The Moral Brain: a Neuropsychiatric Perspective on Moral Behavior and Motivation.

This review explores the interplay between neurobiological, psychological, and social factors that underpin moral behavior and motivation. Integrating insights from neuropsychiatry, it examines the roles of key brain regions such as the prefrontal cortex, amygdala, and anterior cingulate cortex, as well as neurotransmitters like serotonin and dopamine, in shaping moral reasoning and ethical decision-making. The historical evolution of moral motivation theories, from ancient philosophy to modern psychological and neurobiological perspectives, provides a foundation for understanding intrinsic and extrinsic motivators, emotional influences, and the impact of social norms and cultural contexts. The review also addresses the effects of psychiatric disorders on moral behavior, highlighting how conditions like antisocial personality disorder, frontotemporal dementia, and schizophrenia can lead to moral deficits. By presenting a multidisciplinary approach, this review offers a comprehensive understanding of moral motivation and behavior, emphasizing the importance of fostering ethical conduct and addressing moral challenges in clinical, educational, and societal settings.

Evolution of the Moral Lexicon.

Morality is central to social well-being and cognition, and moral lexicon is a key device for human communication of moral concepts and experiences. How was the moral lexicon formed? We explore this open question and hypothesize that words evolved to take on abstract moral meanings from concrete and grounded experiences. We test this hypothesis by analyzing semantic change and formation of over 800 words from the English Moral Foundations Dictionary and the Historical Thesaurus of English over the past hundreds of years. Across historical text corpora and dictionaries, we discover concrete-to-abstract shifts as words acquire moral meaning, in contrast with the broad observation that words become more concrete over time. Furthermore, we find that compound moral words tend to be derived from a concrete-to-abstract shift from their constituents, and this derivational property is more prominent in moral words compared to alternative compound words when word frequency is controlled for. We suggest that evolution of the moral lexicon depends on systematic metaphorical mappings from concrete domains to the moral domain. Our results provide large-scale evidence for the role of metaphor in shaping the historical development of the English moral lexicon.

What motivates early lies? Deception in 2½- to 5-year-olds.

What motivates young children to produce early lies? A total of 217 2½- to 5-year-old children (Mage = 44.5 months, SD = 8.45; 54% girls; 61.7% White) from the southeastern United States were tested using a modified third-party transgression paradigm to examine the motivation behind their deception. Children were assigned to one of three conditions-baseline, self-motivated, or other-motivated condition-and their propensity to lie was captured through both verbal and nonverbal measures. Results show that children's early lies are primarily driven by a self-serving motivation. However, the motivation to lie diversifies by 4 years of age, when children begin to lie for both self-serving and other-serving motivations.

People's judgments of humans and robots in a classic moral dilemma.

How do ordinary people evaluate robots that make morally significant decisions? Previous work has found both equal and different evaluations, and different ones in either direction. In 13 studies (N = 7670), we asked people to evaluate humans and robots that make decisions in norm conflicts (variants of the classic trolley dilemma). We examined several conditions that may influence whether moral evaluations of human and robot agents are the same or different: the type of moral judgment (norms vs. blame); the structure of the dilemma (side effect vs. means-end); salience of particular information (victim, outcome); culture (Japan vs. US); and encouraged empathy. Norms for humans and robots are broadly similar, but blame judgments show a robust asymmetry under one condition: Humans are blamed less than robots specifically for inaction decisions-here, refraining from sacrificing one person for the good of many. This asymmetry may emerge because people appreciate that the human faces an impossible decision and deserves mitigated blame for inaction; when evaluating a robot, such appreciation appears to be lacking. However, our evidence for this explanation is mixed. We discuss alternative explanations and offer methodological guidance for future work into people's moral judgment of robots and humans.

The Rhetoric of Healthcare and the Moral Debate About Theatre-Funded Hospitals in Early Modern Spain.

