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BACKGROUND: NSCLC is a malignant tumor with a high incidence. Ferroptosis presents an essential function in regulating carcinogenesis and tumor progression. However, the ferroptosis-associated prognostic model based on single-cell sequencing of NSCLC remains unexplored. Our study aims to establish a potential predictive model for NSCLC patients and provide available targeted drugs for clinical treatment. METHODS: The data on NSCLC patients were collected from TCGA and GEO databases to analyze their gene expression profiles. ConsensusCluster was adopted to divide the patients into different groups based on ferroptosis-related genes. Then, the univariable Cox and LASSO analyses were applied to data analysis and model establishment. Single-cell analysis was used to explore the risk score genes in different cell populations and states. The protein levels of these genes were also investigated through the HPA database. Drug sensitivity was evaluated in CellMiner database. CCK8 and colony formation assays were performed to validate potential drugs' effects on lung cancer cell lines. RESULTS: A ferroptosis-related prognostic model involving 14 genes in NSCLC patients was established. The risk score model was developed in training set GSE31210 and validated in the test set TCGA. The low-risk score group showed a better prognosis than the high-risk score group. The single-cell analysis revealed that the risk score genes were mainly derived from lung tumor cells. Most risk score genes were more highly expressed in tumor tissue than in normal tissue, according to the HPA database. Besides, these genes were associated with 106 drugs in CellMiner database. Finally, the drug effects on NSCLC cell growth were evaluated by cck8 and colony formation. CONCLUSIONS: We identified an effective ferroptosis-related prognostic model based on single-cell sequencing. The potential prediction model is devoted to exploring clinical therapeutic targets for NSCLC.
Subject(s)
Carcinoma, Non-Small-Cell Lung , Ferroptosis , Lung Neoplasms , Humans , Carcinoma, Non-Small-Cell Lung/drug therapy , Carcinoma, Non-Small-Cell Lung/genetics , Lung Neoplasms/drug therapy , Lung Neoplasms/genetics , Ferroptosis/genetics , Biomarkers , Prognosis , Biomarkers, Tumor/geneticsABSTRACT
OBJECTIVE: To illustrate the academic influence of Chinese Journal of Integrated Traditional and Western medicine, and provide suggestions for further development of the Journal. METHODS: Taking the China National Knowledge Infrastructure (CNKI) database as main source and the Chinese Science Citation Database (CSCD) as reference, the researchers retrieved the related data of the Journal such as its publication quantity, citations, fund projects, authors, institutions and regions from 1981 to 2018, analyzed these data by means of bibliometrics and information visualization with EXCEL, SPSS, VISIO, MATLAB and other softwares. RESULTS: Through the analysis of the main indicators, the relevant indicators of the Journal's academic influence revealed the developing trend of the Journal. Cardiovascular and cerebrovascular diseases, endocrine, digestive system, pharmacological research of Chinese medicine and gynecology, as the hot topics in the discipline and academic, were clarified. CONCLUSIONS: All indicators show that the Journal is a high-quality journal reflecting the excellent achievements in the field of integrated Chinese and Western medicine in China. Through further analysis of relevant indicators, the authors put forward some specific suggestions on how to run the Journal well.
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Bibliometrics , Medicine, East Asian Traditional , ChinaABSTRACT
OBJECTIVE@#To illustrate the academic influence of Chinese Journal of Integrated Traditional and Western medicine, and provide suggestions for further development of the Journal.@*METHODS@#Taking the China National Knowledge Infrastructure (CNKI) database as main source and the Chinese Science Citation Database (CSCD) as reference, the researchers retrieved the related data of the Journal such as its publication quantity, citations, fund projects, authors, institutions and regions from 1981 to 2018, analyzed these data by means of bibliometrics and information visualization with EXCEL, SPSS, VISIO, MATLAB and other softwares.@*RESULTS@#Through the analysis of the main indicators, the relevant indicators of the Journal's academic influence revealed the developing trend of the Journal. Cardiovascular and cerebrovascular diseases, endocrine, digestive system, pharmacological research of Chinese medicine and gynecology, as the hot topics in the discipline and academic, were clarified.@*CONCLUSIONS@#All indicators show that the Journal is a high-quality journal reflecting the excellent achievements in the field of integrated Chinese and Western medicine in China. Through further analysis of relevant indicators, the authors put forward some specific suggestions on how to run the Journal well.
