CURRENT PROBLEMS IN COMMUNICATIVE DEVELOPMENT OF CHILDREN WITH SPECIAL EDUCATIONAL NEEDS: UKRAINIAN AND EUROPEAN SCIENTIFIC CONTEXTS.

OBJECTIVE: The aim is to analyze the current problems in communicative development of children with special educational needs. PATIENTS AND METHODS: Materials and methods: The research used a number of scientific methods: general scientific (analysis, synthesis, generalization), historical, specific research, comparative-historical, and others, which ensured the selection and analysis of the source base, made it possible to determine the general trends in the study of the problem of the communicative development of the child, the achievements of Ukrainian and foreign scientists in the field of research on the language of children with special educational needs, to distinguish the common and the different in the scientific research of scientists. CONCLUSION: Conclusions: Updated studies of scientists from Ukraine, Poland, Sweden, Britain and other countries testify that communication skills are key in the language development of a preschool child, they form the basis without which the child's further education, socialization, etc. are impossible. Meanwhile, there is no unity among scientists in their views on the nature of language disorders and their classification. The contribution of domestic and foreign authors to the study of the communicative development of a child with speech difficulties is singled out.

Incidental pulmonary agenesis with multiple associated anomalies: A case report.

Pulmonary agenesis is an uncommon congenital abnormality of the lungs that occurs either in isolation or in association with other anomalies in several organ systems. Right sided pulmonary agenesis is reported to have a worse prognosis owing to the more severe mediastinal shift and resultant compression of mediastinal structures. We present a case of right-side pulmonary agenesis with multiple associated anomalies found incidentally in a 19-year-old female patient.

Assessing China's development zones and carbon emissions.

The present article evaluates establishment of development zones and its association with carbon emissions. In the process of industrialization, carbon emissions in underdeveloped regions of the world increase with economic growth. In order to promote economic growth in the western region and strengthen the management of enterprise pollution emissions, the Chinese government has set up hundreds of development zones. Existing research shows that development zone establishment can promote economic growth; however, literature is scarce when the relationship is tested across region. Based on the panel data of five provinces with relatively backward economy in western China from 2001 to 2017, this paper constructs a "multi-period difference-in-difference" (DID) model with the establishment of development zones as a "quasi-natural experiment" to test the relationship. Findings reveal that development zone establishment increases carbon emissions in the region, and has a significant inhibitory effect on carbon emissions at national level. The conclusions of this paper provide empirical evidence and policy implications for reducing carbon emissions in economically underdeveloped areas.

Fam83h mutation causes mandible underdevelopment via CK1α-mediated Wnt/ß-catenin signaling in male C57/BL6J mice.

Truncation mutations in FAM83H are the major cause of autosomal dominant hypocalcified amelogenesis imperfecta. Some studies also indicated that FAM83H could be involved in osteogenic differentiation; however, the function of FAM83H in bone formation was rarely explored. This study aimed to explore the effect of Fam83h mutation on skeletal development. We generated Fam83h c.1186C>T (p.Q396*) knockin C57/BL6J mice by CRISPR/Cas9 technology and found that the Fam83hQ396⁎/Q396⁎ male mice presented skeletal development retardation that was inconspicuous at birth but progressively worsened as they grew up. Alcian and Alizarin Red staining of the whole-mount skeleton showed Fam83hQ396⁎/Q396⁎ mice presented obvious skeletal development retardation. Moreover, Micro-computed tomography (Micro-CT) analysis and H&E staining showed that the mandible of Fam83hQ396⁎/Q396⁎ mice exhibited decreased bone trabecula and slight bone rarefaction compared with wild-type mice. Calcium and phosphorus content of serum and bone, and serum ALP activity analysis showed that the serum ALP activity and value of bone calcium were decreased in Fam83hQ396⁎/Q396⁎ mice. The reduced expression of mineralization markers of RUNX2, OSX, OCN, and COL1, the reduced ALP activity and the weakened ARS staining exhibited in osteoblasts isolated from 3-day-old Fam83hQ396⁎/Q396⁎ mice. The increased protein expression of casein kinase 1α (CK1α) in the cytoplasm and the decreased expression of ß-CATENIN in the nucleus indicated the inhibiting Wnt/ß-catenin signaling in osteoblasts from Fam83hQ396⁎/Q396⁎ mice. Furthermore, agonists of Wnt/ß-catenin signaling and Ck1α siRNA partially reversed the mineralization inhibition and the decreased expression of key signaling molecules in osteoblasts of Fam83hQ396⁎/Q396⁎ mice. In conclusion, Fam83h mutation caused the increase of cytoplasmic CK1α (as one of the components of the degradation complex), which in turn promoted degradation of ß-CATENIN in the cytoplasm and reduced ß-CATENIN translocation into the nucleus, subsequently inhibited Wnt/ß-catenin signaling in osteoblast differentiation, and thus resulted in the mandible underdevelopment in Fam83hQ396⁎/Q396⁎ male mice.

