How does the data element-driven industry affect corporate cash holdings? Evidence from Chinese listed companies.

The data element-driven industry (DEDI) generates large amounts of data, thereby mitigating information asymmetry. Does this affect corporate cash holdings? On the basis of theoretical analysis, this study empirically analyzes the impact of DEDI on enterprises' cash holdings and its transmission path using data of Chinese cities and A-share listed enterprises from 2008 to 2020. First, the results indicate that the DEDI reduces corporate cash holdings. As the development level of the DEDI improves, the corporate cash holdings gradually decrease. Second, the DEDI indirectly affects corporate cash holdings by influencing debt-financing and external credit supply capacities. Specifically, the DEDI increases the upstream corporate debt-financing and downstream corporate external credit supply capacities. Improvements in debt-financing and the external credit supply capacities can reduce corporate cash holdings. Third, the DEDI has a heterogeneous impact. For enterprise with CEO duality, small and medium-sized, and information technology enterprises, the impact of DEDI in reducing cash holdings is greater.

How does urbanization impact China's carbon emissions: A regional heterogeneity perspective.

In the context of China's green development and "dual carbon" goal, urbanization, as a way to achieve Chinese modernization, has a particularly important effect on green and low-carbon economic development. Firstly, this paper empirically analyzed the influence of urbanization on per capita carbon emissions using Chinese city data and a panel fixed-effects model. Then, the impact mechanisms of urbanization on carbon emissions were examined from both the demand and supply sides. Finally, we analyzed the differences in the transmission mechanisms of urbanization affecting carbon emissions in the eastern, central, and western regions. The results show that (1) urbanization increases per capita carbon emissions. However, this effect shows inter-regional differences, with more significant promotion effects in the eastern and central regions; (2) on the demand side, the residents' consumption intensity can drive carbon emissions, while the rise of human capital agglomeration suppresses carbon emissions; on the supply side, industrial structure can drive carbon emissions, while the increase of green technological innovation suppresses carbon emissions; (3) the consumption effect and the industry effect play a major role in the eastern and central regions, while the intermediary effect is not obvious in the western region. This study can provide important insights for synergizing urbanization and achieving carbon reduction commitments.

Rethinking counterfeit medical supply chains: A critical review of the current literature.

The medical device and pharmaceutical industries include a range of drugs, machines, instruments, and apparatuses used to prevent, diagnose, treat disease and illness, or aid in rehabilitation for patients, and are expected to grow substantially in the coming years. However, they are often targets of criminal organizations who manufacture and profit from fraudulent products, infiltrating the market with counterfeit medical supply chains. In this paper, we discuss and analyze the extent and nature of this problem and make suggestions for mitigation and prevention of this worldwide challenge. Ultimately, we argue that a holistic approach is essential to addressing this problem, including the creation and dissemination of reliable and good quality data, developing healthcare systems to be more robust, establishing/enhancing intra- and international cooperation around this issue, and employing effective technological solutions, such as digital tracing.

Convergent technologies to tackle challenges of modern food authentication.

The authentication process involves all the supply chain stakeholders, and it is also adopted to verify food quality and safety. Food authentication tools are an essential part of traceability systems as they provide information on the credibility of origin, species/variety identity, geographical provenance, production entity. Moreover, these systems are useful to evaluate the effect of transformation processes, conservation strategies and the reliability of packaging and distribution flows on food quality and safety. In this manuscript, we identified the innovative characteristics of food authentication systems to respond to market challenges, such as the simplification, the high sensitivity, and the non-destructive ability during authentication procedures. We also discussed the potential of the current identification systems based on molecular markers (chemical, biochemical, genetic) and the effectiveness of new technologies with reference to the miniaturized systems offered by nanotechnologies, and computer vision systems linked to artificial intelligence processes. This overview emphasizes the importance of convergent technologies in food authentication, to support molecular markers with the technological innovation offered by emerging technologies derived from biotechnologies and informatics. The potential of these strategies was evaluated on real examples of high-value food products. Technological innovation can therefore strengthen the system of molecular markers to meet the current market needs; however, food production processes are in profound evolution. The food 3D-printing and the introduction of new raw materials open new challenges for food authentication and this will require both an update of the current regulatory framework, as well as the development and adoption of new analytical systems.

