Historical development, impact mechanism and future trends of nitrogen footprint in Wuxi City, China.

Human activities have changed the biogeochemical cycle of nitrogen, leading to a large amount of reactive nitrogen (Nr) into the environment, aggravating a series of environmental problems, affecting human and ecosystem health. Cities are the core areas driving nitrogen cycling in terrestrial ecosystems, however, there are numerous influencing factors and their contributions are unclear. The nitrogen footprint is an important index to understand the impact of human activities on the environment, however, the calculation of urban nitrogen footprint needs a simplified and accurate system method. Here we use a nitrogen footprint calculation model at the urban system level based on system nitrogen balance, and a multi-factor extended STIRPAT (stochastic impact by regression on population, affluence, and technology) model suitable for analyzing the impact mechanism of nitrogen footprint to estimate nitrogen footprint of Wuxi City during 1990-2050. We find that: (1) from 1990 to 2020, the total nitrogen footprint of Wuxi City was in an increasing trend, but the per capita nitrogen footprint was in a decreasing trend. The per capita nitrogen footprint of 22.36 kg capita-1 in 2020 was at a lower level globally. (2) Nr discharge from fossil fuel combustion and Haber-Bosch nitrogen fixation accounted for the main proportion of nitrogen footprint. (3) Dietary choice (Ad), GDP per capita (Ag), urbanization rate (Au), population (P), and fossil energy productivity (Te) were the key factors contributing to the increase of the nitrogen footprint, which resulted in an annual increase of 1.39 %. While nitrogen footprint productivity (Tn), nitrogen use efficiency in crop farming (Tc), and nitrogen use efficiency in animal breeding (Ta) were the key inhibit factors that inhibit the increase of nitrogen footprint, and these factors slow down the annual growth rate of nitrogen footprint by 0.39 %. (4) The continuous growth of nitrogen footprint in the baseline and population growth scenarios will bring more environmental problems and greater environmental governance pressure to Wuxi City, while the sustainable scenario that includes comprehensive means such as economic adaptation and technological improvement is more in line with the requirements of high-quality development in China. Several mitigation measures are then proposed by considering Wuxi's realities from both key impact factors and potential for nitrogen footprint reduction in different scenarios, which can provide valuable policy insights to other cities, especially lakeside cities to mitigate nitrogen footprint.

Evaluation of rural vitality and development types in mountainous areas of southwestern China: A case study of Wuxi County, Chongqing.

Protecting and stimulating rural vitality is a critical step towards driving rural revitalization and development; This study outlined the application of a measurement system that indexes rural vitality levels at the township scale and evaluates rural vitality in terms of potential regeneration, survivability, and development. This study combined the CRITIC weighting method, the TOPSIS pros and cons solution-distance method, and a vertical-horizontal comparison method to evaluate the rural vitality of 30 townships in Wuxi County, Chongqing. Using these results, this study divided the townships according to their type of rural development. A natural breakpoint method was used to visualize the spatial pattern of rural development levels.The research showed that: (1) The average value of the composite score of rural vitality in Wuxi County is 0.342, and more than half of the townships' composite vitality values are lower than the average value of the overall vitality, which leads to the conclusion that the overall level of rural vitality is low; (2) the comprehensive level of rural vitality in Wuxi County decreased from southwest to northeast, and showed local variations; (3) the degree of development within the study area was categorized as either dominant, comprehensive, or polarized, developmental deficiency type. This research argued that promoting the development of rural vitality in different villages requires careful scientific planning, detailed knowledge of individual geographic characteristics, and a clear rural development path that spans a range of spatial scales. Specific and specialized rural development strategies are thus required for each type of development.

Metatranscriptomics revealed the molecular characterization of circulating enterovirus strains causing aseptic meningitis in children in Wuxi, China.

