Initial Results From a New Model of Posterior Chamber Implantable Phakic Contact Lens: IPCL V2.0.

The aim of this study was to evaluate the corneal safety, intraocular pressure (IOP), vault and refractive efficiency of the new implantable phakic contact lens, IPCL V2.0 (Care Group, India). A prospective case series study was performed to evaluate 100 consecutive surgeries with IPCL V2.0 (spherical and toric models). Refractive results, corneal endothelial cell density (CD) and central corneal thickness (CCT) were measured at baseline and 6 months after surgery. Intraocular pressure was measured at baseline, 1 day and 6 months, and vault, 3 and 6 months after surgery. Surgical complications and cataract development were also evaluated. The mean corneal endothelial CD decreased by 2.9% with a statistically significance difference (p: 0.03). The mean CCT decreased by 0.87% at 6 months postoperative, without a statistical significance difference (p: 0.35). The mean ± standard deviation (SD) of IOP at baseline was 13.72 ±1.4 mm Hg, at 1 day postoperative was 13.88 ±1.2 mm Hg, and at 6 months was 13.62 ±1.3 mm Hg. These differences were not statistically significant (p: 0.37). The difference in vault between 3 and 6 months after surgery was not statistically significant (p: 0.97). The coefficient of correlation between the attempted versus achieved spherical equivalent (SE) change was R2: 0.958. Postoperative SE was between -0.50 D to +0.50 D in 52% of cases. The remaining of the eyes had SE values ranging from -1.5 D to +1.35 D. No intra or postoperative complications occurred and specifically cataract was not developed. The corneal endothelial CD, CCT, vault and IOP remained stable 6 months after surgery. Refraction was improved and the IPCL V 2.0 was implanted safely.

Pre-biopsy MRI as an adjunct for cancer detection in men with elevated PSA and no previous biopsy.

The role of magnetic resonance imaging (MRI) prior to biopsy in the diagnosis of prostate cancer in biopsy-naïve patients has been strengthened by recent developments such as the PIRADS V2 criteria, which cover acquisition, interpretation, and reporting for clinical practice and data collection for research. Important questions on the role of prostate MRI remain: can MRI be used as a triage test before first biopsy series? Can it be used to avoid the use of systematic biopsies (SB) and instead use only targeted biopsies (TB) to MRI-suspicious lesions? Studies to evaluate image guided TB compared to SB have started to accumulate. Objectives of these studies should be to reduce the detection of clinically insignificant disease, to maximize the detection of clinically significant cancer (CSC), to better assess disease size, grade and location. Accurate diagnosis will allow the choice of the most appropriate treatments options, minimising side effects and reducing overtreatment. Study results on MRI-TB detection rates are promising however some limitations should be considered. The majority of published and ongoing studies have been performed at expert centres, in order to demonstrate the optimal performance of MRI. Then, the validation of this strategy in less specialised institutions will be necessary before incorporating recommendations in international guidelines. It necessitates training for radiologists and urologists to perform and read MRI and MRI-targeted biopsy through education programs and standardization tools. All these advances will be consolidated with expected genetic screening tools to improve the detection of aggressive cancer.

Impacto prospectivo da tecnologia do xaxim agroecológico utilizando o Inova-Tec System v 2.0 / Prospective Impact of technology Xaxim Agroecological using the Inova-Tec System v 2.0

O Xaxim, vaso ou suporte utilizado para o cultivo de diversas espécies de plantas ornamentais, tinha sua produção realizada a partir do caule de plantas de Dicksonia sellowiana. Atualmente esta espécie está ameaçada de extinção sendo sua extração proibida por lei federal. Como solução, a Embrapa Agrobiologia desenvolveu o Xaxim Agroecológico, tecnologia inovadora, que utiliza o enraizamento do milheto (Pennisetum glaucum) para agregar o substrato e formar a estrutura do vaso. Com o intuito de uma gestão adequada da inovação procurou-se realizar estudo do impacto tecnológico pautado em parâmentros econômicos e mercadológicos mensurados via análises prospectivas. Nesta situação a avaliação ex-ante representa um componente essencial para elaboração de cenários prospectivos e fator orientador para a empresa geradora da inovação. Nesta pesquisa procurou-se realizar uma avaliação ex-ante da tecnologia do Xaxim Agroecológico dentro do proposto metodologicamente pelo INOVA-tec System v 2.0., pautada em indicadores pertinentes a invenção. Resultados encontrados apontam para a confiabilidade do uso do programa em avaliações prospectivas de tecnologia agroecológica, desde que sejam considerados indicadores adicionais, conforme a situação a ser analisada. O uso do INOVA-tec System v 2.0 para o Xaxim Agroecológico, demonstrou potencial tecnológico com cenário propicio para a inovação, desde que ocorram melhorias nos indicadores que compõe as dimensões ambiental e econômica.

The Xaxim, vase or medium used for the cultivation of various species of ornamental plants, their production was made from the stems of plants of Dicksonia sellowiana. Currently this species is endangered and its extraction prohibited by federal law. As a solution, Embrapa Agrobiology developed Xaxim Agroecological, innovative technology that utilizes the roots of pearl millet (Pennisetum glaucum) to add the substrate and form the structure of the vase. In order to proper management of innovation attempted to make the study of technological impact parameter settings guided by economic and market measured via prospective analyzes. In this situation the ex-ante evaluation is an essential component for developing future scenarios and guiding factor for the company generating innovation. In this research we tried to carry out an ex-ante evaluation of Xaxim Agroecological within the methodology proposed by INOVA-tec System v 2.0. based on indicators relevant to the invention. For Xaxim Agroecológico, using INOVA-tec System v 2.0, demonstrated with a potential scenario conducive to technological innovation from occurring improvements in indicators that make up the environmental and economic.

