ABSTRACT
Diabetic kidney disease is one of the complications of diabetes mellitus, which can eventually progress to end-stage kidney disease. The increasing prevalence of diabetic kidney disease has brought huge economic burden to society and seriously jeopardized public health. Ferroptosis is an iron-dependent, non-apoptosis-regulated form of cell death. The regulation of ferroptosis involves different molecular mechanisms and multiple cellular metabolic pathways. In recent years, ferroptosis has been proved to be closely related to the occurrence and development of diabetic kidney disease, and can interact with pathological changes such as fibrosis, inflammation, oxidative stress, and disorders of glucose and lipid metabolism, destroying the structure, form and function of the inherent cells of the kidney, and promoting the progression of the disease. Traditional Chinese medicine has a long history of treating diabetic kidney disease with remarkable curative effect. Current scholars have shown that the oral administration of traditional Chinese medicine and the external treatment of Chinese medicine can regulate GPX4, Nrf2, ACSL4, PTGS2, TFR1 and other key signaling molecules, curb ferroptosis, and prevent the progressive deterioration of diabetic kidney disease. In this paper, the mechanism of ferroptosis and diabetic kidney disease and the prevention and treatment of traditional Chinese medicine are analyzed and summarized, in order to provide new ideas and new plans for the treatment of diabetic kidney disease.
Subject(s)
Diabetes Mellitus , Diabetic Nephropathies , Ferroptosis , Humans , Diabetic Nephropathies/drug therapy , Diabetic Nephropathies/prevention & control , Medicine, Chinese Traditional , Kidney , Administration, OralABSTRACT
ObjectiveTo observe the clinical efficacy of compound Huangbai liquid fomentation on diabetic foot ulcer of Wagner grade 1-2. MethodPatients were classified into the observation group and control group， with 41 cases in either group. The observation group received routine therapy and compound Huangbai liquid fomentation， while the control group was treated by routine therapy and medical silver nanoparticles-containing dressing. Ulcer area， ulcer depth， traditional Chinese medicine （TCM） syndrome score， ankle-brachial index， transcutaneous oxygen pressure， vascular endothelial growth factor， epidermal growth factor， advanced glycation end product， high-sensitivity C-reactive protein， interleukin-6， erythrocyte sedimentation rate， and adverse events were observed before and after treatment in two groups. ResultAfter treatment， the ulcer area， ulcer depth， TCM syndrome score， vascular endothelial growth factor， epidermal growth factor， advanced glycation end product， high-sensitivity C-reactive protein， interleukin-6（IL-6）， and erythrocyte sedimentation rate were lower than those before treatment in two groups （P<0.05）， and ankle-brachial index， transcutaneous oxygen pressure， vascular endothelial growth factor， and epidermal growth factor were higher than those before treatment in two groups （P<0.05）. After treatment， the ulcer area， ulcer depth， TCM syndrome score， advanced glycation end product， high-sensitivity C-reactive protein， IL-6， and erythrocyte sedimentation rate were lower in the observation group than in the control group （P<0.05）， and ankle-brachial index， transcutaneous oxygen pressure， vascular endothelial growth factor， and epidermal growth factor were higher in the observation group than in the control group （P<0.05）. The clinical efficacy of observation group was better than that of the control group （P<0.05）. There was no significant difference in the incidence of adverse events and endpoint events between two groups. ConclusionCompound Huangbai liquid fomentation is effective for diabetic foot ulcer of Wagner grade 1-2， as it is beneficial to the healing of the ulcer. This study provides clinical evidence for the further promotion of Chinese medicine fomentation.
ABSTRACT
Objective: To observe the effect of Sanshencao essential oil on the model of thromboangiitis obliterans in rats. Method: Male Wistar rats were randomly divided into five groups according to body weight:sham operation group, model group, Tongsaimai group (1.05 g·kg-1), large and small-dose Sanshencao essential oil groups (0.125 mL·cm-2, twice a day, 0.125 mL·cm-2, once a day), with 10 in each group. The model of occlusive vasculitis was established by injecting sodium laurate solution (10 g·L-1) into the left lower limb artery of rats. Sham operation group was injected with the same amount of normal saline at the same position. Large and small doses of Sanshencao essential oil were applied directly to the affected area, and the remaining groups were given corresponding drugs or pure water for 10 days. One hour after the last administration, the pathological changes were graded; the levels of thromboxane B2(TXB2), interleukin-1 (IL-1), 6-oxo-prostaglandinF1α (6-K-PGF1α), endothelin (ET) were measured by radioimmunoassay. Hematoxylin-eosin(HE) staining was used to observe the pathological changes of the femoral arteries in the left lower limbs. Result: Compared with sham operation group, the degree, extent, inflammation and thrombosis of the affected limbs in model group increased significantly (PPPP2, ET and IL-1 in serum (PP1α (PPConclusion: Sanshencao essential oil has a good therapeutic effect on thrombosis angiitis obliterans model in rats, which related to its anti-oxidation and alleviating inflammation of vascular wall.
ABSTRACT
With the rapid rise of modern drug-derived diseases, the external treatment has received extensive attention at home and abroad, due to its small adverse reactions, convenient application and accurate efficacy.At present, although there are many clinical applications of Chinese medicine external treatment, there are few unified norms and strong arbitrariness in related external treatment techniques, for example, external methods, dosage forms, means, dosage, time, etc.As a result, the development of Chinese medicine external treatment is slow and chaotic, and it can not serve the clinic well.It also hinders the development and expansion of external treatment techniques.This paper discusses the current status of external treatment techniques, and clarifies the development trend of Chinese medicine external treatment, in order to pointing out the direction for the development of Chinese medicine external treatment, it will promote the standardization of Chinese medicine external treatment techniques, and it will be better servicing the clinical practice.
