Childhood adversity in a youth psychiatric population: prevalence and associated mental health problems.

Background: Childhood adversity can have lasting negative effects on physical and mental health. This study contributes to the existing literature by describing the prevalence rates and mental health outcomes related to adverse childhood experiences (ACEs) among adolescents registered for mental health care.Methods: Participants in this cross-sectional study were youths (aged 12-18 years) who were referred to outpatient psychiatric departments in the Netherlands. Demographic information was collected from the medical records. The Child Trauma Screening Questionnaire (CTSQ) was used to examine the presence of ACEs and posttraumatic stress symptoms (PTSS). To assess mental health problems, we used the Dutch translation of the Youth Self Report. Descriptive statistics and frequencies were used to calculate prevalence rates across the various ACEs domains. ANOVA and chi-square tests were used to explore the relationship between ACEs and mental health.Results: Of the 1373 participants, 69.1% reported having experienced at least one ACE and 17.1% indicated exposure to four or more ACEs in their lives. Although there was substantial overlap among all ACE categories, the most frequently reported were bullying (49.2%), emotional abuse (17.8%), physical abuse (12.2%), and sexual abuse (10.1%). Female adolescents (72.7%) reported significantly more ACEs than their male counterparts (27.0%). Furthermore, a higher number of ACEs was associated with significantly more self-reported general mental health problems, an elevated prevalence of both mood and post-traumatic stress disorders, and a greater presence of two or more co-existing psychiatric diagnoses (comorbid psychiatric classification).Conclusions: This cross-sectional study on childhood adversity and its association with mental health showed that ACEs are highly prevalent in youth registered for mental health care. This study provides support for a graded and cumulative relationship between childhood adversity and mental health problems.

This study investigated the prevalence of adverse childhood experiences and associated mental health problems among Dutch youth registered for mental health care. Almost seven out of ten patients reported having been exposed to childhood adversity, and two out of ten patients reported exposure to four or more adverse childhood experiences.The results indicated a significant association between exposure to childhood adversity and mental health problems.Analysis of the data showed a cumulative effect of adverse childhood experiences, meaning that patients who reported exposure to more childhood adversity also showed more severe internalizing and externalizing mental health problems, a significant increase in both posttraumatic stress disorder and mood disorder diagnoses, and a general increase in psychiatric comorbidities.

Posttraumatic stress and depression symptom classes in parents of trauma-exposed children: a transdiagnostic perspective using pooled individual participant data.

Background: In the aftermath of child trauma, post-traumatic stress (PTS) and depression symptoms often co-occur among trauma exposed children and their parents. Studies have used latent class analysis (LCA) to examine PTS and depression symptoms and identify homogeneous subgroups among trauma exposed children. However, little is known about subgroups or classes of PTS and depression reactions of parents of traumatised children.Objectives: (1) Determine PTS and depression symptom classes at 2-9 months post-trauma, and (2) to examine sociodemographic covariates among parents of trauma exposed children.Methods: Using harmonised individual participant data (n = 702) from eight studies (Australia, UK, US) included in the Prospective studies of Acute Child Trauma and Recovery Data Archive (PACT/R), we modelled these phenomena at the symptom level using LCA.Results: Our LCA yielded three solutions: 'high internalizing symptom' class (11%); 'low PTS-high depression' class (17%); and 'low internalizing symptom' class (72%). Parents of children in the 'low PTS-high depression' class were more likely to have children of older age and be part of an ethnic minority, compared to the 'low internalizing symptoms' class. Mothers were more likely to be in the 'high internalizing symptom' class compared to the 'low internalizing symptoms' class.Conclusions: These findings reveal a qualitative structure and relationship between depression and PTS symptoms that highlights the importance of assessing and targeting a broad range of internalising symptoms in post-trauma psychological treatment.

Using harmonised individual participant data from eight studies included in the Prospective studies of Acute Child Trauma and Recovery (PACT/R) Data Archive we identified three distinct classes of parental internalising reactions using Latent Class Analysis.Mothers, family ethnic minority status, and children of older age were associated with distinct classes of problematic symptoms.The findings from the present study highlight the need for assessing and targeting a broad range of internalising symptoms after trauma, and that mothers, parents of older children and families with ethnic minority status might be at risk for elevated symptoms.

Relationship between hair cortisol concentrations and cognitive functioning in adolescents with ADHD.

Background: Our study aimed to explore whether the hair cortisol concentration (HCC), a measure of long-term cortisol output, is associated with poorer cognitive functioning in adolescents with attention deficit and hyperactivity disorder (ADHD). We further aimed to test the potential moderating effects of sex and childhood maltreatment.Methods: In this cross-sectional study, fifty-three adolescents with ADHD were studied. The ADHD Rating Scale (ADHD-RS) and Childhood Trauma Questionnaire (CTQ) were administered. Seven cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were administered, and two cognitive factors (attention and memory and executive functioning) were identified by confirmatory factor analysis. A 3-cm hair sample from the posterior vertex region of the head was obtained. HCCs were determined by a high-sensitivity enzyme immunoassay kit. Multiple linear regression analyses were used to explore the association between HCCs and either cognitive performance or ADHD severity while adjusting for sex, childhood maltreatment and the ADHD-RS total score.Results: Sex moderated the relationship between HCCs and attention/memory confirmatory factor analysis (CFA) scores, with better performance in boys with higher HCCs. HCCs were not associated with executive functioning or ADHD symptoms. Childhood maltreatment was associated with inattention symptoms in adolescents with ADHD.Conclusions: Our study suggests that HCCs are positively associated with attention and memory performance in adolescents with ADHD, with a moderating effect of sex (the relationship is strongest in boys).

We studied the relationship between cortisol and cognition in adolescents with ADHD.Hair cortisol concentrations (HCCs) were determined.We explored the moderating effects of sex and childhood trauma.Sex moderated the relationship between HCCs and attention and memory.Childhood trauma did not moderate the relationship between HCCs and cognition.

