One story as part of the Global Conversation on Sustainability: dye adsorption studies using a novel bio-derived calcite material.

Many of the United Nations' Sustainable Development Goals (SDGs) can be addressed through chemistry. Researchers at Memorial University of Newfoundland, Canada, have been sharing their stories on September 25 for the past two years through the Global Conversation on Sustainability. This article describes the details of one of these stories. As the global population increases, food production including aquaculture is increasing to provide for this. At the same time, this means more waste is produced. Waste from aquaculture is often overlooked as a source of valuable chemicals. By-products from farming blue mussels (Mytilus edulis) is dominated by shells rich in calcite. A 'soft' calcite material prepared from waste mussels, via a combination of heat and acetic acid treatment, was investigated for its adsorptive properties and its possible use in wastewater remediation. The adsorption of two cationic dyes, methylene blue and safranin-O, on this material were evaluated through isothermal and kinetic modelling. The adsorption systems for both methylene blue and safranin-O can best be described using Langmuir isotherms and the respective adsorption capacities were 1.81 and 1.51 mg/g. The adsorption process was dominated by pseudo-second order rate kinetics. Comparisons are made with other mollusc-derived materials reported to date.

How should climate actions be planned? Model lessons from published action plans.

To effectively protect against the increasingly pervasive effects of climate change, countries and cities around the world are tasked with formulating and implementing climate actions that effectively respond to the challenges ahead. However, choosing the optimal climate actions is complex, since it is necessary to consider many external impacts as early on as the planning phase. Our novel methodology uncovers and integrates into first-of-its-kind decision support framework the identified climate actions of 443 European cities (from 32 countries) and the city structure-related features that influence the basic success of strategy creation into a first-of-its-kind decision support framework. Depending on their budget, population density, development and energy consumption portfolio, the results highlight that the analyzed European cities need to adopt a different way of thinking. The research results lay the foundation for the decision support of evidence-based climate action planning and contribute towards strengthening the role of cities worldwide in the fight against climate change in the future.

Molecular detection and genotyping of HMPV in patients with severe acute respiratory infection in India.

BACKGROUND: Human metapneumovirus (HMPV) is a common respiratory pathogen that causes respiratory tract infections. In India, HMPV has been identified as one of the leading causes of morbidity and mortality in infants and young children with respiratory tract infections. The most reported sublineages of HMPV in India are B1, B2, A2b and A2c. OBJECTIVE: A retrospective study was conducted to determine the circulating genotypes of HMPV among SARI cases from January 2016 to December 2018. MATERIALS AND METHODS: Positive throat swab samples were confirmed with real-time RT-PCR. Subsequently, these samples were analysed using semi-nested conventional RT-PCR targeting the G gene, followed by sequencing and phylogenetic analysis. Clinical data analysis was also performed using SPSS 15.0 software. RESULTS: All 20 samples from the SARI cases were classified under the A2c sublineage of HMPV. Phylogenetic analysis indicated that these strains were genetically related to those circulating in Japan, China, and Croatia. Among the samples, ten showed 111-nucleotide duplications, while the other ten had 180-nucleotide duplications. CONCLUSION: Clinical analysis showed that four cases had coinfections with other pathogens. Our extensive analysis of patient samples determined that HMPV, especially the A2c genotype, significantly contributed to SARI cases within our study population, which signifies the importance of considering HMPV as a probable aetiological agent when investigating SARI outbreaks.

Fish mortality in the Amazonian drought of 2023: the role of experimental biology in our response to climate change.