Dependency Theory: An Evaluation of the Period-Based Changes in the Utilization of Maternal Health Care and Neonatal Mortality in Tanzania Between 1991 and 2016.

While efforts have been made to increase maternal health care (MHC) utilization and decrease neonatal mortality in Tanzania, much remains to be known about the effect of dependency (particularly on reproductive policy changes) on the use of MHC and neonatal health over time among varying socioeconomic groups. This study applied dependency theory to cross-sectional secondary data (collected by the Tanzania Demographic Health Surveys between 1991 and 2016) to investigate period-based changes in MHC and neonatal mortalities in Tanzania. Results from the data analysis found that while neonatal mortalities were decreasing in Tanzania (from 1991 to 2016), the odds of neonatal mortality were still greater in 2016. Also, a decline in the recommended skilled delivery assistance and 4 + antenatal care visits occurred in the data period. A significant increase in socioeconomic inequality around MHC use and neonatal mortality occurred during the study period as well. Policy recommendations to reduce these inequalities and move toward meeting Sustainability Development Goals for maternal and neonatal health in Tanzania are discussed.

Gestational Diabetes Mellitus Impedes Fetal Lung Development Through Exosome-Dependent Crosstalk Between Trophoblasts and Lung Epithelial Cells.

Background: Fetal lung underdevelopment (FLUD) is associated with neonatal and childhood severe respiratory diseases, among which gestational diabetes mellitus (GDM) play crucial roles as revealed by recent prevalence studies, yet mechanism underlying GDM-induced FLUD, especially the role of trophoblasts, is not all known. Methods: From the perspective of trophoblast-derived exosomes, we established in vitro, ex vivo, in vivo and GDM trophoblast models. Utilizing placenta-derived exosomes (NUB-exos and GDMUB-exos) isolated from normal and GDM umbilical cord blood plasma and trophoblast-derived exosomes (NC-exos and HG-exos) isolated from HTR8/SVneo trophoblasts medium with/without high glucose treatment, we examined their effects on fetal lung development and biological functions. Results: We found that, compared with the NUB-exos group, the exosome concentration increased in GDMUB-exos group, and the content of exosomes also changed evidenced by 61 dysregulated miRNAs. After applying these exosomes to A549 alveolar type II epithelial cells, the proliferation and biological functions were suppressed while the proportion of apoptotic cells was increased as compared to the control. In ex vivo studies, we found that GDMUB-exos showed significant suppression on the growth of the fetal lung explants, where the number of terminal buds and the area of explant surface decreased and shrank. Besides, the expression of Fgf10, Vegfa, Flt-1, Kdr and surfactant proteins A, B, C, and D was downregulated in GDMUB-exos group, whilst Sox9 was upregulated. For in vivo studies, we found significant suppression of fetal lung development in GDMUB-exos group. Importantly, we found consistent alterations when we used NC-exos and HG-exos, suggesting a dominant role of trophoblasts in placenta-derived exosome-induced FLUD. Conclusion: In conclusion, GDM can adversely affect trophoblasts and alter exosome contents, causing crosstalk disorder between trophoblasts and fetal lung epithelial cells and finally leading to FLUD. Findings of this study will shine insight into the theoretical explanation for the pathogenesis of FLUD.

Mediastinal Shift Angle in Fetal MRI Is Associated With Prognosis, Severity, and Cardiac Underdevelopment in Left Congenital Diaphragmatic Hernia.

