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1.
Behav Anal Pract ; 17(2): 500-513, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38966265

ABSTRACT

Characteristics of emotional and behavioral disorders (EBD) include learning difficulties that cannot be explained by intellectual, sensory, or health factors and difficulties in building or maintaining interpersonal relationships with peers and teachers. Children with or at risk for an EBD often have a tendency to have negative experiences in school and engage in challenging behavior in the classroom including out-of-seat behavior. One possible antecedent manipulation, alternative seating, may reduce challenging behavior and involves exchanging the typical seating in classrooms for different types of seating options. The purpose of this study was to evaluate the use of stability stools and scoop rocker chairs on in-seat behavior and on-task behavior in classrooms with kindergarten students who engaged in challenging behavior and were at risk for EBD. All three participants demonstrated improvements in in-seat behavior using both types of alternative seating compared to a standard classroom chair. On-task behavior improved for all students but was variable for two students. Teachers indicated a preference for the stability stool, whereas results were mixed between the stool and the rockers for student preference.

2.
Article in English | MEDLINE | ID: mdl-39023650

ABSTRACT

PURPOSE: Our study examines the socio-demographic, forensic psychiatric, and childhood trauma exposure (CTE) data of Turkish intimate partner violence (IPV) perpetrators and draws comparisons with the violence data. METHODS: Data of male perpetrators referred to the domestic violence outpatient clinic by judicial authorities between November 2019 and June 2022 were retrospectively examined, with a focus on CTE data. RESULTS: The mean age of the male perpetrators examined in the study was 37.1 years. Among the overall sample, 16.2% (n = 17) had experienced violence at school in childhood, and 22.9% (n = 24) had experienced CTE. Regarding the frequency of domestic violence in their households, of the perpetrators admitted to the clinic for IPV, 40% (n = 42) reported rarely, 43.8% (n = 46) sometimes, and 16.2% (n = 17) often engaged in violent acts. There is a significant relationship between the frequency of IPV and the level of CTE (χ2: 13.052, SD: 2, p = 0.001, Cramer's V: 0.353). Similarly, individuals who witnessed domestic violence during childhood were found to commit partner violence more frequently (χ2: 8.157, SD: 2, p = 0.017, Cramer's V: 0.279). CONCLUSIONS: In this study, we found a strong relationship between CTE and IPV. To the best of our knowledge, our study is only example that investigates the relationship between CTE and IPV in a Turkish sample.

3.
Article in Russian | MEDLINE | ID: mdl-39003542

ABSTRACT

According to official figures, almost 1 billion people suffer from mental disorders worldwide, including adolescents 10-19 years old account for about 13% of the global burden of disease in this age group. The current state of the problem of mental health of children and adolescents, which is formed under the influence of environmental factors and is critical for the personal, social and socio-economic development of a person in subsequent stages of life, is considered. The results of monitoring the mental health of the children's population of the Russian Federation, differentiated at the age of 0-14 and 15-17 years, including under the influence of the COVID-19 pandemic, which were the basis for improving the complex of measures for the prevention of mental disorders and disorders of the contingent's behavior. The terminology used is analyzed. The purpose of the study is to analyze the leading trends in recent years of the state and dynamics of statistical indicators of mental health of children and adolescents with an emphasis on understanding the basic conceptual apparatus, theoretical aspects of the problem from the standpoint of specialists in the field of public health and healthcare.


Subject(s)
COVID-19 , Mental Disorders , Mental Health , Humans , Adolescent , Child , Russia/epidemiology , COVID-19/epidemiology , COVID-19/prevention & control , COVID-19/psychology , Mental Disorders/epidemiology , Mental Health/statistics & numerical data , Child, Preschool , Infant , Infant, Newborn , SARS-CoV-2
4.
J Affect Disord ; 361: 589-595, 2024 Sep 15.
Article in English | MEDLINE | ID: mdl-38908558

