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1.
ACS Appl Mater Interfaces ; 16(29): 38733-38743, 2024 Jul 24.
Article in English | MEDLINE | ID: mdl-38985460

ABSTRACT

Cilia are hair-like organelles present on cell surfaces. They often exhibit a collective wave-like motion that can enhance fluid or particle transportation function, known as metachronal motion. Inspired by nature, researchers have developed artificial cilia capable of inducing metachronal motion, especially magnetic actuation. However, current methods remain intricate, requiring either control of the magnetic or geometrical properties of individual cilia or the generation of a complex magnetic field. In this paper, we present a novel elegant method that eliminates these complexities and induces metachronal motion of arrays of identical microscopic magnetic artificial cilia by applying a simple rotating uniform magnetic field. The key idea of our method is to place arrays of cilia on surfaces with a specially designed curvature. This results in consecutive cilia experiencing different magnetic field directions at each point in time, inducing a phase lag in their motion, thereby causing collective wave-like motion. Moreover, by tuning the surface curvature profile, we can achieve diverse metachronal patterns analogous to symplectic and antiplectic metachronal motion observed in nature, and we can even devise novel combinations thereof. Furthermore, we characterize the local flow patterns generated by the motion of the cilia, revealing the formation of vortical patterns. Our novel approach simplifies the realization of miniaturized metachronal motion in microfluidic systems and opens the possibility of controlling flow pattern generation and transportation, opening avenues for applications such as lab-on-a-chip technologies, organ-on-a-chip platforms, and microscopic object propulsion.


Subject(s)
Cilia , Magnetic Fields , Surface Properties , Motion
2.
Eur J Cardiothorac Surg ; 66(1)2024 Jul 01.
Article in English | MEDLINE | ID: mdl-39024021

ABSTRACT

OBJECTIVES: The objective of the present study was to model the effects of a reduced number of treatment centres for acute type A aortic dissection on preclinical transportation distance and time. We examined whether treatment in selected centres in Germany would be implementable with respect to time to treatment. METHODS: For our transportation model, the number of aortic dissections and respective mean annual volume were collected from the annual quality reports (2015-2017) of all German cardiac surgery centres (n = 76). For each German postal code, the fastest and shortest routes to the nearest centre were calculated using Google Maps. Furthermore, we analysed data from the German Federal Statistical Office from January 2005 to December 2015 to identify all surgically treated patients with acute type A aortic dissection (n = 14 102) and examined the relationship between in-hospital mortality and mean annual volume of medical centres. RESULTS: Our simulation showed a median transportation distance of 27.13 km and transportation time of 35.78 min for 76 centres. Doubling the transportation time (70 min) would allow providing appropriate care with only 12 medical centres. Therefore, a mean annual volume of >25 should be obtained. High mean annual volume was associated with significantly lower in-hospital mortality rates (P < 0.001). A significantly lower mortality rate of 14% was observed (P < 0.001) if a mean annual volume of 30 was achieved. CONCLUSIONS: Operationalizing the volume-outcome relationship with fewer but larger medical centres results in lower mortality, which outweighs the disadvantage of longer transportation time.


Subject(s)
Aortic Dissection , Hospital Mortality , Humans , Aortic Dissection/surgery , Germany/epidemiology , Transportation/statistics & numerical data , Female , Male , Aortic Aneurysm/surgery , Aortic Aneurysm/mortality , Acute Disease , Time-to-Treatment/statistics & numerical data , Middle Aged
3.
Nano Lett ; 24(29): 9017-9026, 2024 Jul 24.
Article in English | MEDLINE | ID: mdl-39007530

ABSTRACT

The development of in situ tumor vaccines offers promising prospects for cancer treatment. Nonetheless, the generation of plenary autologous antigens in vivo and their codelivery to DC cells along with adjuvants remains a significant challenge. Herein, we developed an in situ tumor vaccine using a supramolecular nanoparticle/hydrogel composite (ANPMTO/ALCD) and a deformable nanoadjuvant (PPER848). The ANPMTO/ALCD composite consisted of ß-cyclodextrin-decorated alginate (Alg-g-CD) and MTO-encapsulated adamantane-decorated nanoparticles (ANPMTO) through supramolecular interaction, facilitating the long-term and sustained production of plenary autologous antigens, particularly under a 660 nm laser. Simultaneously, the produced autologous antigens were effectively captured by nanoadjuvant PPER848 and subsequently transported to lymph nodes and DC cells, benefiting from its optimized size and deformability. This in situ tumor vaccine can trigger a robust antitumor immune response and demonstrate significant therapeutic efficacy in inhibiting tumor growth, suppressing tumor metastasis, and preventing postoperative recurrence, offering a straightforward approach to programming in situ tumor vaccines.