Recycling channel strategy in the presence of free-riding in the carbon neutrality era.

Recycling has become a critical response to the goals of reaching a carbon peak and achieving carbon neutrality. This study explores the effects of consumer free-riding behavior, the quality of recycling services, and the costs of channel transfers on the profitability of manufacturers and retailers in a dual-channel closed-loop supply chain (CLSC), focusing on the importance of recycling practices for carbon neutrality. Using consumer utility theory and a Stackelberg game model, we analyze the dynamics among these factors. Our results show that: (i) Consumer free-riding behavior slightly increases market demand and recycling volumes, enhancing profitability for both manufacturers and retailers in the dual-channel CLSC. (ii) The quality of recycling services and the transfer costs associated with retailer free-riding behavior jointly influence the profits of manufacturers and retailers. (iii) The effect of free-riding behavior on recycling services affects both forward sales and reverse recycling channels equally. This study provides valuable insights for decision-making in sustainable development practices in the recycling sector, significantly contributing to the goal of achieving carbon neutrality.

COVID-19 as a catalyst for alcohol policy change: A case study of the Gove Peninsula.

In many ways, the COVID-19 pandemic provided a natural experiment for alternate ways of living and working. Although alcohol supply was one of many aspects impacted by COVID-19 restrictions, few of those alcohol-related measures have been continued. This commentary presents a unique case study from the Gove Peninsula in northern Australia, where pandemic restrictions acted as a catalyst for a review of an established alcohol management system. A permit system was introduced on the Gove Peninsula in 2008 to control who can purchase takeaway alcohol and how much they could buy each day. Development of the system was rooted in the principles of community development and self-determination. This commentary describes how COVID-19 and associated changes in levels of alcohol harms mobilised community support for a review of the system, that had operated unchanged for the past decade. COVID-19 was adventitious in revealing compelling localised information which encouraged examination of potential improvements to the system. An updated regime is now being trialled, which sets daily limits on the alcohol purchases of everyone in the area. This experience illustrates the benefits of timely and relevant data to assist communities in formulating local solutions to local problems.

Optimizing zoning for ecological management in alpine region by combining ecosystem service supply and demand with ecosystem resilience.

In order to enhance ecosystem stability and promote sustainable regional ecological, social, and economic development, it is crucial to explore the coupling relationship between ecosystem service supply and demand and the resilience of ecosystem, so as to propose scientific ecological management zones and strategies. Taking the vulnerable alpine ecosystem in Gannan Tibetan Autonomous Prefecture (Gannan Prefecture) as the study area, this paper comprehensively utilized multi-source data, grid analysis, ecosystem service supply and demand estimation model, and coupled coordination model to analyze the spatio-temporal differentiation and coordination pattern of ecosystem service supply and demand in the study area from 2000 to 2020. With the assistance of the Analytic Hierarchy Process (AHP), the ecosystem resilience index system was constructed to evaluate the regional ecological resilience. The results reveal the following: (1) In the past 20 years, the ecosystem service supply and resilience in Gannan Prefecture showed a fluctuating upward trend, and the demand continued to grow steadily. Their spatial differentiation were obvious, but the pattern remained stable. (2) There was a moderate incoordination indicated by the average coordination degree of the supply and demand coupling of ecosystem services, which rangeed between 0.3 and 0.4. (3) Gannan Prefecture was split into three ecological management zones, considering the spatial distribution of ecosystem service supply and demand, as well as resilience. Through system function monitoring and other measures, the ecological conservation zone will rely on its high resilience to support the restoration and self-sufficiency of the system, ensuring the stability and well-being of the ecosystem. The primary objectives of general protected zone includes environmental preservation, strict regulations, and the prevention of human intervention. To enhance their ecological background, key restoration zone must intensify the implementation of ecological restoration initiatives. To address the needs of the locals, strategies such as ecological compensation, optimizing the land use structure, and fostering the growth of environmentally friendly companies can be implemented simultaneously.

Exploring the potential for improving material utilization efficiency to secure lithium supply for China's battery supply chain.