ABSTRACT

BACKGROUND: This study aimed to explore and evaluate the development trends and differential changes in the prevalence of mental and behavioral disorders among the earthquake survivors in exposure groups (highly hard-hit areas) and control groups (general disaster areas) from 2015 to 2019, as well as to investigate the potential influencing factors. METHODS: Data was obtained from the Sichuan Health Information System and the Sichuan Health Yearbook, the prevalence of the exposure group and the control group were calculated, the difference between the two groups was evaluated using the prevalence rate ratio, and a fixed effect model was developed to investigate the potential influencing factors of the prevalence. RESULTS: The prevalence by gender and age in the exposure group was always greater than those in the control group (RR>1), although the disparity between the two proceeded to diminish with time. The urbanization rate (ß = 0.0448, P < 0.05) and disaster area levels (ß = 0.0104, P < 0.05) were risk factors for the prevalence of mental and behavioral disorders. LIMITATIONS: The study only collected data at the group level following the Wenchuan earthquake. Consequently, the findings are only applicable at the group level. Furthermore, diagnostic criteria for various types of mental and behavioral disorders diseases were not provided. CONCLUSIONS: The earthquake has a significant long-term impact on mental health. It is necessary to continuously monitor the mental health of Wenchuan earthquake survivors and take appropriate post-disaster intervention measures.


Subject(s)
Big Data , Disasters , Earthquakes , Mental Disorders , Survivors , Humans , China/epidemiology , Male , Female , Middle Aged , Adult , Mental Disorders/epidemiology , Disasters/statistics & numerical data , Survivors/psychology , Survivors/statistics & numerical data , Prevalence , Adolescent , Aged , Young Adult , Risk Factors , Child , Urbanization
5.
Biomedicines ; 12(6)2024 Jun 11.
Article in English | MEDLINE | ID: mdl-38927503

ABSTRACT

Toxoplasma gondii is the etiologic agent of toxoplasmosis, a highly prevalent parasitosis. Toxoplasma gondii (T. gondii) transits in the brain from acute (AT) to chronic toxoplasmosis (CT), under host immune control. In immunocompromised patients, reactivation of CT is potentially life-threatening. Behavioral and neurological complications have been associated with CT. Furthermore, an effective treatment targeting CT is still lacking. We previously reported the efficacy of imiquimod against CT. Here, we demonstrate the molecular effects of imiquimod or imiquimod followed by the clinically used combination of sulfadiazine and pyrimethamine (SDZ + PYR) on CT-associated behavior in a rat model. Imiquimod decreased the number of cysts in the brains of chronically infected rats due to an induced reactivation of bradyzoites into tachyzoites. Importantly, this decrease was more pronounced in rats treated with imiquimod followed by SDZ + PYR. Rats chronically infected with T. gondii exhibited an anxiety-like behavior. Notably, treatment with imiquimod reversed this behavior aberrancy, with even a more pronounced effect with imiquimod followed by SDZ/PYR. Similarly, rats chronically infected with T. gondii exhibited learning deficits, and imiquimod alone or followed by SDZ/PYR reversed this behavior. Our results enhance our knowledge of the implications of CT on behavioral aberrancies and highlight the potency of imiquimod followed by SDZ + PYR on these CT-associated complications.

6.
Article in English | MEDLINE | ID: mdl-38928929

ABSTRACT

This study addressed the harmful effects of artificial colors in pediatric populations, including children diagnosed with Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD), as well as those without behavioral disorders. There is a consensus that synthetic food colorings have several impacts on consumers, especially pediatrics, due to their influence on sensory appeal, which can encourage preference for certain foods. The results revealed that these color additives are directly linked to a series of health problems, with a greater impact on children, including a predisposition to pathological conditions such as carcinogenic, allergenic, mutagenic, cytotoxic, and clastogenic activities, as well as gastrointestinal and respiratory problems, in addition to behavioral changes in children with and without diagnosed disorders. The harms of synthetic dyes in children with or without comorbidities are worrying and require a careful and proactive approach from parents, caregivers and public authorities.


Subject(s)
Child Health , Food Coloring Agents , Humans , Child , Food Coloring Agents/adverse effects , Attention Deficit Disorder with Hyperactivity , Autism Spectrum Disorder , Child, Preschool
7.
Cereb Circ Cogn Behav ; 6: 100224, 2024.
Article in English | MEDLINE | ID: mdl-38868624

ABSTRACT

This Commentary describes the 20th Anniversary of VasCog 2023, held in Gothenburg, Sweden.

