as Thera-SAbDab (Therapeutic Structural Antibody Database), PharmGKB (a comprehensive resource curating knowledge on the impact of genetic variation on drug response), PubMed, and HGNC (HUGO Gene Nomenclature Committee), IMGT/mAb-KG is an essential resource for mAb development. A user-friendly web interface facilitates the exploration and analyse of the content of IMGT/mAb-KG.


Subject(s)
Antibodies, Monoclonal , Humans , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal/immunology , Immunogenetics/methods , Databases, Factual
20.
Front Psychol ; 15: 1406811, 2024.
Article in English | MEDLINE | ID: mdl-38984271

ABSTRACT

This research explores the mechanisms underlying the intuitive processing of semantic coherence, focusing on the effects of semantic and perceptual priming on semantic coherence detection. Two studies examined how these priming types influence individuals' abilities to discern semantic incoherence. In Study 1, we used solutions to semantically coherent triads as primes, finding that such priming significantly improves participants' accuracy and confidence in identifying incoherent elements within word tetrads. These results corroborate the hypothesis that intuitive judgments in linguistic tasks are closely tied to the processing fluency elicited by semantic connections. In Study 2, we show that perceptual priming does not significantly enhance accuracy, albeit it does increase the confidence with which individuals make their judgments. Distinct effects of semantic and perceptual priming on intuitive judgments highlight the complex interplay between processing fluency and affect in shaping intuitive judgments of semantic coherence. We discuss the nuanced roles of semantic and perceptual factors in influencing the accuracy and confidence of intuitive decisions.

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