ABSTRACT
OBJECTIVE: To investigate the clinical effectiveness and safety of tanshinone capsules combined with varying concentrations of 5-aminoketovaleric acid photodynamic therapy (5-ALA-PDT) in the treatment of cystic acne. METHODS: A total of 97 patients with cystic acne treated in our hospital were enrolled in the study and divided into group A (n = 34, tanshinone capsules combined with 5% 5-ALA-PDT), group B (n = 31, tanshinone capsules combined with 7.5% 5-ALA-PDT), and group C (n = 32, tanshinone capsules combined with 10% 5-ALA-PDT). The number of skin lesions, the global acne grading system (GAGS) scores, the clinical effectiveness, the adverse reactions, and the recurrence rates were compared among the three groups. RESULTS: The number of skin lesions and the GAGS scores were lower in all three groups at two weeks, one month, and three months of treatment (P<0.05), and the numbers of skin lesions in groups B and C were significantly lower than the number in group A (P<0.05). The clinical effectiveness in groups B and C was better than it was in group A (P<0.05), and the overall effective rates in groups B and C (87.10% and 87.50%) were significantly higher than the overall effective rate in group A (41.18%) (P<0.05). The adverse reaction rates in groups A and B (5.88% and 6.45%) were significantly lower than the adverse reaction rate in group C (25.00%) (P<0.05), and the recurrence rate in group A (17.65%) was significantly higher than the recurrence rates in groups B and C (3.23% and 0.00%) (P<0.05). CONCLUSIONS: Tanshinone capsules combined with 7.5% 5-ALA-PDT showed the optimal clinical effectiveness and safety in the treatment of cystic acne.
ABSTRACT
OBJECTIVE:To study the effects of Tanshinone capsules on glucose and lipid metabolism and serum sex hormone level in rats with polycystic ovary syndrome (PCOS). METHODS:90 female SD rats were randomly divided into normal group (distilled water),model group (distilled water),positive control group (metformin 200 mg/kg) and Tanshinone capsules low-dose,medium-dose and high-dose groups(30,60,90 mg/kg),with 15 rats in each group. Those groups were induced PCOS mod-el except for normal group;after modeling,those groups were given relevant medicine intragastrically for consecutive 28 d,once a day. The ovulation rate was compared before intervention and 28 d after intervention. Body weight,fat wet weight,fasting insulin (FINS),fasting blood-glucose (FPG),AUC of glucose,HOMA-IR,ISI,serum levels of FSH,LH and T were detected. RE-SULTS:Compared with normal group,anovulation,body weight,fat wet weight,FINS,FPG,AUC of glucose,HOMA-IR, FSH,LH and T were all increased significantly in model group,while ISI decreased significantly(P<0.05). Compared with mod-el group,ovulation rate and ISI of positive control group and Tanshinone capsules groups were increased significantly after interven-tion, while body weight (except for Tanshinone capsules low-dose group), fat wet weight (except for Tanshinone capsules low-dose group),FINS,FPG,AUC of glucose,HOMA-IR,FSH,LH and T were all decreased significantly(P<0.05),especial-ly in Tanshinone capsules high-dose group and positive control group. CONCLUSIONS:Tanshinone capsules can regulate glucose and lipid metabolism and serum sex hormone secretion disorder in PCOS rats.