While early modern Spain may seem a world away, it is an extremely rich and relevant context for gaining a better understanding of the Rhetoric of Health, specifically the power of metaphor, in the related spheres of policy-making and public debate. It was a time and place in which the urban populace's physical well-being depended upon the fortunes of theatrical performances due to a system of alms for hospitals driven by ticket receipts. Anti-theatricalists argued that the immoral nature of theatrical performances made them spiritually and medically detrimental to society. Pro-theatricalists argued that plays were always a public good on balance because they raised much-needed funds for hospitals. Instead of producing a conflict between morality and public health, each side reinforced their connection until the two topics became nearly inseparable in the sphere of public debate. While pro-theatricalists mainly stayed with their arguments about funding hospitals, anti-theatricalists developed a new strategy of literalising the metaphor of theatre as a "plague of the republic" and arguing that immoral entertainment brought literal disease to the populace as a punishment from God. This exemplifies Stephen Pender's observation of how, in an early modern medical context, "Rhetoric as a way of perceiving probabilities and adjusting one's argument to the audience and circumstance offers a model of ethical action and interaction". This article is organised chronologically to track specific adjustments to a specific public-health debate that rely upon moral metaphors of medicine. Each side wrangled over these metaphors in an effort to break a deadlock in a public-health policy debate with entertainment, finance, and morality at its centre. By the end of the seventeenth century, anti-theatricalists finally found their best rhetorical weapon in the literalisation of the "plague of the republic" metaphor, but it only offered a short-term solution to banning theatre contingent upon the ebb and flow of epidemics. Simultaneously, the finance structure of funding hospitals began to erase the role of hospitals from the longstanding debate about the morality of public theatre. The case of early modern Spain provides valuable lessons about the power of metaphor in the Rhetoric of Healthcare that are still applicable today.

Striving Against Sonlessness: The Moral Uses of Medical Pluralism in Western Indian Quests for a Boy.

Amid patriarchal conditions that render one son necessary and multiple daughters burdensome, selective abortion of female fetuses has become pervasive in India. Public responses often cast sex selection as self-evidently ignorant, cruel, and misogynistic - an obvious evil meriting denunciation and eradication. Drawing on ethnographic fieldwork in Gujarat state, this article zooms out from ultrasound and abortion to survey the landscape of biomedical, herbal, and religious son production techniques surrounding them. Doing so clarifies the lived moral experience in which sex selection is embedded. Resort to multiple son production techniques is both an abstract moral indicator reflecting prevailing concerns and a pragmatic moral intervention aimed at harnessing every available means in response to those concerns. Fundamentally, people live out the multimodal quest that sometimes leads to selective abortion as aspiration - social, bodily, spiritual - toward an indispensable good, not as heartless rejection of daughters. Pluralistic son production illuminates the moral uses of medical pluralism for care-seekers, social scientists, and policymakers and practitioners. The case underscores that "complementary" therapies, rather than being just desperate behaviors, barriers to biomedical therapy, or curiosities to be integrated into care, may in fact be the clearest markers of the moral conditions in which public health problems unfold.

Is Doing Good Good Enough? A Motivation, Action, Sacrifice, and Temptation (MAST) View of Moral Praiseworthiness.

We present the Motivation, Action, Sacrifice, and Temptation (MAST) view of moral praiseworthiness and evaluate four components shaping judgments of an actor's morality: (a) How did the person act? (b) Why did the person act? (c) Did the person sacrifice something when acting? and (d) Was the person tempted to avoid the sacrifice? Across multiple moral domains, we evaluate moral impressions of hypothetical actors who acted ostensibly morally under different motivational, sacrificial, and temptational conditions. Across four studies (total N > 1,200) and 150 morally relevant scenarios, all components shaped moral impressions, with motivational purity having the strongest impact. Exploring motivation more deeply via Self-Determination Theory, we found effects of internalized (vs. externalized) motivations. Broadly speaking, judges prefer actors to act automatically and in an idealized manner rather than with deliberation and effort. This work address questions that have fascinated philosophers, psychologists, and laypeople, advancing understanding of moral impression formation.

How people evaluate individuals who act morally prior to acting immorally: An examination of developmental change in moral evaluation, social preference, and prediction of moral behaviors.