Subject(s)
Adjuvants, Immunologic , Cancer Vaccines , Immunotherapy , Nanoparticles , Cancer Vaccines/chemistry , Cancer Vaccines/administration & dosage , Cancer Vaccines/immunology , Cancer Vaccines/therapeutic use , Animals , Mice , Immunotherapy/methods , Nanoparticles/chemistry , Adjuvants, Immunologic/chemistry , Adjuvants, Immunologic/administration & dosage , Adjuvants, Immunologic/therapeutic use , Adjuvants, Immunologic/pharmacology , Hydrogels/chemistry , Humans , Cell Line, Tumor , Dendritic Cells/immunology , beta-Cyclodextrins/chemistry , Neoplasms/therapy , Neoplasms/immunology , Alginates/chemistry , Adamantane/chemistry , Adamantane/therapeutic use
4.
BMC Public Health ; 24(1): 1940, 2024 Jul 19.
Article in English | MEDLINE | ID: mdl-39030511

ABSTRACT

BACKGROUND: In the context of socially sustainable urban development, comfortable, safe, and accessible public transport is crucial to motivating people to travel more sustainably. Using the framework given by Masoumi and Fastenmeier (2016) to examine the concepts of safety and security, we explore how perceptions of safety about different transport modes shaped the mobility of older adults in Bengaluru, India. METHODS: In-depth telephonic interviews were conducted with 60 adults, aged 50 years and over, residing in urban Bengaluru, using a semi-structured in-depth interview guide to explore the perceptions of safety in different transport modes. Observations were conducted prior to the COVID-19 pandemic. Applying thematic analysis, we present how the perceptions of safety during their everyday travel shaped their mobility. RESULTS: According to our research, older adults' perception of safety during their everyday travel is shaped by past negative experiences with accidents, pickpocketing, theft of mobile phones, and chain snatching. In addition, the Covid-19 pandemic exacerbated the already existing inequalities, further limiting older adults' mobility to carry out regular activities such as buying groceries, socialising, making a hospital visit, or going to work due to the fear of getting infected. CONCLUSION: Our findings indicate that the use of public transport needs to be encouraged among older adults by enhancing necessary safety features following the age-friendly cities framework. Furthermore, it can help policymakers develop transport polices, which suit the mobility needs of older adults.


Subject(s)
COVID-19 , Safety , Travel , Humans , India , Male , COVID-19/prevention & control , COVID-19/epidemiology , COVID-19/psychology , Female , Aged , Middle Aged , Travel/psychology , Transportation , Qualitative Research , Interviews as Topic , SARS-CoV-2 , Urban Population , Aged, 80 and over , Perception
5.
Health Justice ; 12(1): 32, 2024 Jul 20.
Article in English | MEDLINE | ID: mdl-39031205

ABSTRACT

BACKGROUND: The COVID-19 pandemic exacerbated existing mental health challenges and introduced new ones, particularly among vulnerable populations such as individuals within the criminal justice system, who disproportionately experienced employment, financial, and housing issues. As mandatory lockdowns and social distancing mandates were implemented, the United States saw unprecedented interruptions to treatment. Telemedicine emerged as a transformative tool in alleviating new and existing treatment barriers. Yet, limited empirical research has examined the impact and implications of telemedicine on mental health treatment in criminal justice populations. METHODS: The timing of this study's data collection overlapped with the spread of COVID-19 in the United States and provided a unique opportunity to examine the impact of telemedicine as part of a natural experiment. Utilizing interviews with 61 community mental health center service providers, this study qualitatively examined service providers' experiences in treating criminal justice-involved individuals with serious mental illness who were receiving mental health treatment through telemedicine. RESULTS: Service providers expressed satisfaction with telemedicine in addressing client transportation and childcare barriers while increasing engagement. Service providers voiced new concerns regarding clients' confidentiality, digital literacy, and limitations to gathering non-verbal client information during virtual treatment. CONCLUSIONS: Mental health treatment offered through telemedicine mitigates barriers to treatment that disproportionately affect criminal justice clients. Despite its benefits, challenges like access to reliable internet and to internet-enabled devices, confidentiality concerns, and information gathering must be addressed to achieve optimal and equitable mental health treatment through telemedicine. The findings support the continued use of telemedicine in mental health treatment delivery for this population.