Higher temperatures exacerbate drought conditions by increasing evaporation rates, reducing soil moisture and altering precipitation patterns. As global temperatures rise as a result of climate change, these effects intensify, leading to more frequent and severe droughts. This link between higher temperatures and drought is particularly evident in sensitive ecosystems like the Amazon rainforest, where reduced rainfall and higher evaporation rates result in significantly lower water levels, threatening biodiversity and human livelihoods. As an example, the serious drought experienced in the Amazon basin in 2023 resulted in a significant decline in fish populations. Elevated water temperatures, reaching up to 38°C, led to mass mortality events, because these temperatures surpass the thermal tolerance of many Amazonian fish species. We know this because our group has collected data on critical thermal maxima (CTmax) for various fish species over multiple years. Additionally, warmer waters can cause hypoxia, further exacerbating fish mortality. Thus, even Amazon fish species, which have relatively high thermal tolerance, are being impacted by climate change. The Amazon drought experienced in 2023 underscores the urgent need for climate action to mitigate the devastating effects on Amazonian biodiversity. The fact that we have been able to link fish mortality events to data on the thermal tolerance of fishes emphasizes the important role of experimental biology in elucidating the mechanisms behind these events, a link that we aim to highlight in this Perspective.

Transformative education for medical postgraduates: centring planetary health

The purpose of this article is to report, reflect upon and learn from a postgraduate course in Planetary Health. The 195 hours postgraduate course occurred in 2022 and involved 44 students at the Department of Pathology at University of São Paulo in Brazil.  The course activities for students were carried out remotely and included self-reflexive, dialogical and creative learning methods. The evaluation was composed of four aspects: participation; poetic memory of encounters; 'plant' or planning a planetary health action; and 'penning'. This study used a qualitative method of thematic analysis to verify three main learning activities: poetic memories, "'Plant' a planetary health action" and 'Penning'. From the 44 students enrolled, 26 fulfilled the optional formulary given consent to participate in this study.  'Planting' a planetary action was organized in different levels: community, work and research, interpersonal, personal. In the 'penning' analysis, students repeatedly referred to art and future as core to learn about planetary health. This could be induced by the way that the course was structured, but rises to a point of the arts' potential to create awareness and a transformative topic for medical education touching other dimensions of learning like emotions and hope. 

Meeting the UN Sustainable Development Goals with Mechanochemistry.

Chemistry traditionally relies on reactions in solution, but this method is increasingly problematic due to the scale of chemical processes and their economic and environmental impact. Handling residual chemical waste, including solvents, incurs significant costs and environmental pressure. Conversely, novel chemical approaches are needed to address pressing societal issues such as climate change, energy scarcity, food insecurity, and waste pollution. Mechanochemistry, a sustainable chemistry discipline that uses mechanical action to induce chemical reactivity without bulk solvents, is a hot topic in academic research on sustainable and green chemistry. Given its fundamentally different working principles from solution chemistry, mechanochemistry offers more efficient chemical processes and the opportunity to design new chemical reactions. Mechanochemistry has a profound impact on many urgent issues facing our society and it is now necessary to use mechanochemistry to address them. This Minireview aims to provide a guide for using mechanochemistry to meet the United Nations (UN) Sustainable Development Goals (SDGs), thereby contributing to a prosperous society. Detailed analysis shows that mechanochemistry connects with most UN SDGs and offers more cost-efficiency than other approaches together with a superior environmental performance.

Social dimensions of climate-induced flooding in Jakarta (Indonesia): The role of non-point source pollution.

