Efeitos da corticoterapia materna nos valores hemogasométricos de cordeiros nascidos a termo e prematuros / Effects of maternal blood gas values corticotherapy of Lambs born at term and premature

The aim of the study was to evaluate blood gas parameters of full-term and premature lambs from birth to 48 hours of life. Four experimental groups were formed: NDG (normal delivery group - lambs vaginally delivered, n=15, average of 146-day gestation); NDEXG (normal delivery with dexamethasone group - lambs vaginally delivered whose mothers received 16 mg of dexamethasone at 141 days of gestation, n=8, average of 143-day gestation); PRE (premature lambs born by cesarean section at 138 days of gestation, n=10) and PREDEX (premature lambs born by cesarean section at 138 days gestation, whose mothers received 16mg of dexamethasone two days before, n=9). Immediately after birth, lambs from all groups showed respiratory acidosis (low pH and high pCO2 ), most obviously in premature animals. The concentration of HCO3 - was lower between 15 and 60 minutes of life, especially in PRE and PREDEX groups with subsequent increase in M24h. The values of base excess were lower in premature lambs, which showed abdominal breathing, severe dyspnea and lots of lung fluid. The stabilization of acid-base balance occurred in all animals during the first 24 hours of life. Dexamethasone had a positive effect on the clinical condition of the premature lambs, resulting in adequate ventilation and tissue perfusion, which guaranteed higher survival rate.(AU)

O objetivo do estudo foi avaliar as variáveis hemogasométricas de cordeiros nascidos a termo e prematuros do nascimento às 48 horas de vida. Foram constituídos quatros grupos experimentais: PN (cordeiros nascidos de parto normal, n=15, média de 146 dias de gestação); PNDEX (cordeiros nascidos de parto normal, cujas mães receberam 16 mg de dexametasona aos 141 de gestação, n=8, média de 143 dias de gestação); PRE (cordeiros prematuros nascidos de cesarianas aos 138 dias de gestação, n=10) e PREDEX (cordeiros prematuros nascidos de cesarianas aos 138 dias de gestação, cujas mães receberam 16 mg de dexametasona dois dias antes do parto, n=9). Imediatamente após o nascimento, os cordeiros de todos os grupos apresentaram quadro de acidose respiratória (pH baixo e pCO2 elevada), com maior ênfase nos animais prematuros. A concentração de HCO3 - diminuiu entre 15 e 60 minutos de vida, principalmente nos grupos PRE e PREDEX, com posterior aumento no M24h. Os valores de diferença de base foram menores nos cordeiros prematuros, os quais apresentaram respiração abdominal, intensa dispneia e grande quantidade de líquido pulmonar. A estabilização do equilíbrio ácidobase ocorreu em todos os animais ao longo das primeiras 24 horas de vida. A dexametasona teve influência positiva sobre a condição clínica dos animais prematuros, resultando em adequada ventilação e perfusão tecidual, o que garantiu maior taxa de sobrevivência.(AU)

Efeitos da corticoterapia materna nos valores hemogasométricos de cordeiros nascidos a termo e prematuros / Effects of maternal blood gas values corticotherapy of Lambs born at term and premature

O objetivo do estudo foi avaliar as variáveis hemogasométricas de cordeiros nascidos a termo e prematuros do nascimento às 48 horas de vida. Foram constituídos quatros grupos experimentais: PN (cordeiros nascidos de parto normal, n=15, média de 146 dias de gestação); PNDEX (cordeiros nascidos de parto normal, cujas mães receberam 16 mg de dexametasona aos 141 de gestação, n=8, média de 143 dias de gestação); PRE (cordeiros prematuros nascidos de cesarianas aos 138 dias de gestação, n=10) e PREDEX (cordeiros prematuros nascidos de cesarianas aos 138 dias de gestação, cujas mães receberam 16 mg de dexametasona dois dias antes do parto, n=9). Imediatamente após o nascimento, os cordeiros de todos os grupos apresentaram quadro de acidose respiratória (pH baixo e pCO2 elevada), com maior ênfase nos animais prematuros. A concentração de HCO3 - diminuiu entre 15 e 60 minutos de vida, principalmente nos grupos PRE e PREDEX, com posterior aumento no M24h. Os valores de diferença de base foram menores nos cordeiros prematuros, os quais apresentaram respiração abdominal, intensa dispneia e grande quantidade de líquido pulmonar. A estabilização do equilíbrio ácidobase ocorreu em todos os animais ao longo das primeiras 24 horas de vida. A dexametasona teve influência positiva sobre a condição clínica dos animais prematuros, resultando em adequada ventilação e perfusão tecidual, o que garantiu maior taxa de sobrevivência.(AU)

