ABSTRACT
Combining traditional Chinese medicine and chemical drugs with antimicrobial activities has become more popular, but there is insufficient relevant research on such combinations. The Tanreqing injection (TRQI), a Chinese compound medicine, exhibits therapeutic effects in treating upper respiratory tract infections, severe influenza, and pneumonia. This research investigates the pharmacokinetics of TRQI in pneumonia model rats and explores the effect of the antibiotic cefixime on its metabolism. The pneumonia model rats were randomly divided into six groups: low, medium, and high (3, 6, and 12 mL kg-1) dose TRQI group, and a medium dose TRQI combined with cefixime (14.4 mg kg-1) group, with the remainder two groups were control group. Blood samples were collected from the tail vein at different time points between 0 and 24 h after injection. A sensitive and quick method based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was established for the simultaneous determination of the 13 TRQI components in the blood samples. The analytes were separated on an XBridge™C18 column (2.1 mm × 150 mm, 5 µm), with the flow phase consisting of methanol and 0.1% formic acid water at a flow rate of 0.3 mL/min. The assay method met the biological sample determination requirements, demonstrating good adaptability and practicability for application in the pharmacokinetic study of TRQI in pneumonia model rats. Moreover, the method was used successfully in the interaction study of TRQI with cefixime. The results indicated that co-administration results in a significant change in the pharmacokinetic parameters of the main TRQI components. However, the changes in the pharmacokinetic characteristics of multiple TRQI components were inconsistent. Thus, the results of this drug combination under different pathological conditions in clinical applications were unpredictable. Therefore, more attention should be paid to the combined use of cefixime and TRQI in clinical applications to avoid the risk of adverse drug reactions in future studies.
Subject(s)
Cefixime/pharmacokinetics , Drugs, Chinese Herbal , Pneumonia , Animals , Chromatography, High Pressure Liquid , Chromatography, Liquid , Drug Interactions , Drugs, Chinese Herbal/pharmacokinetics , Pneumonia/drug therapy , Rats , Tandem Mass SpectrometryABSTRACT
Objective:To study the efficacy of ribavirin injections combined with Tanreqing in the treatment of children with epi-demic parotitis. Methods:From January 2012 to September 2013, 128 children with mumps in our hospital were selected and random-ly divided into the treatment group and the control group with 64 cases in each. The control group was intravenously given ribavirin in-jections, 5-7. 5 mg·kg-1 , ivd, bid, and the treatment group was given Tanreqing injections additionally, 0. 25-0. 4 ml·kg-1 ·d-1 , ivd,qd. After the 5-day treatment, the extinction time of parotid swelling and pain, defervesce time and the decrease of TNF- α and CRP were observed in the two groups. Results: The total effective rate in the treatment group was 93. 8%, which was significantly higher than that in the control group (84. 4%) with significant difference (P<0. 05). The extinction time of parotid swelling and pain and defervesce time in the treatment group were significantly shorter than those in the control group (P<0. 05). After the treatment, TNF- α and CRP in the two groups were significantly decreased (P<0. 05), and the decrease in the treatment group was much notable than that in the control group (P<0. 05). Conclusion:Ribavirin injections combined with Tanreqing in the treatment of children with mumps can significantly shorten the extinction time of parotid swelling and pain and defervesce time, and inhibit TNF-αand CRP with significant effect, which is valuable in clinical promotion and application.
ABSTRACT
Objective: To investigate the effect of Tanreqing injections combined with azithromycin in the treatment of children bronchial pneumonia. Methods:Totally 56 cases of pediatric bronchial pneumonia were selected in our hospital from September 2012 to September 2013 and randomly divided into the observation group and the control group with 28 cases in each. The control group was with azithromycin treatment, and the observation group was with Tanreqing injections additionally. The effect and adverse reactions of the two groups were studied and compared. Results:In the observation group, the effective rate was 92. 9%, which was significantly higher than that in the control group(P<0. 05). The hospitalization time and the symptoms disappearance time in the observation group were significantly shorter than those in the control group (P<0. 05). The adverse reactions showed no significant difference be-tween the two groups. Conclusion:Tanreqing injections in the treatment of children bronchial pneumonia is rapid, effective and safe.
ABSTRACT
Objective To observe the effects of treatment with Tanreqing injections combined routine methods in acute COPD and study the mechanism of action. Methods 104 patients with COPD were divided into two groups randomly. In the combined group,we add Tanreqing injections to treatment.We observed the effects of treatment and detected IL-17 and IL-8 levels of patients. Results The combined group's effective rate was 67.92%,and routine methods group was 54.90%. Difference was apparent(P