Because of its low-lying location, urbanization, and inadequate infrastructure, Jakarta (Indonesia) has experienced an increase in annual flooding events, rising from an average of five significant floods per year in the 1990s to over 20 annually (2010-2020). With climate change exacerbating extreme weather events, Jakarta encounters escalating risks of flooding. Although the recurrent flooding is exacerbated by non-point source (NPS) of pollution such as urban runoff and agricultural discharge that contribute to 40% of total pollutants leading to flood-related issues in Jakarta, none has investigated this research gap. To reflect its novelty, this work explores the implications of climate change on the annual flooding in Jakarta by focusing on NPS and analyzes their impacts from social perspectives. This work also underscores the implications of flooding on livelihoods, health, and social cohesion in Jakarta. Focus group discussion with affected residents was used to shed light on the coping strategies employed in response to recurrent floods, ranging from community-based initiatives to reliance on informal networks. The empirical findings show that the implications of flooding extend beyond physical damages. Displacement of communities, loss of livelihoods, disruption of essential services, and increased health risks are among the social impacts experienced by local residents. Vulnerable populations, including low-income communities residing in informal settlements, bear their consequences. Economic losses from flooding amount to USD 500 million annually, impacting over 1 million residents. However, recent interventions have led to a 15% reduction in peak flood levels and a 20% reduction in flood duration in affected areas. Community resilience has also improved, with a 25% increase in flood insurance coverage and a 20% rise in community response initiatives. Overall, this study highlights that climate change exacerbates annual flooding in Jakarta, significantly impacting vulnerable communities through NPS pollution. Addressing the challenges requires integrated approaches combining effective pollution control, resilient infrastructure, and community engagement to mitigate social and long-term environmental impacts. PRACTITIONER POINTS: Climate-induced flooding disproportionately affects vulnerable communities in Jakarta. Non-point source pollution from urban runoff contributes to the severity of flooding in Jakarta. Waterborne diseases, disruption of livelihoods, and reduced access to clean water are major concerns identified in the study. The study highlights the importance of community-based adaptation strategies to mitigate the impact of flooding and pollution.

Spatial heterogeneity in the potential distribution of Aedes mosquitoes in India under current and future climatic scenarios.

Aedes is the most globally distributed mosquito genus in the 21st century and transmits various arboviral diseases. The rapid expansion of Ae. Aegypti and Ae. albopictus breeding habitats is a significant threat to global public health, driven by temperature and precipitation changes. In this study, bioclimatic variables were employed to predict the spatial distribution of Ae. aegypti and Ae. albopictus in India. The reference coordinate points of (n = 583) Aedes occurrences at a scale of ∼1 km and nineteen bioclimatic factors were retrieved to train SDM (Species Distribution Models) for both species. Maximum entropy modelling was used to predict the species' fundamental climatic niche distributions. Future projections were made using global climate models for 2021-2040 and 2081-2100 separately. The models performed reasonably well (AUC > 0.77). Both species thrived in reduced diurnal temperature and higher annual mean temperatures, with suitability increasing alongside precipitation. Ae. aegypti's projected present and future distribution was broader than that of Ae. Albopictus. The expansion of Aedes suitability varied under different future climatic scenarios. Suitability for Ae. aegypti could expand from between 17.6 and 41.1 % in 2100 under SSP (shared socioeconomic pathways) scenarios 1 and 3, respectively, whereas for Ae. albopictus suitability increased from between 10.2 and 25 % under SSP scenarios 1 and 3 respectively. Preparing for future epidemics and outbreaks requires robust vector distribution models to identify high-risk areas, allocate resources for surveillance and control, and implement prevention strategies.

Energy efficiency in medium-scale airports: Two Mexican airports as case of study.

Reducing energy consumption in the operation of airports has been identified as one of the approaches to achieve the commitments of the countries in reducing their greenhouse gas (GHG) emissions. The first step in this approach is the development of an energy diagnostic. However, multiple practical aspects remain unresolved when applying the existing methodologies to perform energy diagnostics, especially in the case of small and medium-scale airports. Seeking to address these issues, this work presents energy diagnostics of two Mexican international airports so that it can be used to carry out energy diagnostics in other airports with similar characteristics. Emphasis is given to identifying and prioritizing, from a sustainable point of view, the strategies to reduce energy consumption and GHG emissions. The Ciudad del Carmen Airport (CME) is located in a nearshore region with high ambient temperatures (27 °C) and humidities. It was found that in 2019, the CME airport consumed 123 MWh with an average of 577 Wh per passenger, with the HVAC system being the primary energy consumer. Critical strategies for the CME airport include photovoltaic systems and HVAC renovation. In contrast, the Puebla airport (PBC) is located in a region with comfortable ambient conditions (16 °C). In 2019, the PBC airport consumed 61.31 MWh/year and 442 Wh per passenger. The main strategies for PBC include expanding its photovoltaic energy generation system, employee awareness programs, and renewing the vehicle fleet with electric vehicles.

