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1.
Gerontol Geriatr Med ; 10: 23337214241278132, 2024.
Article in English | MEDLINE | ID: mdl-39372892

ABSTRACT

This study aimed to describe the gender roles of people interested in an exercise program done on outdoor exercise structures and test if gender roles were associated with studied outcomes. Older adults aged 65+ who were not currently performing resistance training were invited to participate. Gender roles were quantified using the Bem Sex Role Inventory 30-item questionnaire (-60 [feminine] to +60 [masculine]). Outcomes included completing the 6-week intervention (Y/N) and changes in physical function (one leg stance, 30-s chair stand), strength (predicted maximal chest press and leg press, grip strength), power (knee extensor power), and overall health via the SF-36 questionnaire. Twenty-nine adults (65.5% female; median 72 years old) participated in the study, and 17 completed the intervention (58.6%). The median (interquartile) gender role score was -13.0 (-19.5 to -8.5), with no gender role difference (p = .62) between completers and non-completers. These results suggest that older adults interested in such a program portray themselves as more feminine. No association was found between gender role scores and changes in any study outcomes. In this setting, gender roles did not seem to impact the study outcomes and therefore may not need to be considered when designing an outdoor exercise structure program.

2.
Scand J Med Sci Sports ; 34(10): e14736, 2024 Oct.
Article in English | MEDLINE | ID: mdl-39366923

ABSTRACT

Skeletal muscle mass plays a pivotal role in metabolic function, but conditions such as bed rest or injury often render resistance training impractical. The beta2-adrenergic receptor has been highlighted as a potential target to promote muscle hypertrophy and treat atrophic conditions. Here, we investigate the proteomic changes associated with beta2-adrenergic-mediated muscle hypertrophy, using resistance training as a hypertrophic comparator. We utilize MS-based proteomics to map skeletal muscle proteome remodeling in response to beta2-adrenergic stimulation or resistance training as well as cell model validation. We report that beta2-adrenergic stimulation mimics multiple features of resistance training in proteome-wide remodeling, comprising systematic upregulation of ribosomal subunits and concomitant downregulation of mitochondrial proteins. Approximately 20% of proteins were regulated in both conditions, comprising proteins involved in steroid metabolism (AKR1C1, AKR1C2, AKRC1C3), protein-folding (SERPINB1), and extracellular matrix organization (COL1A1, COL1A2). Among overall most significantly upregulated proteins were kelch-like family members (KLHL) 40 and 41. In follow-up experiments, we identify KLHL41 as having novel implications for beta2-adrenergic-mediated muscle hypertrophy. Treating C2C12 cells with beta2-agonist for 96 h increased myotube diameter by 48% (p < 0.001). This anabolic effect was abolished by prior knockdown of KLHL41. Using siRNA, KLHL41 abundance was decreased by 60%, and the anabolic response to beta2-agonist was diminished (+ 15%, i.e., greater in the presence of KLHL41, knock-down × treatment: p = 0.004). In conclusion, protein-wide remodeling induced by beta2-adrenergic stimulation mimics multiple features of resistance training, and thus the beta2-adrenergic receptor may be a target with therapeutic potential in the treatment of muscle wasting conditions without imposing mechanical load.


Subject(s)
Muscle, Skeletal , Resistance Training , Humans , Muscle, Skeletal/drug effects , Muscle, Skeletal/metabolism , Male , Adaptation, Physiological , Adrenergic beta-2 Receptor Agonists/pharmacology , Proteomics , Adult , Proteome , Cell Line , Muscle Proteins/metabolism , Mice , Young Adult , Receptors, Adrenergic, beta-2/metabolism , Animals
3.
Article in English | MEDLINE | ID: mdl-39357505