6.
Traffic Inj Prev ; : 1-9, 2024 Jul 24.
Article in English | MEDLINE | ID: mdl-39046253

ABSTRACT

OBJECTIVES: This article presents an analysis of the traffic-calming effects of bus rapid transit (BRT) by studying changes to motor vehicle speeds before and after implementation of Albuquerque Rapid Transit (ART) infrastructure in Albuquerque, New Mexico. METHODS: While ART construction was completed in spring 2018, the BRT buses did not operate until December 2019; providing a unique opportunity to explore the influence of BRT infrastructure sans BRT buses (i.e., to tease apart the effects of BRT infrastructure and operations). We used validated data from StreetLight InSight to compare before/after changes to average motor vehicle speeds and 85th percentile motor vehicle speeds at 46 ART sites and 36 control sites. RESULTS: Findings suggest that infrastructure associated with BRT systems can improve traffic safety by reducing vehicle speeds. Speed decreases at the ART sites were especially strong in terms of 85th percentile decreases, suggesting that the BRT infrastructure is especially effective at limiting excessive speeding. Motor vehicle 85th-percentile speeds along the ART corridor were reduced by 11.5% (compared to a 5.8% decrease at control sites). The 85th-percentile speeds at the ART sites decreased from 32.3 mph to 28.6 mph, which is an especially important range for vulnerable road-user safety outcomes. While ART intersections saw the largest decreases in absolute speeds (a reduction of 4.1 mph in 85th-percentile speeds), ART mid-block sites had larger decreases relative to the control mid-block sites (decreases in 85th-percentile speeds were 73.7% greater at ART mid-block sites than at control mid-block sites). BRT-related lane reductions were linked with particularly strong speed reductions; there were 85th-percentile speed reductions of 4.1 mph (12.6%) when general vehicle lanes were removed versus 2.2 mph (7.8%) when lanes were not removed. CONCLUSIONS: Speed reductions were experienced across the ART corridor even though 87.0% of BRT locations did not have a change in posted speed limit, suggesting that physical changes to the roadway associated with BRT were impactful in terms of speed reductions and in turn could possibly promote traffic injury prevention by decreasing the number and severity of crashes.

7.
Talanta ; 279: 126567, 2024 Jul 14.
Article in English | MEDLINE | ID: mdl-39059065

ABSTRACT

Identifying the time of ovulation is an important process for women seeking and avoiding pregnancy. Luteinizing hormone (LH) plays an important role in ovulation, which is very important in the reproductive mechanism. Therefore, detecting the LH level is of great importance in monitoring ovulation. In this study, sensitive, rapid and selective electrochemical biosensors were developed to detect LH quantitatively from human urine samples and to monitor the ovulation period. Isopotential region and current density optimization studies revealed that sensors with an electrode width and spacing of 1 mm had the optimum performance. Electrochemical impedance spectra evidenced immobilization of DSP self-assembled monolayers and anti-LH-beta antibody on the surface. While the mobile phone vibrator led to a 3.5-fold enhancement in response signals, the agitation system developed resulted in a 10-fold improvement. The sensors displayed detection limits of 1.02 and 1.53 mIU/ml in the range of 0-40 mIU/ml LH concentration obtained using two statistical approaches. Additionally, the sensors showed no cross-reactivity to hCG, which is very similar in structure and is widely reported to have high cross-reactivity.