Enteroviruses are major etiological agents of aseptic meningitis globally, however information on circulating enterovirus types associated with this disease in Wuxi, China is limited. In this study, cerebrospinal fluid samples were collected from 20 pediatric aseptic meningitis cases in a Wuxi hospital in 2020 and subjected to metagenomic analysis to detect pathogens. Enterovirus B was detected in 9 cases, including 7 echovirus 18 (E18) and 2 echovirus 11 (E11) strains. The E18 strains exhibited 87.5-98.2% nucleotide identity and phylogenetically clustered with other China E18 strains, while the E11 strains showed 97.59% identity and clustered within the D5 subgroup along with other China E11 strains. One E18 strain was identified as a novel recombinants with a distinct recombination breakpoint within 3D gene. These findings expand knowledge on enteroviruses associated with pediatric aseptic meningitis in Wuxi, and highlight the circulation of genetically diverse E18 and E11 strains, including novel E18 recombinants. Characterization of enterovirus diversity by metagenomic analysis is important for molecular diagnosis and epidemiological tracking of aseptic meningitis cases. Continued surveillance of circulating enterovirus strains in Wuxi that may cause future outbreaks is warranted.

Impact of environmental comfort on urban vitality in small and medium-sized cities: A case study of Wuxi County in Chongqing, China.

China's urbanization has exceeded 64% and a large number of small and medium-sized cities are the key development areas in the new stage. In urban planning, it is very important to reveal the influence of environmental comfort on urban vitality to improve the life quality of residents in these towns. Thus, the study investigated the impact of environmental comfort on urban vitality using ordinary least squares regression in Wuxi County. Environmental comfort was assessed through a comprehensive analysis of a built-up area and urban vitality was represented by vitality intensity. In addition, the influence pathways were identified and model validation was verified. The conclusions are as follows: (1) Environmental comfort and urban vitality are distributed spatially similarly, and both gradually decline from the center to the periphery. It is high in the east and low in the west, high in the south and low in the north. (2) Population density, POI mixing degree, building density, and road network density have significant positive effects on urban vitality. Population density has the greatest impact on urban vitality. Building height, building age, and river buffer have significant negative effects on urban vitality. (3) The impact of comprehensive environmental comfort on urban vitality is positive, and in terms of time, the order of impact is afternoon > morning > evening. Finally, a method for assessing the impact of environmental comfort on urban vitality was constructed, and the promoting effect of environmental comfort improvements on the vitality was verified. These findings will fill the gap between urban physical space and social needs in planning practices and provide reference to improve vitality for urban planning in small and medium-sized cities.

Segmental and suprasegmental encoding of speaker confidence in Wuxi dialect vowels.

Introduction: Wuxi dialect is a variation of Wu dialect spoken in eastern China and is characterized by a rich tonal system. Compared with standard Mandarin speakers, those of Wuxi dialect as their mother tongue can be more efficient in varying vocal cues to encode communicative meanings in speech communication. While literature has demonstrated that speakers encode high vs. low confidence in global prosodic cues at the sentence level, it is unknown how speakers' intended confidence is encoded at a more local, phonetic level. This study aimed to explore the effects of speakers' intended confidence on both prosodic and formant features of vowels in two lexical tones (the flat tone and the contour tone) of Wuxi dialect. Methods: Words of a single vowel were spoken in confident, unconfident, or neutral tone of voice by native Wuxi dialect speakers using a standard elicitation procedure. Linear-mixed effects modeling and parametric bootstrapping testing were performed. Results: The results showed that (1) the speakers raised both F1 and F2 in the confident level (compared with the neutral-intending expression). Additionally, F1 can distinguish between the confident and unconfident expressions; (2) Compared with the neutral-intending expression, the speakers raised mean f0, had a greater variation of f0 and prolonged pronunciation time in the unconfident level while they raised mean intensity, had a greater variation of intensity and prolonged pronunciation time in the confident level. (3) The speakers modulated mean f0 and mean intensity to a larger extent on the flat tone than the contour tone to differentiate between levels of confidence in the voice, while they modulated f0 and intensity range more only on the contour tone. Discussion: These findings shed new light on the mechanisms of segmental and suprasegmental encoding of speaker confidence and lack of confidence at the vowel level, highlighting the interplay of lexical tone and vocal expression in speech communication.

[Occurrence Characteristics and Health Risk Assessment of Endocrine Disrupting Chemicals in Groundwater in Wuxi-Changzhou].