Lithium-ion battery (LIB) is the key technology for climate change mitigation. The sustainability of LIB supply chain has caused widespread concern since the material utilization efficiency of LIB supply chain has not been well investigated. This study aims to fill this research gap by conducting a dynamic material flow analysis of lithium in China from 2015 to 2021. Results indicate that within the temporal boundary, lithium flow and in-use stock grew significantly in China due to the rapid development of the EV market, with lithium flow in domestic production of basic chemicals increasing by 614% to 100 kt, end-use consumption increasing by 160% to 35 kt, and in-use stock increasing by 62% to 195 kt. China has been a net importer of lithium, of which cumulative imports and exports were 343 kt and 169 kt, respectively. In addition, 103 kt of lithium was converted to inventories or was lost during the processing from 2015 to 2021. By optimizing inventory and processing, developing substitutes for lithium for non-battery applications, and improving lithium recycling, China's net import dependency of lithium could be reduced from 27%-86% to 0%-16%. Our study demonstrates that it is urgent to improve material utilization efficiency so that the lithium resource supply can be secured.

Risk management of sports service supply chain using fuzzy comprehensive evaluation and intelligent neural network.

The sports service supply chain faces various potential risks, such as market fluctuations, logistics issues, and partner uncertainties. To address these risks effectively, this study employs a combination of fuzzy comprehensive evaluation (FCE) methods and intelligent neural networks to create an innovative risk management framework. By considering diverse uncertainties and leveraging the analytical power of intelligent neural networks, this study aims to optimize the operation of the sports service supply chain and explore the risk factors within the public service supply chain of stadiums. This framework provides policy references to promote the healthy and sustainable development of the sports service industry. The main empirical findings, based on a representative survey of experts in China, are as follows: (1) When determining the weights of risk indicators for managing the public service supply chain of stadiums using the FCE method, the customer risk indicator is of paramount importance, with a weight of 0.286, accounting for 95.2 % of the total significance; and (2) In evaluating various risk indicators of the public service supply chain of stadiums through the neural network method, the customer risk indicator scores the highest, achieving a score of 76.02. Notably, the customer complaint risk indicator scores slightly higher at 79.33. Based on these findings, the study recommends focusing on enhancing customer experience within risk management strategies. Additionally, it suggests strengthening the supervision of platforms and third-party activities to ensure the stability and efficient operation of the stadium service supply chain. This study aims to provide theoretical support and reference indicators for evaluating the public service capabilities of stadiums.

Research and Technologies to Reduce Grain Postharvest Losses: A Review.

Reducing postharvest losses offers a significant opportunity to enhance food availability without requiring extra production resources. A substantial portion of cereal grain goes to waste annually due to a lack of science-based knowledge, unconscious handling practices, suboptimal technical efficiency, and inadequate infrastructure. This article extensively reviews losses occurring during postharvest operations across various crops, examining diverse postharvest operations in different countries. Recent advancements in postharvest technology research are thoroughly discussed. The primary obstacles and challenges hindering the adoption and implementation of postharvest technologies are also explored. The appropriate postharvest technology relies on specific factors, including the kind of crops, production locales, seasons, and existing environmental and socioeconomic conditions.

Trends in the availability and prices of quality-assured tuberculosis drugs: a systematic analysis of Global Drug Facility Product Catalogs from 2001 to 2024.

BACKGROUND: The Global Drug Facility (GDF) of the Stop TB Partnership was launched in 2001 with the goal of increasing access to quality-assured tuberculosis (TB) drugs and products. We aimed to describe the TB drugs and prices available from the GDF over time and to assess trends. METHODS: We searched the internet, including an internet archive, for past and recent GDF Product Catalogs and extracted the listed TB drugs and prices. We calculated the lowest price for the most common drug formulations assuming drugs with similar active pharmaceutical ingredients (APIs) are substitutes for each other. We assessed time trends in the TB drugs and prices offered by the GDF in univariable regressions over the longest possible period. RESULTS: We identified 43 different GDF Product Catalogs published between November 2001 and May 2024. These product catalogs included 122 single medicines (31 APIs), 28 fixed-dose combinations (9 API combinations), and 8 patient kits (8 API regimens and other materials). The number of TB drugs listed in the GDF Product Catalog increased from 9 (8 APIs) to 55 (32 APIs). The price decreased for 17, increased for 19, and showed no trend for 12 APIs. The price of 15 (53.6%) of 28 APIs used against drug-resistant TB decreased, including the price of drugs used in new treatment regimens. The decreasing price trend was strongest for linezolid (-16.60 [95% CI: -26.35 to -6.85] percentage points [pp] per year), bedaquiline (-12.61 [95% CI: -18.00 to -7.22] pp per year), cycloserine (-11.20 [95% CI: -17.40 to -4.99] pp per year), pretomanid (-10.47 [95% CI: -15.06 to -5.89] pp per year), and rifapentine (-10.46 [95% CI: -12.86 to -8.06] pp per year). The prices of 16 (61.5%) of 23 APIs for standard drug-susceptible TB treatment increased, including rifampicin (23.70 [95% CI: 18.48 to 28.92] pp per year), isoniazid (20.95 [95% CI: 18.96 to 22.95] pp per year), ethambutol (9.85 [95% CI: 8.83 to 10.88] pp per year), and fixed-dose combinations thereof. CONCLUSIONS: The number of TB drugs available from the GDF has substantially increased during its first 23 years of operation. The prices of most APIs for new TB treatments decreased or remained stable. The prices of most APIs for standard drug-sensitive TB treatment increased.