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In 2006, the Hepatology Committee, Chinese Association of the Integration of Traditional and Western Medicine issued the "Guidelines for the Prevention and Treatment of Liver Fibrosis with Integrated Traditional Chinese and Western Medicine" . In recent years, in the field of modern medicine and integrated Chinese and Western medicine, the basic and clinical research into chronic liver disease has made rapid progress, and accumulated new evidence for the prevention and treatment of liver fibrosis. Therefore, in order to meet the clinical needs, experts of integrated traditional Chinese and Western medicine of liver diseases were united to revise the previous guidelines in order to help physicians make correct and reasonable decisions in the diagnosis and treatment of liver fibrosis.
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Liver Cirrhosis/diagnosis , Liver Cirrhosis/therapy , Medicine, Chinese Traditional , Humans , Practice Guidelines as TopicABSTRACT
In 2006, the Hepatology Committee, Chinese Association of the Integration of Traditional and Western Medicine issued the "Guidelines for the Prevention and Treatment of Liver Fibrosis with Integrated Traditional Chinese and Western Medicine" . In recent years, in the field of modern medicine and integrated Chinese and Western medicine, the basic and clinical research into chronic liver disease has made rapid progress, and accumulated new evidence for the prevention and treatment of liver fibrosis. Therefore, in order to meet the clinical needs, experts of integrated traditional Chinese and Western medicine of liver diseases were united to revise the previous guidelines in order to help physicians make correct and reasonable decisions in the diagnosis and treatment of liver fibrosis.
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In 2006, the Hepatology Committee, Chinese Association of the Integration of Traditional and Western Medicine issued the "Guidelines for the Prevention and Treatment of Liver Fibrosis with Integrated Traditional Chinese and Western Medicine" . In recent years, in the field of modern medicine and integrated Chinese and Western medicine, the basic and clinical research into chronic liver disease has made rapid progress, and accumulated new evidence for the prevention and treatment of liver fibrosis. Therefore, in order to meet the clinical needs, experts of integrated traditional Chinese and Western medicine of liver diseases were united to revise the previous guidelines in order to help physicians make correct and reasonable decisions in the diagnosis and treatment of liver fibrosis.
Subject(s)
Humans , Liver Cirrhosis , Diagnosis , Therapeutics , Medicine, Chinese Traditional , Practice Guidelines as TopicABSTRACT
In 2006, the Hepatology Committee, Chinese Association of the Integration of Traditional and Western Medicine issued the "Guidelines for the Prevention and Treatment of Liver Fibrosis with Integrated Traditional Chinese and Western Medicine" . In recent years, in the field of modern medicine and integrated Chinese and Western medicine, the basic and clinical research into chronic liver disease has made rapid progress, and accumulated new evidence for the prevention and treatment of liver fibrosis. Therefore, in order to meet the clinical needs, experts of integrated traditional Chinese and Western medicine of liver diseases were united to revise the previous guidelines in order to help physicians make correct and reasonable decisions in the diagnosis and treatment of liver fibrosis.