Child maltreatment and resilience in adulthood: a protocol for a systematic review and meta-analysis.

Background: Although child maltreatment (CM) has been linked to health problems and poor psychosocial functioning, not all individuals exposed to CM develop or experience negative consequences later in life. This suggests that some individuals show resilience after being exposed to CM. However, conclusions have been limited by inconsistent findings across different CM subtypes and resilience domains.Objective: To develop a protocol for conducting a systematic review and meta-analysis to quantify associations between CM (overall and its subtypes) and resilience (global and its multiple domains) in adulthood, and to examine moderators and mediators of these associations.Method: PubMed, PsycINFO, Embase, Scopus, and Web of Science will be searched to identify relevant studies on the association between CM (exposure) and resilience (outcome) in adults (≥ 18 years). Data will be screened and extracted by at least two independent reviewers. The methodological quality of the included studies will be independently assessed with a modified version of the Newcastle-Ottawa Scale (NOS). If deemed viable, a meta-analysis will be conducted using a random effects model. Heterogeneity of evidence will be estimated with the I2 statistic, and publication bias will be assessed. The effects of potential moderators (e.g. timing and severity of CM, age, sex, family cohesion, socio-economic status, country/region) will be analysed using meta-regression and subgroup analyses, and meta-analytical structural equation modelling will be employed to synthesise indirect mediation effects. Candidate moderators and mediators (e.g. genetic factors, brain functioning, attachment style, personality traits, physical activity, and social support) will be also examined qualitatively.Conclusions: This protocol will facilitate a systematic review and meta-analysis that has the potential to enhance our knowledge about the association between CM exposure in early life and resilience in adulthood. Understanding associations and underlying mechanisms between CM and resilience is potentially important in informing prevention and interventions to sustain health and improve outcomes among adults with a history of CM.PROSPERO registration: CRD42023394120.

In this study protocol, we propose to quantitatively summarise the existing literature on the relationship between child maltreatment and resilience with regard to mental health consequences and psychosocial functioning later in life.This preregistered systematic review and meta-analysis will establish the procedures to investigate associations between an overall classification of child maltreatment and its different associated subtypes, and a global/trait classification of resilience and its different domains in adults.This protocol will further determine the analytical approach to explore and summarise effect moderators and mediators of the association between child maltreatment and resilience in adulthood.The resulting synthesis, that will be based on this protocol, could enhance our understanding of the strength of the association between child maltreatment and resilience and inform prevention strategies and clinical interventions to improve health and psychosocial functioning in adult survivors.

The effect of childhood trauma on complex posttraumatic stress disorder: the role of self-esteem.

Background: Due to the short time that complex posttraumatic stress disorder (CPTSD) has been an independent diagnosis, few studies have explored the role that self-esteem might play in the relationship between childhood trauma and CPTSD.Objective: The current study aimed to explore the impact of childhood trauma on CPTSD and the role of self-esteem in this relationship.Methods: Study 1 involved a questionnaire survey in which a total of 360 young Chinese adults with childhood trauma participated. Study 2 used experimental research by manipulating short-term self-esteem to explore the effect of self-esteem on CPTSD. A total of 80 young Chinese adults with childhood trauma participated.Results: The results of Study 1 showed that childhood trauma positively predicts adulthood CPTSD, while self-esteem partially mediates the relationship between the two. It also found that self-esteem has a greater mediating effect on the disordered self-organization (DSO) dimension of CPTSD than on the PTSD dimension. In Study 2, participants in the high manipulated-self-esteem group reported fewer CPTSD symptoms than those in the low manipulated-self-esteem group.Conclusion: Overall, this study emphasized the role of self-esteem in CPTSD among individuals with a childhood trauma history. In practice, we provided a potential optimization direction for CPTSD clinical treatment, suggesting a method of self-esteem reconstruction.

Self-esteem mediates the relationship between childhood trauma and CPTSD.Short-term self-esteem decrease may contribute to CPTSD symptoms.Self-esteem has greater effects on disordered self-organization than PTSD symptoms.

Biological embedding of early trauma: the role of higher prefrontal synaptic strength.

Background: Early trauma predicts poor psychological and physical health. Glutamatergic synaptic processes offer one avenue for understanding this relationship, given glutamate's abundance and involvement in reward and stress sensitivity, emotion, and learning. Trauma-induced glutamatergic excitotoxicity may alter neuroplasticity and approach/avoidance tendencies, increasing risk for psychiatric disorders. Studies examine upstream or downstream effects instead of glutamatergic synaptic processes in vivo, limiting understanding of how trauma affects the brain.Objective: In a pilot study using a previously published data set, we examine associations between early trauma and a proposed measure of synaptic strength in vivo in one of the largest human samples to undergo Carbon-13 (13C MRS) magnetic resonance spectroscopy. Participants were 18 healthy controls and 16 patients with PTSD (male and female).Method: Energy per cycle (EPC), which represents the ratio of neuronal oxidative energy production to glutamate neurotransmitter cycling, was generated as a putative measure of glutamatergic synaptic strength.Results: Results revealed that early trauma was positively correlated with EPC in individuals with PTSD, but not in healthy controls. Increased synaptic strength was associated with reduced behavioural inhibition, and EPC showed stronger associations between reward responsivity and early trauma for those with higher EPC.Conclusion: In the largest known human sample to undergo 13C MRS, we show that early trauma is positively correlated with EPC, a direct measure of synaptic strength. Our study findings have implications for pharmacological treatments thought to impact synaptic plasticity, such as ketamine and psilocybin.

Abnormalities in the strength of synaptic connections have been implicated in trauma and trauma-related disorders but not directly examined.We used magnetic resonance spectroscopy to investigate the association between early trauma and an in vivo measure of synaptic strength.For people with posttraumatic stress disorder, as early trauma severity increased, synaptic strength increased, highlighting the potential for treatments thought to change synaptic connections in trauma-related disorders.

Empirically-derived dimensions of childhood adversity and cumulative risk: associations with measures of depression, anxiety, and psychosis-spectrum psychopathology.

