ABSTRACT
INTRODUCTION: Excess visceral adipose tissue (VAT) is associated with insulin resistance in early pregnancy and VAT measurement better explains the association between obesity and insulin resistance than the body mass index. First trimester homeostatic model assessment of insulin resistance (HOMA-IR) or the insulin sensitivity index proved to have positive correlation with late development of gestational diabetes mellitus (GDM) in late pregnancy. Greater VAT depth in the first trimester of pregnancy will be associated with hyperglycemia at 24-28 weeks' gestation. OBJECTIVES: To study the relationship between abdominal visceral adiposity and insulin resistance in early pregnancy as a predictor for development of GDM in late pregnancy. PATIENTS AND METHODS: This prospective cohort study included 83 pregnant women at 11-14-week gestation subjected to abdominal adiposity measurement through VAT and subcutaneous adipose tissue (SAT) measurements, then at 16-22 completed a two-hour 75 g OGTT and fasting one-hour and two-hour serum insulin concentration. The HOMA-IR and insulin resistance index (IRI) were calculated. Patients were divided into two groups: group I: pregnant women who did not developed GDM; group 2: pregnant women who developed GDM. RESULTS: Significant statistical difference in both groups as regarding VAT (p = .001). With mean ± S.D. of VAT increase in Group 2. Mean ± S.D. of HOMA-IR increase in group 2 with significant statistical difference in both groups (p =.001). Also mean ± S.D. of ISI increase in group 2 with significant statistical difference in both groups (p = .001). There was positive relationship between visceral adiposity and HOMA-IR and negative relationship between visceral adiposity and insulin sensitivity. Also, in this study, there was no significant relation between SAT and HOMA-IR. CONCLUSIONS: From our study, we concluded that measurement of VAT during a routine 11-14 weeks' gestation ultrasound might improve the performance of screening for GDM and correlates with metabolic risk factors even better than BMI.
Subject(s)
Diabetes, Gestational , Insulin Resistance , Blood Glucose , Body Mass Index , Diabetes, Gestational/diagnostic imaging , Egypt/epidemiology , Female , Humans , Insulin , Intra-Abdominal Fat/diagnostic imaging , Pregnancy , Prospective StudiesABSTRACT
PURPOSE: This study aims to comprehensively evaluate the deformation of the skull base and fronto-temporal soft tissue in the patients with anterior plagiocephaly over 1 year of age by three-dimensional (3D) imaging after fronto-orbital advancement (FOA). METHODS: We quantitatively analyzed the surgical results and outcome of FOA performed in 10 patients with anterior plagiocephaly. The measurements of the skull base and fronto-temporal soft tissue were performed based on 3D computed tomography (CT) scan. We assessed symmetry of the skull base and fronto-temporal soft tissue change. RESULTS: The mean age of patients at FOA was 38.9 months. A significant asymmetry of the skull base was found in all the patients. The growth of the anterior and middle fossae was restricted and the deformation of the fronto-temporal region was marked by soft tissue measurements in different grades. On the follow-up CT images 23.6 months after surgery, there was prominent change (p < 0.05) between the two hemibases (CSO^ ratio) and between the lengths and angles of the anterior and middle cranial hemi-fossae (CX, CSX^, XSM^, XM ratio), especially in grade IIA. Anterior cranial vault asymmetry index obviously decreased to - 1.2 from 12% after surgery (p < 0.05). What's more, ACA^ was also proved to be less after surgical correction (19.91° versus 8.29°, p < 0.01) in grade IIA. The change of fronto-temporal soft tissue was significant such as the frontal angle, the angle of the frontal plane, the fontal-temporal angle, and the angle of the temporal plane in different grades. CONCLUSIONS: The asymmetry of the skull base and the deformation of the fronto-temporal region can be presented by intracranial view at over 1 year of age in different grades. FOA can correct the skeletal malformation of the fronto-temporal region as well as soft tissue and the asymmetry of the skull base was improved after surgical treatment.