The aim of the study was to evaluate blood gas parameters of full-term and premature lambs from birth to 48 hours of life. Four experimental groups were formed: NDG (normal delivery group - lambs vaginally delivered, n=15, average of 146-day gestation); NDEXG (normal delivery with dexamethasone group - lambs vaginally delivered whose mothers received 16 mg of dexamethasone at 141 days of gestation, n=8, average of 143-day gestation); PRE (premature lambs born by cesarean section at 138 days of gestation, n=10) and PREDEX (premature lambs born by cesarean section at 138 days gestation, whose mothers received 16mg of dexamethasone two days before, n=9). Immediately after birth, lambs from all groups showed respiratory acidosis (low pH and high pCO2), most obviously in premature animals. The concentration of HCO3 - was lower between 15 and 60 minutes of life, especially in PRE and PREDEX groups with subsequent increase in M24h. The values of base excess were lower in premature lambs, which showed abdominal breathing, severe dyspnea and lots of lung fluid. The stabilization of acid-base balance occurred in all animals during the first 24 hours of life. Dexamethasone had a positive effect on the clinical condition of the premature lambs, resulting in adequate ventilation and tissue perfusion, which guaranteed higher survival rate.(AU)

Changes in hematological parameters in cattle infected with Bovine Viral Diarrhea Virus

Background: The bovine viral diarrhea virus (BVDV) causes mucosal lesions, respiratory disorders, spontaneous abortion, congenital abnormalities, and stillbirth in cattle and wild ruminant populations worldwide. Clinical categories ofBVDV infection include persistent subclinical infection, acute transient infection, and mucosal disease. Virus neutralization, enzyme-linked immunosorbent assay (ELISA), and reverse transcription and polymerase chain reaction have beenused for the detection of BVDV-infected cattle, but are time-consuming and costly methods, especially when screeninglarge herds for persistent subclinical infections. In the current research, it was hypothesized that hemogram and blood gasvalues can be valuable indicator in the diagnosis and prognosis of infectious disease like metabolic disorders. The aim ofthis current study was to determine whether changes in the hematological parameters of BVDV-infected cattle representpotentially useful diagnostic factors.Materials, Methods & Results: Blood samples were collected from the jugular vein of 15 BVDV-antigen-positive (sick group)and 15 BVDV-antigen-negative (control group) Holstein cattle on a dairy farm in Konya Province in the Central Anatoliaregion of Turkey between January 2012 and September 2012. The presence of the BVDV antigen in the blood sampleswas determined with commercially available ELISA kit by using ELISA reader. Hemogram parameters [white blood cellcounts (WBC), lymphocytes, monocytes, granulocytes, red blood cell counts (RBC), hematocrit (Hct), hemoglobin (Hb)and thrombocyte counts (THR)] obtained from anticoagulated bloods were measured with automatic cell counter. Bloodgas values [power of hydrogen (pH), partial pressure of carbon dioxide (pCO2), partial pressure of oxygen (pO2), sodium(Na+2), potassium (K+), calcium (Ca+2), glucose (Glu), lactate (Lac), actual bicarbonate (HCO3act), standard bicarbonate(HCO3std), total carbon dioxide (tCO2)...

Changes in hematological parameters in cattle infected with Bovine Viral Diarrhea Virus

Background: The bovine viral diarrhea virus (BVDV) causes mucosal lesions, respiratory disorders, spontaneous abortion, congenital abnormalities, and stillbirth in cattle and wild ruminant populations worldwide. Clinical categories ofBVDV infection include persistent subclinical infection, acute transient infection, and mucosal disease. Virus neutralization, enzyme-linked immunosorbent assay (ELISA), and reverse transcription and polymerase chain reaction have beenused for the detection of BVDV-infected cattle, but are time-consuming and costly methods, especially when screeninglarge herds for persistent subclinical infections. In the current research, it was hypothesized that hemogram and blood gasvalues can be valuable indicator in the diagnosis and prognosis of infectious disease like metabolic disorders. The aim ofthis current study was to determine whether changes in the hematological parameters of BVDV-infected cattle representpotentially useful diagnostic factors.Materials, Methods & Results: Blood samples were collected from the jugular vein of 15 BVDV-antigen-positive (sick group)and 15 BVDV-antigen-negative (control group) Holstein cattle on a dairy farm in Konya Province in the Central Anatoliaregion of Turkey between January 2012 and September 2012. The presence of the BVDV antigen in the blood sampleswas determined with commercially available ELISA kit by using ELISA reader. Hemogram parameters [white blood cellcounts (WBC), lymphocytes, monocytes, granulocytes, red blood cell counts (RBC), hematocrit (Hct), hemoglobin (Hb)and thrombocyte counts (THR)] obtained from anticoagulated bloods were measured with automatic cell counter. Bloodgas values [power of hydrogen (pH), partial pressure of carbon dioxide (pCO2), partial pressure of oxygen (pO2), sodium(Na+2), potassium (K+), calcium (Ca+2), glucose (Glu), lactate (Lac), actual bicarbonate (HCO3act), standard bicarbonate(HCO3std), total carbon dioxide (tCO2)...(AU)