Objective: Fetal MRI has played an essential role in the evaluation and management of congenital diaphragmatic hernia (CDH). We aimed to investigate whether the mediastinal shift angle (MSA) value was associated with the prognosis and the severity of left CDH and explore the relationship between the MSA value and fetal and neonatal cardiac structures and functions. Methods: From January 2012 to December 2020, the fetal MSA values of left CDH in our institution were retrospectively measured. Other prenatal parameters and clinical outcomes of them are collected. We also measured the fetal and postnatal echocardiography parameters to analyze linear correlation with MSA values. Results: A total of 94 patients with left CDH were included. MSA was significantly higher in the deceased group than in the survived group [((38.3 ± 4.7)° vs. 32.3 ± 5.3)°, p < 0.001]. The MSA value of the high-risk defect group [CDH Study Group (CDHSG) C/D type] was significantly higher than that of the low-risk defect group [CDHSG A/B type; (36.0 ± 4.9)° vs. (30.1 ± 4.8)°, p < 0.001]. The AUC for severity was 0.766 (95% CI, 0.661-0.851, p < 0.0001) and the best cut-off value for MSA was 30.7°. Higher MSA correlates with decreased fetal Z-score of left ventricle (LV) width, the diameter of the mitral valve (MV), peak velocity of MV and tricuspid valve (TV), and neonatal LV end-diastolic diameter (LVEDD) and velocity of tricuspid regurgitation (TR; p < 0.05). Conclusion: A high MSA value can effectively predict high-risk defects and high mortality of left CDH. The higher the MSA value, the worse the neonatal conditions, the respiratory and cardiovascular prognosis. The MSA values could reflect the level of left heart underdevelopment, including decreased dimensions and diastolic dysfunction of the left ventricle.

An Exploratory Study of the Social Contract of Research and Innovation in Africa.

This exploratory study adds to the under-developed literature on a Research Topic that laden with epistemological, philosophical, and ideological overtones, and that begs many questions. The literature on political economy generally, and that for Africa, enjoys full disciplinary status. In contrast the political economy of research and innovation remains an emerging interdisciplinary field that examines the overlap between innovation studies and political economy. The pursuit of "science and technology" was expected to play its part in the imperialist and colonial agendas, and in the post-colonial project, when science and technology policy was a strong element in advocacy for Africa's post-independence development. What have the policies achieved, and what explains the shortfalls? What indeed is the relationship between industrial policy and research and innovation policy? What is the social contract with research and innovation? The study commences with a general overview of the social contract for science before turning to Africa's post-independence modernizing agenda, and the roles ascribed to industrial policy and research and innovation policy. An eclectic methodology drawing on Cloutier (2021) is deployed to characterize and measure the social contract between research and innovation. The methodology adapts Cloutier (2021) to the functionality of national innovation systems. The responsiveness of STI policy is further probed using Martin, 2015 categorization of innovation policy informed by Theory of Change. Where possible reference is made to conventional STI indicators. Research and innovation policy is then assessed at continental and national levels, with attention given to the extent of linkages in national innovation systems. Further to tease out the various forms of social contract, five country-level STI policies are analyzed using the Martin categorization and Theory of Change methodology. It will be argued that a binding, social contract for inclusive research and innovation policy is largely absent, so that the prospects for attaining the SDGs remain elusive. Post Glasgow COP-26, donor pressure might be re-oriented to promote engagement with the Sustainable Development Goals, though the upholding research sovereignty could mitigate against this. Africa might rightly chide against such pressure, given her experience of what has been labeled as "vaccine apartheid."

Surgical outcomes of pulmonary artery sling and congenital tracheal stenosis with right lung anomaly.

OBJECTIVES: This study aimed to investigate whether computed tomographic indices support surgical decision-making in patients with pulmonary artery sling, congenital tracheal stenosis and right lung underdevelopment. METHODS: A total of 38 patients with pulmonary artery sling and congenital tracheal stenosis underwent tracheoplasty. Patients were divided into 3 groups based on anatomical categorization: group normal lung (NL; n = 21), group H (right lung hypoplasia, n = 12) and group A (right lung agenesis or aplasia, n = 5). Using preoperative computed tomographic images, the severity of the tracheal bending due to the right posterior deviation of the aortic arch and the relative length of the left pulmonary artery for reimplantation was evaluated. RESULTS: Slide tracheoplasty posterior to the aortic arch with pulmonary artery reimplantation was performed in 32 patients (21, 10 and 1 in groups NL, H and A, respectively). Slide tracheoplasty anterior to the aortic arch was performed in 4 patients (2 patients each in groups H and A). Among the 6 patients with severe tracheal bending who underwent slide tracheoplasty posterior to the aortic arch, 5 required aortopexy for tracheomalacia. The overall mortality rate was 3% (group NL, n = 1). The relative length of the left pulmonary artery in group H (0.85) was significantly shorter than that in group NL (1.36, P < 0.0001). CONCLUSIONS: In patients with right lung underdevelopment, preoperative computed tomography elucidated the tracheal bending due to right posterior deviation of the aortic arch, which compromised tracheoplasty and shortness of the left pulmonary artery for pulmonary artery sling repair.