Background: Investigating different approaches to operationalizing childhood adversity and how they relate to transdiagnostic psychopathology is relevant to advance research on mechanistic processes and to inform intervention efforts. To our knowledge, previous studies have not used questionnaire and interview measures of childhood adversity to examine factor-analytic and cumulative-risk approaches in a complementary manner.Objective: The first aim of this study was to identify the dimensions underlying multiple subscales from three well-established childhood adversity measures (the Childhood Trauma Questionnaire, the Childhood Experience of Care and Abuse Interview, and the Interview for Traumatic Events in Childhood) and to create a cumulative risk index based on the resulting dimensions. The second aim of the study was to examine the childhood adversity dimensions and the cumulative risk index as predictors of measures of depression, anxiety, and psychosis-spectrum psychopathology.Method: Participants were 214 nonclinically ascertained young adults who were administered questionnaire and interview measures of depression, anxiety, psychosis-spectrum phenomena, and childhood adversity.Results: Four childhood adversity dimensions were identified that captured experiences in the domains of Intrafamilial Adversity, Deprivation, Threat, and Sexual Abuse. As hypothesized, the adversity dimensions demonstrated some specificity in their associations with psychopathology symptoms. Deprivation was uniquely associated with the negative symptom dimension of psychosis (negative schizotypy and schizoid symptoms), Intrafamilial Adversity with schizotypal symptoms, and Threat with depression, anxiety, and psychosis-spectrum symptoms. No associations were found with the Sexual Abuse dimension. Finally, the cumulative risk index was associated with all the outcome measures.Conclusions: The findings support the use of both the empirically-derived adversity dimensions and the cumulative risk index and suggest that these approaches may facilitate different research objectives. This study contributes to our understanding of the complexity of childhood adversity and its links to different expressions of psychopathology.

We investigated how different approaches to operationalizing childhood adversity relate to transdiagnostic psychopathology.Four childhood adversity dimensions were found to underlie multiple subscales from three well-established childhood adversity measures.The childhood adversity dimensions demonstrated some specificity in their associations with the psychopathology symptom domains and the cumulative risk index was associated with all the outcomes.

A systematic literature review of the relationship between parenting responses and child post-traumatic stress symptoms.

Background: Parents are a key source of support for children exposed to single-incident/acute traumas and can thereby play a potentially significant role in children's post-trauma psychological adjustment. However, the evidence base examining parental responses to child trauma and child posttraumatic stress symptoms (PTSS) has yielded mixed findings.Objective: We conducted a systematic review examining domains of parental responding in relation to child PTSS outcomes.Method: Studies were included if they (1) assessed children (6-19 years) exposed to a potentially traumatic event, (2) assessed parental responses to a child's trauma, and (3) quantitatively assessed the relationship between parental responses and child PTSS outcomes. A systematic search of three databases (APAPsycNet, PTSDpubs, and Web of Science) yielded 27 manuscripts.Results: Parental overprotection, trauma communication, avoidance of trauma discussion and of trauma reminders, and distraction were consistently related to child PTSS. There was more limited evidence of a role for trauma-related appraisals, harsh parenting, and positive parenting in influencing child outcomes. Significant limitations to the evidence base were identified, including limited longitudinal evidence, single informant bias and small effect sizes.Conclusion: We conclude that key domains of parental responses could be potential intervention targets, but further research must validate the relationship between these parental responses and child PTSS outcomes.

Child post-traumatic stress symptoms following acute trauma are consistently related to post-trauma parental overprotection, avoidance of trauma discussion and of trauma reminders, and promotion of distraction from trauma-related thoughts and stimuli.The findings from this review provide a potential rationale for targeting these parental domains in clinical interventions addressing children's post-traumatic stress symptoms.Future research is needed to validate the longitudinal relationship between parental response domains following children's traumatic exposure and child post-traumatic stress symptoms.

Abuso sexual infantil y su retorno en la adultez: reflexiones desde un caso clínico / Abús sexual infantil i el retorn a l’adultesa: reflexions des d’un cas clínic / Childhood sexual abuse and its return in adulthood: reflections from a clinical case

La clínica con adultosabusados sexualmente en la infancia es una línea de investigación muy abordada en estudios sobre el abusosexual infantil. El presente trabajo es un estudio descriptivo de caso único con el objetivo de analizar el materialclínico de una paciente de veinticinco años que sufrió abuso intrafamiliar en la infancia. Este material se extraede entrevistas de un proceso psicoterapéutico. En primer lugar, se realiza la descripción del caso clínico y lue-go se articula con análisis teórico psicoanalítico. Se profundiza en: desubjetivación, traumatismo, mecanismosdefensivos y desamparo, acomodación, síntomas, elaboración terapéutica y contexto patriarcal. Por último, sereflexiona sobre el ideal de familia como dadora incondicional de cuidado y se plantea al abuso sexual infantilcomo síntoma social, siendo una compleja problemática que requiere de abordajes interdisciplinarios.(AU)

The clinic with sexually abu-sed adults in childhood is a line of research that has been widely addressed in studies on child sexual abuse. Thepresent work is a descriptive single case study with the aim of analyzing the clinical material of a twenty-five yearold patient who suffered intrafamilial abuse in childhood. This material is extracted from interviews of a psychothe-rapeutic process. First, a description of the clinical case is made and then it is articulated with psychoanalytictheoretical analysis. It is deepened in: desubjectivation, traumatism, defensive mechanisms and helplessness, ac-commodation, symptoms, therapeutic elaboration and patriarchal context. Finally, we reflect on the ideal of thefamily as an unconditional giver of care and consider child sexual abuse as a social symptom, a complex problemthat requires interdisciplinary approaches.(AU)