Subject(s)
Humans , Liver Cirrhosis/therapy , Medicine, Chinese Traditional , Practice Guidelines as TopicABSTRACT
OBJECTIVE:To observe the clinical efficacy and safety of Fuyankang combined with azithromycin in the treat-ment of pelvic inflammatory disease. METHODS:90 patients with pelvic inflammatory disease were selected and randomly divided into observation group and control group,with 45 cases in each group. Control group was given Lactose acid azithromycin for injec-tion 500 mg,ivgtt,qd,and then Azithromycin capsule 250 mg,po,qd;observation group was additionally given Fuyankang Tab-let 1.56 g,tid,on the basis of control group. A treatment course of 2 groups lasted for 7 d,and both received 3 courses of treat-ment. Clinical efficacies of 2 groups were observed as well as the level of CRP,IL-2 and life quality score before and after treat-ment,and the occurrence of ADR was compared between 2 groups. RESULTS:Total effective rate of observation group was 97.78%,which was significantly higher than that of control group (86.67%),with statistical significance (P<0.05). The level of CRP,IL-2 and life quality score of 2 groups were improved significantly after treatment,and the observation group was more better than the control group,with statistical significance (P<0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:Fuyankang combined with Azithromycin is effective for pelvic inflammatory disease,and can improve the quali-ty of life,reduce inflammation cytokines infiltration and the generation of inflammatory medium with good safety.
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OBJECTIVE:To investigate the clinical efficacy of integrated treatment of traditional Chinese medicine and west-ern medicine for subacute thyroiditis. METHODS:98 patients with subacute thyroiditis were randomly divided into control group and observation group by random number table with 49 patients in each group. Control group was given conventional oral treat-ment of prednisone tablets,and observation group was additionally treated with Chinese patent medicine(Shuanghuanglian oral so-lution+Antiviral oral solution+Tripterygium glycosides tablet)on the basis of control group. A treatment course lasted for 4 weeks, and both groups received 2 courses of treatment. Therapeutic efficacy,symptom and sign improvement time,total treatment course,recurrence rate and ADR were observed and compared between 2 groups. RESULTS:the total effective rate of observation group was 100%,significantly better than the control group 79.59%,and there were significant differences(P<0.01). The defer-vescence time,thyroid pain recovery time,thyroid swelling fadeaway and total treatment course of observation group was shorter than those of control group,with statistical significance(P<0.01). Following up 2 months after drug withdrawal,the recurrence rate of observation group was 6.12%,which was significantly lower than that of control group(22.45%),with statistical signifi-cance (P<0.05). Small number of ADR occurred in 2 groups. CONCLUSIONS:The integrated treatment of traditional Chinese medicine and western medicine for subacute thyroiditis can control the symptom rapidly,reduce the possibility of palindromia and reduce ADR.
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AIM: To study the clinical efficacy of traditional Chinese medicine (TCM) intervention "tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment" ("TTK") for treating liver failure due to chronic hepatitis B. METHODS: We designed the study as a randomized controlled clinical trial. Registration number of Chinese Clinical Trial Registry is ChiCTR-TRC-12002961. A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study. Participants were randomly assigned to the following three groups: (1) a modern medicine control group (MMC group, 36 patients); (2) a "tonifying qi and detoxification" ("TQD") group (72 patients); and (3) a "tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment" ("TTK") group (36 patients). Patients in the MMC group received general internal medicine treatment; patients in the "TQD" group were given a TCM formula "tonifying qi and detoxification" and general internal medicine treatment; patients in the "TTK" group were given a TCM formula of "TTK" and general internal medicine treatment. All participants were treated for 8 wk and then followed at 48 wk following their final treatment. The primary efficacy end point was the patient fatality rate in each group. Measurements of various virological and biochemical indicators served as secondary endpoints. The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups. RESULTS: At the 48-wk post-treatment time point, the patient fatality rates in the MMC, "TQD", and "TTK" groups were 51.61%, 35.38%, and 16.67%, respectively, and the differences between groups were statistically significant (P < 0.05). However, there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups (P > 0.05). Patients in the "TTK" group had significantly higher levels of serum total bilirubin compared to MMC subjects (339.40 µmol/L ± 270.09 µmol/L vs 176.13 µmol/L ± 185.70 µmol/L, P = 0.014). Serum albumin levels were significantly increased in both the "TQD" group and "TTK" group as compared with the MMC group (31.30 g/L ± 4.77 g/L, 30.72 g/L ± 2.89 g/L vs 28.57 g/L ± 4.56 g/L, P < 0.05). There were no significant differences in levels of alanine transaminase among the three groups (P > 0.05). Safety data showed that there was one case of stomachache in the "TQD" group and one case of gastrointestinal side effect in the "TTK" group. CONCLUSION: Treatment with "TTK" improved the survival rates of patients with liver failure due to chronic hepatitis B. Additionally, liver tissue was regenerated and liver function was restored.