Subject(s)
Craniosynostoses/complications , Frontal Bone/diagnostic imaging , Imaging, Three-Dimensional , Orbit/diagnostic imaging , Skull Base/diagnostic imaging , Soft Tissue Injuries/etiology , Tomography Scanners, X-Ray Computed , Child , Child, Preschool , Craniosynostoses/diagnostic imaging , Female , Humans , Infant , Male , Plastic Surgery Procedures , Skull Base/pathology , Soft Tissue Injuries/diagnostic imagingABSTRACT
Maternal obesity is an emerging challenge in contemporary obstetrics. To date there has been no study analysing the relationship between specific maternal body composition measurements and foetal soft-tissue measurements. The aim of this study was to determine whether measurement of maternal body composition at booking predicts foetal soft-tissue trajectories in the third trimester. We analysed the relationship between foetal thigh in the third trimester and both maternal BMI and body composition using the Tanita digital scales in the first trimester. Foetal subcutaneous thigh tissue measurements were obtained at intervals of 28, 32 and 36 weeks of gestation. A total of 160 women were identified. There was a direct correlation between MTST at 36 weeks and BMI (p = .002). There was a positive correlation between MTST at 36 weeks and leg fat mass (p = .13) and leg fat free mass (p = .013). There was a positive correlation between arm fat free mass and MTST at 36 weeks. We showed there is an association between maternal fat distribution and foetal subcutaneous thigh tissue measurements. MTST may be more useful in determining if a child is at risk of macrosomia. Impact statement Previous studies have suggested that maternal obesity programmes intrauterine foetal adiposity and growth. The aim of this study was to examine the relationship in a high-risk obstetric population between measurements of maternal body composition in early pregnancy and the assessment of foetal adiposity in the third trimester using serial ultrasound measurements of mid-thigh soft-tissue thickness. BMI is only a surrogate measurement of fat and does not measure fat distribution. Our study shows the distribution of both maternal fat and fat-free mass in early pregnancy may be positively associated with foetal soft-tissue measurements in the third trimester. Maternal arthropometric measurements other than BMI may help predict babies at risk of macrosomia and neonatal adiposity.
Subject(s)
Adiposity , Fetal Development , Adult , Body Mass Index , Electric Impedance , Female , Humans , Pregnancy , Pregnancy Trimester, ThirdABSTRACT
The control of the secretory activity of serotonergic neurons has been pointed out to reduce motor and non-motor side effects of the antiparkinsonian drug L-DOPA. This strategy deserves further investigation because it is presently unclear whether L-DOPA promotes a non-vesicular release of dopamine and serotonin from serotonergic neurons. To get a full neurochemical picture compatible with the existence of such a mechanism, we combined multisite intracerebral microdialysis, post mortem tissue measurement and single unit extracellular recordings in the dorsal raphe nucleus from hemiparkinsonian rats. L-DOPA (3-100mg/kg, ip.) non-homogeneously decreased extracellular serotonin levels in the striatum, substantia nigra pars reticulata, hippocampus and prefrontal cortex and homogenously serotonin tissue content in the striatum, cortex and cerebellum. L-DOPA (12mg/kg) did not modify the firing rate or pattern of serotonergic-like neurons recorded in the dorsal raphe nucleus. When focusing on serotonin release in the prefrontal cortex and the hippocampus, we found that L-DOPA (12 or 100mg/kg) enhanced serotonin extracellular levels in both regions upon Ca(2+) removal. Concomitantly, L-DOPA-stimulated dopamine release partly persisted in the absence of Ca(2+) in a region-dependent manner. Local application of the serotonin reuptake inhibitor citalopram (1µM) blunted the responses to L-DOPA (3-12mg/kg), measured as extracellular dopamine levels, most prominently in the hippocampus. These data stress that L-DOPA, already at low to moderate doses, promotes non-vesicular releases of serotonin and dopamine in a region-dependent manner.