8.
Front Public Health ; 12: 1343550, 2024.
Article in English | MEDLINE | ID: mdl-38883192

ABSTRACT

Introduction: The precise associations between temperature-related indices and mental and behavioral disorders (MBDs) have yet to be fully elucidated. Our study aims to ascertain the most effective temperature-related index and assess its immediate impact on emergency ambulance dispatches (EADs) due to MBDs in Shenzhen, China. Methods: EADs data and meteorological data from January 1, 2013, to December 31, 2020, in Shenzhen were collected. Distributed lag non-linear models (DLNMs) were utilized to examine the non-linear and lagged effects of temperature-related indices on EADs due to MBDs. The Quasi Akaike Information criterion (QAIC) was used to determine the optimal index after standardizing temperature-related indices. After adjusting for confounding factors in the model, we estimated the immediate and cumulative effects of temperature on EADs due to MBDs. Results: The analysis of short-term temperature effects on EADs due to MBDs revealed Humidex as the most suitable index. Referring to the optimal Humidex (3.2th percentile, 12.00°C), we observed a significant effect of Humidex over the threshold (34.6th percentile, 26.80°C) on EADs due to MBDs at lag 0-5. The cumulative relative risks for high temperature (90th percentile, 41.90°C) and extreme high temperature (99th percentile, 44.20°C) at lag 0-5 were 1.318 (95% CI: 1.159-1.499) and 1.338 (95% CI: 1.153-1.553), respectively. No significant cold effect was observed on EADs due to MBDs. Conclusion: High Humidex was associated with more EADs due to MBDs in subtropical regions. Health authorities should implement effective measures to raise public awareness of risks related to high temperature and protect vulnerable populations.


Subject(s)
Ambulances , Mental Disorders , Temperature , Humans , China , Ambulances/statistics & numerical data , Mental Disorders/epidemiology , Male , Female , Adult , Middle Aged , Emergency Medical Dispatch/statistics & numerical data
9.
JMIR Ment Health ; 11: e56812, 2024 May 14.
Article in English | MEDLINE | ID: mdl-38771217

ABSTRACT

Background: Mental, emotional, and behavioral disorders are chronic pediatric conditions, and their prevalence has been on the rise over recent decades. Affected children have long-term health sequelae and a decline in health-related quality of life. Due to the lack of a validated database for pharmacoepidemiological research on selected mental, emotional, and behavioral disorders, there is uncertainty in their reported prevalence in the literature. objectives: We aimed to evaluate the accuracy of coding related to pediatric mental, emotional, and behavioral disorders in a large integrated health care system's electronic health records (EHRs) and compare the coding quality before and after the implementation of the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) coding as well as before and after the COVID-19 pandemic. Methods: Medical records of 1200 member children aged 2-17 years with at least 1 clinical visit before the COVID-19 pandemic (January 1, 2012, to December 31, 2014, the ICD-9-CM coding period; and January 1, 2017, to December 31, 2019, the ICD-10-CM coding period) and after the COVID-19 pandemic (January 1, 2021, to December 31, 2022) were selected with stratified random sampling from EHRs for chart review. Two trained research associates reviewed the EHRs for all potential cases of autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), major depression disorder (MDD), anxiety disorder (AD), and disruptive behavior disorders (DBD) in children during the study period. Children were considered cases only if there was a mention of any one of the conditions (yes for diagnosis) in the electronic chart during the corresponding time period. The validity of diagnosis codes was evaluated by directly comparing them with the gold standard of chart abstraction using sensitivity, specificity, positive predictive value, negative predictive value, the summary statistics of the F-score, and Youden J statistic. κ statistic for interrater reliability among the 2 abstractors was calculated. Results: The overall agreement between the identification of mental, behavioral, and emotional conditions using diagnosis codes compared to medical record abstraction was strong and similar across the ICD-9-CM and ICD-10-CM coding periods as well as during the prepandemic and pandemic time periods. The performance of AD coding, while strong, was relatively lower compared to the other conditions. The weighted sensitivity, specificity, positive predictive value, and negative predictive value for each of the 5 conditions were as follows: 100%, 100%, 99.2%, and 100%, respectively, for ASD; 100%, 99.9%, 99.2%, and 100%, respectively, for ADHD; 100%, 100%, 100%, and 100%, respectively for DBD; 87.7%, 100%, 100%, and 99.2%, respectively, for AD; and 100%, 100%, 99.2%, and 100%, respectively, for MDD. The F-score and Youden J statistic ranged between 87.7% and 100%. The overall agreement between abstractors was almost perfect (κ=95%). Conclusions: Diagnostic codes are quite reliable for identifying selected childhood mental, behavioral, and emotional conditions. The findings remained similar during the pandemic and after the implementation of the ICD-10-CM coding in the EHR system.


