ABSTRACT
The use of cosmetic fillers agents in orofacial region has become more often used for esthetic concern. Although adverse effects are rare, some patients may develop foreign body reaction to such fillers. Hyaluronic acid (HA) is a biomaterial in the spotlight, because it is normally present in several tissues of human body. The aim of this study was to report a case of a 54-year-old white woman with granulomatous reaction to the HA located in the lips. In addition, a review of the English-language literature of all previously described cases of this condition in oral and perioral region was performed. The location, clinical features, symptoms, time between injection and reaction, type of treatment and treatment outcome of 17 cases were summarized. The clinical and histopathological examination along with a detailed history about this condition is very important to management of patients with nodular lesions in maxillofacial region.
Subject(s)
Dermal Fillers/adverse effects , Granuloma, Foreign-Body/chemically induced , Granuloma, Foreign-Body/diagnosis , Hyaluronic Acid/adverse effects , Lip , Cosmetic Techniques/adverse effects , Female , Granuloma, Foreign-Body/pathology , Humans , Middle AgedABSTRACT
Granulomatous reactions to tattoo ink are most commonly associated with mercury sulfide, a component of red pigments. Treatment options show limited results. Allopurinol, an inhibitor of xanthine oxidase, has been reported as a successful alternative treatment to granulomatous disorders, such as sarcoidosis and granulomatous reactions to fillers and tattoos. We report a case of granulomatous reaction to red tattoo pigment treated with allopurinol for 6 months. Good clinical improvement could be noticed during this time. Two months after we stopped the treatment, the lesion recurred. Allopurinol emerges as an important drug for the management of granulomatous reactions caused by tattoo pigments. Based on the significant clinical improvement noticed during its use, we recommend new studies to elucidate all the potential benefits of the use of allopurinol for the treatment of granulomatous reactions to tattoo ink.
Subject(s)
Allopurinol/therapeutic use , Coloring Agents/adverse effects , Enzyme Inhibitors/therapeutic use , Granuloma/chemically induced , Granuloma/drug therapy , Tattooing/adverse effects , Xanthine Oxidase/antagonists & inhibitors , Edema/chemically induced , Female , Humans , Recurrence , Young AdultABSTRACT
Presentamos el caso de un niño con numerosas placas tumorales discrómicas bien definidas, algunas atróficas, otras levantadas, cubiertas por formaciones escamo-costrosas, indoloras, localizadas en extremidad inferior derecha, de curso lentamente progresivo. No se encuentran otros hallazgos clínicos acompañantes de importancia. El diagnóstico de certeza se efectúo mediante estudio de imagen e histopatológico; el tratamiento consistió en extirpación quirúrgica a intervalos irregulares.
An eleven-year old child with multiple depressed and raised skin pigmented tumors and plaques, with adherent desquamation and crusts on their skin suface was located in his right lower extremity. There are not any other clinical manifestation of interest. Diagnostic approach was based on radiological and pathology examinations. Surgical treatment was the suitable option.
ABSTRACT
Presentamos el caso de un niño con numerosas placas tumorales discrómicas bien definidas, algunas atróficas, otras levantadas, cubiertas por formaciones escamo-costrosas, indoloras, localizadas en extremidad inferior derecha, de curso lentamente progresivo. No se encuentran otros hallazgos clínicos acompañantes de importancia. El diagnóstico de certeza se efectúo mediante estudio de imagen e histopatológico; el tratamiento consistió en extirpación quirúrgica a intervalos irregulares.(AU)
An eleven-year old child with multiple depressed and raised skin pigmented tumors and plaques, with adherent desquamation and crusts on their skin suface was located in his right lower extremity. There are not any other clinical manifestation of interest. Diagnostic approach was based on radiological and pathology examinations. Surgical treatment was the suitable option.(AU)