8.
Food Res Int ; 191: 114702, 2024 Sep.
Article in English | MEDLINE | ID: mdl-39059909

ABSTRACT

Sterilization of Northern shrimp (Pandalus borealis) is a key tool to ensure their freshness for post-production transportation. However, in the face of the specific problem of quality deterioration caused by the increase of storage environment temperature due to unexpected circumstances or the prolongation of temporary storage time, it is still a technical challenge to realize intelligent decision-making and higher sterilization efficiency. In this paper, we propose an intelligent UV-Ozone sterilization system suitable for cold chain transportation of Northern shrimp (Pandalus borealis). Using hierarchical analysis, equipartition method and the prediction method of generalized linear model, combined with the technology of intelligent control and remote control, we realized the automatic control of the system's UV irradiance from 324 âˆ¼ 1620 J/m2, and ozone concentration from21.4 ∼ 107 mg/cm3 in a graded manner. The accuracy of the predicted structure was verified using a combination of direct measurement and simulation. In addition, the key model of the system, the intensity level decision model, was tested, and the test results showed that the decision model was able to accurately make decisions during the sterilization of Northern shrimp (Pandalus borealis), and the system was able to achieve a sterilization effect of 1-3 orders of magnitude. This reduces quality loss due to unexpected conditions, facilitates real-time monitoring of transported samples by staff, extends the shelf life of the samples, and improves the accuracy of sterilization, increasing the economic value of Northern shrimp (Pandalus borealis).


Subject(s)
Food Storage , Ozone , Pandalidae , Sterilization , Ultraviolet Rays , Animals , Sterilization/methods , Food Storage/methods , Food Preservation/methods , Shellfish , Refrigeration
9.
Nano Lett ; 2024 Jul 25.
Article in English | MEDLINE | ID: mdl-39052536

ABSTRACT

Metallic nanoclusters (MNCs) were developed rapidly in recent decades, owing to their unique electronic structures and excited state characteristics, leading to their wide applications. Luminescence as one of the most important functions for MNCs has also been used to realize biodetection, displays, and lighting, through either electrochemiluminescence (ECL) or electroluminescence (EL). Both emissive properties and electrochemical activities of MNCs were utilized to enhance ECL and EL through facilitating exciton formation and radiation, rendering the rapid emerging of the latter in the last ten years. Through ligand modification, radiative excited-state components were increased to realize state-of-the-art photo- and electroluminescence efficiencies up to ∼100% and ∼30%, as well as ultralow biodetection limits. Nonetheless, material selection space and processing technologies are still limited. Herein, we overview and discuss recent advances of MNCs-based ECL and EL, through both aspects of materials/systems and devices, which would enlighten continuous innovations in optoelectronic MNCs.

10.
Sci Total Environ ; : 174724, 2024 Jul 25.
Article in English | MEDLINE | ID: mdl-39059649

ABSTRACT

Sustained deep emission reduction in road transportation is encountering bottleneck. The Intelligent Transportation-Speed Guidance System (ITSGS) is anticipated to overcome this challenge and facilitate the achievement of low-carbon and clean transportation. Here, we compiled vehicle emission datasets collected from real-world road experiments and identified the mapping relationships between four pollutants (CO2, CO, NOx, and THC) and their influencing factors through machine learning. We developed random forest models for each pollutant and achieved strong predictive performance, with an R2 exceeding 0.85 on the test dataset for all models. The environmental benefits of ITSGS at the urban scale were quantified by combining emission models with large-scale real trajectory data from Zibo, Shandong Province. Based on temporal and spatial analyses, we found that ITSGS has varying degrees of emission reduction potential during the morning peak, flat peak, and evening peak hours. Values can range from 5.71 %-8.16 % for CO2 emissions, 13.63 %-16.25 % for NOx emissions, 13.69 %-16.45 % for CO emissions, and 4.84-7.07 % for THC emissions, respectively. Additionally, ITSGS can significantly expand the area of low transient emission zones. The best time for achieving maximum environmental benefits from ITSGS is during the workday flat peak. ITSGS limits high-speed and aggressive driving behavior, thereby smoothing the driving trajectory, reducing the frequency of speed switches, and lowering road traffic emissions. The results of the ITSGS environmental benefits evaluation will provide new insights and solutions for sustainable road traffic emission reduction. SYNOPSIS: Large-scale deployment of Intelligent Transportation - Speed Guidance System is a sustainable solution to help achieve low-carbon and clean transportation.