Evaluating Sustainable Practices for Managing Residue Derived from Wheat Straw.

Farm leftovers, particularly crop residues, are a key source of renewable energy in Canada. The nation's robust agricultural industry provides ample biomass, derived from forestry and agriculture resources, for energy generation. Crop residues, such as straws and husks, play a crucial role in this biomass reservoir, contributing to biofuel production and greenhouse gas mitigation efforts. Focusing on supply chains, waste management, and emission reduction, this study evaluates the sustainability of wheat straw, an agricultural biomass by-product. The environmental issues of various approaches to managing agricultural biomass were explored. Following an evaluation of biomass features, conversion methods, and economic and environmental advantages, the results show anaerobic digestion to be the most sustainable approach. Four metrics were examined in relation to social elements, and numerous aspects were considered as inputs in the evaluation of transportation costs. The use of electric trucks versus fuel-based trucks resulted in an 18% reduction in total operating costs and a 58% reduction in consumption costs. This study examined CO2 emissions over four different transportation distances. The data indicate that a significant reduction of 36% in kg CO2 equivalent emissions occurred when the distance was lowered from 100 km to 25 km. These findings offer insights for creating practical plans that should increase the sustainability of agricultural biomass leftovers.

Vulnerability Assessment and Protection Zone Delineation for Water Supply Schemes in the Upper Awash Subbasin, Ethiopia, Sub-Saharan Africa.

Water quality issues in Ethiopia necessitate the implementation of the Water Safety Plan (WSP) to safeguard drinking water. Despite its benefits, WSP implementation is underutilized, a situation exacerbated by urbanization, agriculture, pollution, and climate change. This study evaluated water supply system vulnerability and delineated protection zones in the Upper Awash River subbasin. By employing the DRASTIC model, the National WASH Inventory-2 (NWI-2), and qualitative methods, this research aims to integrate the NWI-2 with vulnerability assessments. The study revealed that, among 2864 schemes, only 14.4% had a water safety plan, while 20.7% practiced water safety, and 6% reported the occurrence of waterborne diseases. Over 39.23% of the schemes were in high vulnerability areas, 12.32% were in very high vulnerability areas, and only 8% were in low vulnerability areas. The validation revealed a 61.7% association between the vulnerability indices and nitrate concentration. The strengths of the strategy included coordination and guideline development, but challenges such as institutionalization, catchment protection, the legal framework, and climate information remain for the Water Safety Plan. To promote public health, these findings help to demonstrate and integrate the NWI-2 with vulnerability assessments to protect drinking water sources. The conclusion also calls for all concerned authorities to implement water source protection, emphasizing the use of GIS technology and the adoption of integrated watershed management practices, which encompass regulatory control and conservation strategies. Furthermore, more research on the pollutant time of travel, assimilation capacity, and land use priorities is needed to delineate specific protection zones.

Achieving sufficient milk supply supports mothers to cope with premature birth.