Unilateral opaque chest radiograph in paediatrics: A case series.

Pulmonary underdevelopment is a rare congenital disease which manifests as persistent hemithorax opacification at chest radiography. We present three patients with different types of pulmonary underdevelopment, their imaging features and associated anomalies. Case 1 is a premature neonate with persistent respiratory distress. Further imaging confirmed right pulmonary hypoplasia, associated with a patent foramen ovale, patent ductus arteriosus and vertebral anomalies. Case 2 is a 6-year-old child with corrected anorectal malformation, and recurrent pneumonia. Further imaging confirmed left pulmonary aplasia, associated with an aberrant right subclavian artery and vertebral anomaly. Case 3 is a full term neonate who developed excessive drooling of saliva and respiratory distress. Further imaging confirmed right pulmonary agenesis, associated with an atrial septal defect, patent ductus arteriosus and tracheo-oesophageal fistula. Pulmonary underdevelopment is classified into three types: hypoplasia, aplasia and agenesis. The majority of them have associated anomalies. This condition should be considered a differential diagnosis in paediatric patients with an opaque hemithorax on chest radiography.

Investigating the Role of Ferritin in Determining Sexual Underdevelopment in Beta-Thalassemia Major Patients: A Cross-Sectional Analysis From Pakistan.

Background Beta-thalassemia major, a genetic disorder, delineates a vast spectrum of hematological and endocrinological complications. Elevated serum ferritin levels in beta-thalassemia patients represent various transfusion-related complications including infection, hemochromatosis, and severe iron overload that might lead to endocrinopathies such as hypogonadism leading to sexual underdevelopment. Our study, thus, aims to explore the role of ferritin in determining sexual underdevelopment in such patients.  Methods This multicentric cross-sectional study included a total of 120 beta-thalassemia patients. The sexual development of the patients was assessed using the Tanner staging system. Serum ferritin levels and other demographical parameters of the patients were collected. Independent-samples t-test, chi-square test, and receiver operating characteristic (ROC) curve were used to analyze the data. Results Out of 120 patients, 70 patients were males with a mean age of 18.95 ± 4.21 years. According to the Tanner staging system, 48 patients were sexually underdeveloped while 72 patients achieved sexual maturity. ROC curve analysis showed that ferritin levels at a cutoff value of 4900 mg/dL were 73.7% sensitive and 71.1% specific to predict sexual underdevelopment in beta-thalassemia patients. Conclusions Elevated serum ferritin levels were moderately sensitive and specific in predicting sexual underdevelopment in beta-thalassemia patients. This can serve as a low-cost parameter in determining sexual underdevelopment in such patients. More prospective cohort studies are needed to establish the association between elevated serum ferritin levels and sexual underdevelopment.

Cerebellum and Prematurity: A Complex Interplay Between Disruptive and Dysmaturational Events.

The cerebellum plays a critical regulatory role in motor coordination, cognition, behavior, language, memory, and learning, hence overseeing a multiplicity of functions. Cerebellar development begins during early embryonic development, lasting until the first postnatal years. Particularly, the greatest increase of its volume occurs during the third trimester of pregnancy, which represents a critical period for cerebellar maturation. Preterm birth and all the related prenatal and perinatal contingencies may determine both dysmaturative and lesional events, potentially involving the developing cerebellum, and contributing to the constellation of the neuropsychiatric outcomes with several implications in setting-up clinical follow-up and early intervention.

Evaluation of respiratory system anomalies associated with microtia in a Chinese specialty clinic population.

BACKGROUND: Microtia is a congenital malformation of the external ear often with one or more associated congenital anomalies. The purpose of this study was to identify the characteristics and prevalence of respiratory anomalies in patients with microtia, and clarify the importance of this association in the perioperative period of patients' external ear reconstruction surgery. METHODS: Data were collected from 923 microtia patients between August 2017 and December 2020 in the Department of Auricular Reconstruction at the Plastic Surgery Hospital of Peking Union Medical College. Co-occurring respiratory anomalies were detected using chest computed tomography plus three-dimensional reconstruction and Chest X-ray. Physical examination was performed to assess the severity and type of microtia by trained clinicians. Fisher's exact test was used to analyze the relation between laterality of pulmonary underdevelopment and microtia type. RESULTS: Among the 923 participants enrolled in the study, we identified 21 cases (2.3%) having respiratory system anomalies, consisting of 6 cases with pulmonary underdevelopment (28.6% of all anomalies of respiratory system detected), 2 cases with tracheal bronchus (9.5%), 1 case with tracheal diverticula (4.8%), 11 cases with lung bullae(52.4%), and 1 case with pulmonary azygos lobe (4.8%). The laterality of pulmonary underdevelopment was related to the type of microtia (difference between types, p < 0.05), as patients with concha-type remnant ear had pulmonary underdevelopment ipsilaterally. CONCLUSIONS: This study represents the first detailed and thematic study of a association featured by microtia and respiratory anomalies. Characteristics and prevalence of respiratory anomalies was observed in a Chinese clinical microtia population. Early diagnosis of associated respiratory malformations had practical clinical significance for microtia patients, plastic surgeons and anesthesiologists. Future studies are required to improve understanding of this association and its cause.

