ABSTRACT
INTRODUCTION AND OBJECTIVES: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the skin with a negative impact on quality of life. Up to now, there are no disease specific instruments in Spanish to assess quality of life in HS. The objective of this study was to develop and validate a questionnaire to evaluate the quality of life in patients with HS. MATERIAL AND METHODS: A multicentre study was carried out in Spain between 2016 and 2017 to develop the questionnaire. Both the conceptual framework and understanding of the patient's situation were considered through a review of the literature, consensus of professionals from different related health areas, and in-depth interviews with patients. The resulting questionnaire was passed to a group of 30 patients with 30±10 days of interval between both assessments. RESULTS: The reliability analysis shows a good internal consistency and reproducibility with Cronbach's alpha score of 0.920 (test) and 0.917 (retest) and intraclass correlation coefficient with DLQI and Skindex-29 of 0.698 IC 95% (0.456-0.844) and 0.900 IC 95% (0.801-0.951) respectively. Cut-off points were established for its use and the instrument was found to be sensitive to change. CONCLUSIONS: The HSQoL-24 is the first disease-specific self-administered instrument to assess quality of life in patients with HS in Spanish. It is user friendly, and easy to score. This study shows that the instrument is reliable, valid and sensitive to change, pending confirmatory study with a larger sample of 100 patients with HS.
Subject(s)
Hidradenitis Suppurativa , Quality of Life , Surveys and Questionnaires , Adult , Female , Humans , Male , Middle Aged , Psychometrics , Reproducibility of Results , Young AdultABSTRACT
Objetivo: Determinar si el cuestionario Impacto del peso en la calidad de vida (IWQOL) es reproducible y sensible para identificar diferencias entre las clases de obesidad establecidas por la Organización Mundial de la Salud. Métodos: El IWQOL fue traducido al castellano de acuerdo a la usanza del lenguaje en México pero manteniendo un vocabulario amplio para América Latina. Investigamos la reproducibilidad del cuestionario por el método de prueba-reprueba (n=82, IMC=37.8±8.4), la sensibilidad para identificar diferencias entre los grados de la obesidad (n=105, IMC=35.1±9.5) y la sensibilidad para detectar diferencias después de recibir algún tratamiento para la pérdida del peso (n=40, IMC=39.2±7). Resultados: El IWQOL mostró buena reproducibilidad y sensibilidad para identificar diferencias entre grupos de obesos y cambios luego de tratamiento. Todos los dominios fueron reproducibles (criterio a priori: la diferencia entre prueba re-prueba no debía ser mayor de 5 puntos porcentuales) y tuvieron alta validez interna (coeficiente alfa de Cronbach>0.92 para todos los dominios). El IWQOL detectó diferencias entre los grupos divididos por la severidad de la obesidad, siendo los más afectados aquellos con IMC>45. Los sujetos sometidos a tratamiento perdieron 6.4 kg (IC95%=4.6-8.2) durante un periodo de 2.70±1 meses e incrementaron la calificación en todos los dominios, excepto el correspondiente a trabajo. Conclusiones: El cuestionario IWQOL es una herramienta confiable y sensible que se puede utilizar para la investigación de la calidad de vida en mexicanos y probablemente en la mayoría de las poblaciones latinoamericanas. Nuestro estudio es el primero envalidar el IWQOL en México.
OBJECTIVE: Determine if the Spanish version of the IWQOL (Impact of Weight on Quality of Life) questionnaire is reproducible and sensitive to detect differences among WHO's classification of obesity. METHODS: The IWQOL was translated into Spanish and adapted to the Mexican context while maintaining a wide comprehensive vocabulary applicable to Latin American countries. We measured reproducibility using a test-retest method (n=82, BMI 37.8+/-8.4), sensitivity to detect differences between types of obesity (n=105, BMI 35.1+/-9.5), and sensitivity to detect differences after treatment for weight loss within groups (n=40, BMI 39.2+/-7). RESULTS: The IWQOL questionnaire was reliable and sensitive enough to detect differences among and within groups. All domains were highly reproducible (scores differed by less than 2 points) and had high internal validity (Cronbach alpha coefficient >0.92 for all scales). The IWQOL detected differences between groups stratfied by severity of obesity, the lowest score was for BMI >45. Subjects who underwent weight loss treatment and lost 6.4 kg (95% CI 4.6, 8.2) during a period of 2.70+/-1 month had an improvement in all scales except for the [quot ]Work[quot ] domain. CONCLUSIONS: The IWQOL questionnaire is a reliable and sensitive tool that can be used for research purposes in Mexico and the Latin America region. Our study validates the use of IWQOL among Mexican subjects.