Subject(s)
COVID-19 , Delivery of Health Care, Integrated , Electronic Health Records , Mental Disorders , Neurodevelopmental Disorders , Humans , Child , Electronic Health Records/statistics & numerical data , Adolescent , Child, Preschool , Male , COVID-19/epidemiology , Female , Neurodevelopmental Disorders/epidemiology , Neurodevelopmental Disorders/diagnosis , Mental Disorders/epidemiology , Mental Disorders/diagnosis , International Classification of Diseases , Clinical Coding
10.
Genes (Basel) ; 15(4)2024 03 24.
Article in English | MEDLINE | ID: mdl-38674334

ABSTRACT

There are about 14,000 pseudogenes that are mutated or truncated sequences resembling functional parent genes. About two-thirds of pseudogenes are processed, while others are duplicated. Although initially thought dead, emerging studies indicate they have functional and regulatory roles. We study 14-3-3ζ, an adaptor protein that regulates cytokine signaling and inflammatory diseases, including rheumatoid arthritis, cancer, and neurological disorders. To understand how 14-3-3ζ (gene symbol YWHAZ) performs diverse functions, we examined the human genome and identified nine YWHAZ pseudogenes spread across many chromosomes. Unlike the 32 kb exon-to-exon sequence in YWHAZ, all pseudogenes are much shorter and lack introns. Out of six, four YWHAZ exons are highly conserved, but the untranslated region (UTR) shows significant diversity. The putative amino acid sequence of pseudogenes is 78-97% homologous, resulting in striking structural similarities with the parent protein. The OMIM and Decipher database searches revealed chromosomal loci containing pseudogenes are associated with human diseases that overlap with the parent gene. To the best of our knowledge, this is the first report on pseudogenes of the 14-3-3 family protein and their implications for human health. This bioinformatics-based study introduces a new insight into the complexity of 14-3-3ζ's functions in biology.


Subject(s)
14-3-3 Proteins , Pseudogenes , Humans , 14-3-3 Proteins/genetics , 14-3-3 Proteins/metabolism , Exons/genetics , Genome, Human , Pseudogenes/genetics
11.
Environ Sci Ecotechnol ; 21: 100415, 2024 Sep.
Article in English | MEDLINE | ID: mdl-38577706

ABSTRACT

Emerging evidence suggests a link between alterations in the gut microbiome and adverse health outcomes in the hosts exposed to environmental pollutants. Yet, the causal relationships and underlying mechanisms remain largely undefined. Here we show that exposure to biotoxins can affect gut pathobiome assembly in amphibians, which in turn triggers the toxicity of exogenous pollutants. We used Xenopus laevis as a model in this study. Tadpoles exposed to tropolone demonstrated notable developmental impairments and increased locomotor activity, with a reduction in total length by 4.37%-22.48% and an increase in swimming speed by 49.96%-84.83%. Fusobacterium and Cetobacterium are predominant taxa in the gut pathobiome of tropolone-exposed tadpoles. The tropolone-induced developmental and behavioral disorders in the host were mediated by assembly of the gut pathobiome, leading to transcriptome reprogramming. This study not only advances our understanding of the intricate interactions between environmental pollutants, the gut pathobiome, and host health but also emphasizes the potential of the gut pathobiome in mediating the toxicological effects of environmental contaminants.