ABSTRACT

Background: Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease associated with respiratory muscle weakness and activity-limiting symptoms such as dyspnea. Respiratory muscle strength training (RMST) is an empirically validated therapy to increase respiratory muscle strength. The theoretically-informed, technology-enhanced RESP-FIT intervention for COPD is a 6-week combined inspiratory and expiratory muscle strength training program with symptom measurement in real time via ecological momentary assessment (EMA). Objectives: In addition to hypothesis generating purposes, the purpose of this randomized control pilot study was to explore whether observed effects (on symptoms, patient-reported outcomes, and respiratory muscle strength) support carrying out a future large-scale trial of RESP-FIT. Methods: Thirty adults with COPD were randomized to intervention (n=15) or control, with intervention group undergoing 6 weeks of mHealth-enhanced RMST. Daily symptom data were collected in real time over the 6-week intervention period using EMA. Results: Compared to the control group, participants in the intervention group reported decreased dyspnea and anxiety, increased happiness, and improved respiratory muscle strength (PIMax). However, reports of fatigue and sleep disturbance increased in the intervention group compared to the control group. Conclusion: Results support the hypothesis that the 6-week RESP-FIT program will improve respiratory muscle strength, emotional state (anxiety and happiness), and breathlessness in COPD but may contribute to fatigue, at least in the short-term. Future work is needed to determine efficacy of RESP-FIT, determine mechanisms of action on dyspnea and fatigue, and conduct within-subject comparisons of EMA data to explore individual or environmental fluctuations in COPD symptoms.

4.
MethodsX ; 13: 102957, 2024 Dec.
Article in English | MEDLINE | ID: mdl-39376683

ABSTRACT

Myotonic dystrophy Type 1 (DM1) is a neuromuscular disease characterized by multisystemic involvement including a progressive loss of muscle mass and strength. Further investigation on the effect of exercise in adults with DM1 is needed to incorporate impactful recent findings to better understand the utility of exercise as an intervention. This review aims to summarize and appraise the literature on the effects of aerobic and strength training on clinical and physiological variables in adults with DM1. Six online databases (PubMed, Scopus, Web of Science, CINAHL, EMBASE, and CENTRAL) will be searched using appropriate search terms. Two reviewers will independently screen the relevant studies and extract the data from the selected articles. The methodological quality of the studies included will be assessed using the Joanna Briggs Critical Appraisal checklist. A meta-analysis will be performed if appropriate. This systematic review and meta-analysis will summarize, synthesize, and appraise evidence on the effect of aerobic and strength training on clinical and physiological variables in adults with DM1. The findings of this review will help in clinical decision-making and guide future researchers working with this patient population.

5.
Eur J Neurosci ; 2024 Oct 02.
Article in English | MEDLINE | ID: mdl-39358929

ABSTRACT

To assess reticulospinal tract excitability, high-intensity transcranial magnetic stimulation (TMS) has been used to elicit ipsilateral motor-evoked potentials (iMEPs). However, there is no consensus on robust and valid methods for use in human studies. The present study proposes a standardized method for eliciting and analysing iMEPs in the biceps brachii. Twenty-four healthy young adults participated in this study. Electromyography (EMG) electrodes recorded contralateral MEPs (cMEPs) from the right and iMEPs from the left biceps brachii. A dynamic preacher curl task was used with ~15% of the subject's one-repetition maximum load. The protocol included maximal compound action potential (M-max) determination of the right biceps brachii muscle, TMS hotspot determination, and four sets of five repetitions where 100% stimulator output was delivered at an elbow angle of 110° of flexion. We normalized cMEP amplitude by M-max (% M-max) and iMEP by cMEP amplitude ratio (ICAR). Clear iMEPs above background EMG were observed in 21 subjects (88%, ICAR = .31 ± .19). Good-to-excellent agreement (intraclass correlation coefficient [ICC] = .795-1.000) and low bias (.01-.08 mV and .60-1.11 ms) were demonstrated when comparing two different analysis methods (i.e. fixed time-window vs. manual onset detection) to determine the cMEP and iMEP amplitude and latency, respectively. Most subjects demonstrated clear iMEPs above background EMG triggered at a pre-determined joint angle during a light-load dynamic preacher curl exercise. Similar results were obtained when comparing a single-trial manual identification of iMEP and a semi-automated time-window data analysis approach.