Disaster, Debt, and 'Underdevelopment': The Cunning of Colonial-Capitalism in the Caribbean.

This article provides a critical overview of the structural forces exacerbating risk related to disasters in the Caribbean. It focuses on the historical antecedents and socio-environmental consequences of extreme weather events across the region via an anti-colonial analysis of Hurricanes Irma and Maria in 2017 and Dorian in 2019. The authors contend that the logics, practices and debts of colonial-capitalist development, neoliberal exploitation and post-independence corruption continue to reduce resilience and threaten public health in the region. They also detail the role that political economy and social geography play in the face of disasters. They end by proposing that future critiques of and solutions to vulnerability, disaster, and catastrophe in the Caribbean be more attentive to the historical trajectories of imperialism, debt and 'underdevelopment'.

Data set of balance of Russia's regional economy in 2005-2024 based on the methodology of calculation of "underdevelopment whirlpools".

The article shows the possibilities of Data Set "Interactive Statistics and Intelligent Analytics of the Balanced State of the Regional Economy of Russia in Terms of Big Data and Blockchain - 2020". For creation of the data set, we formed time rows of the values of the selected indicators, which characterize the balance of Russia's regional economy. The indicators are systematized and classified into two categories. The first category includes the indicators of the level of socio-economic development: GDP per capita and "underdevelopment whirlpools", balanced financial result of companies' activities, population's employment level, and balance of the regional budget, calculated by finding the difference between revenues and expenditures. The second category includes the indicators of potential of socio-economic development: investments into fixed capital per capita, share of innovations-active organizations, share of innovative products, and digitization level. The data are collected in a table, based on which - with the help of programming and web-design - a data set is created - an interactive platform for working with data. The data set is available in Russian and English at the official web-site of the Institute of Scientific Communications [12]. The data set unifies and transfers into the digital form the data on the level and potential of Russia's regions' potential of socio-economic development. The data set allows for flexible setting of data for any research. The data set allows - based on the statistics of a region's socio-economic development - determining its position in the Russian national ranking, category by the "TRMS" matrix, calculating the integral index for each region, and comparing its values. Using the proprietary methodology of calculation of "underdevelopment whirlpools" of Prof. Popkova, the data set reflects the balance of Russia's regional economy in 2005-2024. The data set allows for automatic visualization of data by creating a blockchain polygon of region's socio-economic development, which includes the chronogram of the region's development and the process of region's pulling into an "underdevelopment whirlpool". The data set's data are presented in the form of an interactive map of Russia's regional economy. Map's color shows categories that are assigned to regions and the borders of regions, as well as information on each region's position in the 2020 rating. The data set allows for large-scale studies of Russia's regional economy with application of technologies of Big Data processing, machine learning, and intellectual analytics.

O cavaleiro andante de destemido coração: Celso Furtado e a saudade do futuro / The Celso Furtado's brave heart and the "missing" of the future

Resumo: Celso Furtado oferece uma vasta literatura para pensar o Brasil por uma perspectiva desde a América Latina, construindo um aporte teórico marcado pela discussão do subdesenvolvimento, criatividade e dependência, que permite a avaliação crítica da realidade brasileira. A materialização de sua teoria encontra aplicação no desenho de um projeto nacional de desenvolvimento, marcado pela reflexão teórica e ação concreta, na busca de superação das amarras colocadas ao desenvolvimento brasileiro.

Abstract: Celso Furtado offers a vast literature to think about Brazil from a Latin American perspective, constructing a theoretical contribution marked by the discussion of underdevelopment, creativity and dependence, that allows the critical evaluation of the Brazilian reality. The materialization of his theory finds application in the design of a national development project, marked by theoretical reflection and concrete action, in the search of overcoming the moorings placed in Brazilian development.

