Consistent exercise timing as a strategy to increase physical activity: A feasibility study.

Introduction/Purpose: Observational research suggests that consistent exercise timing could be leveraged to promote moderate-to-vigorous physical activity (MVPA) among adults with obesity. However, the feasibility and acceptability of prescribed consistent exercise timing in a free-living setting is unknown. The purpose of this study was to assess the feasibility and acceptability of prescribed consistent exercise timing in a free-living setting among inactive adults with obesity (primary) and to compare MVPA timing prescriptions and characterize exercise barriers/facilitators (secondary). Methods: Using a within-subjects design, inactive adults with obesity (n=15) were randomized in counterbalanced order to three 3-wk exercise timing conditions separated by 2-wk washout periods: 1) consistent morning, 2) consistent evening, and 3) choice timing (control). Feasibility was assessed using prespecified benchmarks. Acceptability and preferred timing were assessed with questionnaires post-intervention. Secondarily, exercise timing and MVPA were assessed via accelerometry and nightly surveys and barriers/facilitators were assessed with nightly surveys. Results: All feasibility benchmarks were achieved (e.g., timing adherence = 69.9% via accelerometry and 87.4% via self-report (target: ≥60%)). Consistent exercise timing was acceptable (mean rating = 3.7 of 5 (target: ≥3.5)). Choice was the most popular prescription. There were medium- to large-sized effects (partial η2 of 0.09-0.16) of condition on MVPA; MVPA was higher during the morning and evening conditions versus choice condition. Facilitators were similar across conditions, while some barriers were time specific. Conclusion: Prescribed exercise timing in a free-living setting appears feasible and acceptable. While choice timing was most preferred, consistent timing appeared most effective for increasing MVPA. Data warrant larger trials to test the efficacy and mechanisms of consistent exercise timing as a translational strategy for promoting MVPA. Pending findings from a fully powered randomized trial, practitioners interested in promoting MVPA among their patients or clients could consider encouraging exercise at a consistent time day-to-day.

Influencia de la musicoterapia en el paciente durante la atención estomatológica

Ser atendido por el estomatólogo es una de las situaciones que genera más miedo y ansiedad en las personas. Se sugiere que la musicoterapia contribuye a reducir estos síntomas. Teniendo en cuenta que muchos pacientes presentan ansiedad y miedo al ser atendidos en el sillón dental y que necesitan un ambiente más agradable, constituye el motivo que condujo a la realización de este trabajo haciendo uso de la musicoterapia con el objetivo de evaluar su influencia en el paciente durante la atención. Se realizó un estudio de intervención, desde marzo a junio del 2022 en el Servicio Estomatológico, Policlínico Tula Aguilera. La muestra, 40 pacientes, fue seleccionada al azar, independientemente de sentir temor o no al tratamiento estomatológico. Las sesiones se dividieron: primera visita (sin música) y segunda visita (con música). Los datos se recogieron en encuesta. Los niveles de miedo disminuyeron con la aplicación de la terapia, por lo cual se constató que la musicoterapia tiene una notable influencia en los pacientes al desaparecer y disminuir el miedo o sensaciones desagradables durante la atención estomatológica. Todos los pacientes manifestaron satisfacción con el uso de la música, durante el servicio.

To be assisted by the odontologist is one of the situations that generates more fear and anxiety in people. It is suggested that the musical-therapy contributes to reduce these symptoms. Keeping in mind that many patients present anxiety and fear when being assisted in the dental armchair and that they need a more pleasant atmosphere, it constitutes the reason that led to the realization of this work making use of the musical-therapy with the objective of evaluating their influence in the patient during the attention. He was carried out an intervention study, from March to June of the 2022 in the Dentistry Service, Clinical Tula Aguilera. The sample, 40 patients, it was selected at random, independently of feeling fear or not to the dentistry treatment. The sessions were divided: first visit (without music) and second visit (with music). The data were picked up in survey. The levels of fear diminished with the application of the therapy, reason why it was verified that the musical-therapy has a notable it influences in the patients when disappearing and to diminish the fear or unpleasant sensations during the dentristry attention. All the patients manifested satisfaction with the music's use, during the service.

Effectiveness of a multicomponent intervention to face the COVID-19 pandemic in Rio de Janeiro's favelas: difference-in-differences analysis.

INTRODUCTION: Few community-based interventions addressing the transmission control and clinical management of COVID-19 cases have been reported, especially in poor urban communities from low-income and middle-income countries. Here, we analyse the impact of a multicomponent intervention that combines community engagement, mobile surveillance, massive testing and telehealth on COVID-19 cases detection and mortality rates in a large vulnerable community (Complexo da Maré) in Rio de Janeiro, Brazil. METHODS: We performed a difference-in-differences (DID) analysis to estimate the impact of the multicomponent intervention in Maré, before (March-August 2020) and after the intervention (September 2020 to April 2021), compared with equivalent local vulnerable communities. We applied a negative binomial regression model to estimate the intervention effect in weekly cases and mortality rates in Maré. RESULTS: Before the intervention, Maré presented lower rates of reported COVID-19 cases compared with the control group (1373 vs 1579 cases/100 000 population), comparable mortality rates (309 vs 287 deaths/100 000 population) and higher case fatality rates (13.7% vs 12.2%). After the intervention, Maré displayed a 154% (95% CI 138.6% to 170.4%) relative increase in reported case rates. Relative changes in reported death rates were -60% (95% CI -69.0% to -47.9%) in Maré and -28% (95% CI -42.0% to -9.8%) in the control group. The case fatality rate was reduced by 77% (95% CI -93.1% to -21.1%) in Maré and 52% (95% CI -81.8% to -29.4%) in the control group. The DID showed a reduction of 46% (95% CI 17% to 65%) of weekly reported deaths and an increased 23% (95% CI 5% to 44%) of reported cases in Maré after intervention onset. CONCLUSION: An integrated intervention combining communication, surveillance and telehealth, with a strong community engagement component, could reduce COVID-19 mortality and increase case detection in a large vulnerable community in Rio de Janeiro. These findings show that investment in community-based interventions may reduce mortality and improve pandemic control in poor communities from low-income and middle-income countries.