The concentrations of 22 endocrine disrupting chemicals, including 4 categories of sex hormones, progesterones, glucocorticoids, and phenolic hormones, in groundwater of Wuxi-Changzhou were analyzed using solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry. The results indicated that 20 EDCs were detected, among which bisphenol A (BPA), estrone (E1), estradiol (E2), and 17α-ethinyl estradiol (EE2) were the main components with detection ratios greater than 90%, followed by estriol (E3) and methyl-prednisolonel (Meprednl), which had detection rates 67.7% and 48.4%, respectively. The average concentration of BPA was the highest (4.95 ng·L-1), followed by that of Meprednl, E2, prednisolone (Prednl), testosterone propionate (TES-pro), and megestrol-acetate (MA; 2.84, 0.71, 0.64, 0.58, and 0.53 ng·L-1, respectively). The total concentration in each site ranged from 0.38 to 147.35 ng·L-1. The sites with higher concentration were mainly distributed in the Xinbei District, Liyang City, and the Zhonglou District of Changzhou City. The potential sources were analyzed by a principal component analysis (PCA) combining the point sources near sample sites. The results showed that domestic sewage, aquaculture, and industrial wastewater were the main sources, following by medical wastewater. A non-carcinogenic risk assessment showed a low risk of EDCs in the groundwater of the study area, and the risk of drinking water was greater than that of skin exposure. EE2 had the highest non-carcinogenic risk and is suggested to be monitored in priority.

Night sky brightness monitoring network in Wuxi, China.

The rapid development of cities has brought tremendous pressure to astronomical observation, energy security, and the ecosystem. Automatic monitoring of night sky brightness (NSB) can help us to understand its regional differences and time variations of NSB effectively and to investigate the human and natural factors which lead to these changes. In this paper, the construction of Wuxi City night sky brightness monitoring network (WBMN) in China is presented. In addition to introducing the equipment and the installation of the network, a brief analysis of the data obtained from the stations will also be presented. The impact of human activities on the NSB is illustrated through its changes during the Spring Festival (lunar new year) and non-festival nights, and through a comparison study between NSB data taken from locations of different land usages. It is concluded that, while the reduction in human activities after non-festival midnights or the reduction in moon illumination near the new moon epoch led to darker night skies, brightening of the night skies may be attributed to firework displays during the nights of Spring Festival in 2019. On the other hand, the absence of firework during the Spring Festival in 2020 may explain the darker night skies. Finally, there is an evidence that the urban developments in Wuxi are degrading night sky quality.

Entrepreneur Hubris, Organizational Ambidexterity, and Dynamic Capability Construction.

This paper demonstrated the influences of initiation, development, turn-down, and reinitiation of the dynamic capability of an entrepreneurial firm in the solar energy industry. The focus is on the impact of entrepreneurial hubris, which may affect the decision of ambidexterity that can vitalize dynamic capability. The findings indicate that, when the major decision maker (the founder entrepreneur) has the trait of hubris, the decision-making process may be overly arbitrary, and a decision of being exploratory or exploitative alone is likely to be made. On the contrary, when the founder entrepreneur is aware of the hubris and shares decisive power, the decision of being ambidextrous as a dynamic capability is more freely achieved. This paper contributes by discovery of the cognitive-based microfoundation of entrepreneurial ventures and linkage of such microfoundation to organizational ambidexterity.

Performance of water transfer in response to water environment issues in Wuxi, China.

The continuous development of industrialization and urbanization resulted in increased pollution in plain river network areas. In response to water environment issues, water transfer can be a countermeasure to improve water environment. There are five basic elements to be determined of water transfer, i.e., water sources, water transfer patterns, regulating rules, water transfer routes, and flow rate of water transfer. In Wuxi City, needs for water transfer were analyzed from the five aspects above. The former three elements were determined based on the results of water transfer measurements. The water source was Yangtze River, the pattern was continuous water transfer, and regulating rules were water transferred by pumping stations and drained by sluices and pumping stations. Besides, a water quantity and quality coupling model was constructed to analyze routes and flow rate of water transfer. Different flow rate of water transfer, from 80 to 130 m3/s, were analyzed. According to the characteristics of regional river system and the requirements of flood control, the Baiqugang River was taken as the clean water route, and the urban flood control enclosure was taken as the clean water transfer station. In the end, it was concluded that the optimal flow rate is 110 m3/s based on the results of different schemes. It indicates that a proper scheme of water transfer can better improve the water environment in plain river network areas.