12.
Article in English | MEDLINE | ID: mdl-38530623

ABSTRACT

Asian Americans have been historically underrepresented in the national drug overdose discourse due to their lower substance use and overdose rates compared to other racial/ethnic groups. However, aggregated analyses fail to capture the vast diversity among Asian-American subgroups, obscuring critical disparities. We conducted a cross-sectional study between 2018 and 2021 examining Asian-American individuals within the CDC WONDER database with drug overdoses as the underlying cause of death (n = 3195; ICD-10 codes X40-X44, X60-X64, X85, and Y10-Y14) or psychoactive substance-related mental and behavioral disorders as one of multiple causes of death (n = 15,513; ICD-10 codes F10-F19). Proportional mortality ratios were calculated, comparing disaggregated Asian-American subgroups to the reference group (Asian Americans as a single aggregate group). Z-tests identified significant differences between subgroups. Compared to the reference group (0.99%), drug overdose deaths were less prevalent among Japanese (0.46%; p < 0.001), Chinese (0.47%; p < 0.001), and Filipino (0.82%; p < 0.001) subgroups, contrasting with a higher prevalence among Asian Indian (1.20%; p < 0.001), Vietnamese (1.35%; p < 0.001), Korean (1.36%; p < 0.001), and other Asian (1.79%; p < 0.001) subgroups. Similarly, compared to the reference group (4.80%), deaths from mental and behavioral disorders were less prevalent among Chinese (3.18%; p < 0.001), Filipino (4.52%; p < 0.001), and Asian Indian (4.56%; p < 0.001) subgroups, while more prevalent among Korean (5.60%; p < 0.001), Vietnamese (5.64%; p < 0.001), Japanese (5.81%; p < 0.001), and other Asian (6.14%; p < 0.001) subgroups. Disaggregated data also revealed substantial geographical variations in these deaths obscured by aggregated analyses. Our findings revealed pronounced intra-racial disparities, underscoring the importance of data disaggregation to inform targeted clinical and public health interventions.

13.
Pediatr Clin North Am ; 71(2): 269-282, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38423720

ABSTRACT

Children with autism are at high risk for experiencing a mental health crisis, which occurs when psychiatric and behavioral symptoms become a danger and caregivers do not have the resources to safely manage the event. Our current mental health systems of care are not fully prepared to manage crisis in autistic individuals, due to the shortage of available mental health providers and programs that are tailored for autistic children. However, new strategies to address crisis are gradually emerging. This article provides a framework to define crisis and implement prevention and intervention approaches that could potentially mitigate risk for crisis.


Subject(s)
Autism Spectrum Disorder , Autistic Disorder , Mental Health Services , Child , Humans , Mental Health , Autistic Disorder/complications , Autistic Disorder/therapy , Primary Health Care
14.
Chronobiol Int ; 41(4): 513-520, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38380819

ABSTRACT

Leisure screen time is associated with poor academic achievement; however, the mechanism underlying this relationship is unclear. Chronotypes and emotional/behavioral problems may be linked to this association. This study aimed to examine the associations between leisure screen time, chronotype, emotional/behavioral problems, and academic achievement using mediation analysis. A total of 113 children aged 9-12 years participated in this study. All participants were assessed for leisure screen time, chronotype, emotional/behavioral problems, and academic achievement. Leisure screen time was evaluated using a self-reported questionnaire. Chronotypes were measured using The Japanese Children's Chronotype Questionnaire, and the morningness/eveningness (M/E) score was calculated. Emotional/behavioral problems were assessed using The Japanese Strengths and Difficulties Questionnaire, and the total difficulties score (TDS) was calculated. Academic achievement was assessed by the homeroom teacher for each of the seven school subjects. Partial correlation analysis adjusted for grade, sex, and sleep duration indicated that leisure screen time was associated with M/E scores and academic achievement (p < 0.05). There was a positive association between M/E score and TDS (p < 0.05) and a negative association between TDS and academic achievement (p < 0.05). A mediation analysis adjusted for grade, sex, and sleep duration was performed. There was a significant total effect of leisure screen time on academic achievement (p < 0.05). Additionally, the M/E score and TDS significantly mediated the association between leisure screen time and academic achievement (p < 0.05). Our findings suggest that the serial path between chronotype and emotional/behavioral problems weakly but significantly mediates the association of leisure screen time with academic achievement.