Blood Pressure Changes After a Health Promotion Program Among Mexican Workers.

Background: Cardiovascular disease is becoming increasingly prevalent in low and middle-income countries (LMIC), and high blood pressure (BP) is one of the main risk factors. The efficacy and sustainability of worksite health promotion (WHP) programs for BP reduction in LMIC have yet to be determined. Methods: This non-randomized company-based trial evaluated 6- and 12-months effects of a WHP intervention on BP among 2,002 participating workers from seven Mexican companies. Intervention and control groups were assigned at the company level. The intervention included nutrition counseling, physical exercise, and stress management components. Mixed models assessed differences in BP change between intervention and control companies in intent-to-treat (ITT), per-protocol (PerP), and as-treated (AsTr) analyses, and also within-group changes stratified by company, intervention component, and baseline cardiovascular risk factor levels. All analyses were adjusted for potential confounders. We accounted for missing data and loss to follow-up using inverse probability of censoring weighting. Results: ITT analyses revealed mean BP change differences of -1.1 mmHg at 12 months (95% CI: -2.9; 0.6) in intervention companies relative to control companies. PerP and AsTr analyses confirmed this finding. Within-group analyses showed consistent BP reductions at both 6 and 12 months. Substantial differences in BP changes ranging from diastolic -6.1 mmHg, (95% CI: -11.2; -1.2) to systolic -13.0 mmHg (95% CI: -16.0; -10.1) were found among individuals with diabetes at baseline in intervention companies relative to control companies. Conclusion: After 1 year, WHP was associated with modest but uncertain BP reductions. Substantial reductions were mainly observed among diabetic workers.

Impacto da intervenção educacional sobre suicídio na percepção de enfermeiras e agentes comunitários de saúde / Impact of the educational intervention about suicide on the perception of nurses and community health agents / Impacto de la intervención educativa sobre el suicidio en la percepción de las enfermeras y agentes comunitarios de salud

OBJETIVO: analisar a percepção de enfermeiras e agentes comunitários de saúde em relação ao suicídio antes e após uma intervenção educativa. MÉTODO: estudo quase experimental, do tipo antes e depois, de abordagem qualitativa, baseado no referencial teórico da Transferência de Conhecimento. Participaram do estudo duas enfermeiras e dez agentes comunitários de saúde de uma unidade básica de saúde de Campo Grande, do estado de Mato Grosso do Sul. Foi utilizada a técnica de grupo focal, para a coleta de dados, antes e após a intervenção educativa. A análise dos dados foi realizada por meio da técnica de Triangulação de Métodos. RESULTADOS: emergiram duas categorias da análise dos dados, "a percepção do suicídio nos seus diferentes aspectos", que traz percepções, compreensões e conceitos relacionados ao suicídio e "o contexto da assistência à saúde no comportamento suicida", que mostra como o suicídio é vivenciado pelos profissionais de saúde nos espaços de cuidado. CONCLUSÃO: a intervenção educativa favoreceu mudanças na percepção dos participantes referentes à identificação e abordagem do comportamento suicida, indicando a importância de ações dessa natureza para abordagens inerentes à prevenção do suicídio.

OBJECTIVE: to analyze the perception of nurses and community health agents in relation to suicide before and after an educational intervention. METHOD: a quasi-experimental research, of the before and after study type and with a qualitative approach, based on the theoretical framework of Knowledge Transfer. Two nurses and ten community health agents from a basic health unit in Campo Grande, state of Mato Grosso do Sul, participated in the study. The focus group technique was used for data collection before and after the educational intervention. Data analysis was performed using the technique of Triangulation of Methods. RESULTS: two categories of data analysis emerged: "the perception of suicide in its different aspects", which brings perceptions, understandings, and concepts related to suicide; and "the context of health care in suicidal behavior", which is characterized by how suicide is experienced by the health professionals in care contexts. CONCLUSION: the educational intervention fostered changes in the participants' perception regarding the identification and approach of suicidal behavior, indicating the importance of actions of this nature for approaches concerning suicide prevention.

OBJETIVO: analizar la percepción de enfermeras y agentes comunitarios de salud en relación con el suicidio, antes y después de una intervención educativa. MÉTODO: estudio cuasi experimental, del tipo antes y después, con enfoque cualitativo, basado en el marco teórico de la Transferencia de Conocimiento. Los participantes del estudio fueron dos enfermeras y diez agentes comunitarios de salud de una unidad básica de salud de Campo Grande en el estado de Mato Grosso do Sul. Se utilizó la técnica del grupo focal se utilizó para recopilar datos antes y después de la intervención educativa. El análisis de los datos se realizó mediante la técnica del Método de Triangulación. RESULTADOS: surgieron dos categorías de análisis de datos, "la percepción del suicidio en sus diferentes aspectos", que trae percepciones, entendimientos y conceptos relacionados con el suicidio y "el contexto de la atención en salud en el comportamiento suicida", que muestra cómo los profesionales de la salud experimentan el suicidio en los espacios de atención. CONCLUSIÓN: la intervención educativa favoreció cambios en la percepción de los participantes con respecto a la identificación y el enfoque del comportamiento suicida, lo que indica la importancia de acciones de esta naturaleza para abordajes inherentes a la prevención del suicidio.