11.
Biomolecules ; 14(7)2024 Jun 27.
Article in English | MEDLINE | ID: mdl-39062478

ABSTRACT

ACE2, part of the angiotensin-converting enzyme family and the renin-angiotensin-aldosterone system (RAAS), plays vital roles in cardiovascular and renal functions. It is also the primary receptor for SARS-CoV-2, enabling its entry into cells. This project aimed to study ACE2's cellular trafficking and maturation to the cell surface and assess the impact of various drugs and compounds on these processes. We used cellular and biochemical analyses to evaluate these compounds as potential leads for COVID-19 therapeutics. Our screening assay focused on ACE2 maturation levels and subcellular localization with and without drug treatments. Results showed that ACE2 maturation is generally fast and robust, with certain drugs having a mild impact. Out of twenty-three tested compounds, eight significantly reduced ACE2 maturation levels, and three caused approximately 20% decreases. Screening trafficking inhibitors revealed significant effects from most molecular modulators of protein trafficking, mild effects from most proposed COVID-19 drugs, and no effects from statins. This study noted that manipulating ACE2 levels could be beneficial or harmful, depending on the context. Thus, using this approach to uncover leads for COVID-19 therapeutics requires a thorough understanding ACE2's biogenesis and biology.


Subject(s)
Angiotensin-Converting Enzyme 2 , COVID-19 Drug Treatment , Protein Transport , SARS-CoV-2 , Angiotensin-Converting Enzyme 2/metabolism , Humans , SARS-CoV-2/drug effects , SARS-CoV-2/metabolism , Protein Transport/drug effects , Antiviral Agents/pharmacology , COVID-19/virology , COVID-19/metabolism , HEK293 Cells , Drug Evaluation, Preclinical
12.
Article in English | MEDLINE | ID: mdl-39037033

ABSTRACT

Therapeutic hypothermia (TH) is the only treatment method that is known to reduce mortality and neurological sequela rates in newborns with moderate and severe hypoxic-ischemic encephalopathy (HIE). We aimed to evaluate the relationship between rectal temperatures measured upon arrival to our unit and short-term outcomes in newborns with HIE/TH. This was a retrospective study conducted between January 2022 and January 2023. The neonates were divided into three groups according to their rectal temperatures measured upon arrival at our unit as follows: Group 1) <33°C, Group 2) 33-34°C (group arriving at target temperature), and Group 3) >34°C. Short-term outcomes and mortality were compared between the groups. Group 1 consisted of 17 (19.8%) neonates, Group 2 consisted of 34 (39.5%) neonates, and Group 3 consisted of 35 (40.7%) neonates who had HIE and an indication for TH. Rectal temperature on arrival to the unit was not related to the rate of clinical convulsions, rates of abnormal attenuated electroencephalography and magnetic resonance imaging findings, rate of pulmonary hypertension, duration of mechanical ventilation and length of hospital stay. Although the mortality rate was 29% in Group 1, it was 3% and 6% in Groups 2 and 3, respectively (p = 0.016). No relationship was found between the rectal temperature upon arrival to the NICU and the short-term outcomes in HIE/TH neonates. However, the mortality rate in those who were overcooled was significantly higher compared with the other groups.

13.
Int J Inj Contr Saf Promot ; : 1-3, 2024 Jul 10.
Article in English | MEDLINE | ID: mdl-38982954

ABSTRACT

The aim of this work is to analyze trends in youth transportation fatalities and injuries in North Carolina (NC), assess the implementation of ignition interlock devices (IIDs) in the United States and abroad, discuss policy implications for IIDs, and highlight health equity considerations related to motor vehicle collisions (MVCs). MVCs cause the highest number of unintentional injury-related deaths for children and teenagers in NC, and policymakers should pay special attention to MVCs related to alcohol consumption. IIDs are effective in reducing collision rates and recidivism for driving under the influence of alcohol (DUI). Ignition interlock device requirements have been increasingly implemented globally over the past three decades. However, the adoption of stricter IID policies after first-time DUI offenses in NC and across the U.S. is a prudent public health measure to enhance transportation safety for both adults and children. Evidence-based interventions such as IIDs must also strive to address inequities in transportation safety, and the framing of proposed policies should reflect the tenets of cultural humility.

14.
Disabil Health J ; : 101666, 2024 Jun 25.
Article in English | MEDLINE | ID: mdl-38964937

ABSTRACT

Social participation is associated with better health, quality of life, physical activity, and engagement in community living and is thus an emerging health priority. Transportation plays an important role in facilitating social participation. Our team recently reported in the Journal of Disability and Health that Missouri-dwelling adults aging with long-term physical disabilities who use paratransit services as their primary transportation mode are more likely to participate in social roles and activities outside the home compared to those who do not use paratransit. In March of 2023, the paratransit company Metro Call-A-Ride that serves St. Louis announced major scale backs to their coverage zones due in part to staffing shortages. This decision has been met with a formal complaint filed to the U.S. Department of Justice as well as protest from the St. Louis disability community and advocates. Thousands of individuals who relied on Call-A-Ride for their routine community outings-to work, grocery stores, or medical appointments, for example-have been affected by the cuts. In this commentary, we will summarize the media coverage this decision has received, including the perspectives of disability rights advocates and individuals who have been directly affected. We will then present an overview of our original research findings in the context of these recent events and a brief synthesis of existing literature on paratransit services in the U.S. The commentary will end with proposed policy, research, and programming solutions for St. Louis's Metro Call-A-Ride and public transportation at large.