Subject(s)
Academic Success , Circadian Rhythm , Emotions , Leisure Activities , Screen Time , Sleep , Humans , Child , Male , Female , Circadian Rhythm/physiology , Emotions/physiology , Surveys and Questionnaires , Sleep/physiology , Problem Behavior , Child Behavior/physiology , Japan , Chronotype
15.
Econ Hum Biol ; 53: 101367, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38340649

ABSTRACT

Retirement, a major transition in the life course, may affect many aspects of retirees' well-being, including health and health care utilization. Leveraging differential statutory retirement age (SRA) by occupation for China's urban female workers, we provide some of the first evidence on the causal effect of retirement on hospitalizations attributable to mental illness and its heterogeneity. To address endogeneity in retirement decisions, we take advantage of exogeneity of the differing SRA cut-offs for blue-collar (age 50) and white-collar (age 55) female urban employees. We apply a Fuzzy Regression Discontinuity Design (RDD) around the SRA cut-offs using nationally representative hospital inpatient claims data that cover these workers. We show that blue-collar females incur more hospitalizations for mental illness after retirement, while no similar change is found for white-collar females. Conditional on blue-collar females being hospitalized, probabilities of overall and ER admissions due to mental illness increase by 2.3 and 1.2 percentage points upon retirement, respectively. The effects are primarily driven by patients within the categories of schizophrenia, schizotypal and delusional disorders; and neurotic, stress-related and somatoform disorders. Moreover, the 'Donut' RDD estimates suggest that pent-up demand at retirement unlikely dominates our findings for blue-collar females. Rather, our results lend support to their worsening mental health at retirement. These findings suggest that occupational differences in mental illness and related health care utilization at retirement should be considered when optimizing retirement policy schemes.


Subject(s)
Hospitalization , Mental Disorders , Occupations , Retirement , Humans , Female , Retirement/statistics & numerical data , China/epidemiology , Middle Aged , Hospitalization/statistics & numerical data , Mental Disorders/epidemiology , Occupations/statistics & numerical data , Age Factors , Aged , Fuzzy Logic
16.
Mov Disord ; 39(2): 235-248, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38234035

ABSTRACT

BACKGROUND: Impulse-control and related behavioral disorders (ICBDs) significantly impact the lives of Parkinson's disease (PD) patients and caregivers, with lasting consequences if undiagnosed and untreated. While ICBD pathophysiology and risk factors are well-studied, a standardized severity definition and treatment evidence remain elusive. OBJECTIVE: This work aimed to establish international expert consensus on ICBD treatment strategies. To comprehensively address diverse treatment availabilities, experts from various continents were included. METHODS: From 2021 to 2023, global movement disorders specialists engaged in a Delphi process. A core expert group initiated surveys, involving a larger panel in three iterations, leading to refined severity definitions and treatment pathways. RESULTS: Experts achieved consensus on defining ICBD severity, emphasizing regular PD patient screenings for early detection. General treatment recommendations focused on continuous monitoring, collaboration with significant others, and seeking specialist advice for legal or financial challenges. For mild to severe ICBDs, gradual reduction in dopamine agonists was endorsed, followed by reductions in other PD medications. Second-line treatment strategies included diverse approaches like reversing the last medication change, cognitive behavior therapy, subthalamic nucleus deep brain stimulation, and specific medications like quetiapine, clozapine, and antidepressants. The panel reached consensus on distinct treatment pathways for punding and dopamine dysregulation syndrome, formulating therapy recommendations. Comprehensive discussions addressed management strategies for the exacerbation of either motor or non-motor symptoms following the proposed treatments. CONCLUSION: The consensus offers in-depth insights into ICBD management, presenting clear severity criteria and expert consensus treatment recommendations. The study highlights the critical need for further research to enhance ICBD management. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.