Challenges and opportunities in the science of research to practice: lessons learned from a randomized controlled trial of a sexual risk-reduction intervention for psychiatric patients in a public mental health system

Objective: Human immunodeficiency virus (HIV) prevention efficacy trials with psychiatric patients have been conducted in research settings in high-resourced countries, establishing short-term efficacy for reducing sexual risk behavior. None has been implemented within systems of care. In the last decade, overcoming this research-to-practice gap has become a focus of implementation science. This paper describes the first and only HIV Prevention intervention trial for psychiatric patients conducted in real-world outpatient psychiatric settings facilitated by trained clinic-based providers. Methods: The HIV Prevention intervention, which uses the Information-Motivation-Behavioral Skills model to achieve sexual risk-reduction, was rigorously adapted to the local context and clinic services' needs. Participants from eight clinics were randomized to HIV Prevention or Health Promotion conditions. Results: HIV Prevention participants showed significant improvement in Information-Motivation-Behavioral domains; in this group, behavioral intentions were associated with significantly fewer unprotected sex occasions, but reduction of unprotected sex occasions was similar in both conditions. Conclusion: Our trial was conducted before implementation studies became widely funded. Transporting an intervention to a new culture or into real-world practice settings may require adaptations. Our results demonstrate that clear guidelines are needed regarding whether to conduct efficacy, effectiveness, and/or implementation research as the most appropriate next step. Clinical trial registration: NCT00881699

Açaí (Euterpe oleracea Mart.) and juçara (Euterpe edulis Mart.) juices improved HDL-c levels and antioxidant defense of healthy adults in a 4-week randomized cross-over study.

OBJECTIVE: To evaluate the effects of moderate-term açaí and juçara juice intake on fasting glucose, lipid profile, and oxidative stress biomarkers in healthy subjects. METHODS: A randomized cross-over study was performed with 30 healthy adults. The subjects were assigned to drink 200 mL/day of açaí or juçara juice for four weeks with a 4-week washout period. Before and after each nutritional intervention, blood samples were obtained to evaluate the outcomes: fasting glucose, total cholesterol, triglycerides, high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), small, dense LDL-c (sd-LDL-c), total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), uric acid, and activity of the enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). RESULTS: After four weeks, açaí and juçara juices increased the concentrations of HDL-c by 7.7% and 11.4%, respectively (P < 0.05). In addition, açaí juice intake promoted significant increases in TAC (66.7%), CAT (275.1%), GPx (15.3%), and a decrease in OSI (55.7%) compared to baseline (P < 0.05 for all). Juçara juice intake significantly increased CAT activity (~15.0%) in relation to baseline. No significant intergroup differences were observed for any outcomes (P > 0.05). CONCLUSION: The results indicated a positive impact of regular consumption of açaí and juçara juices on the HDL-c levels, as well as on the antioxidant enzyme activities, which may contribute to cardiovascular health.

Impact of multidimensional interventions on quality of life and depression among older adults in a primary care setting in Brazil: a quasi-experimental study

Objective: To evaluate the impact of multidimensional interventions on quality of life (QoL) and depressive symptoms in Brazilian older adults living in the community. Methods: Longitudinal, quasi-experimental study of older adults receiving conventional primary health care (PHC). The interventions were designed in response to a first round of data collection and validated through pilot testing in groups of older adults from another community. The validated interventions were then applied to an intervention group (IG). To measure their effect, we used the Medical Outcomes Short-Form Health Survey (SF-36) quality of life scale and the Geriatric Depression Scale (GDS-30). Results: The sample comprised 118 participants. IG participants exhibited significant improvement in several QoL domains (SF-36): mental health (p = 0.010), general health perceptions (p = 0.016), and physical functioning (p = 0.045). No such improvement occurred in controls (p > 0.050). The prevalence of depression (GDS-30) fell from 36.7 to 23.3% in the IG, despite no significant difference (p = 0.272). Controls also reported a reduction in depressive symptoms, but only from 44.8 to 41.4% (p = 0.112). Conclusions: This multidimensional intervention was associated with significant improvement in mental health, general health perceptions, and physical functioning in a sample of Brazilian older adults. Clinical trial registration: RBR-92dbtx.

Impact of the mHealth strategy in sodium consumption markers: AvaliaSal study / Impacto da estratégia mHealth em marcadores do consumo de sódio: estudo AvaliaSal

ABSTRACT Objective Evaluate the effectiveness of mHealth strategy on sodium consumption markers. Methods Intervention study carried out with 175 adults (20-59 years), from an educational institution of Vitória, Espírito Santo State. Participants were made aware through posters, oral approach and electronic media. Anthropometric, hemodynamic, socioeconomic, health, and dietary practices data was collected in two stages. After the first assessment, participants were randomized into two groups: Intervention Group and Control Group. The Intervention Group included 21 electronic messages and 3 videos on healthy eating focusing on the goal to reduce sodium intake for 3 months. Behavioral changes were assessed using the Generalized Estimation Equation (p-value <0.05). Results At baseline, no significant differences in socioeconomic, anthropometric and health variables, and eating practices between groups were observed. The stock broth cube was the most used ready processed seasoning. After the intervention, a reduction in the use of stock broth was observed only in the intervention group (β=0.615; p=0.016). In addition, 73% of the intervention group participants reported that the messages were clear, 67% reported that they were useful, and 48% stated they followed the guidelines. Conclusion There was a reduction in the frequency of use of stock broth cubes, demonstrating the potential effect of the m-Health strategy on sodium consumption markers in individuals without a hypertension medical diagnosis.