6.
Front Psychol ; 15: 1439431, 2024.
Article in English | MEDLINE | ID: mdl-39286563

ABSTRACT

Background: Despite extensive research on the relationship between psychological factors and aerobic training, there remains a gap in understanding these relationships within resistance training (RT), particularly barbell-based RT. This study aimed to examine the associations between basic psychological needs, behavioral regulation, self-efficacy, and a longitudinal barbell-based RT program for adults. Methods: Forty-three adults (M age = 45.09 ± 10.72) were recruited from the Competitive Edge resistance training program at a medical fitness center in Northwest Montana. The study followed an 18-week schedule: 8 weeks of training, 1 week of active recovery, and 8 additional weeks of training. Results: The results reveal several significant findings. First, the basic psychological need for competence significantly increased from baseline (M = 5.06) to post-program (M = 5.30), (p = 0.017). Second, the composite score of the BREQ-3 significantly predicting muscular strength improvements in the deadlift (ß = 3.64, p = 0.039). Third, both mastery (p = 0.021) and resilience (p = 0.007) self-efficacy subscales increased from baseline to post-program. Fourth, exploratory analyses indicated that the reasons to exercise scale predicted increases in muscular endurance with the weight management (ß = 10.016, p = 0.046) and solitude (ß = 6.792, p = 0.037) subscales. Conclusion: These findings highlight the importance of psychological factors in predicting strength outcomes and muscular endurance, suggesting that psychological interventions may complement physical training to maximize benefits. This research contributes valuable insights into how psychological factors influence training outcomes, potentially guiding future interventions and program designs to better support strength development and endurance in resistance training contexts.

7.
Exp Gerontol ; 196: 112582, 2024 Oct 15.
Article in English | MEDLINE | ID: mdl-39288885

ABSTRACT

INTRODUCTION: Older adults are at risk of developing new or worsened disability when hospitalized for acute medical illness. This study is a secondary analysis of the STAND-Cph trial on the effect of a simple strength training intervention initiated during hospitalization and continued after discharge. We investigated the between-group difference in change in functional performance outcomes, the characteristics of patients who experienced a relevant effect of the intervention, and the characteristics of those who were compliant with the intervention, using an expanded sample size as protocolized. METHODS: The STAND-Cph was a randomized controlled trial conducted at a major Danish university hospital. Acutely admitted older adult patients (65+) from the Emergency Department were randomized to the intervention group receiving progressive strength training and a protein supplement during and after hospitalization (12 sessions over 4 weeks) or control group receiving usual care. The primary outcome was the de Morton Mobility Index assessed at baseline and 4 weeks after discharge. The secondary outcomes were 24-h mobility (assessed by ActivPAL accelerometers), isometric knee-extension strength, 30 s. sit-to-stand performance, and habitual gait speed. RESULTS: Between September 2013 and September 2018, a total of 158 patients were included and randomized to either the intervention group (N = 80; mean age 79.9 ± 7.6 years) or the control group (N = 78; mean age 80.8 ± 7.4 years). We found no significant between-group difference in change in our primary outcome (p > 0.05). Both the intention-to-treat (difference in change 0.14 Nm/kg (95 % CI 0.03;0.24), p = 0.01) and the per protocol (difference in change 0.16 Nm/kg (95 % CI 0.04;0.29), p = 0.008) analyses showed that between baseline and 4 weeks, knee-extension strength increased significantly more in the intervention group than in the control group. Also, the per protocol analysis showed that the intervention group increased their daily number of steps significantly more than the control group (difference in change 1088 steps (95 % CI 44; 2132); p = 0.04). When examining subgroups of patients, we found no significant differences neither between those who experienced a clinically relevant improvement in the de Morton Mobility Index and those who did not, nor between those who were compliant and those who were not. CONCLUSION: This exploratory analysis indicates that while simple progressive strength training and protein supplementation does not improve functional performance assessed by the de Morton Mobility Index, it can benefit specific facets of physical activity and muscle strength among geriatric patients.