Subject(s)
Deep Brain Stimulation , Disruptive, Impulse Control, and Conduct Disorders , Mental Disorders , Parkinson Disease , Humans , Parkinson Disease/therapy , Parkinson Disease/drug therapy , Consensus , Mental Disorders/therapy , Dopamine/metabolism , Dopamine Agonists/therapeutic use , Disruptive, Impulse Control, and Conduct Disorders/etiology , Disruptive, Impulse Control, and Conduct Disorders/therapy
17.
J Pediatr Gastroenterol Nutr ; 78(4): 810-816, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38284650

ABSTRACT

BACKGROUND: Treatment of functional constipation (FC) in children with autism spectrum disorder (ASD) is challenging due to sensory and behavioral issues. We aimed to understand whether antegrade continence enemas (ACEs) are successful in the treatment of FC in children with ASD. METHODS: A single-institution retrospective review was performed in children diagnosed with ASD and FC who underwent appendicostomy or cecostomy placement from 2007 to 2019. Descriptive statistics regarding soiling and complications were calculated. RESULTS: There were 33 patients included, with a median age of 9.7 years at the time of ACE initiation. The average intelligence quotient was 63.6 (SD = 18.0, n = 12), the average behavioral adaptive score was 59.9 (SD = 11.1, n = 13), and the average total Child Behavioral Checklist score was 72.5 (SD = 7.1, n = 10). Soiling rates were significantly lower following ACE initiation (42.3% vs. 14.8%, p = 0.04). Behavioral issues only prevented 1 patient (3.0%) from proper ACE use. Eleven patients (36.6%) were able to transition to laxatives. There were significant improvements in patient-reported outcomes measures and quality of life. CONCLUSION: Placement of an appendicostomy or cecostomy for management of FC in children with severe ASD was successful in treating constipation and improving quality of life.


Subject(s)
Autism Spectrum Disorder , Fecal Incontinence , Child , Humans , Quality of Life , Autism Spectrum Disorder/complications , Autism Spectrum Disorder/therapy , Constipation/therapy , Constipation/complications , Cecostomy/adverse effects , Enema/adverse effects , Retrospective Studies , Fecal Incontinence/etiology , Fecal Incontinence/therapy , Treatment Outcome
18.
J Neural Transm (Vienna) ; 131(2): 173-180, 2024 02.
Article in English | MEDLINE | ID: mdl-38200268

ABSTRACT

OBJECTIVES: The Caregiver's Inventory Neuropsychological Diagnosis Dementia (CINDD) is an easy tool designed to quantify cognitive, behavioural and functional deficits of patients with cognitive impairment. Aim of the present study was to analyse the psychometric properties of the CINDD in Mild Cognitive Impairment (MCI) and Dementia (D). DESIGN, SETTING AND PARTICIPANTS: The CINDD, composed by 9 sub-domains, was administered to fifty-six caregivers of patients with different types of dementia (D) and 44 caregivers of patients with MCI. All patients underwent an extensive neuropsychological assessment, the Neuropsychiatric Inventory (NPI) and functional autonomy scales. The reliability, convergent construct validity and possible cut-off of CINND were measured by Cronbach's alpha (α), Pearson's correlation and ROC analysis, respectively. RESULTS: The D and MCI patients differed only for age (p=0.006). The internal consistency of CINDD was high (α= 0.969). The α-value for each CINDD domain was considered acceptable, except the mood domain (α=0.209). The CINDD total score correlated with cognitive screening tests; each domain of the CINDD correlated with the corresponding score from either tests or NPI (p<0.05), except for visuo-spatial perception skills and apathy. A screening cut-off equal to 59, can be used discriminate D from MCI (Sensitivity=0.70, Specificity=0.57). CONCLUSION: The CINDD is a feasible, accurate and reliable tool for the assessment of cognitive and behavioural difficulties in patients with different degree of cognitive impairment. It may be used to quantify and monitor caregiver-reported ecological data in both clinical and research settings.


Subject(s)
Cognitive Dysfunction , Dementia , Humans , Caregivers/psychology , Psychometrics , Reproducibility of Results , Cognitive Dysfunction/diagnosis , Cognitive Dysfunction/psychology , Neuropsychological Tests
19.
Biosystems ; 235: 105110, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38176518

ABSTRACT

In this paper, we examine how deep learning can be utilized to investigate neural health and the difficulties in interpreting neurological analyses within algorithmic models. The key contribution of this paper is the investigation of the impact of a dead neuron on the performance of artificial neural networks (ANNs). Therefore, we conduct several tests using different training algorithms and activation functions to identify the precise influence of the training process on neighboring neurons and the overall performance of the ANN in such cases. The aim is to assess the potential application of the findings in the biological domain, the expected results may have significant implications for the development of effective treatment strategies for neurological disorders. Successive training phases that incorporate visual and acoustic data derived from past social and familial experiences could be suggested to achieve this goal. Finally, we explore the conceptual analogy between the Adam optimizer and the learning process of the brain by delving into the specifics of both systems while acknowledging their fundamental differences.