La clínica amb adults abusats sexual-ment a la infància és una línia de recerca molt abordada en estudis sobre l'abús sexual infantil. Aquest treball ésun estudi descriptiu de cas únic amb l'objectiu d'analitzar el material clínic d'una pacient de vint-i-cinc anys queva patir abús intrafamiliar a la infància. Aquest material s’extreu d’entrevistes d’un procés psicoterapèutic. Enprimer lloc, es fa la descripció del cas clínic i després s’articula amb anàlisi teòrica psicoanalítica. S'aprofundeixen: desubjectivació, traumatisme, mecanismes defensius i desemparament, acomodació, símptomes, elaboracióterapèutica i context patriarcal. Finalment, es reflexiona sobre l’ideal de família com a donadora incondicionalde cura i es planteja l’abús sexual infantil com a símptoma social, cosa que és una problemàtica complexa querequereix abordatges interdisciplinaris.(AU)

Trauma infantil en esquizofrenia. Implicaciones en los síntomas psicóticos positivos y negativos / Childhood trauma and schizophrenia. Implications for positive and negative psychotic symptomsresumen

La relación entre trauma infantil (TI) y la psicosis está bien establecida y son diversas las teorías sobre los factores que median en esta relación. También son muchos los estudios que exploran la influencia del TI en el curso de la psicosis en distintas áreas. El objetivo de este estudio fue explorar la influencia del TI en la presencia e intensidad de los síntomas psicóticos positivos (SPP) y negativos (SPN) en pacientes con trastornos del espectro esquizofrénico. Se incluyeron un total de 45 pacientes con diagnóstico de esquizofrenia o trastorno esquizoafectivo. Se valoraron datos sociodemográficos, los antecedentes de TI mediante el Childhood Trauma Questionnaire, Short Form (CTQ-SF), así como la intensidad de los síntomas psicóticos positivos y negativos mediante la Positive and Negative Syndrome Scale (PANSS+ y -).De la totalidad de la muestra, 35 pacientes, el 77,8 %, habían padecido algún tipo trauma infantil; el 55,6%, negligencia emocional; el 48,9%, abuso emocional: el 46,7%, negligencia física y el 40,0%, abuso sexual. No encontramos correlación entre CTQ-SF y PANSS+ y sí una relación inversa ente CTQ-SF v PANSS- (Rho -0.300, p=0.045). A diferencia de otros estudios no encontramos una correlación entre el TI y los SPP, a excepción del abuso físico con el ítem de excitación, tal vez debido a la cronicidad de los pacientes de nuestra muestra. La correlación moderada e inversa entre el TI y los SPN sugerimos que podría deberse a que los síntomas psicóticos positivos y negativos surgirían de diátesis distintas. Los síntomas negativos estarían en relación con déficits de neurodesarrollo y no relacionados con el estrés, como se ha sugerido en los síntomas psicóticos positivos. Sin embargo, dado que es trata de un hallazgo poco replicado, es difícil establecer conclusiones claras.(AU)

The relationship between childhood trauma (CT) and psychosis is well established and theories about the factors mediating this relationship are diverse. CT is associated with a worse prognosis of psychosis The aim of this study was to explore the influence of childhood trauma on the presence and intensity of positive (PPS) and negative psychotic symptoms (NPS) in patients with schizophrenic spectrum disorders. Forty-five patients with a diagnosis of schizophrenia or schizo affective disorder were included. Sociodemographic data, childhood trauma history using the Childhood Trauma Questionnaire Short Form (CTQ-SF) and the intensity of positive and negative psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS + and -), were valued. Of the total sample, 35 patients, 77.8%, had suffered some type of childhood trauma; 55.6%, emotional neglect; 48.9%, emotional abuse: 46.7%, physical neglect and 40.0%, sexual abuse. We did not find a correlation between CTQ-SF and PANSS+ and an inverse relationship between CTQ-SF v PANSS- (Rho -0.300, p=0.045). Unlike other studies, we did not find a correlation between CT and PPS, except for physical abuse with the excitation item, perhaps due to the chronicity of patients in our sample. The inverse corre lation between CT and NPS may be due to positive and negative psychotic symptoms arising from different diameters. NPS could be related to neurological development deficits and not related to stress, as suggested in PPS. However, since it is a finding with little replication, it is difficult to draw clear conclusions.(AU

Prevalência de experiências traumáticas na infância entre usuários na atenção primária no centro-oeste do Brasil / Prevalence of traumatic childhood experiences in users of primary care in the midwest region of Brazil / Prevalencia de experiencias infantiles traumáticas entre usuarios en la atención primaria en centro-oeste de Brasil

Objetivo: analisar as experiências traumáticas na infância e sua associação com características sociodemográficas, da infância e da família de usuários da Atenção Primária de Saúde. Método: Estudo transversal com adultos atendidos nas unidades básicas de saúde de Cuiabá, MT. Utilizou-se um questionário autoaplicável e as experiências traumáticas foram avaliadas por meio do Questionário sobre Traumas na Infância (QUESI). Os testes Qui-quadrado e Exato de Fisher avaliaram a associação entre as variáveis. Resultados: Dos 463 entrevistados, 78,8% vivenciaram pelo menos um tipo de trauma na infância. Os abusos (físico, sexual e emocional) e negligência emocional estiveram associados a grande parte dos fatores relacionados à família e à infância. Conclusão: Evidenciou-se elevadas prevalências de abusos e negligências, mostrando-se associados a grande parte dos fatores relacionados à família e à infância em usuários da atenção primária da capital matogrossense e pouca distinção segundo características sociodemográficas (AU).

Objective: to analyze traumatic experiences in childhood and their association with sociodemographic, childhood and family characteristics of users of Primary Health Care. Method: Cross-sectional study with adults assisted at basic health units in Cuiabá, MT. A self-administered questionnaire was used, and traumatic experiences were assessed using the Childhood Trauma Questionnaire (QUESI). Chi-square and Fisher's exact tests assessed the association between variables. Results: Of the 463 respondents, 78.8% experienced at least one type of trauma in childhood. Abuse (physical, sexual and emotional) and emotional neglect were associated with most factors related to family and childhood. Conclusion: There was a high prevalence of abuse and neglect, being associated with most of the factors related to family and childhood in users of primary care in the capital of Mato Grosso and little distinction according to sociodemographic characteristics (AU).