15.
Sci Rep ; 14(1): 15470, 2024 Jul 05.
Article in English | MEDLINE | ID: mdl-38969682

ABSTRACT

Fuel cell vehicles (FCVs) are gaining significance due to their potential to reduce greenhouse gas emissions and dependence on fossil fuels. Their efficient fuel cell cycle makes them ideal for last-mile transportation, offering zero emissions and longer range compared to battery electric vehicles. Additionally, the generation of electricity through fuel cell stacks is becoming increasingly popular, providing a clean energy source for various applications. This paper focuses on utilizing the energy from fuel cycle bicycles when it's not in use and feeding it into the home DC grid. To achieve this, a dual-phase DC to DC converter is proposed to boost stack voltage and integrate with the 24 V DC home grid system. The converter design is simulated using the PSIM platform and tested in a hardware-in-the-loop (HIL) environment with real-time simulation capabilities.

16.
Synth Syst Biotechnol ; 9(4): 742-751, 2024 Dec.
Article in English | MEDLINE | ID: mdl-38974023

ABSTRACT

Plant natural products (PNPs) exhibit a wide range of biological activities and have essential applications in various fields such as medicine, agriculture, and flavors. Given their natural limitations, the production of high-value PNPs using microbial cell factories has become an effective alternative in recent years. However, host metabolic burden caused by its massive accumulation has become one of the main challenges for efficient PNP production. Therefore, it is necessary to strengthen the transmembrane transport process of PNPs. This review introduces the discovery and mining of PNP transporters to directly mediate PNP transmembrane transportation both intracellularly and extracellularly. In addition to transporter engineering, this review also summarizes several auxiliary strategies (such as small molecules, environmental changes, and vesicles assisted transport) for strengthening PNP transportation. Finally, this review is concluded with the applications and future perspectives of transportation engineering in the construction and optimization of PNP microbial cell factories.

17.
Sci Total Environ ; 948: 174701, 2024 Jul 10.
Article in English | MEDLINE | ID: mdl-38997012

ABSTRACT

Holistic study of glacial lakes and glacial lake outburst floods (GLOFs) in the strategically important China-Nepal transportation corridors is imperative for regional connectivity and disaster risk reduction. This study focuses on four China-Nepal transportation corridors, namely Chentang-Kimathanka, Zhangmu-Kodari, Keyrung-Kathmandu and Taklakot-Hilsa from east to west in the Himalayan region. Within a remote integrated framework, we present the latest high-resolution inventory of glacial lakes, assess their decadal spatio-temporal changes (1992-2022), identify potentially dangerous glacial lakes, and apply hydrodynamic model to assess downstream impacts of possible GLOFs along the study area. The results show 2688 glacial lakes (≥0.001 km2) with a total area of 116.10 ± 8.53 km2 over the study area in 2022. Glacial lakes exhibited spatiotemporal heterogeneity in expansion, with overall expansion of 32 % during 30 years. Keyrung-Kathmandu corridor, among others, was assessed with high GLOF susceptibility. Furthermore, hydrodynamic modeling of four highly dangerous lakes in each transportation area reveals that GLOFs have cross-border effects, impacting ∼103 km of China-Nepal highway, 103 bridges, two major dry ports and 3301 buildings in both countries. Based on these findings, we emphasize the joint efforts of both countries for integrated disaster management for smooth connectivity between two countries and saving downstream population through joint cooperation from central to local government levels by initiating artificial lake lowering, developing cross-border early warning systems and cooperation. This study is valuable for presenting a synergistic study of glacial lakes and GLOF for informing decision- and policy-makers of both China and Nepal for a joint approach to disaster mitigation.