Subject(s)
Muscle Strength , Resistance Training , Humans , Aged , Male , Female , Resistance Training/methods , Muscle Strength/physiology , Single-Blind Method , Aged, 80 and over , Hospitalization , Denmark , Sample Size , Walking Speed , Treatment Outcome , Dietary Supplements
8.
Front Physiol ; 15: 1455506, 2024.
Article in English | MEDLINE | ID: mdl-39268192

ABSTRACT

Optimal load training is a method of training that aims to maximize power output. This is achieved by arranging optimal loads (optimal ratios of load intensity and load volume) during strength training. The fixed load intensity and number of repetitions employed in traditional strength training. The present study will investigate the applicability of these two load arrangements to female elite boxers. Twenty-four elite female boxers were divided into three groups [optimal load (OL = 8), traditional load (TL = 8) and control group (CG = 8)]. The six-week intervention consisted of strength training with different loading arrangements. The punching ability and strength were tested before and after the intervention. We found that optimal load training enhances a boxer's punching ability and economy, which aligns with the demands of boxing and is suitable for high-level athletes, whose strength training loads require a more individualised and targeted approach.

9.
Sports Med Health Sci ; 6(4): 324-330, 2024 Dec.
Article in English | MEDLINE | ID: mdl-39309458

ABSTRACT

Obesity has a complex multifactorial etiology and is characterized by excessive accumulation of adipose tissue. Visceral adipose tissue has deleterious effects on health because it secretes large amounts of inflammatory cytokines. Nutritional calorie restriction associated with strength training may be useful in managing chronic systemic inflammation. This study aimed to evaluate the acute effect of a single strength-training session on plasma adipokine levels in sedentary, overweight, and obese young men. This study included twelve men (Age: [34.95 â€‹± â€‹9.77] years; Height: [174.16 â€‹± â€‹3.66] centimeter [cm]; Weight: [97.83 â€‹± â€‹12.87] kilogram (kg); body mass index [BMI]: [32.30 â€‹± â€‹4.51] kg/m2), who performed a single strength training session. The strength training protocol consisted of 4 sets of 12 repetitions in the following six exercises, 45° leg press, bench press, leg extension, machine row, leg curl, and shoulder press. Blood samples were collected before, immediately after, and 1-h subsequent after strength training. The plasma levels of resistin and leptin were measured. A significant decrease in resistin levels were found 1 â€‹h after the strength training session if compared to levels before the training session (pre-[before] [2 390 â€‹± â€‹1 199] picograms per milliliter [pg/mL] vs post-1 h [1-h subsequent] [1 523 â€‹± â€‹798],6 â€‹pg/mL, p â€‹= â€‹0.002 8). The plasma leptin levels did not differ at any time point. In conclusion, a very well controlled single session of strength training significantly decreased the plasma levels of resistin without altering the concentration of leptin in overweight and obese individuals. This effect, at least in part, supports the benefits of exercise by reducing the low grade inflammation and insulin resistance in obesity.

10.
Sleep ; 2024 Sep 19.
Article in English | MEDLINE | ID: mdl-39297486

ABSTRACT

STUDY OBJECTIVES: This study aimed to evaluate and compare the effects of high and low-intensity expiratory muscle strength training (EMST) on disease severity, systemic inflammation, oxidative stress, respiratory muscle strength, exercise capacity, symptoms, daytime sleepiness, fatigue severity, and sleep quality in male patients with obstructive sleep apnea syndrome (OSAS). METHODS: Thirty-one male patients diagnosed with moderate OSAS were included in this double-blind, randomized, parallel study. Patients were randomized into two groups: High-EMST and Low-EMST groups. EMST was used at home 7 days/week, once a day, for 25 breaths, 12 weeks. Respiratory muscle strength was measured using a mouth pressure device. Disease severity (Apne Hipopne Index-AHI) and, respiratory sleep events by polysomnography, total oxidant level(TOS), total antioxidant level(TAS), oxidative stress index (OSI), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels by blood serum were evaluated. RESULTS: The percentage of AHI change in the High-EMST group(50.8%) was significantly higher than in the Low-EMST group(6.3%) (p=0.002, d=1.31). In general, as MEP increased by one unit, AHI decreased by 0.149 points (b=-0.149; CR=-3.065; p=0.002), and as AHI increased by one unit, ODI increased by 0.746 points (b=0.746; CR=10.604; p<0.001). TOS, OSI, TNF-α and IL-6 levels decreased at similar rates in both groups. CONCLUSION: EMST significantly reduces systemic inflammation and oxidative stress while improving expiratory muscle strength in male patients with moderate OSAS. High-EMST is more effective in enhancing the severity of disease than Low-EMST. EMST is a practical, effective, and promising treatment for pulmonary rehabilitation in patients with moderate OSAS.

