ABSTRACT
Objective To observe the therapeutic effect of Xingnaojing Injection ( XI) combined western medicine for the treatment of septic encephalopathy (SE) . Methods A total of 60 SE patients were evenly randomized into treatment group and control group. Both groups were given routine western medicine therapy such as anti-inflammation, immunological and cerebral preventive treatment, or even mechanical ventilation, sub-hypothermia therapy, and insulin intensification therapy if necessary. Additionally, the treatment group was given intravenous drip of XI. The treatment for both groups lasted one week. Glasgow Coma Scale ( GCS) scores were observed before and after treatment for the evaluation of therapeutic effect of both groups. Moreover, the serum levels of C-reactive protein (CRP) and procalcitonin (PCT) , and the hospitalization fee and time in Intensive Care Unit were compared in both groups. Results ( 1) After treatment for one week, the improvement of GCS scores in the treatment group was superior to that in the control group ( P<0.05); the total effective rate was 90.0% in the treatment group and was 56.7% in the control group, the difference being significant ( P<0.05). ( 2) After treatment for 24 hours, serum CRP and PCT levels were decreased obviously in both groups (P<0.05), and the decrease in the treatment group after treatment for 24, 48, and 72 hours and for one week was superior to that in the control group ( P<0.05). ( 3) Hospitalization fee was less and hospitalization time in ICU was shorter in the treatment group than those in the control group ( P<0.05). Conclusion XI shows satisfactory effect on relieving illness and increasing cure rate, and on decreasing hospitalization fee and time in ICU.
ABSTRACT
Objective To observe the protective effect to Ulinastatin combined with Xingnaojing Injection (XI) for acute cerebral hemorrhage. Methods One hundred and eight cases of acute cerebral hemorrhage were randomly divided into treatment group ( N=56) and control group ( N=52) . All of the patients were given conventional western medical treatment including relieving cerebral edema, regulating blood pressure, maintaining electrolyte balance, anti-inflammation, preventing epilepsy. Additionally, the control group was given intravenous drip of Ulinstatin, and the treatment group was given intravenous drip of Ulinstatin and XI. The clearance of intracranial hematoma in the two groups was observed on treatment day 3, 7, 14, the absorption of cerebral edema was observed after treatment for one treatment course of 14 days, neurological deficit scores ( NDS) were compared on treatment day 14, 30, and the clinical efficacy was evaluated. Results ( 1) After treatment, hematoma area was reduced in the two groups ( P0.05); on treatment day 7 and 14, hematoma area in the treatment group was less than that of the control group, the difference being significant (P<0.05) . (2) On treatment day 14, the total effective rate for absorption of cerebral edema was 89.3% in the treatment group, and was 65.4% in the control group, the difference being significnat ( P<0.05) . ( 3) After treatment, NDS of the treatment group was less than that of the control group, and the total effective rate on NDS was 89.3% in the treatment, higher than 71.2% in the control group, the difference being significant ( P<0.05) . ( 4) In the treatment group, 3 cases had slight increase of aminotransferase. Eight cases of the control group had increased aminotransferase, and then the aminotransferase level recovered to normal after suspension. In the treatment group, 2 cases were dropped out for receiving emergency operation due to rehaemorrhagia during the treatment, and 3 cases were death for illness deterioration. In the control group, 7 cases gave up the treatment for illness deterioration and then were dead during the follow-up. Conclusion Ulinastatin combined with XI shows certain protective effect in treating acute cerebral hemorrhage.
ABSTRACT
Objective To observe the therapeutic effect of Xingnaojing Injection(XI) combined with head temperature-decreasing instrument in the treatment of patients with acute hemorrhagic stroke(AHS).Methods Sixty AHS patients were randomized into two groups: the control group received routine western treatment of decreasing intracranial pressure,controlling cerebral edema,protecting brain cells,and preventing infection and complications;the treatment group received XI combined with lowering head temperature based on the routine western treatment.Twenty-one days constituted one treatment course.After one treatment course,therapeutic effect was evaluated,and the volume of intracerebral hematoma and the cerebral edema was observed.After two treatment courses,the scores of neurological deficit and the activities of daily life(ADL) were observed.Results(1) After one treatment course,the total effective rate was 80.0% in the treatment group and 63.3% in the control group,the difference being significant(P