Fitting consistent knowledge into the planning process: An integrated database on adaptation and mitigation measures in Europe.

Climate action is far from meeting the internationally agreed adaptation and mitigation goals. Even though climate action planning has increased since the Paris Agreement in 2015, the implementation rate of those plans remains low. Climate planning literature claims that accounting for long-term planning and implementation times, accurately estimating costs, identifying synergies and trade-offs between measures, or considering justice and equity issues might increase the quality of climate plans and facilitate the further implementation of climate actions. Also, there is no uniform way of responding to the climate crisis. Existing climate action databases typically focus on a particular type of response, sector, hazard, or type. In parallel, national governments and international initiatives provide tools and guidelines to facilitate the development of climate action plans. However, the primary climate action recording and monitoring initiatives and projects do not share the same framework as those tools, resulting in a lost opportunity to improve climate actions' knowledge transferability. Thus, we reviewed nine existing databases of adaptation and five mitigation databases, comprising a total of 7.130 adaptation actions and 11.409 mitigation actions, and detected a lack of alignment with climate planning practices and claims. Furthermore, we revealed a lack of coherency regarding the level of abstraction of climate actions and their role in the implementation process. Not all climate actions are meant to operate similarly from a planning perspective: while some had a direct outcome on the target indicators, others are thought to facilitate their implementation. Ultimately, we created a new integrated database of adaptation and mitigation measures in Europe, focusing exclusively on climate planning and implementation practices. First, we identified specific and transferable mitigation and adaptation measures and instruments through an originally designed decision tree. Second, we harmonised the collection of climate actions in a unique framework based on one of the biggest climate planning initiatives: the Sustainable and Energy Climate Action Plans by the Covenant of Mayors. Our integrated database of adaptation and mitigation measures (1) classifies and relates the different types of climate actions; (2) provides data that may improve the quality of climate plans and facilitate implementation; (3) allows a better perspective of systematic problems by identifying potential synergies and trade-offs; and (4) defines and characterises measures using a framework that draws on actual practice. The database compiles a total of 191 adaptation measures, 188 mitigation measures, and 97 measures that account for each, and a total of 609 associated instruments. For monitoring their outcomes, 93 Sustainable Development Goals relevant indicators are included.

Synthesis of aminopropyl triethoxysilane/melamine incorporated superhydrophilic membranes for simultaneous removal of oil, metals, and Salt ions from produced water.

Water treatment has turned out to be more important in most societies due to the expansion of most economies and to advancement of industrialization. Developing efficient materials and technologies for water treatment is of high interest. Thin film nanocomposite membranes are regarded as the most effective membranes available for salts, hydrocarbon, and environmental pollutants removal. These membranes improve productivity while using less energy than conventional asymmetric membranes. Here, the polyvinylidene fluoride (PVDF) membranes have been successfully modified via dip single-step coating by silica-aminopropyl triethoxysilane/trimesic acid/melamine nanocomposite (Si-APTES-TA-MM). The developed membranes were evaluated for separating the emulsified oil/water mixture, the surface wettability of the membrane materials is therefore essential. During the conditioning step, that is when the freshwater was introduced, the prepared membrane reached a flux of about 27.77 L m-2 h-1. However, when the contaminated water was introduced, the flux reached 18 L m-2 h-1, alongside an applied pressure of 400 kPa. Interestingly, during the first 8 h of the filtration test, the membrane showed 90 % rejection for ions including Mg2+, and SO42- and ≈100 % for organic pollutants including pentane, isooctane, toluene, and hexadecane. Also, the membrane showed 98 % rejection for heavy metals including strontium, lead, and cobalt ions. As per the results, the membrane could be recommended as a promising candidate to be used for a mixture of salt ions, hydrocarbons, and mixtures of heavy metals from wastewater.

Perspectives on climate action and the changing burden of infectious diseases among young Italian doctors and students: a national survey.

