ABSTRACT
Objective To explore the characteristics of both clinical symptoms and thyroid function between depressive patients with and without attempted suicide behavior. Methods Depressive patients were divided into two groups. The first group was composed of patients with attempted suicide behavior (n = 56) and the second group without attempted suicide behavior ( n = 85 ). Thyroid function (FT3, FT4 )were determined by radioimmunoassay method. The patients were evaluated by symptom checklist 90 (SCL90). Results The score of depressive factor in the group with attempted suicide [(2. 90 ± 1. 01 ) score]was higher than that of the group without attempted suicide [(2.51±0.77) score] ( ( t =2. 127, P =0. 036). The serum level of FT3 in the group with attempted suicide [(3.92 ±0. 52) pmol/L] was lower than that of the group without attempted suicide[(4.18 ±0.71) pmol/L] ( t =-2.219, P =0.028).Conclusions There were certain characteristics on clinical symptoms of depressive patients with attempted suicide. The low serum levels of FT3 might play an important role in the risk of suicide in depressive patients.
ABSTRACT
Objective To investigate the state of thyroid hormones and thyrotropin level in different gestation periods. Methods FT3, FT4, TSH and hCG were measured in 623 patients by ACS-180 automatic chemiluninescence analyzer. The urinary iodine was random measured by the use of iodine catalytic reaction mechanism of Arsenic-Cerium, rapid urinary iodine was detected with cold digestion method of quantitative detection. Result Serum FT3,FT4 ,and hCG levels in the first and second trimester were higher than in the third trimester ( F =53. 19,78.00,58.77, P ＜0. 05) ,and TSH levels were lower than in the third trimester ( F =5.68, P ＜0.05). The incidence of thyrotropin level disorder was 7. 54%, there were no significant differences in the gestation periods ( χ2 = 3.92, P ＞ 0. 05 ). The incidence of subclinical hypothyroidism,subclinical hyperthyroidism, hypothyroidism and hyperthyroidism were 3.53%, 2. 57%, 1.12% and 0. 32%, respectively. The incidence of subclinical hypothyroidism in the first and third trimester was high, while the incidence of subclinical hyperthyroidism in the second trimester was high. Conclusions Thyrotropin level in the third trimester was lower than that of the first and second trimester. HCG changes were not the main reason that caused the thyrotropin level disorder during the pregnancy.