Objetivo: analizar las experiencias traumáticas en la infancia y su asociación con las características sociodemográficas, infantiles y familiares de los usuarios de la Atención Primaria de Salud. Método: Estudio transversal con adultos en la unidades basicas de salud de Cuiabá, MT. Se utilizó un cuestionario autoadministrado y las experiencias traumáticas se evaluaron mediante el Cuestionario de Trauma Infantil. Las pruebas de chi-cuadrado y exacta de Fisher evaluaron la asociación entre variables. Resultados: De los 463 encuestados, el 78,8% experimentó al menos un tipo de trauma en la infancia. El maltrato (físico, sexual y emocional) y el abandono emocional se asociaron con la mayoría de los factores relacionados con la familia y la infancia. Conclusión: Hubo una alta prevalencia de maltrato y abandono, siendo asociado a factores relacionados con la familia y la infancia en los usuarios de la atención primaria de Cuiabá y poca distinción según las características sociodemográficas (AU).

Thinking the unthinkable: trauma, defence and early states of mind in the work of Alessandra Cavalli.

From my experience of working with her as the editor of many of her papers, this paper seeks to elucidate the late Alessandra Cavalli's clinical and theoretical approach to analytic work through a study of the editorial process her papers went through on their way to publication. This highlights a consistent theoretical synthesis integrating Klein, Fordham, Bion, Matte-Blanco and Ferrari in an archetypal structure that was firmly rooted in Jung. This synthesis, closely interwoven into Alessandra's clinical work but never fully articulated, was primarily concerned with the impact of trauma on the developing self and how this could be ameliorated through the analytic process, especially through the transformation of raw primitive affect into representational form via the containment provided by an emotionally attuned other.

A partir de mon travail avec elle en tant qu'éditeur d'un certain nombre de ses articles, cet article cherche à mettre en lumière l'approche théorique et clinique aboutie d'Alessandra Cavalli à travers l'étudedu processus éditorial de ses articles jusqu'à leur publication. Ceci permet de souligner une synthèse cohérente qui intègre Klein, Fordham, Bion, Matte-Blanco et Ferrari dans une structure archétypale fermement ancrée chez Jung. Cette synthèse, finement entremêlée avec son travail clinique mais jamais complètement explicite, est principalement soucieuse de l'impact du traumatisme sur le développement du soi et comment cela pourrait être amélioré par le processus analytique, particulièrement par la transformation d'affects primitifs sensibles en forme représentationnelle grâce au contenant fourni par la relation à un autre bien accordé émotionnellement.

El presente trabajo busvca elucidar el abordaje teórico y clínico en el trabajo analítico de los últimos tiempos de Alessandra Cavalli, a través del estudio del proceso editorial de los mismos en vías a su publicación, a partir de mi experiencia de trabajar con ella como editor de la mayor parte de sus escritos. Se destaca una consistente síntesis teórica intengrando Klein, Fordham, Bion. Matte-Blanco y Ferrari en una estrauctura arquetipal firmemente enraizada en Jung. Esta síntesis, entrelazada en su trabajo clínico pero nunca totalmente articulada, se refirió al impacto del trauma en el desarrollo del self y como este podría ser mejorado a través del proceso analítico, especialmente a través de la transformación de la emoción arcaica en forma representacional vía la contención ofrecida por un otro emocionalmente-entonado.

Borderline states: a topography of contemporary psyche.

This paper presents a discussion of issues concerning the concept of borderline personality disorder. We start from the constitution of the borderline structure, and move towards understanding particular aspects of borderline development, both on an individual and a collective level. This discussion is based on the examination of a progression in three different concentric circles: first, the context of child-parent relationships; second, interpersonal relationships established in the school environment; and, finally, an amplification of some aspects of contemporary culture that could be related to the current importance of this condition.

Cet article présente une discussion sur les questions relatives au concept de trouble de la personnalité borderline. Nous partons de la constitution de la structure borderline, pour aller ensuite vers la compréhension d'aspects particuliers du développement borderline, à la fois au niveau individuel et collectif. La discussion est fondée sur l'étude d'une progression dans trois cercles concentriques différents: premièrement le contexte des relations enfant-parent, deuxièmement les relations interpersonnelles établies dans l'environnement scolaire, et en dernier une amplification de certains aspects de la culture contemporaine qui pourraient rendre compte de l'importance actuelle de ce trouble.

El presente trabajo presenta una discusión sobre temas que conciernen al concepto del trastorno límite de la personalidad (borderline). Comenzamos con la constitución de la estructura borderline, para luego movernos hacia la comprensión de aspectos particulares del desarrollo borderline, tanto a nivel individual como colectivo. La discusión se basa en el análisis de la progresión a través de tres círculos concéntricos: primero, el contexto de la relación parental; segundo, las relaciones interpersonales en el contexto escolar; y finalmente una amplificación de ciertos aspectos de la cultura contemporánea que podrían estar relacionados con la importancia actual de esta condición.

Este artigo apresenta uma discussão de questões relacionadas ao conceito de transtorno de personalidade limítrofe. Partimos da constituição da estrutura limítrofe e avançamos para a compreensão de aspectos particulares do desenvolvimento limítrofe, tanto em nível individual quanto coletivo. A discussão baseia-se no exame de uma progressão em três círculos concêntricos diferentes: primeiro, o contexto das relações filho-pai; segundo, as relações interpessoais estabelecidas no ambiente escolar; e, finalmente, uma ampliação para alguns aspectos da cultura contemporânea que poderiam estar relacionados à importância atual dessa condição.

