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OBJECTIVE: To investigate the distribution of irregular blood group antibodies in patients with malignant tumors, and to analyze the relationship between it and efficacy of blood transfusion in patients. METHODS: 5 600 patients with malignant tumors treated in Shanxi Bethune Hospital from January 2019 to December 2021 were selected as the research subjects. All patients received blood transfusion, and cross matching test was conducted before blood transfusion, irregular antibody results of patients were tested; the irregular distribution of blood group antibodies was observed, and the relationship between it and efficacy of blood transfusion in patients was analyzed. RESULTS: Among 5 600 patients with malignant tumors, 96 cases were positive for irregular antibody, and the positive rate was 1.71%; the main blood group systems involved in the irregular antibody positive of 96 patients with malignant tumors were RH, MNSs and Duffy system, among which Rh blood group was the most common, and the proportion of anti-E was the highest; among the malignant tumor patients with positive blood group irregular antibody, the proportion of female was higher than that of male; the proportion of patients aged >60 years was the highest, followed by patients aged >40 and ≤50 years, and the proportion of patients aged 18-30 years was the lowest; the patients with positive blood group irregular antibody were mainly in blood system (including lymphoma), digestive system, reproductive and urinary system; the positive rate of irregular antibody of patients in the ineffective group was higher than that of patients in the effective group, the difference was statistically significant (P<0.05). Logistic regression analysis results showed that, irregular antibody positive was a risk factor for ineffective blood transfusion in patients with malignant tumor (OR>1, P<0.05). CONCLUSION: The irregular blood group antibody positive of patients with malignant tumor are mostly female, and the proportion of patients aged >60 is the highest, which is mainly distributed in malignant tumors of blood system, digestive system and urogenital system, and the positive blood group irregular antibody is related to the efficacy of blood transfusion in patients.
Subject(s)
Blood Group Antigens , Neoplasms , Humans , Male , Female , Blood Transfusion , Rh-Hr Blood-Group System , Antibodies , Neoplasms/therapy , IsoantibodiesABSTRACT
OBJECTIVE@#To investigate the distribution of irregular blood group antibodies in patients with malignant tumors, and to analyze the relationship between it and efficacy of blood transfusion in patients.@*METHODS@#5 600 patients with malignant tumors treated in Shanxi Bethune Hospital from January 2019 to December 2021 were selected as the research subjects. All patients received blood transfusion, and cross matching test was conducted before blood transfusion, irregular antibody results of patients were tested; the irregular distribution of blood group antibodies was observed, and the relationship between it and efficacy of blood transfusion in patients was analyzed.@*RESULTS@#Among 5 600 patients with malignant tumors, 96 cases were positive for irregular antibody, and the positive rate was 1.71%; the main blood group systems involved in the irregular antibody positive of 96 patients with malignant tumors were RH, MNSs and Duffy system, among which Rh blood group was the most common, and the proportion of anti-E was the highest; among the malignant tumor patients with positive blood group irregular antibody, the proportion of female was higher than that of male; the proportion of patients aged >60 years was the highest, followed by patients aged >40 and ≤50 years, and the proportion of patients aged 18-30 years was the lowest; the patients with positive blood group irregular antibody were mainly in blood system (including lymphoma), digestive system, reproductive and urinary system; the positive rate of irregular antibody of patients in the ineffective group was higher than that of patients in the effective group, the difference was statistically significant (P<0.05). Logistic regression analysis results showed that, irregular antibody positive was a risk factor for ineffective blood transfusion in patients with malignant tumor (OR>1, P<0.05).@*CONCLUSION@#The irregular blood group antibody positive of patients with malignant tumor are mostly female, and the proportion of patients aged >60 is the highest, which is mainly distributed in malignant tumors of blood system, digestive system and urogenital system, and the positive blood group irregular antibody is related to the efficacy of blood transfusion in patients.