11.
J Musculoskelet Neuronal Interact ; 24(3): 276-283, 2024 Sep 01.
Article in English | MEDLINE | ID: mdl-39219325

ABSTRACT

OBJECTIVE: The bench press is a resistance training exercise that targets several upper body muscles, including the pectoralis major (PM), anterior deltoid (AD), and triceps brachii (TB). The purpose of this study was to influence the PM activity pattern during the bench press after a 10-week targeted resistance training intervention. METHODS: Sixteen men with significant experience in strength training participated in this study. They were divided into two groups: experimental and control. The experimental group underwent targeted training of PM and bench press, while the control group only did bench press. Electromyography (EMG) was used to assess muscle activity before and after the intervention. RESULTS: The experimental group had a significant increase in PM activity after the intervention (p=0.0002; ES=2.6), while the control group did not show any significant change (p=0.14). The activity of AD and TB remained relatively stable across both groups and time points. CONCLUSIONS: These findings indicate that focused resistance training can improve PM involvement in the bench press, potentially optimizing muscle excitation patterns and performance.


Subject(s)
Electromyography , Pectoralis Muscles , Resistance Training , Humans , Male , Resistance Training/methods , Pectoralis Muscles/physiology , Adult , Young Adult , Weight Lifting/physiology
12.
Article in English | MEDLINE | ID: mdl-39259166

ABSTRACT

BACKGROUND: Resistance exercise (RE) increases collagen synthesis in young and older men, while hydrolyzed collagen (HC) ingestion improves this response to RE in a dose-response manner in young men. However, the collagen synthesis response to RE with and without HC in middle-aged men is unknown. METHODS: Eight resistance-trained men (age: 49±8 years; height: 1.78±0.02m; mass: 90±4kg) took part in this double-blind, crossover design study, and undertook 4×10 repetitions of lower-limb RE at maximum load, after consuming 0g, 15g, or 30g vitamin C-enriched HC. We analyzed venous blood samples for N-terminal propeptide of type 1 pro-collagen (PINP), ß-isomerized C-terminal telopeptide of type 1 collagen (ß-CTx) and 18 collagen amino acids throughout all three interventions. RESULTS: The serum PINP concentration×time area-under-the-curve (AUC) was higher following 30g (169±28 µg/mL×h) than 15g (134±23 µg/mL×h, P<0.05) HC ingestion, and both 15g and 30g were higher than 0g HC (96±23 µg/mL×h, P<0.05). RE with 0g HC showed no change in serum PINP concentration. The AUCs for glycine, proline, hydroxyproline, alanine, arginine, lysine, serine, leucine, valine and isoleucine were greater with 30g than 15g and 0g HC ingestion (P<0.05), and greater with 15g than 0g HC ingestion (P<0.05). Plasma ß-CTx concentration decreased after RE independently of HC dose. CONCLUSIONS: Our study suggests connective tissue anabolic resistance to RE in middle-aged men but ingesting 15g HC rescues the collagen synthesis response, and 30g augments that response further. This dose-response is associated with the increased bioavailability of collagen amino acids in the blood, which stimulate collagen synthesis.

13.
Dev Neurorehabil ; 27(7): 235-242, 2024 Oct.
Article in English | MEDLINE | ID: mdl-39311681

ABSTRACT

PURPOSE: This pilot study assessed the safety and effects of progressive functional high-intensity training in a group setting for adolescents with unilateral cerebral palsy (CP) on daily function indicators. METHODS: Nine adolescents (mean age 16.9 years, GMFCS levels I-II) participated in 12 weeks of training (2x/week). Evaluations included 3D gait analysis, the 6-min walking test (6MWT), clinical exams, and the Gross Motor Function Measure-66 (GMFM-66). RESULTS: No adverse events occurred, and GMFM-66 scores significantly improved (p = .031, Δ = 2.19%). Although increases in 6MWT (p = .09, Δ = 29.8 m) performance and propulsion ratio (p = .067, Δ = 5.4%) for the affected leg were observed, they were not statistically significant. DISCUSSION: The study suggests that this training is safe and may enhance gross motor function, endurance, and gait asymmetry in unilateral CP. Future research should include upper limb evaluations and out-of-clinic motion analysis with wearable inertial measurement units (IMUs) to provide a more comprehensive assessment of functional movements.