Subject(s)
Drugs, Chinese Herbal/therapeutic use , Hepatitis B, Chronic/complications , Kidney/drug effects , Liver Failure/drug therapy , Liver Regeneration/drug effects , Liver/drug effects , Stem Cell Niche/drug effects , Stem Cells/drug effects , Adult , Cell Proliferation/drug effects , China , Female , Hepatitis B, Chronic/diagnosis , Hepatitis B, Chronic/mortality , Hepatitis B, Chronic/physiopathology , Humans , Kidney/physiopathology , Liver/physiopathology , Liver/virology , Liver Failure/diagnosis , Liver Failure/mortality , Liver Failure/physiopathology , Liver Failure/virology , Liver Function Tests , Male , Middle Aged , Time Factors , Treatment OutcomeABSTRACT
@#Objective To explore the effect of enhanced physical therapy with integrated traditional and western medicine on muscularweakness after selective posterior rhizotomy. Methods 44 children with muscular weakness after selective posterior rhizotomy were dividedinto the treatment group (n=28) and the control group (n=16). Exercise therapy, physical therapy, electroacupuncture and Chinese massagewere applied to the treatment group, while exercise therapy was applied to the control group only. The muscle strength of the leg of childrenwere compared right after the surgery and 2 weeks after the surgery. Results The muscle strength of the leg of children in treatment group recoveredbetter than the control group 2 weeks after the surgery (P<0.05), and it was almost at the same level with that before surgery (P<0.05). Conclusion The enhanced physical therapy with integrated traditional and western medicine method could rapidly recover the musclestrength of the leg of children after SPR.
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The authors stated post-operative adjuvant therapy, combined chemotherapy, and palliative treatment for colorectal cancer, trying to summarize progress of the treatment of colorectal cancer with integrated traditional Chinese and western medicine, researching the mechanism of action. The authors also presented their arguments.
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Objective To study the effects of treating cholecystotomy syndrome with LiDan decoction. Methods All patients were recruited into a control group and a treatment group, with 50 patients in each group. The treatment group was taken with LiDan decoction orally, and the control group was treated with conventional western medicines. Results The total effective rate of the treatment group and the control group was 92.0% and 80.0% respectively, showing significant difference. Conclusion It was effective to treat cholecystotomy syndrome With LiDan decoction.
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Objective To evaluate the curative effect of integrated traditional Chinese and western medicine in treating diabetic nephropathy. Methods 114 cases of type 2 diabetes were randomly separated into experiment group and control group. Members in the experiment group were treated by integrated traditional Chinese and western medicine and Members in the control group were treated with western medicine alone for 8 weeks' course separately. At the end of therapeutic courses, levels of 24 h total proteinuria, serum creatinine, blood-fasting sugar were evaluated. Results In the experiment group, 8 cases got outstanding effects(11.1%), 50 cases got improvement(69.4%), and 14 cases got no effect (19.4%), with a total effective rate of 80.6%. In the control group, 0 cases got significant effect, 24 cases got improvement(33.3%), and 48 cases got no effect(66.7%), with a total effective rate of 33.3%. There was significant difference in total effective rate between the two groups (P＜0.05), that the total effective rate of the experiment group was significantly higher than that of the control group. Conclusion Integrated traditional Chinese and western medicine therapy can be more effective in treating diabetic nephropathy.