Subject(s)
Algorithms , Neural Networks, Computer , Neurons/physiology , Brain/physiology
20.
Podium (Pinar Río) ; 18(3)dic. 2023.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1521345

ABSTRACT

La Educación Física, el deporte y la recreación constituyen herramientas efectivas en la educación para corregir o compensar los modos de actuación de los educandos con trastornos en la conducta, manifestaciones que muchas veces son motivo de exclusión por parte del grupo de coetáneos, docentes y/o la comunidad donde reside. Ante las exigencias actuales de crear escuelas verdaderamente inclusivas en su funcionamiento, no siempre se encuentran en las aulas los profesionales competentes que garanticen una educación de calidad y equidad, capaz de aprovechar los beneficios de la actividad física y el deporte, tanto en el desarrollo social como en el psicológico; debido a su impacto en la construcción de las identidades individuales y colectivas, los educandos sienten la necesidad de su participación, la satisfacción con la tarea desarrollada y pueden valorar sus resultados, lo que permite la formación de actitudes y valores positivos hacia las diferentes esferas de la vida social. Es por ello que el siguiente artículo tiene como objetivo diseñar un sistema de talleres que contribuyan a la preparación de los docentes para la inclusión de escolares con trastornos de la conducta desde la actividad física y deportes. Para ello se utilizaron métodos como el histórico-lógico, el análisis documental, la entrevista y la observación científica, los que permitieron constatar el estado actual de la preparación de dichos profesionales y plantear desde la vía científica una respuesta de solución que promueva nuevos modos de actuación profesional.


A Educação Física, o esporte e a recreação constituem ferramentas eficazes na educação para corrigir ou compensar o comportamento dos alunos com distúrbios comportamentais, manifestações que muitas vezes são motivo de exclusão por parte do grupo de pares, professores e/ou da comunidade onde reside. Dadas as atuais exigências de criação de escolas verdadeiramente inclusivas no seu funcionamento, nem sempre se encontram profissionais competentes que garantam uma educação de qualidade e equidade, capazes de aproveitar os benefícios da atividade física e do desporto, tanto no desenvolvimento social como nas salas de aula. nas salas de aula, como no psicológico; Pelo seu impacto na construção de identidades individuais e coletivas, os alunos sentem necessidade da sua participação, satisfação com a tarefa realizada e podem valorizar os seus resultados, o que permite a formação de atitudes e valores positivos perante as diferentes esferas da vida social. vida. É por isso que o artigo a seguir tem como objetivo desenhar um sistema de oficinas que contribua para a preparação de professores para a inclusão de escolares com distúrbios comportamentais por meio da atividade física e esportiva. Para isso, foram utilizados métodos como histórico-lógico, análise documental, entrevistas e observação científica, que permitiram verificar o estado atual da preparação destes profissionais e propor, numa perspectiva científica, uma resposta de solução que promova novas formas de atuação profissional.


Physical Education, sports and recreation constitute effective tools in education to correct or compensate for the behavior of students with behavioral disorders, manifestations that are often a reason for exclusion by the group of peers, teachers and/or or the community where you reside. Given the current demands to create schools that are truly inclusive in their operation, competent professionals who guarantee quality and equity education, capable of taking advantage of the benefits of physical activity and sport, both in social development and in the classrooms, are not always found in the classrooms. as in the psychological; Due to its impact on the construction of individual and collective identities, students feel the need for their participation, satisfaction with the task carried out and can value their results, which allows the formation of positive attitudes and values towards the different spheres of social life. That is why the following article aims to design a system of workshops that contribute to the preparation of teachers for the inclusion of schoolchildren with behavioral disorders through physical activity and sports. To do this, methods such as historical-logical, documentary analysis, interviews and scientific observation were used, which made it possible to verify the current state of the preparation of these professionals and propose, from a scientific perspective, a solution response that promotes new ways of professional performance.

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