Background: The eco-climatic crisis has been defined by the World Health Organization as the "single biggest health threat facing humanity," influencing both the emergence of zoonoses and the spread of vector-borne and water-borne diseases. The aim of this survey was to explore knowledge, eco-anxiety and attitudes toward the ecological and climate crisis among young Italian doctors and medical students. Methods: A cross-sectional, multicenter survey was conducted from November 2022 to June 2023, by administering an anonymous questionnaire to Italian doctors and students of medicine. Endpoint of the study was a Knowledge, Attitudes and Practices (KAP) score on ecological and climate crisis (0-20 points). Association between variables and KAP score was assessed by Kruskal-Wallis' or Spearman's test, as appropriate, and significant variables were included into ordinal regression model and reported as adjusted odds ratio (aOR) with their 95% confidence intervals (CI). Results: Both KAP and eco-anxiety scores showed acceptable levels of consistency with Cronbach's alpha. A total of 605 medical doctors and students living in 19 Italian regions were included in the study. Median age [Q1-Q3] was 27.6 [24.1-31.3] and females were 352 (58.2%). Despite showing good attitudes toward climate action, knowledge gap were found, with 42.5% (n = 257) of the respondents not knowing the temperature limits set by the Paris Agreements and 45.5% (n = 275) believing that climate change is caused by sunspots. Fears suggestive for eco-anxiety were common. At multivariable ordinal regression, high levels of eco-anxiety (aOR 1.29, p = 0.001) and low trust in government action (aOR 1.96, p = 0.003) were associated with a higher KAP score. Only one Italian medical school offered an educational module on climate change. Conclusion: Young Italian doctors and medical students are concerned about the climate crisis but show poor knowledge of these topics. The Italian academic system should urgently respond to this need.

Floods and droughts research progress and its contributions toward sustainability.

In 2015, the United Nations General Assembly launched seventeen Sustainable Development Goals (SDGs), aimed at being achieved by 2030. The SDGs 6 (clean water & sanitation) and 13 (climate actions) are two critically important goals concerning water resources that need to be addressed. This study used the Scopus database to explore climate extremes, specifically droughts and floods, in East Asia and highlight the region's efforts and contributions towards achieving SDGs 6 and 13. We found that even before the implementation of SDGs, the topics related to solving the problems of water resources, water quality, and treatment of wastewater using different conceptual models and methodologies were the main concerns in the region. The adoption of SDGs has led to a heightened focus on water and climate sustainability in East Asia, with the considerable surge in climate-related studies after 2019. Under SDG 13, all countries have contributed substantially to climate action research. Keyword analysis indicates that climate change, water management, water treatment, water quality, and adsorption remain prominent. SDGs 6 and 13 have emerged as crucial areas of focus for research and initiatives as the global community grapples with escalating water resources and climate challenges. Under specific keywords search, China has 2nd place in the search with climate and water during the SDGs period, accounting for 21 % of the entire publication from 2015 to 2023. Japan and South Korea account for of 4 % and 3 %, respectively. The research on floods and droughts has garnered significant attention, with half of the ten highly co-cited literature examining the changing pattern of drought, the influence of extreme events on crop yield, and other related topics. Despite the positive contribution of the East Asia region towards SDGs 6 and 13, there is still an urgent need for a more robust framework to improve the complex interconnections between climate actions, clean water, and sanitation for a sustainable soil-water-plant-atmosphere ecosystem.

Applying cultural perspective in Indonesia municipal solid waste management process towards a grounded climate concept and action: A mini-review of opportunities and challenges.

This mini-review emphasises the role of municipal solid waste (MSW) as the biggest contributor to climate change, as well as the need for more grounded climate action. The UN Framework Convention on Climate Change (UNFCCC) 2023 Synthesis Report by the co-facilitators on the technical dialogue Key Finding 3 of applying the 'whole-of-society' approach in this article is interpreted as a cultural approach in MSW management planning and implementation process. Using anthropological critiques of development, the cultural approach is frequently considered an obstacle or a justification for a project's failure rather than an important aspect of the people being developed. Therefore, the goal of this mini-review is to showcase the findings and explore the practical application of UNFCCC Key Finding 3, emphasising its importance in every phase of the solid waste management process for climate action. This mini-review argues that applying a cultural perspective presents both opportunities and challenges. More importantly, without careful acknowledgement and consideration, opportunities can become challenges, if not vice versa. The discussion section explores the ways in which religious and economic conditions might offer a contextual understanding and effective techniques for managing MSW at the local level. To apply Key Finding 3 in practice, academia needs to move away from generality and embrace multiple 'modernities', while practitioners also need to include cultural perspectives to complement scientific knowledge.