Genetic polymorphisms, forensic efficiency and phylogenetic analysis of 17 autosomal STR loci in the Han population of Wuxi, Eastern China.

The autosomal short tandem repeat (STR) plays a unique role in population comparisons, phylogenetic reconstruction and migration history tracing. This study investigated the frequencies of 17 autosomal STR loci in the Han population from Wuxi, Eastern China, with the aim of expanding the available population information in human genetic databases and for forensic DNA analysis. The genetic polymorphisms of 17 STR loci were analysed in 5358 individuals of the Han population from Wuxi, Eastern China. Population comparisons including genetic distances, the neighbour-joining tree and multidimensional scaling plot were carried out between the Wuxi Han population and different ethnic groups. A total of 777 alleles at 17 autosomal STR loci were observed, with the corresponding allelic frequencies ranging from 0.0001-0.5210. The combined power of discrimination and exclusion for the 17 autosomal STR loci were 0.0000 and 0.000, respectively. Moreover, the phylogenetic analysis was performed between the Wuxi Han population and other relevant populations. The neighbour-joining tree and multidimensional scaling plot were generated based on Nei's standard genetic distance. Population comparisons indicated that the Wuxi Han population had the closest genetic relationship with the Hubei Han population, relative to the other populations, which mirrors the historical and geographical background of the populations compared.

Fate and Ecological Risk Assessment of Nutrients and Metals in Sewage Sludge from Ten Wastewater Treatment Plants in Wuxi City, China.

The concentrations of nutrients (total nitrogen, total phosphorus and organic matter) and metals (Cu, Pb, Zn, Ni, Cd, Cr, As and Hg) in sewage sludge samples were determined to evaluate the level of contamination. Sewage sludge samples were collected from ten wastewater treatment plants from 2016 to 2018 in Wuxi city, China. All the studied sewage sludge samples displayed high fertility properties due to their richness. Total concentrations of metals in the sewage sludge samples were within the regulation of the Chinese legislation. The levels of the eight metals temporally varied. Sewage sludge pollution assessment was undertaken using pollution index, geo-accumulation index, potential ecological risk index and aggregative toxicity index. Multivariate statistical analysis indicated that Pb, Cr, As and Hg may have similar transport behavior and derive from anthropogenic sources. Ecological risk assessment revealed that Hg contamination is the major concern for human health, since the treated sewage sludge is used for agricultural purposes.

[Survey on Toxoplasma gondii infections among three types of populations in Wuxi City].

OBJECTIVE: To investigate the seroprevalence of Toxoplasma gondii infections among patients with rheumatoid arthritis, malignant tumors and schizophrenia in Wuxi City, so as to provide data support for the control of toxoplasmosis in these patients. METHODS: A total of 205 cases with definitive diagnosis of rheumatoid arthritis, 257 cases with definitive diagnosis of malignant tumors and 235 cases with definitive diagnosis of schizophrenia were recruited, while 250 healthy volunteers served as controls. The demographic features were captured from the study subjects and serum samples were collected. The serum IgG and IgM antibodies against T. gondii were detected using an enzyme-linked immunosorbent assay (ELISA) in all study subjects, and the positive rates of anti-T. gondii IgG and IgM antibodies were compared between the patients and controls. RESULTS: The seroprevalence of the anti-T. gondii IgG antibody was 20.98%, 24.12% and 24.68% in patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly greater than in healthy controls (χ2 = 31.54, 42.12 and 42.98, all P values < 0.01), and the seroprevalence of the anti - T. gondii IgM antibody was 1.46%, 2.72% and 1.70% among patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly higher than in healthy controls (χ2 = 0.06, 1.52 and 0.21, all P values > 0.05). CONCLUSIONS: The patients with rheumatoid arthritis, malignant tumors and schizophrenia present with higher seroprevalence of the anti-T. gondii IgG antibody than healthy controls in Wuxi regions. Screening of T. gondii infections among the patients with rheumatoid arthritis, malignant tumors and schizophrenia should be intensified to prevent the damages caused by T. gondii infections.

