ABSTRACT
[Objective] To further explore the mechanism of Zhuyun 3, a formula mainly composed of Radix Astragali seu Hedysari, Radix Codonopsis Pilosulae, Rhizoma Atractylodis Macrocephalae, Semem Cuscutae, Radix Dipsaci and Radix Polygoni Multiflori, in preventing and treating spontaneous abortion. [ Methods ] Contractility of isolated and in - vivo uterine in Zhuyun 3 group and saline group were observed by phannacological and sero - pharmacological methods. The strength, tension and frequency of uterine contraction and the area under curve were used as the indexes. [Results] Water extract of Zhuyun 3 ( WEZ3) and WEZ3 - contained serum can decrease the contractility of isolated and in - vivo rat uterine, the differences being significant (P
ABSTRACT
The pharmacodynamics of compound Guhuanzhixue granule(CGH- ZX)was studied.The results showed that CGHZX inhibited the contraction of rat's uterine smooth muscle and antagonized the vigorous contraction induced by oxytoxin in vitro,It exerted an anti-inflammatory effect in rats and miee with uteritis caused by various foreign bodies,This preseription also shertened the bleeding and coagulation times in mice.It is suggested that CGHZX is applicable to metrorrhagia,pain and uteritis occurring after setting of contra- ceptive ring.