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OBJECTIVE:To observe the therapeutic effect of Tanreqing injection in combination with Piperacillin sodium and Amikacin sulfate for hospital-acquired pneumonia.METHODS:104 cases of hospital-acquired pneumonia were enrolled and randomly assigned to receive Tanreqing Injection+Piperacillin Sodium+Amikacin Sulfate(treatment group,n=52) or Piperacillin Sodium+Amikacin sulfate(control group,n=52) for 7～10days.The clinical indexes including the total effective effect,cardinal symptoms,physical signs,and chest X-ray film in two groups after treatment were observed.RESULTS:The total effective rate in the treatment group was 86.54% as compared 67.31% in control group(P
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0.05).There was statistically significant difference between the groups with integrated traditional Chinese and Western medicine and the group with Western medicine alone(P
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[Objective]To observe the therapeutic effect of the combined external fixator and traditional Chinese medicine for senile femoral intertrochanteric fracture.[Method]There were sixty-eight cases for study .Thirty-five cases in treatment group were treated with external fixator in perculaneous transhepatic through Minimally Invasive Skill (MIK),together with oral medication of traditional Chinese medicine,while thirty-three cases in the control group only underwent external fixator.[Result]All of the cases had been followed up for an average period of three years and ten months,which arranged from one year and eight month to six years and nine months . The fracture healing time in the treated group was 12.4?2.5 weeks and that in the control group was 15.5?2.9 weeks,showing significant difference between them (P
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According to the causes and pathogenesis of lung cancer in traditional medicine,the principle of syndrome differentiation and treatment,the research achievements of modern medicine,we discuss the idea and method of syndrome differentiation and treatment of lung cancer by integrated traditional and western medicine.We believe the treatment of lung cancer can be taken from several aspects:strengthening body essence and eliminating pathogen;individualized treatment according to the principle of syndrome differentiation and treatment;combining differential symptoms and diagnosis of diseases according to achievements of lung cancer treatment in traditional medicine;choosing suitable treatment by integrated traditional and western medicine considering the different stage of lung cancer.
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Objective To probe the significance of treatment with Integrated traditional And westem medicaine for migraine.Methods 54 cases of migraine that were treated by Nimodipine Tablets and Tea of rhizoma ligustici wallichi were taken as a treatement group.Their therapeutic evaluation was based on the headache indcx and headache period(numbers of day)within 4 weeks before and after treatment.Results In treatment group,marked,slight and no improvement of clinincal symptom were achieved in 30,12and3 patients respectively.The total cffective rate was 94.4%,Vomitiong and nausea wasn't observed in all cases.In 11,7and9 cases respectively.Vomiting and nausea was observed in 7cases,dizziness and palpitation in 9 cases,blood pressure reductio in 12 cases,the total effective rate was 66.7%.The differene in therapeatic effect between two groups was statistically singnificant(P
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Objective: To observe the effect of representative formula of nourishing yin and invigorating the kidney(Liuweidihuang Granula) cooperating with Flixotide aerosol inhalation on the allergic airway inflammation of asthma rat models.Methods: Wistar rats were randomly divided into six groups.Except the norma1 control group,all the other 5 groups were sensitized by injecting into the abdominal cavity of the ovalbumin(OVA) together with aluminum hydroxide as adjuvants,2 weeks later followed by aerosolized OVA challenge to prepare the asthma models.From the eighth day of the experiment,in medication administration teams, rats were sprayed with Flixotide aerosol and given intragastric administration with Liuweidihuang Granula.The normal control group and the asthma model group were drenched with normal saline.Results: There was no difference between the groups given Liuweidihuang Granula and different dosages of Flixotide aerosol but the amount of IFN-? and IFN-?/IL-4 in BALF in the Liuweidihuang Granula cooperating with Flixotide aerosol group were higher than that in the model group(P