AIM: To explore whether and how expressing breast milk is perceived as helpful in coping with negative emotions due to premature birth by mothers of very low birth weight (VLBW) infants. METHODS: Qualitative interviews and a retrospective cross-sectional questionnaire with mothers of VLBW infants were conducted and analysed using an exploratory sequential mixed-method design. Hypotheses were built using qualitative content analysis and quantitatively tested using multivariate regression analysis. RESULTS: Interviews with 12 mothers and questionnaires of 518 mothers were analysed. Coping with prematurity by expressing milk was seen as a way to maintain the caregiving role for the mothers, where three relevant factors arouse: making up for what happened, providing the best for their infant and fear of low milk supply. Quantitative analysis showed that mothers with a high milk supply (Coef. = 1.1, p < 0.000) and more feelings of guilt due to premature birth (Coef. = -0.1; p = 0.015) perceived expressing breast milk significantly more as a resource for coping. CONCLUSION: This study adds knowledge on how expressing breast milk for their VLBW infant may support mothers in coping with premature birth, by revealing the association with milk supply and feelings of guilt due to premature birth.

Quantifying the supply-demand relationship of ecosystem services to identify ecological management zoning: A case study in mountainous areas of northwest Yunnan, China.

Establishing ecological management zones based on the supply-demand relationship of ecosystem services (ESs) is essential for fostering sustainable development within social-ecological systems and improving human well-being. In this study, the spatial pattern between supply and demand in five ESs (grain production (GP), carbon sequestration (CS), soil conservation (SC), water conservation (WC), and habitat quality (HQ)) is analyzed using the ESs supply-demand ratio (ESDR) method, the spatial autocorrelation method, and the coupled coordination degree model. Zoning is performed according to the differences in their spatial combinations, and differential zoning management policies are proposed. The following results were obtained: (1) In terms of the ESDR, except for a slight increase in GP surplus from 2010 to 2020, there is a decline in the surplus of the other four ESs. (2) CS, WC, and HQ are dominated by cluster types LH and HL. GP and SC are dominated by cluster types HH and LL. The average value of the coupling coordination degree (CCD) of comprehensive ESs supply and demand show five types: moderate disharmony, slight disharmony, near disharmony, basic coordination, and slight coordination. (3) Based on the multiple spatial heterogeneity of ESs supply and demand, differentiated ecological management strategies are proposed at the grid scale. Overall, this study discover the spatial pattern of mismatch between the supply and demand of ecosystem services (ESs) in mountainous urban areas. This contribution enhances the discourse surrounding sustainable development theory and advances research on the coupling of social-ecological systems. Furthermore, it offers valuable insights for the formulation of sustainable ecological management policies tailored to mountainous urban settings.

Water consumption and biodiversity: Responses to global emergency events.

Given that it was a once-in-a-century emergency event, the confinement measures related to the coronavirus disease 2019 (COVID-19) pandemic caused diverse disruptions and changes in life and work patterns. These changes significantly affected water consumption both during and after the pandemic, with direct and indirect consequences on biodiversity. However, there has been a lack of holistic evaluation of these responses. Here, we propose a novel framework to study the impacts of this unique global emergency event by embedding an environmentally extended supply-constrained global multi-regional input-output model (MRIO) into the drivers-pressure-state-impact-response (DPSIR) framework. This framework allowed us to develop scenarios related to COVID-19 confinement measures to quantify country-sector-specific changes in freshwater consumption and the associated changes in biodiversity for the period of 2020-2025. The results suggest progressively diminishing impacts due to the implementation of COVID-19 vaccines and the socio-economic system's self-adjustment to the new normal. In 2020, the confinement measures were estimated to decrease global water consumption by about 5.7% on average across all scenarios when compared with the baseline level with no confinement measures. Further, such a decrease is estimated to lead to a reduction of around 5% in the related pressure on biodiversity. Given the interdependencies and interactions across global supply chains, even those countries and sectors that were not directly affected by the COVID-19 shocks experienced significant impacts: Our results indicate that the supply chain propagations contributed to 79% of the total estimated decrease in water consumption and 84% of the reduction in biodiversity loss on average. Our study demonstrates that the MRIO-enhanced DSPIR framework can help quantify resource pressures and the resultant environmental impacts across supply chains when facing a global emergency event. Further, we recommend the development of more locally based water conservation measures-to mitigate the effects of trade disruptions-and the explicit inclusion of water resources in post-pandemic recovery schemes. In addition, innovations that help conserve natural resources are essential for maintaining environmental gains in the post-pandemic world.