Subject(s)
Antiparkinson Agents/therapeutic use , Disease Models, Animal , Dopaminergic Neurons/drug effects , Levodopa/therapeutic use , Parkinson Disease/drug therapy , Serotonergic Neurons/drug effects , Serotonin/metabolism , Action Potentials/drug effects , Animals , Antiparkinson Agents/administration & dosage , Antiparkinson Agents/pharmacology , Cholestanols , Citalopram/pharmacology , Dopamine Agents/administration & dosage , Dopamine Agents/pharmacology , Dopamine Agents/therapeutic use , Dopaminergic Neurons/metabolism , Dose-Response Relationship, Drug , Hippocampus/drug effects , Hippocampus/metabolism , Hippocampus/physiopathology , Hydroxyindoleacetic Acid/metabolism , Levodopa/administration & dosage , Levodopa/metabolism , Levodopa/pharmacology , Male , Organ Specificity , Parkinson Disease/physiopathology , Prefrontal Cortex/drug effects , Prefrontal Cortex/metabolism , Prefrontal Cortex/physiopathology , Rats, Sprague-Dawley , Serotonergic Neurons/metabolism , Selective Serotonin Reuptake Inhibitors/pharmacology , Single-Cell Analysis , Synaptic Transmission/drug effectsABSTRACT
The digital cushion is characterized as a modified subcutaneous tissue that absorbs the shock during gait, assists venous return of the hoof and supports a considerable part of body weight. Digital cushions have particular importance in the pathogenesis of the hoof, since they need to properly work in order to prevent compression and traumas in soft tissues. This study aimed to measure and determine how is the arrangement of these structures, and for this it was established the proportions of connective, adipose, vascular tissues and collagen fibers and collagen types found in palmar and plantar digital cushion of bovine using fore and hindlimbs of twelve adult zebu cattle of both sexes, 11 male and one female, with 269kg average carcass weight and without limb disorders. Fragments of cushions were subjected to conventional histology, cut to a thickness of 4µm and stained with Red Picrosirius. With digital optical microscope, the quantification of the connective tissue and differentiation of types of collagen used the Image Pro Plus® software, and of adipose and vascular tissue, the test point system. The mean and standard error were estimated with the GraphPad Prism 5.0 software, and then data were subjected to Kolmogorov-Smirnov normality test and Student's t-test with significance level set at 5% for determining the amount of different tissues between fore and hindlimbs of studied animals. In forelimbs the mean and standard error of the connective tissue proportion was 50.10%+1.54, of the adipose tissue was 21.34%+1.44, and of vascular tissue was 3.43%+0.28. Hindlimbs presented a proportion of connective tissue of 61.61%+1.47, 20.66%+1.53 of adipose tissue, and 3.06%+0.20 of vascular tissue. A significant difference (p<0.001) was detected in the connective tissue proportion between fore and hindlimbs. Types I and II collagen fibers have presented, respectively, a proportion of 31.89% and 3.9% in forelimbs and 34.05% and 1.78% in hindlimbs...