RESUMO Objetivo Avaliar a efetividade da estratégia mHealth sobre marcadores do consumo de sódio. Métodos Estudo de intervenção realizado com 175 adultos (20-59 anos), vinculados a uma instituição de ensino de Vitória, no Estado do Espirito Santo. Os participantes foram contatados por através da exposição a de um pôster, de abordagem oral e mídia eletrônica. Dados antropométricos, hemodinâmicos, socioeconômicos, de saúde e práticas alimentares foram coletados em dois momentos. Os participantes foram randomizados em dois grupos: Grupo de Intervenção e Grupo de Controle. Durante a intervenção, que durou três meses, os participantes receberam 21 mensagens eletrônicas e assistiram a três vídeos sobre alimentação saudável, com foco na redução do consumo de sódio. Mudanças foram avaliadas por Equação de Estimativa Generalizada e adoção de valor de p<0,05. Resultados Na linha de base, não foram observadas diferenças significativas em relação às variáveis antropométricas, socioeconômicas, de saúde e práticas alimentares entre os grupos. Caldo pronto foi o condimento industrializado mais utilizado pelos participantes durante o estudo. Foi observada uma redução do uso de caldo pronto apenas no Grupo de Intervenção (β=0,615; p=0,016). Além disso, 73% do Gruo de Intervenção relataram que as mensagens foram claras; 67% afirmaram que as mensagens foram úteis e 48% disseram que seguiram as orientações. Conclusão Foi observada uma redução da frequência do uso de caldo pronto, demonstrando potencial da estratégia m-Health sobre marcadores do consumo de sódio em participantes sem diagnóstico de hipertensão.

Programa de remediação com a nomeação rápida e leitura para escolares com dislexia: elaboração e significância clínica / Remediation program with automatized naming and reading for students with dyslexia: elaboration and clinical significance

RESUMO Objetivo: Elaborar um programa de remediação com a nomeação rápida e leitura, bem como verificar a significância clínica da aplicação do programa elaborado em escolares com dislexia. Método: Participaram cinco sujeitos do terceiro ao quinto ano do ensino fundamental, com idade de 8 a 11 anos, de ambos os sexos, com diagnóstico interdisciplinar de dislexia. Todos os escolares foram submetidos na pré e pós-testagem à aplicação das provas de habilidades metalinguísticas e de leitura, compreensão de leitura e da prova de nomeação automática rápida. Resultados: A análise foi realizada pelo Método JT, que permitiu verificar se houve mudança positiva ou negativa e significância clínica na pós-testagem. Os resultados mostraram ter havido significância clínica nas provas de identificação; adição e combinação de sílaba, de fonema final e medial, além de repetição de não palavras, leitura de palavras reais e pseudopalavras, compreensão leitora, além de nomeação automática rápida quando comparada a pré com a pós-testagem. Conclusão: O programa elaborado mostrou-se eficaz e com aplicabilidade, podendo ser utilizado instrumento de intervenção baseada em evidência científica para escolares com dislexia, pois ocorreu significância clínica para o desempenho em leitura.

ABSTRACT Purpose: Elaborate a remediation program with rapid automatized naming and reading, as well as to verify the clinical significance of the elaborated program for students with dyslexia. Method: The study involved five students from 3rd to the 5th grade of elementary school, aged 8 to 12 years, of both genders, with an interdisciplinary diagnosis of dyslexia. All students were submitted to pre- and post-test application of metalinguistic skills and reading test, reading comprehension and rapid automatized naming test. Results: The analysis was performed using the JT method that allowed to verify positive or negative change and clinical significance in the post-testing. The results showed clinical significance in the tests of identification, syllable addition and combination, final and medial phoneme; in addition to nonwords repetition, real words and pseudowords reading, reading comprehension and rapid automatized naming test when comparing the pre- and post-testing. Conclusion: The elaborated program was efficient and applicable as an intervention instrument based on scientific evidence for students with dyslexia since it showed clinical significance for reading performance.

Effectiveness of an educational strategy to increase plain water consumption in children / Efectividad de una estrategia educativa para incrementar el consumo de agua simple en niños

Abstract: Objective: We tested the effectiveness of the I prefer plain water educational strategy used to increase water consumption in elementary school children. Materials and methods: A community intervention trial was performed in eight public elementary schools in Mexico City. The schools were randomized into an intervention (IG) and a control (CG) group. Each school was provided water dispensers inside the classrooms. The IG received the educational strategy. The strategy was considered effective if the students increased their water consumption by ≥220 ml. Results: Water consumption in the IG increased 167 ml vs. 37 ml in CG (p < 0.001). The goal of the educational strategy for water consumption was achieved in 166/413 children in the IG and 95/364 children in the CG (p < 0.001). Conclusions: I prefer plain water, associated with free access to water inside the classrooms, proved to be effective to increase water consumption.

Resumen: Objetivo: Evaluar la efectividad de la estrategia Prefiero agua simple para incrementar el consumo de agua en niños de escuelas primarias públicas. Material y métodos: Ensayo de intervención comunitaria en ocho escuelas en la Ciudad de México. Las escuelas se aleatorizaron en grupo de intervención (GI) y de control (GC). Se instalaron dispensadores de agua dentro de las aulas. Implementamos la estrategia al GI. Consideramos efectiva la estrategia si los estudiantes incrementaron su consumo de agua en ≥220 ml. Resultados: El incremento global en el consumo de agua del GI fue de 167 ml vs. 37 ml en GC (p <0.001). La efectividad de la estrategia para el consumo de agua se logró en 166/413 niños del GI y en 95/364 niños del GC (p <0.001). Conclusiones: Prefiero agua simple, asociada con libre acceso al agua dentro de las aulas, demostró ser efectiva para incrementar el consumo de agua.

Effectiveness of an educational strategy to increase plain water consumption in children.

