ABSTRACT
The Chinese herbal compound formula preparation,which is guided by traditional Chinese medicine (TCM) theories,and based on long-term clinical application,has its unique value.The multi-compound and multi-target characteristics are also features of Chinese materia medica (CMM).The finding and exploration of innovation CMM in modern times should be based on TCM theory and clinical application,as well as the combination of efficacy in the concept of holism and biomedical technology.Key issue in the research,development and evaluation of innovation Chinese medicine is to use to the methodology to illustrate the scientific meaning in according to the clinical application characteristics of Chinese herbal compound formula preparation.During the research and development process,considerations on CMM characteristics should be taken from research evidence,to pharmacodynamics and toxicology studies.Pharmacodynamics researches should reflect the properties of TCM syndrome.Aspects,such as research and application of TCM syndrome model,correspondence between disease and syndrome model,research method of correspondence between syndrome and prescription,identification of biological markers corresponding to CMM pharmacologic effect,are important.So we should catch up the historical chance for TCM development,speedily develop the advantage areas,and promote the modernization and innovation of TCM.