An urgent need for community lot testing of lateral flow fentanyl test strips marketed for harm reduction in Northern America.

BACKGROUND: Fentanyl test strips (FTS) are lateral flow immunoassay strips designed for detection of ng/mL levels of fentanyl in urine. In 2021, the US Centers for Disease Control and the Substance Abuse and Mental Health Administration stated that federal funds could be used for procurement of FTS for harm reduction strategies approved by the government such as drug checking. The market for FTS has expanded rapidly in the US and Canada. However, there is no regulatory oversight by either government to ensure proper function of FTS that are being marketed for drug checking. MAIN BODY: Many brands of FTS have rapidly entered the harm reduction market, creating concerns about the reproducibility and accuracy of their performance from brand to brand and lot to lot. Some examples are provided in this Comment. Similar problems with product quality were observed in the mid 2000's when lateral flow immunoassays for malaria were funded in many countries and again in 2020, when COVID-19 tests were in huge demand. The combination of high demand and low levels of regulation and enforcement led some manufacturers to join the goldrush without adequate field testing or quality assurance. We argue that the harm reduction community urgently needs to set a lot checking program in place. A set of simple protocols for conducting the tests and communicating the results have been developed, and are described in the following Perspectives paper in this issue. CONCLUSION: In the absence of governmental regulation and enforcement, the harm reduction community should implement a FTS lot checking program. Based on previous experience with the malaria diagnostic lot checking program, this inexpensive effort could identify products that are not suitable for harm reduction applications and provide valuable feedback to manufacturers. Dissemination of the results will help harm reduction organizations to ensure that FTS they use for drug checking are fit for the purpose.

A method for durian precise fertilization based on improved radial basis neural network algorithm.

Introduction: Durian is one of the tropical fruits that requires soil nutrients in its cultivation. It is important to understand the relationship between the content of critical nutrients, such as nitrogen (N), phosphorus (P), and potassium (K) in the soil and durian yield. How to optimize the fertilization plan is also important to the durian planting. Methods: Thus, this study proposes an Improved Radial Basis Neural Network Algorithm (IM-RBNNA) in the durian precision fertilization. It uses the gray wolf algorithm to optimize the weights and thresholds of the RBNNA algorithm, which can improve the prediction accuracy of the RBNNA algorithm for the soil nutrient content and its relationship with the durian yield. It also collects the soil nutrients and historical yield data to build the IM-RBNNA model and compare with other similar algorithms. Results: The results show that the IM-RBNNA algorithm is better than the other three algorithms in the average relative error, average absolute error, and coefficient of determination between the predicted and true values of soil N, K, and P fertilizer contents. It also predicts the relationship between soil nutrients and yield, which is closer to the true value. Discussion: It shows that the IM-RBNNA algorithm can accurately predict the durian soil nutrient content and yield, which is benefited for farmers to make agronomic plans and management strategies. It uses soil nutrient resources efficiently, which reduces the environmental negative impacts. It also ensures that the durian tree can obtain the appropriate amount of nutrients, maximize its growth potential, reduce production costs, and increase yields.

Use of dairy industry side-stream lactose for tablet manufacturing - proof of concept study.

During recent years there have been shortages of certain drugs due to problems in raw material supply. These are often related to active ingredients but could also affect excipients. Lactose is one of the most used excipients in tableting and comes in two anomeric and several solid-state forms. The aim of this study was to utilize lactose from a dairy side-stream and compare it against a commercial reference in direct compression. This would be a sustainable option and would secure domestic availability during crises. Two types of lactose, spray-dried and freeze-dried, were evaluated. Lactose was mixed with microcrystalline cellulose in different ratios together with lubricant and glidant, and flowability and tabletability of the formulations was characterized. The fully amorphous and small particle-sized spray-dried lactose flowed inadequately but exhibited good tabletability. The larger particle-sized, freeze-dried lactose exhibited sufficient flow and better tabletability than the commercial reference. However, disintegration and drug release were slower when using the investigational lactose formulations. This was most likely due to remaining milk proteins, especially caseins, in the lactose. Overall, the investigational lactose provides promise for the use of such a side-stream product during crisis situations but enhancing their properties and/or purity would be needed.