Contribution of Brain Cortical Features to the Psychological Risk Profile of Juvenile Offenders

Objectives: This study contributes to the neuroscience of offending behavior by addressing two aims: a) to examine differences in the cortical features in a group of male serious juvenile offenders (21 OG), versus controls (28 CG), both ranging from 18 to 21 years old; and b) to determine to what extent the differential cortical features and the risk psychological profile discriminate between the two groups. Method: Besides cortical measures, demographics, executive functioning, childhood trauma, psychopathic traits, psychopathological symptoms, and antisocial and delinquent behavior were assessed. Results: Whole-brain analysis of the cortical mantle identified increased cortical thickness in the cluster comprising the right middle temporal gyrus and a smaller surface area in the lateral orbitofrontal cortex for the OG compared to the CG. The discriminant function correctly classified 100% of cases of the CG and 94.7% of the OG. Right temporal cluster, childhood trauma, callousness and symptoms of interpersonal sensitivity, psychoticism, depression, phobic anxiety, and obsessive-compulsive behavior contributed to the OG. In turn, the lateral orbitofrontal cluster, psychopathic traits of grandiosity, unemotionality, and thrill seeking, and working memory contributed to the CG. Conclusions: The increased right middle temporal gyrus of the OG could be indicative of impaired brain development in social cognition processes since it appeared in combination with the higher risk profile. The reduced orbitofrontal cortex could be indicative of immature brain development in emotional control processes since it appeared in combination with the normative psychological profile in adolescence. Based on these novel findings, areas of potential improvement for research and intervention are suggested. (AU)

Objetivos: Este estudio contribuye a la neurociencia de la conducta delictiva abordando dos objetivos: a) examinar las diferencias en las características corticales en un grupo de delincuentes juveniles de sexo masculino (21 GD), frente a los controles (28 GC), ambos con edades comprendidas entre los 18 y los 21 años; y b) determinar hasta qué punto las características corticales diferenciales y el perfil psicológico de riesgo discriminan entre los dos grupos. Método: Además de las medidas corticales, se evaluaron los datos demográficos, el funcionamiento ejecutivo, el trauma infantil, los rasgos psicopáticos, los síntomas psicopatológicos y el comportamiento antisocial y delictivo. Resultados: El análisis del manto cortical de todo el cerebro mostró un mayor grosor cortical en el clúster que comprende la circunvolución temporal media derecha y una menor superficie en la corteza orbitofrontal lateral para el GD con respecto al GC. La función discriminante clasificó correctamente el 100% de los casos del GC y el 94,7% del GD. El clúster temporal derecho, el trauma infantil, la insensibilidad y los síntomas de sensibilidad interpersonal, psicoticismo, depresión, ansiedad fóbica y comportamiento obsesivo-compulsivo contribuyeron al GD. Por su parte, el clúster orbitofrontal lateral, los rasgos psicopáticos de grandiosidad, impasibilidad y búsqueda de emociones y la memoria de trabajo contribuyeron al GC. Conclusiones: La alteración temporal media derecha del GD podría ser indicativa de un desarrollo cerebral alterado en los procesos de cognición social, ya que este rasgo cortical apareció en combinación con el perfil de mayor riesgo. La reducción en el área orbitofrontal podría ser indicativa de un desarrollo cerebral inmaduro en los procesos de control emocional, ya que apareció en combinación con el perfil psicológico normativo en la adolescencia. A partir de estos hallazgos novedosos, se proponen áreas posibles de mejora para la investigación y la intervención. (AU)

Effects of childhood trauma on facial recognition of fear in psychosis.

INTRODUCTION: Childhood trauma has been reported as a risk factor for psychosis. Different types of traumatic experiences in childhood could lead to different clinical manifestations in psychotic disorders. METHODS: We studied differences in social cognition (emotion recognition and theory of mind) and clinical symptoms in a sample of 62 patients with psychosis (less than five years of illness) and childhood trauma, analysing performance by trauma type. RESULTS: Psychotic patients with a history of childhood trauma other than sexual abuse were more capable of recognizing fear as a facial emotion (especially when facial stimuli were non-degraded) than participants with a history of sexual abuse or with no history of childhood trauma (P = .008). We also found that the group that had suffered sexual abuse did not show improvement in fear recognition when exposed to clearer stimuli, although this intergroup difference did not reach statistical significance (P = .064). We have not found other differences between abuse groups, neither in clinical symptoms (PANSS factors) nor in Hinting Task scores. CONCLUSION: We have found differences in fear recognition among patients with psychotic disorders who have experienced different types of childhood trauma.

Efectos del trauma infantil en el reconocimiento de la expresión facial de miedo en psicosis / Effects of childhood trauma on facial recognition of fear in psychosis

Introducción: El trauma infantil ha sido descrito como un factor de riesgo para la psicosis. Diferentes tipos de experiencias traumáticas en la infancia podrían conducir a distintas manifestaciones clínicas en los trastornos psicóticos.Material y métodos: Estudiamos las diferencias en la cognición social (reconocimiento de emociones y teoría de la mente) y los síntomas clínicos en una muestra de 62 pacientes con psicosis (menos de 5 años de enfermedad) y trauma infantil, analizando los resultados en cada tarea según el tipo de trauma.Resultados: Los pacientes psicóticos con antecedentes de trauma infantil distinto al abuso sexual fueron más capaces de reconocer el miedo en una tarea de reconocimiento facial de emociones (especialmente cuando la imagen facial no estaba degradada) que los participantes con antecedentes de abuso sexual o sin antecedentes de trauma infantil (p=0,008). También encontramos que el grupo que había sufrido abuso sexual no mostró mejora en el reconocimiento del miedo cuando se le expuso a estímulos más intensos (comparación forma degradada y no degradada), aunque esta diferencia intergrupal no alcanzó significación estadística (p=0,064). No hemos encontrado otras diferencias entre los grupos de abuso, ni en los síntomas clínicos (factores PANSS) ni en las puntuaciones de Hinting Task.Conclusión: Hemos encontrado diferencias en el reconocimiento del miedo entre pacientes con trastornos psicóticos que han experimentado diferentes tipos de trauma infantil. (AU)