Subject(s)
Humans , Male , Female , Blood Transfusion , Blood Group Antigens , Rh-Hr Blood-Group System , Antibodies , Neoplasms/therapy , IsoantibodiesABSTRACT
Objective To study effect of high titer cold lectin on positive and negative typing of ABO blood group and electron cross matching test .Methods A total of 500 patients needed emergency blood transfusion were selected from November 2015 to October 2016 in People′s Hospital of Qinbei District .To observe the results of electron crossover and serum cross primary and sec-ondary matching ,ABO blood group positive and negative and electronic cross matching experimental results at different tempera-tures ,cold agglutinin test erythrocyte agglutination and cross matching results .Results There was no significant difference on the main side between the electronic cross matching and serological cross matching (P>0 .05) ,but the difference was significant on sec-ondary side(P<0 .05) .In electron cross test ,18 cases appeared agglutination at 20 ℃ ,which was obviously more than that at 37 ℃(P<0 .05) .Patients blood in the positive stereotypes A type ,anti stereotypes B type ,O type all appeared agglutination ,and at 20 ℃O type and self control also appeared agglutination .Cold agglutinin test results showed that when the temperature was lower than 31 ℃ ,red cell agglutination occurred ,when the temperature was lower than 4 ℃ ,visible agglutination ,but when the temperature rose to 37 ℃ ,agglutination disappeared .Conclusion High titer cold lectin could promote the aggregation of red blood cell at low temperature conditions ,and effect the results of ABO blood group positive and negative and electronic cross matching test ,then effect transfusion therapy .
ABSTRACT
Objective To study effect of high titer cold lectin on positive and negative typing of ABO blood group and electron cross matching test .Methods A total of 500 patients needed emergency blood transfusion were selected from November 2015 to October 2016 in People′s Hospital of Qinbei District .To observe the results of electron crossover and serum cross primary and sec-ondary matching ,ABO blood group positive and negative and electronic cross matching experimental results at different tempera-tures ,cold agglutinin test erythrocyte agglutination and cross matching results .Results There was no significant difference on the main side between the electronic cross matching and serological cross matching (P>0 .05) ,but the difference was significant on sec-ondary side(P<0 .05) .In electron cross test ,18 cases appeared agglutination at 20 ℃ ,which was obviously more than that at 37 ℃(P<0 .05) .Patients blood in the positive stereotypes A type ,anti stereotypes B type ,O type all appeared agglutination ,and at 20 ℃O type and self control also appeared agglutination .Cold agglutinin test results showed that when the temperature was lower than 31 ℃ ,red cell agglutination occurred ,when the temperature was lower than 4 ℃ ,visible agglutination ,but when the temperature rose to 37 ℃ ,agglutination disappeared .Conclusion High titer cold lectin could promote the aggregation of red blood cell at low temperature conditions ,and effect the results of ABO blood group positive and negative and electronic cross matching test ,then effect transfusion therapy .
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Objective To evaluate the application of Erytra automatic blood analyzer (Erytra) on blood grouping and cross matc‐hing .Methods 9 860 cases of EDTA‐K2 anticoagulant specimens for blood grouping test and 5 099 cases of EDTA‐K2 anticoagu‐lant specimens for cross matching were both detected by Erytra and manual tube method .Results There was no significant differ‐ence in the accuracy of blood grouping detected by Erytra and manual tube method (P>0 .05) .Both of the positive rate and the false positive rate of cross matching detected by Erytra were higher than those detected by manual tube method .Conclusion Erytra automatic blood analyzer can be applied for the detection of blood grouping and cross matching ,and its performance can meet the needs of blood safety in clinic .
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Objective To analyze the coincidence situation of the results of neonatal ABO blood group reciprocal stereotypy with crossmatching test of allotype blood and to investigating the limitations of cross-matching test in infant blood transfusion and effec-tive measures for ensuring the neonatal safe blood transfusion.Methods The micro-column gel test was adopted to identify the ABO blood group and conduct the crosshatching test of allotype blood in 1 095 cases of neonatal blood samples.Results Among the 1 095 samples,the detected rates of weak A and weak B antigen were 3.99% and 17.93% respectively,and the weak B antigen was predominant.The negative rates of anti-A and anti-B antibody were 53.72% and 60.70% respectively;in the cross-matching test with allotype blood,the main side without appearing agglutination accounted for 52.87% and weak agglutination accounted for 33.27%,and the secondary side appearing weak agglutination accounted for 9.49%.Conclusion The maturity of antibody and an-tigen and the coincidence rates of group typing and reciprocal stereotypy in the newborns are less than those in the adults;so blood transfusion according to the cross-matching test results has certain limitation;high attention should be paid to the accuracy of neo-natal ABO blood type,the individual blood transfusion strategy in the newborn should be determined in order to avoid hemolytic blood transfusion reaction caused by ABO allotype blood transfusion and ensure the blood transfusion safety in newborns.