Subject(s)
Cerebral Palsy , Humans , Cerebral Palsy/rehabilitation , Cerebral Palsy/physiopathology , Pilot Projects , Adolescent , Male , Female , Young Adult , Gait/physiology , Physical Endurance/physiology , High-Intensity Interval Training/methods , Exercise Therapy/methods , Treatment Outcome
14.
Dysphagia ; 2024 Sep 19.
Article in English | MEDLINE | ID: mdl-39299941

ABSTRACT

Despite the high estimated prevalence of dysphagia in OSA, there is a paucity of evidence supporting behavioral interventions for treatment. The purpose of this study was to assess the impact of expiratory muscle strength training (EMST) on validated, standardized metrics of swallow and airway clearance capacity functions in moderate-to-severe OSA. 10 participants with OSA (mean age = 65.2 years) completed four weeks of EMST training employing a prospective single-arm, double-baseline interventional design. The Modified Barium Swallow Impairment Profile (MBSImP) Component and Composite (Oral Total [OT] and Pharyngeal Total [PT]) scores measured swallow physiology. Airway clearance capacity measures included maximum expiratory pressure (MEP) and peak cough flow (PCF). A historical normative database was used for OSA patient comparison of swallowing metrics. A total of 234 swallows were analyzed. At baseline, impairments in lingual control, oral residue and esophageal clearance were observed. However, no significant differences in the MBSImP Composite (OT/PT) scores were observed between the OSA and healthy referent group. After EMST intervention, there were no significant differences in pre- to post-intervention Composite (OT/PT) scores. However, large effect size was observed for MEP (p < 0.001, d = 3.0), and non-significant, but moderate effect size was observed in PCF (p = 0.19, d = 0.44). Study findings further quantify swallowing in moderate-to-severe OSA and provide preliminary evidence supporting the impact of EMST on airway clearance capacity.

15.
Front Physiol ; 15: 1449149, 2024.
Article in English | MEDLINE | ID: mdl-39345786

ABSTRACT

Background: Adolescent tennis players encounter critical physical demands, but the lack of comprehensive analysis of training types hampers the selection of optimal training programs. This study aims to conduct a systematic literature review to analyze the effectiveness and limitations of various training types on the physical demands of adolescent tennis players, summarizing the optimal training methods to enhance these physical qualities. Methods: From March 2024, a comprehensive search was conducted across four electronic databases: SCOPUS, PubMed, EBSCOhost (SPORTDiscus), and Web of Science. Additionally, Google Scholar and other sources of gray literature were referenced. Original research articles with an experimental design were included. The methodological quality of the included studies was evaluated using the Physiotherapy Evidence Database (PEDro) scale, and the overall scientific evidence was determined through the best evidence synthesis (BES). Results: Eighteen articles on exercise training met all inclusion criteria and were included in this systematic review. These studies maintained a high standard of quality, making their findings relatively credible. Among them, five studies investigated plyometric training, five focused on neuromuscular training, three explored functional training, two examined traditional strength training, and three assessed High-Intensity Interval Training. Conclusion: To enhance speed, strength, power, agility, and dynamic balance, it is recommended to prioritize plyometric training, neuromuscular training, and functional training over traditional tennis training. Functional training is particularly effective for improving flexibility and balance, while plyometric training is more suited for increasing power and speed. Neuromuscular training, when performed before routine workouts, is beneficial for enhancing speed, flexibility, and strength. Hard surface training is ideal for boosting power, whereas sand training excels in improving strength, speed, and balance. Combining HIIT with strength training is especially advantageous for enhancing short-distance sprinting, repeated sprint ability, and power. By appropriately combining and utilizing these training methods, the physical capabilities and sports performance of adolescent tennis players can be comprehensively optimized. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42024578147.