18.
Sci Total Environ ; 948: 174597, 2024 Jul 08.
Article in English | MEDLINE | ID: mdl-38986691

ABSTRACT

The spatial pattern of toxic metals plays a major role in watershed diffuse metal non-point source pollution, particularly during stream sediment transportation at hills mines. This study investigated a typical hilly mine area to quantitatively analyze the characteristics, sensitivities, and influencing factors of toxic elements transported in stream sediments through field research and Geodetector models. The results showed that the spatial patterns of toxic elements in stream sediment transportation at the hills mine area were significantly influenced by water erosion and sulfate. Water erosion and sulfate promoted the transport differences of stream sediment metals from upstream to downstream at the hills mine area. Arsenic, cadmium, mercury, and antimony in the stream sediments at the hills mine exhibited higher coefficients of variation (101 % to 397 %) than those in plain and basin topographies. Potential ecological risks of arsenic and cadmium were assessed as high-risk levels, at 19 % and 64 %, respectively. Metal import in the midstream sediments of the hills mine area was accelerated by strong water erosion. Sulfate and dissolved organic matter (DOM) were highly enriched in stream sediments, with sulfate showing a strong correlation with toxic metals (24 %). Positive responses were observed between arsenic, mercury, antimony, and sulfate in sediments, with sensitivities of 41 %, 25 %, and 16 %, respectively, while cadmium was associated with DOM, with a sensitivity of 46 %. Importantly, water erosion interactions with functional type of mine significantly influenced on the spatial transportation patterns of toxic metals in stream sediments. The interactive influences of sulfate combined with bicarbonate on arsenic, mercury, and antimony and bicarbonate combined with DOM on cadmium were enhanced compared to individual factors (>20 %). This study elucidates the spatial patterns of metals during stream sediment transportation in hills mine and offers the novel insights for developing effective watershed metal management strategies in hilly mine environments.

19.
Heliyon ; 10(12): e32895, 2024 Jun 30.
Article in English | MEDLINE | ID: mdl-39005922

ABSTRACT

The present study investigates a Multi-Objective Transportation Problem within a fuzzy environment. The cost of transportation, supply, and demand data are assumed to be inaccurate due to market variations. As a result, the parameters are imprecise or fuzzy data. We offer a multi-objective, balanced transportation problem during this work, where all the parameters are fuzzy numbers. Following a mathematical formulation, fuzzy arithmetic will be used to divide the Fuzzy MOTP into three levels MOTP (lower, medium, upper). After reducing the problem to a crisp MOTP and applying a harmonic mean to each objective function, a suggested solution procedure is presented. Determining the optimal solutions for the FMOTP under unknown situations is, thus, the most important objective of this research.

20.
Sci Rep ; 14(1): 15752, 2024 Jul 08.
Article in English | MEDLINE | ID: mdl-38977818

ABSTRACT

Governmental policies, regulations, and responses to the pandemic can benefit from a better understanding of people's resulting behaviours before, during, and after COVID-19. To avoid the inelasticity and subjectivity of survey datasets, several studies have already used some objective variables like air pollutants to estimate the potential impacts of COVID-19 on the urban transportation system. However, the usage of reactant gases and a narrow time scale might weaken the results somehow. Here, both the objective passenger volume of public transport and the concentration of private traffic emitted black carbon (BC) from 2018 to 2023 were collected/calculated to decipher the potential relationship between public and private traffic during the COVID-19 period. Our results indicated that the commuting patterns of citizens show significant (p < 0.01) different patterns before, during, and after the pandemic. To be specific, public transportation showed a significant (p < 0.01) positive correlation with private transportation before the pandemic. This public transportation was significantly (p < 0.01) affected by the outbreaks of COVID-19, showing a significant (p < 0.01) negative correlation with private transportation. Such impacts of the virus and governmental policy would affect the long-term behaviour of individuals and even affect public transportation usage after the pandemic. Our results also indicated that such behaviour was mainly linked to the governmental restriction policy and would soon be neglected after the cancellation of the restriction policy in China.


Subject(s)
COVID-19 , Quarantine , Transportation , Humans , COVID-19/epidemiology , COVID-19/prevention & control , Pandemics/prevention & control , SARS-CoV-2 , Cities , Air Pollution/analysis , Air Pollution/prevention & control , Air Pollution/legislation & jurisprudence , Air Pollutants/analysis , China/epidemiology , Vehicle Emissions/analysis , Vehicle Emissions/prevention & control , Vehicle Emissions/legislation & jurisprudence
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