OBJECTIVE: We tested the effectiveness of the I prefer plain water educational strategy used to increase water consumption in elementary school children. MATERIALS AND METHODS: A community intervention trial was performed in eight public elementary schools in Mexico City. The schools were randomized into an intervention (IG) and a control (CG) group. Each school was provided water dispensers inside the classrooms. The IG received the educational strategy. The strategy was considered effective if the students increased their water consumption by ≥220 ml. RESULTS: Water consumption in the IG increased 167 ml vs. 37 ml in CG (p < 0.001). The goal of the educational strategy for water consumption was achieved in 166/413 children in the IG and 95/364 children in the CG (p < 0.001). CONCLUSIONS: I prefer plain water, associated with free access to water inside the classrooms, proved to be effective to increase water consumption.

OBJECTIVE: Evaluar la efectividad de la estrategia Prefiero agua simple para incrementar el consumo de agua en niños de escuelas primarias públicas. MATERIALS AND METHODS: Ensayo de intervención comunitaria en ocho escuelas en la Ciudad de México. Las escuelas se aleatorizaron en grupo de intervención (GI) y de control (GC). Se instalaron dispensadores de agua dentro de las aulas. Implementamos la estrategia al GI. Consideramos efectiva la estrategia si los estudiantes incrementaron su consumo de agua en ≥220 ml. RESULTS: El incremento global en el consumo de agua del GI fue de 167 ml vs. 37 ml en GC (p < 0.001). La efectividad de la estrategia para el consumo de agua se logró en 166/413 niños del GI y en 95/364 niños del GC (p < 0.001). CONCLUSIONS: Prefiero agua simple, asociada con libre acceso al agua dentro de las aulas, demostró ser efectiva para incrementar el consumo de agua.

School-Based Intervention on Cardiorespiratory Fitness in Brazilian Students: A Nonrandomized Controlled Trial.

BACKGROUND: In response to the worldwide increasing prevalence of low cardiorespiratory fitness (CRF), several interventions have been developed. The aim of this study was to examine the effect of a school-based intervention on CRF in Brazilian students. METHODS: A nonrandomised controlled design tested 432 students (intervention group: n = 247) from 6th to 9th grade recruited from two public secondary schools in Florianopolis, in 2015. The intervention entitled "MEXA-SE" (move yourself), applied over 13 weeks, included four components: (1) increases in physical activity during Physical Education classes; (2) active recess; (3) educational sessions; and (4) educational materials. CRF (20-m shuttle run test) was the primary outcome. RESULTS: The effect size of the intervention on CRF was 0.15 (CI 95% = -0.04; 0.34). In the within-group comparisons, VO2max decreased significantly from baseline to follow-up in the control group but remained constant in the intervention group. After adjustment variables, differences between intervention and control group were not statistically significant (p > 0.05). CONCLUSION: The "MEXA-SE" intervention did not have an effect on adolescents' CRF. However, maintenance of VO2max in intervention group and a reduction within control group demonstrates that this intervention may be beneficial for long-term CRF and, possibly, the increased intervention time could result in a better effect.

Effect of photobiomodulation therapy on postoperative pain after endodontic treatment: a randomized, controlled, clinical study.

OBJECTIVE: The aim of this prospective, randomized, clinical study was to assess the effect of photobiomodulation therapy (PBM) with low-level laser irradiation (LLLI) on postoperative pain after endodontic treatment. MATERIALS AND METHODS: Sixty patients, diagnosed with irreversible pulpitis in lower molar teeth, participated in the study. All treatments were performed by a single operator. Participants were randomly divided into two groups: in the experimental group (EG), endodontic treatment was performed with a reciprocating system, immediately followed by PBM with LLLI; and only endodontic treatment was performed in the control group (CG). Postoperative pain was assessed by a second examiner, who was blinded, using two scales: verbal rating scale (VRS) and numerical rating scale (NRS). Assessment was carried out at 6, 12, and 24 h after treatment. Data were analyzed using chi-squared, Fisher's exact, Mann-Whitney tests, ordinal, and non-parametric regression analyses. RESULTS: For the prevalence of pain, the difference between the groups was significant for the evaluations performed after 6 h (p = 0.04) and 24 h (p = 0.02). The difference after 24 h remained significant after stratification by sex and extrusion of filling material. Increased pain intensity was associated with extrusion of root canal filling material to the periapical region in the two scales used. CONCLUSION: The effect of PBM therapy after endodontic treatment showed a significant decreasein prevalence of postoperative pain. CLINICAL RELEVANCE: The PBM reduces the prevalence of postoperative pain and may benefit patients who need endodontic treatment.

Ácido fólico em excesso: efeitos sobre o metabolismo das vitaminas B2 e B6, o catabolismo do triptofano e a resposta imune / Folic acid excess: effects on vitamin B2 and B6 metabolism, tryptophan catabolism and immune response