Introduction: Childhood trauma has been reported as a risk factor for psychosis. Different types of traumatic experiences in childhood could lead to different clinical manifestations in psychotic disorders.Material and methods: We studied differences in social cognition (emotion recognition and theory of mind) and clinical symptoms in a sample of 62 patients with psychosis (less than 5 years of illness) and childhood trauma, analysing performance by trauma type.Results: Psychotic patients with a history of childhood trauma other than sexual abuse were more capable of recognizing fear as a facial emotion (especially when facial stimuli were non-degraded) than participants with a history of sexual abuse or with no history of childhood trauma (P=.008). We also found that the group that had suffered sexual abuse did not show improvement in fear recognition when exposed to clearer stimuli, although this intergroup difference did not reach statistical significance (P=.064). We have not found other differences between abuse groups, neither in clinical symptoms (PANSS factors) nor in Hinting Task scores.Conclusion: We have found differences in fear recognition among patients with psychotic disorders who have experienced different types of childhood trauma. (AU)

Contributions from functional neuroimaging studies to the comprehension of traumatic child experiences: preliminary findings / Aportes de los estudios de neuroimagen funcional a la comprensión del trauma infantil: estudio preliminar

Abstract This study aimed to describe the cerebral activation patterns using fMRI (Functional Magnetic Resonance Imaging) technology in a sample of 15 children with Posttraumatic Stress Disorder (PTSD) and 7 with no PTSD. The study used a Quasi-experimental methodology where two experimental tasks were applied: an emotional face task and a version of an emotional Stroop task. The results point out differences in the group of PTSD on the processing of negative stimuli and changes in their frontal lobe activation. These preliminary results suggest that early traumatic experiences affect typical brain development patterns. And explicit and implicit variables involved in the traumatic experiences are discussed as a part of any intervention process.

Resumen El presente estudio tuvo como objetivo describir patrones de activación cerebral mediante una técnica de Imagen por resonancia magnética funcional -fMRI- (abreviatura en inglés de Functional Magnetic Resonance Imaging) en una muestra de niños con Trastorno de estrés postraumático (TEPT) y compararlos con un grupo de controles. Estudio cuasi-experimental en el que se tomó un grupo de 15 niños con TEPT y se comparó con un grupo de 7 niños sin TEPT. Se emplearon dos tareas experimentales: una prueba de caras y una versión del Stroop emocional. Los resultados preliminares, señalan diferencias en el procesamiento de estímulos, principalmente de carácter negativo en los niños con TEPT y cambios en los patrones de activación a nivel de estructuras frontales. Se concluye que el trauma a edad temprana afecta el curso normal del desarrollo cerebral y se evidencia la importancia de abordar los aspectos explícitos e implícitos asociados a la experiencia traumática como parte de la intervención.

Association between childhood trauma and brain anatomy in women with post-traumatic stress disorder, women with borderline personality disorder, and healthy women.

Background: Childhood trauma (CT) is associated with altered brain anatomy. These neuroanatomical changes might be more pronounced in individuals with a psychiatric disorder. Post-traumatic stress disorder (PTSD) and borderline personality disorder (BPD) are more prevalent in individuals with a history of CT. Objective: In this study, we examined limbic and total brain volumes in healthy women with and without a history of CT and in females with PTSD or BPD and a history of CT to see whether neuroanatomical changes are a function of psychopathology or CT. Method: In total, 128 women (N = 70 healthy controls without CT, N = 25 healthy controls with CT, N = 14 individuals with PTSD, and N = 19 individuals with BPD) were recruited. A T1-weighted anatomical MRI was acquired from all participants for Freesurfer-based assessment of total brain, hippocampus, and amygdala volumes. Severity of CT was assessed with a clinical interview and the Childhood Trauma Questionnaire. Group differences in hippocampal and amygdala volumes (adjusted for total brain volume) and total brain volume (adjusted for height) were characterized by analysis of covariance. Results: Volume of the total brain, hippocampus, and amygdala did not differ between the four groups (p > .05). CT severity correlated negatively with total brain volume across groups (r = -0.20; p = .029). Conclusions: CT was associated with reduced brain volume but PTSD or BPD was not. The association between CT and reduced brain volume as a global measure of brain integrity suggests a common origin for vulnerability to psychiatric disorders later in life.

Antecedentes: El trauma infantil (TI) se asocia con alteraciones en la anatomía cerebral. Estos cambios neuroanatómicos pueden ser más pronunciados en individuos con trastornos psiquiátricos. El trastorno de estrés postraumático (TEPT) y el trastorno de personalidad limítrofe (TPL) son más prevalentes en individuos con historia de TI.Objetivo: En este estudio, examinamos los volúmenes límbico y cerebral total en mujeres sanas con y sin historia de TI y mujeres con TEPT o TPL e historia de TI para ver si los cambios neuroanatómicos son una función de la psicopatología o del TI.Método: En total, 128 mujeres (N= 70 controles sanas sin TI, N= 25 controles sanas con TI, N= 14 individuos con TEPT y N= 19 individuos con TPL) fueron reclutadas. Se obtuvo una RNM anatómica ponderada en T1 de todas las participantes para la evaluación basada en Freesurfer de los volúmenes totales del cerebro, hipocampo y amígdala. La severidad del TI fue evaluada con una entrevista clínica y con el Cuestionario de Trauma Infantil. Las diferencias grupales en los volúmenes del hipocampo y amígdala (ajustadas por el volumen cerebral total) y el volumen cerebral total (ajustadas por altura) se caracterizaron mediante análisis de covarianza.Resultados: El volumen total del cerebro, hipocampo y amígdala no difirieron entre los cuatro grupos (p > .05). La severidad del TI se correlacionó negativamente con el volumen cerebral total en todos los grupos (r = −0.20; p =.29).Conclusiones: El TI estuvo asociado a un volumen cerebral reducido, pero el TEPT o TPL no se asociaron. La asociación entre TI y volumen cerebral disminuido como una medida global de la integridad cerebral sugiere un origen común de vulnerabilidad a los trastornos psiquiátricos más adelante en la vida.