Survey on Toxoplasma gondii infections among three types of populations in Wuxi City / 中国血吸虫病防治杂志

Objective To investigate the seroprevalence of Toxoplasma gondii infections among patients with rheumatoid arthritis, malignant tumors and schizophrenia in Wuxi City, so as to provide data support for the control of toxoplasmosis in these patients. Methods A total of 205 cases with definitive diagnosis of rheumatoid arthritis, 257 cases with definitive diagnosis of malignant tumors and 235 cases with definitive diagnosis of schizophrenia were recruited, while 250 healthy volunteers served as controls. The demographic features were captured from the study subjects and serum samples were collected. The serum IgG and IgM antibodies against T. gondii were detected using an enzyme-linked immunosorbent assay (ELISA) in all study subjects, and the positive rates of anti-T. gondii IgG and IgM antibodies were compared between the patients and controls. Results The seroprevalence of the anti-T. gondii IgG antibody was 20.98%, 24.12% and 24.68% in patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly greater than in healthy controls (χ2 = 31.54, 42.12 and 42.98, all P values < 0.01), and the seroprevalence of the anti - T. gondii IgM antibody was 1.46%, 2.72% and 1.70% among patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly higher than in healthy controls (χ2 = 0.06, 1.52 and 0.21, all P values > 0.05). Conclusions The patients with rheumatoid arthritis, malignant tumors and schizophrenia present with higher seroprevalence of the anti-T. gondii IgG antibody than healthy controls in Wuxi regions. Screening of T. gondii infections among the patients with rheumatoid arthritis, malignant tumors and schizophrenia should be intensified to prevent the damages caused by T. gondii infections.

Survey on Toxoplasma gondii infections among three types of populations in Wuxi City / 中国血吸虫病防治杂志

Objective To investigate the seroprevalence of Toxoplasma gondii infections among patients with rheumatoid arthritis, malignant tumors and schizophrenia in Wuxi City, so as to provide data support for the control of toxoplasmosis in these patients. Methods A total of 205 cases with definitive diagnosis of rheumatoid arthritis, 257 cases with definitive diagnosis of malignant tumors and 235 cases with definitive diagnosis of schizophrenia were recruited, while 250 healthy volunteers served as controls. The demographic features were captured from the study subjects and serum samples were collected. The serum IgG and IgM antibodies against T. gondii were detected using an enzyme-linked immunosorbent assay (ELISA) in all study subjects, and the positive rates of anti-T. gondii IgG and IgM antibodies were compared between the patients and controls. Results The seroprevalence of the anti-T. gondii IgG antibody was 20.98%, 24.12% and 24.68% in patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly greater than in healthy controls (χ2 = 31.54, 42.12 and 42.98, all P values < 0.01), and the seroprevalence of the anti - T. gondii IgM antibody was 1.46%, 2.72% and 1.70% among patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly higher than in healthy controls (χ2 = 0.06, 1.52 and 0.21, all P values > 0.05). Conclusions The patients with rheumatoid arthritis, malignant tumors and schizophrenia present with higher seroprevalence of the anti-T. gondii IgG antibody than healthy controls in Wuxi regions. Screening of T. gondii infections among the patients with rheumatoid arthritis, malignant tumors and schizophrenia should be intensified to prevent the damages caused by T. gondii infections.

Analysis of reciprocal sharing of large medical devices at the medical alliance headed by the Third People′s Hospital of Wuxi / 中华医院管理杂志

Reciprocal sharing of medical devices plays a breakthrough point for strengthening medical alliances, while promoting efficiency building is the core work of medical devices sharing as well. Taking this medical alliance as an example, this paper discussed the effective strategies of large medical devices sharing within the medical alliance. The measures taken include basic information research and expert interview, high-level planning, and information platform, as well as incentive protection, effectiveness evaluation and atmosphere construction. These efforts can enhance the service support, satisfaction, inspection income, full usage, work ability, new function extension, and equipment management. Furthermore, it can promote the service ability, telemedicine and hierarchical medical of the medical alliance.