Introdução: A suplementação com ácido fólico (AF) é recomendada em algumas condições para evitar a deficiência de folato, como para mulheres no período periconcepcional e durante a gestação. Atualmente, existe uma preocupação quanto ao consumo excessivo de AF pela população pelo uso de suplementos com altas doses dessa vitamina. As vitaminas B6 e B2 agem como cofatores no metabolismo de um carbono, e o uso de altas doses de AF pode influenciar o metabolismo de ambas vitaminas e, consequentemente, interferir em metabolismos importantes das quais elas participam, como a via das quinureninas, e no sistema imune. Objetivo: Avaliar os efeitos da intervenção diária com uma alta dose de AF (5 mg) por 90 dias sobre marcadores do estado das vitaminas do complexo B, e as consequências sobre os metabólitos da via das quinureninas e o sistema imune em adultos saudáveis. Material e Métodos: 64 indivíduos saudáveis foram submetidos à intervenção diária com 5 mg de AF por 90 dias. Coletas de sangue foram realizadas antes (baseline) e após 45 e 90 dias de intervenção. As concentrações séricas de folato e vitamina B12 foram avaliadas por métodos microbiológicos. As concentrações séricas das vitaminas B6 (piridoxal 5'-fosfato (PLP), piridoxal (PL) e ácido 4-piridóxico (PA)), B2 (riboflavina e flavina mononucleotídeo (FMN)), B1 (tiamina e tiamina monofosfato (TMP)) e B3 (ácido nicotínico, nicotinamida e N1-metilnicotinamida), bem como de triptofano, quinurenina e metabólitos, foram avaliadas por LC-MS/MS. A proteína C-reativa ultrassensível (PCRus) foi determinada por imunoturbidimetria, e as concentrações séricas de interleucina (IL)-6, IL-8, IL-10, interferon gama (IFN-γ) e fator de necrose tumoral alfa (TNF-α) foram avaliadas por ensaio multiplex. A expressão de RNAm de DHFR (dihidrofolato redutase), MTHFR (metilenotetrahidrofolato redutase), IL8, TNFA e IFNG em leucócitos mononucleares (PBMC) foram avaliadas por PCR em tempo real. O número de células T regulatórias (Treg) (CD3+, CD4+, CD25high, FoxP3+, CD127-) foi avaliado após incubação dos PBMC com PMA e ionomicina ou veículo por 18h, por imunofenotipagem. Resultados: Houve um grande aumento das concentrações de folato sérico após 45 e 90 dias de intervenção com AF. Não houve diferença nas concentrações de vitamina B12 antes e após a intervenção. As concentrações séricas de PLP foram semelhantes antes e após a intervenção, entretanto, um aumento de PL sérico foi observado após 45 e 90 dias, e de PA após 45 dias, quando comparado ao baseline. Riboflavina e FMN foram maiores após 45 e 90 dias em relação ao baseline. A tiamina sérica foi menor após 45 dias, e as concentrações de TMP foram maiores após 90 dias quando comparados aos períodos anteriores. Não houve diferença nas concentrações de vitamina B3 antes e após a intervenção. Dentre os metabólitos da via das quinureninas, apenas o ácido antranílico apresentou aumento após 45 e 90 dias, enquanto o ácido picolínico diminuiu após 90 dias. PCRus, IL-6, IL-8, IL-10, IFN-γ e TNF-α séricos foram semelhantes no baseline e após a intervenção. Um aumento da expressão de RNAm de DHFR e TNFA foi observado após, respectivamente, 90 dias e 45 e 90 dias de intervenção. Após 90 dias de intervenção com AF, foi observada diminuição do número de células Treg após estímulo com PMA e ionomicina. Conclusão: O uso diário de 5 mg de AF foi associado a alterações nas concentrações séricas de marcadores do estado de vitaminas do complexo B e da via das quinureninas, bem como a diminuição do número de células Treg

Introduction: Folic acid (FA) supplementation is recommended in some conditions to avoid folate deficiency, as women during periconceptional period and pregnancy. Currently, there is a concern about the excessive consumption of FA by population by using supplements with high doses of this vitamin. Vitamins B6 and B2 are cofactors of enzymes of one carbon metabolism and, consequently, may disturb key metabolism in which they participate, as kynurenine pathway, and the immune system. Aim: To assess the effects of a daily intervention with high dose of FA (5 mg) for 90 days on biomarkers of complex B vitamins status and its outcomes in kynurenine pathway metabolites and immune system in healthy adults. Material and Methods: 64 healthy individuals were submitted to a daily intervention with 5 mg of FA for 90 days. Blood samples were collected before (baseline) and after 45 and 90 days of intervention. Serum folate and vitamin B12 were assessed by microbiological assays. Serum vitamin B6 (pyridoxal 5'-phosphate (PLP), pyridoxal (PL) and 4-pyridoxic acid (PA)), vitamin B2 (riboflavin and flavin mononucleotide (FMN)), vitamin B1 (thiamin and thiamin monophosphate)) and vitamin B3 (nicotinic acid, nicotinamide and N1-methylnicotinamide), as well as tryptophan, kynurenine and metabolites, were assessed by LC-MS/MS. C-reactive protein (hs-CPR) was assessed by immunoturbidimetry, and serum interleukin (IL)-6, IL-8, IL-10, interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) were assessed by multiplex assay. Mononuclear leukocytes mRNA expression of DHFR (dihydrofolate reductase), MTHFR (methylenetetrahydrofolate reductase), IL8, TNFA and IFNG were assessed by real time PCR. Regulatory T Cell (Treg) number (CD3+, CD4+, CD25high, FoxP3+, CD127-) was determined after mononuclear leukocytes incubation with PMA and ionomycin or vehicle for 18h, by immunophenotyping. Results: A great increase on serum folate was observed after 45 and 90 days of FA intervention. No differences in serum vitamin B12 were observed before and after intervention. Serum PLP was similar before and after intervention, however, an increase in serum PL was observed after 45 and 90 days, and in PA after 45 days, when compared to baseline. Riboflavin and FMN were increased after 45 and 90 days than in baseline. Serum thiamine was decreased after 45 days than in baseline. Serum TMP was increased after 90 days when compared with previous timepoints. No differences in vitamin B3 were observed after and before FA intervention. Among kynurenine pathway metabolites, anthranilic acid was increased after 45 and 90 days, while picolinic acid was decreased after 90 days. hs-CPR, serum IL-6, IL-8, IL-10, IFN-γ and TNF-α were similar at baseline and after intervention. An increase on mRNA expression of DHFR and TNFA was observed after, respectively, 90 days and 45 and 90 days of intervention. After 90 days of FA intervention, it was observed a decrease on Treg cell number after PMA and ionomycin stimulation. Conclusion: Daily use of 5 mg of FA was associated with changes in serum markers of B-complex vitamins status and kynurenine pathway, as well as decreased number of Treg cells