Mapping Sub-surface Distribution of Soil Organic Carbon Stocks in South Africa's Arid and Semi-Arid Landscapes: Implications for Land Management and Climate Change Mitigation.

Soil organic carbon (SOC) stocks are critical for land management strategies and climate change mitigation. However, understanding SOC distribution in South Africa's arid and semi-arid regions remains a challenge due to data limitations, and the complex spatial and sub-surface variability in SOC stocks driven by desertification and land degradation. Thus, to support soil and land-use management practices as well as advance climate change mitigation efforts, there is an urgent need to provide more precise SOC stock estimates within South Africa's arid and semi-arid regions. Hence, this study adopted remote-sensing approaches to determine the spatial sub-surface distribution of SOC stocks and the influence of environmental co-variates at four soil depths (i.e., 0-30 cm, 30-60 cm, 60-100 cm, and 100-200 cm). Using two regression-based algorithms, i.e., Extreme Gradient Boosting (XGBoost) and Random Forest (RF), the study found the former (RMSE values ranging from 7.12 t/ha to 29.55 t/ha) to be a superior predictor of SOC in comparison to the latter (RMSE values ranging from 7.36 t/ha to 31.10 t/ha). Nonetheless, both models achieved satisfactory accuracy (R2 ≥ 0.52) for regional-scale SOC predictions at the studied soil depths. Thereafter, using a variable importance analysis, the study demonstrated the influence of climatic variables like rainfall and temperature on SOC stocks at different depths. Furthermore, the study revealed significant spatial variability in SOC stocks, and an increase in SOC stocks with soil depth. Overall, these findings enhance the understanding of SOC dynamics in South Africa's arid and semi-arid landscapes and emphasizes the importance of considering site specific topo-climatic characteristics for sustainable land management and climate change mitigation. Furthermore, the study offers valuable insights into sub-surface SOC distribution, crucial for informing carbon sequestration strategies, guiding land management practices, and informing environmental policies within arid and semi-arid environments.

Views of Psychiatrists and Psychiatry Trainees on Climate Change: Distress, Training Needs, and Envisioned Role.

OBJECTIVE: Increasing evidence demonstrates that climate change has effects on mental health. Given the magnitude of climate change's health consequences, mitigation and adaptation will require massive societal changes and the involvement of individuals and professional organizations. The aim of this research was to assess the views of psychiatrists and psychiatrists-in-training about climate change and its effects on health, perceived barriers to discussing climate change in their clinical, teaching, research, and advocacy work, personal preparedness for climate action, and expected roles of their professional organizations. METHODS: The authors administered an online anonymous survey to members of two mid-Atlantic professional psychiatric organizations. Measures included an adaptation of The International Climate and Health Survey and demographic and career characteristics. Descriptive statistics for categorical variables were conducted. RESULTS: The majority of the 67 participants who completed the survey were White and senior in their career, and almost all were clinicians. Most were concerned about climate change and its mental health effects on patients and supported their organizations' engagement in activities related to this topic. Barriers to engagement in climate change action included lack of time and believing it would not make a difference. CONCLUSIONS: These findings demonstrate a desire of psychiatrists involved in teaching, research, and clinical work to address climate change and a need for training. These findings highlight the need for preparedness as newer generations face more disasters related to climate change, and experience psychological distress related to climate change.

Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022.