Iron therapy substantially restores qEEG maturational lag among iron-deficient anemic infants.

OBJECTIVE: To use quantitative electroencephalography (qEEG) to assess the impact of iron-deficiency anemia on central nervous system maturation in the first year of life. METHOD: Twenty-five infants (3-12 months old) presenting ferropenic anemia (IDA) and 25 healthy controls (CTL1), matched by age/gender with the former, were studied in two stages. Electroencephalogram during spontaneous sleep was recorded from all participants; the fast Fourier transform was calculated to obtain absolute power (AP) and relative power (RP) qEEG measures. In the first stage, a qEEG comparison between CTL1 and IDA was performed. Second stage consisted in comparing qEEG of the IDA infants before and after supplementation with iron (IDA-IS group), and comparing qEEG of the IDA-IS group with another control age-matched group (CTL2). Non-parametric multivariate permutation tests (NPT) were applied to assess differences between CTL1 and IDA groups, as well as IDA vs. IDA-IS, and IDA-IS vs. CTL2. RESULTS: More power in slow frequency bands and less power in fast frequency bands in 64% of IDA babies were observed. NPT evinced higher alpha AP and RP (P < 0.001), less theta AP, and less delta and theta RP in CTL1 than in IDA. After iron-restoration therapy, alpha AP and RP increased while theta AP and theta and delta RP decreased, reaching almost normal values. DISCUSSION: This work reveals CNS developmental delay through the study of qEEG (less rapid and more slow frequencies) which recovered significantly with iron supplementation. It is concluded that IDA constitutes a high risk factor for a lag of CNS maturation.

Binder syndrome: Clinical findings and surgical treatment of 18 patients at the Department of Plastic Surgery in Polanica Zdrój.

BACKGROUND: Binder syndrome (BS) is an uncommon congenital underdevelopment of the maxilla and nasal skeleton. Other clinical features include a hypoplastic or absent anterior nasal spine; a short, flat nose with short columella; an acute nasolabial angle; a convex upper lip and class III malocclusion. OBJECTIVES: The aim of the study was to outline the major characteristics of BS and to present a variety of surgical treatment methods. MATERIAL AND METHODS: The study included 18 patients treated in the authors' department from 1989 to 2013. RESULTS: The patients were predominantly women, aged 6 months to 34 years. Nine patients did not present any co-morbidities, but in the other 9 the most common co-morbidities were a unilateral cleft lip and palate, followed by a cleft palate, a bilateral cleft lip and palate, a cleft lip, GERD, gluten intolerance, oligophrenia, goiter and foot malformation. Most of the patients had not been operated on previously. The most common procedure carried out was an iliac crest bone graft. In 4 patients, no procedures other than cleft lip and palate repair were undertaken. In 3 cases a Le Fort I osteotomy was performed to correct the patients' orthognathic status. No major or life-threating complications were noted. In 2 cases, due to a high degree of resorption of bone grafts, multiple secondary grafting of bone, cartilage and deepithelialized skin was necessary to obtain satisfactory results. CONCLUSIONS: In BS surgical treatment is the treatment of choice. It results in adequate correction of facial retrusion. However, due to various degrees of bone resorption, the results are not lifelong. No unequivocally superior surgical strategy in BS has been presented so far. Most disagreement among authors is related to the need for and timing of maxillary osteotomy, the choice between bone and cartilage grafting in nose reconstruction and columella lengthening. Although alloplastic materials offer the tempting advantage of fast and simultaneous augmentation of deficient tissues, their use may risk prolonged infections and extrusion, resulting in exacerbations of deformities.

Centro y periferia en el marxismo de posguerra / Downtown and periphery in the post-war Marxism

Cuatro economistas marxistas desenvolvieron en la posguerra importantes estudios de la relacióncentro-periferia. Mientras que Paul Baran y Paul Sweezy fueron precursores de ese abordaje, SamirAmín y Ernest Mandel aportaron desarrollos más elaborados del mismo tema. Todos investigaron en un período de reconstrucción pos-bélica y expansión capitalista, que amplió la brecha entre las economías avanzadas y atrasadas. ¿Cuál fue su visión de esa asimetría?.

Important studies of the downtown-periphery relationship were developed by four Marxist economists in the postwar. While Paul Baran and Paul Sweezy were precursors to this approach, Samir Amín and Ernest Mandel provided more elaborate developments of the same subject. All of them investigated in a post-war reconstruction and a capitalist expansion period, which widened the gap between the advanced and the lagged economies. What was your vision of this asymmetry?.