Cognitive stimulations effects and Taigeiko in elderly women's cognition: an intervention / Los efectos de estímulos cognitivos y Taigeiko en la cognición de idosas: una intervención / Efeitos de estímulos cognitivos e Taigeiko na cognição de idosas: uma intervenção

ABSTRACT Objective: To evaluate the effectiveness of an intervention through cognitive stimulation associated with Taigeiko practice in memory performance and executive function of elderly women, compared to a group exposed to Taigeiko alone. Method: A quasi-experimental study was performed with 16 elderly women. 10 were allocated to the experimental group (EG) submitted to 16 sessions of cognitive stimulation and Taigeiko, and 6 elderly women in the control group (CG) submitted to Taigeiko alone. Cognition was assessed before and after intervention by the tests: Rey Auditory-Verbal Learning (RAVLT); Rey-Osterrieth Complex Figure Test; Trail-Making Test; Stroop Effect; Digit Span Test and Semantic Verbal Fluency Test. Results: Both groups presented differences in RAVLT domains (EG p=0.004, CG p=0.005) and Stroop Effect (EG p=0.012; CG p=0.024). However, in EG, better scores were shown in the tests, although not statistically significant. Conclusion: Taigeiko has been shown to be a potential activity in obtaining cognitive gains, independently of the associated cognitive stimulation.

RESUMEN Objetivo: Evaluar la efectividad de una intervención por medio de estímulos cognitivos asociados a la práctica de Taigeiko en el desempeño de la memoria y función ejecutiva de ancianas, comparado a un grupo expuesto al Taigeiko aisladamente. Método: Estudio casi experimental con 16 ancianas, siendo 10 asignadas en el grupo experimental (GE) y sometidas a 16 sesiones de estimulación cognitiva y Taigeiko; y 6 ancianas en el grupo control (GC), sometidas al Taigeiko aisladamente. La cognición fue evaluada antes y después de la intervención por medio de las pruebas: Aprendizaje Aditivo-Verbal de Rey (RAVLT); Figuras Complejas de Rey; Rutas; Efecto Stroop; Span de Dígitos y Fluidez Verbal Semántica. Resultados: Los dos grupos presentaron diferencias en los dominios del RAVLT (GE p=0,004; GC p=0,005) y en el Efecto Stroop (GE p=0,012; GC p=0,024). Sin embargo, en el GE se evidenciaron mejores puntuaciones en las pruebas, aunque sin significancia estadística. Conclusión: El Taigeiko demostró ser una potencial actividad en la obtención de ganados cognitivos, independientemente de la estimulación cognitiva asociada.

RESUMO Objetivo: Avaliar a efetividade de uma intervenção por meio de estímulos cognitivos associados à prática de Taigeiko no desempenho da memória e função executiva de idosas, comparado a um grupo exposto ao Taigeiko isoladamente. Método: Estudo quase-experimental com 16 idosas, sendo 10 alocadas no grupo experimental (GE) submetidas a 16 sessões de estimulação cognitiva e Taigeiko, e 6 idosas no grupo controle (GC) submetidas ao Taigeiko isoladamente. A cognição foi avaliada pré e pós-intervenção pelos testes: Aprendizagem Aditivo-Verbal de Rey (RAVLT); Figuras Complexas de Rey; Trilhas; Stroop; Span de Dígitos e Fluência Verbal Semântica. Resultados: Ambos os grupos apresentaram diferenças em domínios do RAVLT (GE p=0,004; GC p=0,005) e do Teste Stroop (GE p=0,012; GC p=0,024). No entanto, no GE foram evidenciados melhores escores nos testes, embora sem significância estatística. Conclusão: O Taigeiko demonstrou ser uma potencial atividade na obtenção de ganhos cognitivos, independente da estimulação cognitiva associada.

Promoting fruit and vegetable consumption: Methodological protocol of a randomized controlled community trial.

This study aimed to develop community educational activities in Brazilian primary health care settings. A randomized controlled community trial was conducted to encourage fruit and vegetable consumption (FV-RCT) in a representative sample of consumers aged 20 years or older in a Brazilian city. The fruit and vegetable consumption was classified according to the transtheoretical model's stages of change, reflecting different degrees of readiness for change. The educational activities were based on the transtheoretical model and a problematizing-dialogic pedagogy, planned by an interdisciplinary team, using information collected in a qualitative pilot study. The actions were conducted over seven months, and baseline data were collected from 1483 participants. The educational strategies included workshops interspersed with motivational messages conveyed via postcard, interactive environment-based activities, and informative material. In the workshops, different techniques were used - conversation circles, image theatre, self-portraits, cooking and art as experience. The applied intervention based on the chosen theories implied in a refinement of the intervention, but, nevertheless, proved to be feasible for large population groups and to the scenario of health services. Thus, this interdisciplinary FV-RCT study represents an effort to advance methodological issues and provide theoretical subsidies for actions.