16.
Front Endocrinol (Lausanne) ; 15: 1383131, 2024.
Article in English | MEDLINE | ID: mdl-39345888

ABSTRACT

Type 2 diabetes mellitus (T2DM) is a complex, chronic metabolic disease that carries with it a high prevalence of comorbid conditions, making T2DM one of the leading causes of death in the U.S. Traditional lifestyle interventions (e.g., diet, exercise) can counter some adverse effects of T2DM, however, participation in these activities is low with reasons ranging from physical discomfort to lack of time. Thus, there is a critical need to develop novel management strategies that effectively reduce cardiometabolic disease risk and address barriers to adherence. High-resistance inspiratory muscle strength training (IMST) is a time-efficient and simple breathing exercise that significantly reduces systolic and diastolic BP and improves vascular endothelial function in adults with above-normal blood pressure. Herein we describe the study protocol for a randomized clinical trial to determine the effects of a 6-week IMST regimen on glycemic control and insulin sensitivity in adults with T2DM. Our primary outcome measures include fasting plasma glucose, fasting serum insulin, and insulin resistance utilizing homeostatic model assessment for insulin resistance (HOMA-IR). Secondary outcome measures include resting systolic BP and endothelium-dependent dilation. Further, we will collect plasma for exploratory proteomic analyses. This trial seeks to establish the cardiometabolic effects of 6 weeks of high-resistance IMST in patients with T2DM.


Subject(s)
Breathing Exercises , Diabetes Mellitus, Type 2 , Resistance Training , Respiratory Muscles , Humans , Diabetes Mellitus, Type 2/therapy , Diabetes Mellitus, Type 2/physiopathology , Respiratory Muscles/physiopathology , Breathing Exercises/methods , Resistance Training/methods , Insulin Resistance , Male , Female , Muscle Strength/physiology , Adult , Middle Aged , Cardiovascular Diseases/prevention & control , Cardiovascular Diseases/etiology , Blood Glucose/metabolism
17.
Obes Surg ; 34(10): 3755-3759, 2024 Oct.
Article in English | MEDLINE | ID: mdl-39251568

ABSTRACT

BACKGROUND: This study examines whether creatine supplementation combined with strength training mitigates muscle mass loss in women during early rehabilitation post-bariatric surgery, as its effectiveness remains untested in this context. METHODS: Fifteen women (37.8 ± 9.6 years; BMI, 38.8 ± 5.6 kg/m2) completed the intervention (creatine group = 7; placebo group = 8). Both groups followed a strength training program three times a week for 8 weeks. The dosage for both the creatine and placebo was 8 g prior to each exercise session. Body weight, skeletal muscle mass, fat mass, handgrip strength, and physical activity levels were measured before and after the intervention. RESULTS: The creatine group showed a reduction of 9.5 ± 1.5 kg in body weight, with a 0.72 ± 0.6 kg decrease in muscle mass and an 8.64 ± 1.2 kg reduction in fat mass. The placebo group had a reduction of 9.6 ± 3.5 kg in body weight, with a 0.6 ± 1.2 kg decrease in muscle mass and an 8.88 ± 3.2 kg reduction in fat mass, without significant differences between groups (p > 0.05). CONCLUSION: The pre-session strength exercise training creatine supplementation is not superior to placebo regarding body weight and fat mass losses and the attenuation of muscle mass loss during the first weeks of rehabilitation following bariatric surgery.


Subject(s)
Bariatric Surgery , Creatine , Dietary Supplements , Muscle, Skeletal , Resistance Training , Humans , Female , Creatine/administration & dosage , Pilot Projects , Adult , Resistance Training/methods , Muscle, Skeletal/drug effects , Weight Loss , Obesity, Morbid/surgery , Hand Strength , Middle Aged , Muscle Strength/physiology , Muscle Strength/drug effects
18.
Cureus ; 16(8): e68033, 2024 Aug.
Article in English | MEDLINE | ID: mdl-39347149