Impacto prospectivo da tecnologia do xaxim agroecológico utilizando o Inova-Tec System v 2.0

The Xaxim, vase or medium used for the cultivation of various species of ornamental plants, their production was made from the stems of plants of Dicksonia sellowiana. Currently this species is endangered and its extraction prohibited by federal law. As a solution, Embrapa Agrobiology developed Xaxim Agroecological, innovative technology that utilizes the roots of pearl millet (Pennisetum glaucum) to add the substrate and form the structure of the vase. In order to proper management of innovation attempted to make the study of technological impact parameter settings guided by economic and market measured via prospective analyzes. In this situation the ex-ante evaluation is an essential component for developing future scenarios and guiding factor for the company generating innovation. In this research we tried to carry out an ex-ante evaluation of Xaxim Agroecological within the methodology proposed by INOVA-tec System v 2.0. based on indicators relevant to the invention. For Xaxim Agroecológico, using INOVA-tec System v 2.0, demonstrated with a potential scenario conducive to technological innovation from occurring improvements in indicators that make up the environmental and economic.

O Xaxim, vaso ou suporte utilizado para o cultivo de diversas espécies de plantas ornamentais, tinha sua produção realizada a partir do caule de plantas de Dicksonia sellowiana. Atualmente esta espécie está ameaçada de extinção sendo sua extração proibida por lei federal. Como solução, a Embrapa Agrobiologia desenvolveu o Xaxim Agroecológico, tecnologia inovadora, que utiliza o enraizamento do milheto (Pennisetum glaucum) para agregar o substrato e formar a estrutura do vaso. Com o intuito de uma gestão adequada da inovação procurou-se realizar estudo do impacto tecnológico pautado em parâmentros econômicos e mercadológicos mensurados via análises prospectivas. Nesta situação a avaliação ex-ante representa um componente essencial para elaboração de cenários prospectivos e fator orientador para a empresa geradora da inovação. Nesta pesquisa procurou-se realizar uma avaliação ex-ante da tecnologia do Xaxim Agroecológico dentro do proposto metodologicamente pelo INOVA-tec System v 2.0., pautada em indicadores pertinentes a invenção. Resultados encontrados apontam para a confiabilidade do uso do programa em avaliações prospectivas de tecnologia agroecológica, desde que sejam considerados indicadores adicionais, conforme a situação a ser analisada. O uso do INOVA-tec System v 2.0 para o Xaxim Agroecológico, demonstrou potencial tecnológico com cenário propicio para a inovação, desde que ocorram melhorias nos indicadores que compõe as dimensões ambiental e econômica.

Impacto prospectivo da tecnologia do xaxim agroecológico utilizando o Inova-Tec System v 2.0

The Xaxim, vase or medium used for the cultivation of various species of ornamental plants, their production was made from the stems of plants of Dicksonia sellowiana. Currently this species is endangered and its extraction prohibited by federal law. As a solution, Embrapa Agrobiology developed Xaxim Agroecological, innovative technology that utilizes the roots of pearl millet (Pennisetum glaucum) to add the substrate and form the structure of the vase. In order to proper management of innovation attempted to make the study of technological impact parameter settings guided by economic and market measured via prospective analyzes. In this situation the ex-ante evaluation is an essential component for developing future scenarios and guiding factor for the company generating innovation. In this research we tried to carry out an ex-ante evaluation of Xaxim Agroecological within the methodology proposed by INOVA-tec System v 2.0. based on indicators relevant to the invention. For Xaxim Agroecológico, using INOVA-tec System v 2.0, demonstrated with a potential scenario conducive to technological innovation from occurring improvements in indicators that make up the environmental and economic.

O Xaxim, vaso ou suporte utilizado para o cultivo de diversas espécies de plantas ornamentais, tinha sua produção realizada a partir do caule de plantas de Dicksonia sellowiana. Atualmente esta espécie está ameaçada de extinção sendo sua extração proibida por lei federal. Como solução, a Embrapa Agrobiologia desenvolveu o Xaxim Agroecológico, tecnologia inovadora, que utiliza o enraizamento do milheto (Pennisetum glaucum) para agregar o substrato e formar a estrutura do vaso. Com o intuito de uma gestão adequada da inovação procurou-se realizar estudo do impacto tecnológico pautado em parâmentros econômicos e mercadológicos mensurados via análises prospectivas. Nesta situação a avaliação ex-ante representa um componente essencial para elaboração de cenários prospectivos e fator orientador para a empresa geradora da inovação. Nesta pesquisa procurou-se realizar uma avaliação ex-ante da tecnologia do Xaxim Agroecológico dentro do proposto metodologicamente pelo INOVA-tec System v 2.0., pautada em indicadores pertinentes a invenção. Resultados encontrados apontam para a confiabilidade do uso do programa em avaliações prospectivas de tecnologia agroecológica, desde que sejam considerados indicadores adicionais, conforme a situação a ser analisada. O uso do INOVA-tec System v 2.0 para o Xaxim Agroecológico, demonstrou potencial tecnológico com cenário propicio para a inovação, desde que ocorram melhorias nos indicadores que compõe as dimensões ambiental e econômica.