Jump gymnastic at school physical education for adolescents and adults: changes and prevalence of success in health-related physical fitness / Ginástica "Jump" na Educação Física escolar para adolescentes e adultos: alterações e prevalência de sucesso na aptidão física relacionada à saúde

This study aimed to verify changes and prevalence of success in health-related physical fitness after an intervention with jump gymnastic at physical education classes for adolescents and adults according to gender. Thirty-nine adolescents and adults (20 women) were selected for convenience, aged between 15-61 years old, at a school in Charqueadas, Rio Grande do Sul, Brazil. The intervention consisted on 60 Jump gymnastic classes, three times per week in a school semester. The body mass index (BMI); waist circumference (WC); cardiorespiratory fitness (CRF); flexibility and abdominal strength were evaluat-ed. The changes and the prevalence of success were calculated according to specific cutoff points for the individual pre- and post-test variation (D%; mean) and Manova analysis was adopted as comparison test for means variation between gender and variation of this groups at time. BMI have not changed (D = -1.17%, p = 0.123) in women, however it increased (D = 2.07%, p = 0.035) in men. PC have not changed (female: D = 0.71%, p = 0.341, male: D = 1.09%, p = 0.564). Abdominal strength increased (D = 145.47%, p = 0.001) in women but not in men (D = 12.82%, p = 0.411). The flexibility increased similarly in women (D = 16.07%, p = 0.041) and men (D = 17.32%, p = 0.039) and CRF increased only in women (D = 14.32%; p = 0.028). The individual prevalence of success was 41% in flexibility, 33% in CRF, 23% in abdominal strength, 15% in WC and only 10% in BMI. Women had stronger benefits compared to men with the Jump in physical education, mainly in abdominal strength and CRF

Este estudo objetivou verificar alterações e a prevalência de sucesso na aptidão física relacionada à saúde após intervenção com ginástica "Jump" na educação física escolar para adolescentes e adultos, estratificado por sexo. Selecionou-se, por conveniência, 39 adolescentes e adultos (20 mulheres), de 15 a 61 anos em uma escola de Charqueadas, Rio Grande do Sul, Brasil. A intervenção consistiu em 60 aulas de ginástica "Jump", três vezes por semana em um semestre de educação física. Avaliou-se o índice de massa corporal (IMC); perímetro da cin-tura (PC); aptidão cardiorrespiratória (APCR); flexibilidade e força abdominal. As alterações e a prevalência de sucesso foram calculadas através da variação individual pré-teste para pós-teste (D% média) e a análise de Manova foi adotada como teste de comparação para variações das médias entre gênero e variação desses grupos no tempo. O IMC do sexo feminino não alterou (D = -1,17%; p = 0,123), diferentemente do masculino que aumentou (D = 2,07%; p = 0,035). O PC médio não alterou significativamente (feminino: D = -0,71%; p = 0,341; masculino: D = 1,09%; p = 0,564). A força abdominal feminina aumentou (D = 145,47%; p = 0,001) e o sexo masculino não teve alteração (D = -12,82%; p = 0,411). A flexibilidade aumentou similarmente no sexo feminino (D = 16,07%; p = 0,041) e no masculino (D = 17,32%; p = 0,039) e a APCR aumentou somente no sexo feminino (D = 14,32%; p = 0,028). A prevalência individual de sucesso foi de 41% na flexibilidade, 33% na APCR, 23% na força abdominal, 15% no PC e apenas 10% no IMC. O sexo feminino teve maiores bene-fícios em relação ao masculino com o Jump na educação física, principalmente na força abdominal e na APCR

Drinking water and rural schools in the Western Amazon: an environmental intervention study.

BACKGROUND: Although water and sanitation are considered human rights, worldwide approximately three of 10 people (2.1 billion) do not have access to safe drinking water. In 2016, 5.6 million students were enrolled in the 34% of Brazilian schools located in rural areas, but only 72% had a public water supply network. The objective was to evaluate effectiveness of environmental intervention for water treatment in rural schools of the Western Amazonia, and determine the efficacy of water treatment using a simplified chlorinator on potability standards for turbidity, fecal coliforms and Escherichia coli. METHODS: A simplified chlorinator was installed for treatment of potable water in 20 public schools in the rural area of Rio Branco municipality, Acre state, Brazil. RESULTS: Before the intervention, 20% (n = 4), 100% (n = 20) and 70% (n = 14) of schools had water that failed to meet potability standards for turbidity, fecal coliforms and E. coli, respectively. However, after intervention, 70% (p = 0.68), 75% (p < 0.001) and 100% (p < 0.001) of schools complied with potability standards. DISCUSSION: This intervention considerably improved schools' water quality, thus decreasing children's health vulnerability due to inadequate water. Ancillary activities including training, educational lectures, installation of equipment, supply of materials and supplies (65% calcium hypochlorite and reagents) were considered fundamental to achieving success full outcomes. Installation of a simplified chlorinator in rural schools of the Western Amazon is therefore proposed as a social technology aiming at social inclusion, as well as economic and environmental sustainability.

Studies About Physical Activity Interventions Including Follow-Up Analysis: A Systematic Review.

BACKGROUND: Some studies have used the follow-up method to analyze real behavioral changes in research involving physical activity (PA) interventions. This has great scientific value; however, it is hard to apply without satisfactory resources and research funding. Little is known about how many studies have used this method to analyze PA interventions in low-income and middle-income countries, especially Brazil. PURPOSE: To describe Brazilian studies using follow-up analysis after PA interventions. METHODS: A systematic review was performed including Brazilian studies with follow-up analysis after PA interventions; the analyzed papers were from the previous 10 years. The search was carried out in Portuguese, English, and Spanish in the following databases: SciELO, Latin American and Caribbean Health Science Literature, PubMed, and Scopus. The Preferred Reporting Items for Systematic Review and Meta-Analysis method was used. RESULTS: In total, 6 of the 7 studies analyzed were from the southeast region, with the intervention time ranging from 2 to 12 months, carrying out follow-up every 5.3 months with 2.2 observations on average. The interventions had a behavioral approach and were generally carried out in universities, hospitals, and ambulatory care. CONCLUSION: Studies on PA interventions using follow-up analysis are scarce. Considering the relevance of follow-up studies to measure behavior changes, the results suggest that more studies about this topic are essential in Brazil.