Experiencias adversas infantiles ycronificación psicótica / Children’s adverse experiences and psychotic chronification

Introducción. La evidencia apunta a un período crítico dealrededor de cinco años tras el primer episodio psicótico decuya resolución depende la cronicidad del trastorno. Además,diversos estudios apuntan la elevada correlación entre psicosis adulta y adversidad infantil, y una relación dosis-respuesta en nivel de gravedad.El objetivo de la presente investigación es determinarla relación dosis-respuesta entre la psicosis adulta y la adversidad infantil y ponerla en relación con la resolución delperíodo crítico.Método. La muestra se obtuvo entre 45 pacientes a tratamiento en el Hospital Universitario San Agustín que habíanexperimentado algún episodio psicótico. Se aplicaron cuestionarios para el análisis de la psicopatología, la adversidadinfantil y otras variables sociodemográficas y clínicas.Resultados. Los resultados confirman la relación entrefrecuencia de adversidad infantil y cronificación psicótica.Conclusiones. Nuestra investigación pone de manifiestola importancia de la adversidad infantil en el futuro cursode una psicosis y destaca la importancia de recoger estos aspectos en la anamnesis. (AU)

Introduction. Research evidence points to a critical period of about five years after the first psychotic episode, beingits resolution of utmost importance for the chronicity of thedisorder. In addition, several studies suggest the high correlation between adult psychosis and childhood adversity, anda dose-response relationship in severity level.This research aims to determine the dose-response relationship between adult psychosis and put it in relation to theresolution of the critical period.Method. The sample was obtained among 45 patientsundergoing treatment at the San Agustín University Hospital who experienced some psychotic episode. Questionnaireswere applied for the analysis of psychopathology, childhoodadversity and other sociodemographic and clinical variables.Results. The results confirm the relationship between thefrequency of childhood adversity and psychotic chronification.Conclusions. Our research highlights the importance ofchildhood adversity in the future course of a psychosis andhighlights the importance of anamnesis focusing this regard. (AU)

Trauma infantil e manifestações histéricas na atualidade: uma revisão da literatura / Child trauma and hysterical manifestations today: a literature review

As reações corporais e emocionais sentidas pelos pacientes com manifestações histéricas podem atingir tamanha intensidade, a ponto de prejudicar sua vida social, familiar e laboral. O trabalho parte dos seguintes questionamentos: como são as manifestações histéricas na atualidade? Qual a compreensão sobre a histeria na literatura da área ao longo do tempo? O objetivo é descrever aspectos teóricos sobre a histeria e o trauma infantil, articulando-os com a clínica atual. Foi desenvolvida uma revisão da literatura por meio do método narrativo. Os resultados encontrados foram 106 estudos nos últimos 6 anos (Bireme e Dialnet), sendo que, de 2017 em diante, houve um decréscimo nas publicações científicas sobre o tema. Apesar de a categoria psicopatológica da histeria ter desaparecido dos manuais de transtornos mentais, na clínica atual as manifestações histéricas são facilmente confundidas com outros transtornos (depressivos, dissociativos e distúrbio borderline). As manifestações somáticas aparecem no corpo para comunicar eventos traumáticos não contidos pelo aparelho psíquico. Conclui-se que as manifestações histéricas seguem presentes nos dias de hoje, e o corpo tende a ser uma via de expressão somática. No contexto da relação entre sintomas histéricos e traumas vivenciados na infância, a psicoterapia ocupa lugar de destaque, promovendo ressignificações para tais eventos traumáticos.(AU)

The bodily and emotional reactions felt by patients with hysterical manifestations can reach such intensity as to harm their social, family and work life, causing several losses for the individual. The study starts from the following questions: how are the hysterical manifestations today? What about understanding hysteria in the literature of the area over time? The objective is to describe theoretical aspects of hysteria and childhood trauma, in conjunction with the current clinic. A literature review using the narrative method was developed. The results found were 106 studies in the last 6 years (Bireme and Dialnet), and as of 2017 there is a decrease in scientific publications on the topic. Although the psychopathological category of hysteria has disappeared from the manuals of mental disorders, nowadays in the clinic the hysterical manifestations are easily confused with other disorders (depressive, dissociative and borderline). Somatic manifestations appear in the body to communicate traumatic events not contained by the psychic apparatus. It is concluded that the hysterical manifestations are still present today, and the body tends to be an important way of expressing symptoms through the somatic path. In the context of the relationship between hysterical symptoms and childhood trauma, psychotherapy occupies a prominent place, promoting reframing for such traumatic events.(AU)

Las reacciones corporales y emocionales que sienten los pacientes con manifestaciones histéricas pueden alcanzar tal intensidad como para dañar su vida social, familiar y laboral, causando varias pérdidas para el individuo. El estudio parte de las siguientes preguntas: ¿Cómo son hoy las manifestaciones histéricas? ¿Cuál es la comprensión de la histeria en la literatura de la zona a lo largo del tiempo? El objetivo es describir aspectos teóricos de la histeria y el trauma infantil, en conjunto con la clínica actual. Se ha elaborado una revisión de la literatura utilizando el método narrativo. Los resultados encontrados fueron 106 estudios en los últimos 6 años (Bireme y Dialnet), y a partir de 2017 hubo una disminución en las publicaciones científicas sobre el tema. Aunque la categoría psicopatológica de histeria ha desaparecido de los manuales de trastornos mentales, hoy en día en la clínica las manifestaciones histéricas se confunden fácilmente con otros trastornos (depresivo, disociativo y borderline). Las manifestaciones somáticas aparecen en el cuerpo para comunicar eventos traumáticos no contenidos por el aparato psíquico. Se concluye que las manifestaciones histéricas todavía están presentes hoy en día, y el cuerpo tiende a ser una forma importante de expresar los síntomas a través de las vías somáticas. En el contexto de la relación entre los síntomas histéricos y el trauma vivido en la infancia, la psicoterapia ocupa un lugar destacado, promoviendo replanteamiento para tales eventos traumáticos.(AU)