Identification and Genotypic Characterization of Potentially Pathogenic Acanthamoeba Isolated from Tap Water in Wuxi, China.

Members of genus Acanthamoeba are widely distributed in the environment. Some are pathogenic and cause keratitis and fatal granulomatous amoebic encephalitis. In this study, we isolated an Acanthamoeba CJW/W1 strain from tap water in Wuxi, Jiangsu Province, China. Its 18S rDNA was sequenced and a phylogenetic tree was constructed. The isolated cysts belonged to morphologic group II. Comparison of 18S rDNA sequences of CJW/W1 strain and other isolates showed high similarity (99.7%) to a clinical isolate Asp, KA/E28. A phylogeny analysis confirmed this isolate belonged to the pathogenic genotype T4, the most common strain associated with Acanthamoeba-related diseases. This is the first report of an Acanthamoeba strain isolated from tap water in Wuxi, China. Acanthamoeba could be a public health threat to the contact lens wearers and, therefore, its prevalence should be monitored.

Practice and reflections of medical alliance development in Wuxi / 中华医院管理杂志

The paper covered attempts of Wuxi city in construction of medical alliances and continuous perfection of primary medical systems within the region.It is pointed out that medical alliances should center on patients'medical needs to build a vertical medical model; build an effective constraint framework and incentive mechanism without involving into unnecessary conflicts of core interests of stakeholders;and leverage highly informationized networks to achieve seamless interconnection of the entire medical process with the IT process.

Identification and Genotypic Characterization of Potentially Pathogenic Acanthamoeba Isolated from Tap Water in Wuxi, China

Members of genus Acanthamoeba are widely distributed in the environment. Some are pathogenic and cause keratitis and fatal granulomatous amoebic encephalitis. In this study, we isolated an Acanthamoeba CJW/W1 strain from tap water in Wuxi, Jiangsu Province, China. Its 18S rDNA was sequenced and a phylogenetic tree was constructed. The isolated cysts belonged to morphologic group II. Comparison of 18S rDNA sequences of CJW/W1 strain and other isolates showed high similarity (99.7%) to a clinical isolate Asp, KA/E28. A phylogeny analysis confirmed this isolate belonged to the pathogenic genotype T4, the most common strain associated with Acanthamoeba-related diseases. This is the first report of an Acanthamoeba strain isolated from tap water in Wuxi, China. Acanthamoeba could be a public health threat to the contact lens wearers and, therefore, its prevalence should be monitored.

Characterization of major natural and anthropogenic source profiles for size-fractionated PM in Yangtze River Delta.

Samples of size-fractionated particles were collected from local natural and anthropogenic sources in two industrial cities in the Yangtze River Delta, using either grab/resuspension sampling or ambient air sampling. The chemical characterizations of twenty one source profiles were obtained, based on elements (Al, As, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, Pb and Zn), soluble ions (Cl-, NO3-, SO42-, NH4+, K+, Na+ and Ca2+) and carbonaceous material such as organic carbon (OC) and elemental carbon (EC). The profiles vary between sources from different areas, as well as between different particulate sizes. Results show that particulate matter that originated as soil dust, construction dust and fugitive dust is typically rich in crustal elements, especially Al, Ca, Fe and Mg, while the presence of calcium is found to be a hallmark of the cement industry and ceramic industry. Dominant compositions of particles from coal-fired power plants are variable, with OC ranging from 2.2%-27%. Garbage-fired power plant and cooking smoke particulate emissions are enriched in Na, Cl-, OC and K due to the presence of salty and organic matter. The element Fe, ranging from 6.1% to 26.0%, is found to be an important marker for steel production dust. Vehicle exhaust profiles are characterized by high abundances of OC (12.1%-53.6%) and EC (3.9%-20.0%). Burning of straw results in K (1.6%-7.2%) and OC (12.4%-25.9%) being the dominant composition. Preliminary work has also been done on establishing local industrial profiles such as textile, ceramic and electroplating industries. This work could be used in receptor model studies to estimate the contributions of different sources to the size-fractionated particulate matter in the Yangtze River Delta.