ABSTRACT

This narrative review analyzes muscle strength recovery following total hip replacement (THR) and looks at various factors affecting postoperative muscle function restoration. The review synthesizes evidence from various studies regarding the timing and degree of muscular strength recovery, different rehabilitation protocols, and patient-specific variables such as age, preoperative physical condition, and comorbidities, among others. Overall, it appears that THR is associated with improved hip function and quality of life, but this usually takes a long time due to individualized physical therapy interventions. In addition, postoperative rehabilitation has been found not to exist without any personal factors involved such as age or gender whereby for instance senior citizens have no alternative but to go for THR surgery, making their lower limbs weaker than those who are younger. Based on the findings in this review on muscle recovery after THR surgeries, one may conclude that this endeavor should begin as early as possible and include regular resistance training programs with performance-focused functional training after surgery. In addition, more longitudinal studies should be conducted regarding post-surgical outcomes comparing other traditional medical practices.

19.
J Sci Med Sport ; 2024 Sep 19.
Article in English | MEDLINE | ID: mdl-39341781

ABSTRACT

BACKGROUNDS: Falls affect a significant number of older Australians and present a major challenge to health care providers and health systems with over 380 older Australians hospitalised for a fall each day. OBJECTIVES: This statement seeks to inform and guide exercise practitioners and health professionals in safe and effective prescription of exercise to prevent falls amongst community-dwelling older people. EXERCISE PRESCRIPTION TO PREVENT FALLS: Exercise is crucial for preventing falls in older age. Research evidence has identified that programmes which include functional balance and muscle strength training are the most effective in preventing falls. It is also important for exercise to be progressively challenging, ongoing and of sufficient dose to maximise its benefits in reducing falls. Additional (non-exercise) interventions are necessary for people with complex medical conditions, recent hospitalisation and/or particular risk factors not improved by exercise. People at a higher risk of falls may need greater support to undertake safe and effective fall prevention exercise. SUMMARY: Global guidelines for fall prevention and management recommend that all older adults should receive advice about exercise to prevent falls. Qualified exercise professionals are well placed to prescribe and supervise functional balance and muscle strength training to older people with varied functional abilities, including those with co-morbidities.

20.
Exp Physiol ; 2024 Sep 05.
Article in English | MEDLINE | ID: mdl-39235953

ABSTRACT

Cross-education describes the training of one limb that leads to performance enhancements in the contralateral untrained limb, driven by neural changes rather than muscle adaptation. In this systematic review and meta-analysis, we aimed to evaluate the efficacy of cross-education (vs. a control group) via resistance exercise training (RET) for improving muscle strength in the untrained lower limb of healthy males and females. A literature search from inception to September 2023 was conducted using MEDLINE (via PubMed), the Cochrane Library (CENTRAL), Web of Science (Core Database), Scopus, EBSCO-host, and Ovid-EMBASE. Independent screening, data extraction and quality assessment were conducted. The measured outcomes were change in one-repetition maximum (1-RM) load, maximum voluntary contraction (MVC), and concentric, eccentric and isometric peak torque. Change in muscle structure (pennation angle and muscle thickness) was also analysed. A total of 29 studies were included. The pooled effect size from the random-effects model shows that cross-education significantly increased 1-RM compared to the control group (standardised mean difference (SMD): 0.59, 95% CI: 0.22-0.97; P = 0.002). Cross-education also significantly improved MVC (SMD: 0.55, 95% CI: 0.16-0.94; P = 0.006), concentric (SMD: 0.61, 95% CI: 0.39-0.84; P < 0.00001), eccentric (SMD: 0.39, 95% CI: 0.13-0.64; P = 0.003) and isometric (SMD: 0.45, 95% CI: 0.26-0.64; P < 0.00001) peak torque, each compared to the control group. When RET was categorised as eccentric or concentric, subgroup analysis showed that only eccentric training was associated with significantly increased isometric peak torque via cross-education (SMD: 0.37, 95% CI: 0.13-0.61; P = 0.003) (concentric, SMD: 0.33, 95% CI: -0.09 to 0.74; P = 0.12). This systematic review and meta-analysis emphasise the potency of cross-education for improving lower limb muscle strength. These findings have potential implications for clinical situations of impaired unilateral limb function (e.g., limb-casting or stroke). Future work exploring the mechanisms facilitating these enhancements will help to develop optimised rehabilitation protocols.

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