BACKGROUND: Dogs are exposed to increasing environmental risk for developing heat-related illness (HRI), with 2022 recorded as the hottest year to date in the UK and most of Europe. METHODS: This study used VetCompass data to report the incidence risk, event fatality rate and canine risk factors for HRI in dogs presenting to Vets Now emergency care practices in the UK during 2022. RESULTS: From the clinical records of 167,751 dogs under care at Vets Now emergency clinics in 2022, 384 HRI events were identified. The 2022 incidence risk of HRI within the Vets Now caseload was 0.23% (95% confidence interval [CI]: 0.21%‒0.25%), with an event fatality rate of 26.56% (95% CI: 21.66%-32.25%). Multivariable analysis identified breed, age and sex/neuter status as risk factors for HRI. Brachycephalic dogs had 4.21 times the odds of HRI compared to mesocephalic dogs (95% CI: 3.22‒5.49, p < 0.001). LIMITATIONS: The clinical data used in this study were not primarily recorded for research and had some substantial levels of missing data (especially patient bodyweight). CONCLUSION: In order to protect canine welfare, improved long-term mitigation strategies are urgently needed to minimise HRI risk and associated fatality in UK dogs.

The untapped health and climate potential of cycling in France: a national assessment from individual travel data.

Background: Promoting active modes of transportation such as cycling may generate important public health, economic, and climate mitigation benefits. We aim to assess the mortality and morbidity impacts of cycling in a country with relatively low levels of cycling, France, along with associated monetary benefits. We further assess the potential additional benefits of shifting a portion of short trips from cars to bikes, including projected greenhouse gas emissions savings. Methods: Using individual data from a nationally representative mobility survey, we described the French 2019 cycling levels by age and sex. We conducted a burden of disease analysis to assess the incidence of five chronic diseases (breast cancer, colon cancer, cardiovascular diseases, dementia, and type-2 diabetes) and the number of deaths prevented by cycling, based on national incidence and mortality data and dose-response relationships from meta-analyses. We assessed the corresponding direct medical cost savings and the intangible costs prevented based on the value of a statistical life year. Lastly, based on individual simulations, we assessed the likely additional benefits of shifting 25% of short (<5 km) car trips to cycling. Findings: The French adult (20-89 years) population was estimated to cycle on average 1 min 17 sec pers-1 day-1 in 2019, with important heterogeneity across sex and age. This yielded benefits of 1,919 (uncertainty interval, UI: 1,101-2,736) premature deaths and 5,963 (UI: 3,178-8,749) chronic disease cases prevented, with males reaping nearly 75% of these benefits. Direct medical costs prevented were estimated at €191 million (UI: 98-285) annually, while the corresponding intangible costs were nearly 25 times higher (€4.8 billion, UI: 3.0-6.5). We estimated that on average, €1.02 (UI: 0.59-1.62) of intangible costs were prevented for every km cycled. Shifting 25% of short car trips to cycling would yield approximatively a 2-fold increase in deaths prevented, while also generating important CO2 emissions reductions (0.257 MtCO2e, UI: 0.231-0.288). Interpretation: In a country with a low- to moderate-cycling culture, cycling already generates important public health and health-related economic benefits. Further development of active transportation would increase these benefits while also contributing to climate change mitigation targets. Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Data Scaling: Implications for Climate Action and Governance in the UK.

Local actors have growing prominence in climate governance but key capacities and powers remain with national policymakers. Coordination between national and local climate action is therefore of increasing importance. Underappreciated in existing academic and policy literature, coordination between actors at different scales can be affected not only by politics and institutional arrangements, but also by methods of data analysis. Exploring two datasets of GHG emissions by local area in England-one of consumption-based emissions and the other of territorial emissions-this paper shows the potential for a data scaling problem known as the modifiable areal unit problem and its possible consequences for the efficacy and equity implications of climate action. While this analysis is conceptual and does not identify specific instances of the modifiable areal unit problem or its consequences, it calls attention to methods of data analysis as possible contributors to climate governance challenges. Among other areas, future analysis is needed to explore how data scaling and other aspects of data processing and analysis may affect our understanding of non-state actors' contribution to climate action.