O tórus digital é caracterizado como um tecido subcutâneo modificado que atua na absorção do impacto durante a locomoção, auxilia o retorno venoso do casco e mantêm o suporte de uma considerável parte do peso corporal. Os tórus possuem particular importância nas patogêneses de casco, já que eles precisam trabalhar corretamente para prevenir compressões e traumas nos tecidos moles. Assim, o objetivo deste estudo foi quantificar e com isso determinar, como se arranjam estas estruturas, para tanto, foram estabelecidas as proporções dos tecidos conjuntivo, adiposo, vascular e ainda das fibras colágenas e dos tipos de colágenos encontrados nos tórus digitais palmares e plantares de bovinos. Foram utilizados membros torácicos e pélvicos de doze bovinos zebuínos adultos, de ambos os sexos, sendo onze machos e uma fêmea, com peso médio de carcaça com 269kg e sem afecções nos membros. Os fragmentos dos tórus foram submetidos à técnica histológica convencional, cortados em espessura de 4µm e corados com Picrosirius Red. Com o uso de microscópio óptico digital, o tecido conjuntivo e a diferenciação dos tipos de colágeno foram quantificados empregando-se o programa de análise de imagem Image Pro Plus® e para a quantificação dos tecidos adiposo e vascular foi utilizada o sistema teste de pontos. Através do programa GraphPad Prism 5.0 foram obtidas por meio de uma analise descritiva a media e o erro padrão da media, em seguida os dados foram submetidos à aplicação do teste de normalidade de Kolmogorov-Smirnov e ao teste "T" Student com nível de significância de 5% para a determinação da quantidade encontrada dos diferentes tecidos entre os membros torácicos e pélvicos dos animais estudados. Nos membros torácicos a média e o erro padrão da proporção de tecido conjuntivo foi de 50,10%+1,54, a de tecido adiposo foi de 21,34%+1,44 e a de tecido vascular foi de 3,43%+0,28. Os membros pélvicos...
Subject(s)
Animals , Cattle , Cattle/injuries , Hoof and Claw/growth & development , Hoof and Claw/injuries , Histology , Soft Tissue Injuries/veterinary , Connective Tissue/physiologyABSTRACT
OBJECTIVE: To compare skin folds in the dominant and nondominant halves of the body in a group (A) of 20 individuals with cerebral palsy and spastic hemiplegia and a group (B) of 30 normal volunteers. METHOD: Body mass, height and skin folds were measured, and the percentage of body fat was estimated by adipose tissue measurement and densitometry. The mean age in group (A) was 24.6 ± 5.6 years (ranging from 16.1 to 38.1 years). The mean age in group (B) was 25.3 ± 3.8 years (ranging from 19.0 to 34.11 years). RESULTS: Statistically significant differences were observed between the dominant and nondominant halves of the body for biceps, triceps, thoracic, suprailiac, thigh and midcalf skin folds in group A; the biceps, subscapular, midaxillary, suprailiac, abdominal, thigh and midcalf skin folds in group B; and the percentage fat obtained by adipose tissue measurement in both groups. Statistically significant differences were observed for the triceps skin fold when the dominant halves of the body in groups A and B were compared. Statistically significant differences were also observed for the biceps, triceps, thigh and midcalf skin folds as well as the adipose tissue measurements between the dominant and nondominant halves of the body in the two groups. The percentage fat as estimated by densitometry was significantly correlated with the adipose tissue measurement. CONCLUSION: There were statistically significant differences between the skin folds in the dominant and nondominant halves of the body, both in group A and in group B (greater in group A). There was a statistically significant correlation in the percentage fat as estimated by densitometry and as measured by adipose tissue in groups A and B.
Subject(s)
Adolescent , Adult , Female , Humans , Male , Young Adult , Anthropometry/methods , Body Composition/physiology , Cerebral Palsy/pathology , Functional Laterality , Hemiplegia/pathology , Skinfold Thickness , Absorptiometry, Photon , Analysis of Variance , Adipose Tissue/pathology , Case-Control Studies , Statistics, Nonparametric , Whole Body Imaging , Young AdultABSTRACT
Objective:To obtain the normal values of the facial soft tissue measurements of the attractive Uygur females in Xinjiang by photogrammetric analysis,and to study the relationship between the facial feature of attractive Uygur females and the neoclassical canons. Methods:31 attractive Uygur women were selected, standardized and referenced frontal photographs of faces were taken,and 14 standard anthropometric marks were determined,then measurements were performed by photoshopCS software.Results:Intercanthal width was rather smaller than nose width and larger than eye fissure width;nose width occupied more than 1/4 of face width or 2/3 of mouth width.The chin occupied 2/3 of the entire mandibular height.There was positive correlation among many horizontal and vertical facial soft tissue measurements.Conclusion:The facial features of the attractive Uygur females in Xinjiang fit the classical facial canons to some extent. There is pertinence in attractive facial form and features.