Recent studies have enthusiastically examined the developmental origin of moral self-licensing, which is a tendency to act immorally after acting morally. However, it has not been considered enough how children evaluate personality traits of individuals who show moral licensing behavior and whether there is any developmental change in this evaluation. This study examined the developmental change in moral evaluation, social preference, and prediction of moral behaviors for moral licensing characters as well as moral or immoral characters. In total, 36 5- and 6-year-old children, 36 7- and 8-year-old children, and 58 university students participated in the study. The results revealed that 7- and 8-year-olds and adults evaluated moral licensing characters as more moral and likable than those who behave immorally, unlike 5- and 6-year-olds, who did not distinguish between the immoral and moral licensing characters. Importantly, 7- and 8-year-olds judged the moral licensing character as neutral in both moral evaluation and judgment of social preference, suggesting that they thought the immoral behavior was canceled out owing to prior moral behavior in the moral licensing character. However, adults still judged the moral licensing character as immoral and dislikable. Moreover, children's prediction of moral behavior for all characters showed the same tendency as moral evaluation, whereas adults' prediction was slightly different from their moral evaluation. Taken together, our findings revealed that the evaluation of individuals who show moral licensing behavior changed developmentally, and a moral licensing effect was found when evaluating others' moral traits from around 7 or 8 years of age.

Travelling beyond time: shared brain system for self-projection in the temporal, political and moral domains.

Mental time travel (MTT), a cornerstone of human cognition, enables individuals to mentally project themselves into their past or future. It was shown that this self-projection may extend beyond the temporal domain to the spatial and social domains. What about higher cognitive domains? Twenty-eight participants underwent functional magnetic resonance imaging (fMRI) while self-projecting to different political, moral and temporal perspectives. For each domain, participants were asked to judge their relationship to various people (politicians, moral figures, personal acquaintances) from their actual or projected self-location. Findings showed slower, less accurate responses during self-projection across all domains. fMRI analysis revealed self-projection elicited brain activity at the precuneus, medial and dorsolateral prefrontal cortex, temporoparietal junction and anterior insula, bilaterally and right lateral temporal cortex. Notably, 23.5% of active voxels responded to all three domains and 27% to two domains, suggesting a shared brain system for self-projection. For ordinality judgement (self-reference), 52.5% of active voxels corresponded to the temporal domain specifically. Self-projection activity overlapped mostly with the frontoparietal control network, followed by the default mode network, while self-reference showed a reversed pattern, demonstrating MTT's implication in spontaneous brain activity. MTT may thus be regarded as a 'mental-experiential travel', with self-projection as a domain-general construct and self-reference related mostly to time. This article is part of the theme issue 'Elements of episodic memory: lessons from 40 years of research'.

Third-party punishment-like behavior in a rat model.

Third-party punishment (TPP) is an altruistic behavior or sense willing to punish transgressors as a third party not directly involved in the transgression. TPP is observed worldwide, regardless of tradition and culture, and is essential for morality in human society. Moreover, even preverbal infants display TPP-like judgement, suggesting that TPP is evolutionarily conserved and innate. Thus, it is possible that non-human animals display TPP-like behavior, although TPP has been said to be human-specific. We investigated whether or not male mature Wistar rats displayed TPP-like behaviors when they witnessed deadly aggression by an unknown aggressive mouse toward another unknown victim mouse. Normally reared rats did not display TPP-like behaviors, but rats reared with extensive affectionate handling by human caretakers as beloved pets contacted the unknown aggressive mice in a gentle manner leading to reduced aggression toward the unknown victim mice, even when the aggressive mice fought back. Furthermore, the handled rats touched unknown rat pups that were drowning in water and anesthesia-induced comatose rats more frequently than control rats. These findings suggest a possibility that TPP is not in fact human-specific and innate but rather an acquired behavior that flourishes in affectionate circumstances.

Association of tooth loss and periodontal disease with all-cause mortality in cancer survivors: A cohort study based on NHANES.

Background: Increasing evidence supports the association between impaired oral health and elevated mortality. However, there is currently a lack of research on the impact of tooth loss and periodontal disease on survival outcomes in cancer survivors. This study aims to clarify the effect of tooth loss and periodontitis on all-cause mortality on cancer survivors. Methods: The clinical data of cancer survivors were collected from National Health and Nutrition Examination Survey (NHANES) 1999-2018. Mortality data were obtained by linking to records in the National Death Index until December 31, 2019. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal threshold for discriminating mortality based on the number of teeth lost. Kaplan-Meier survival curves and Cox regression analysis were performed to calculate hazard ratios (HRs) and 95 % confidence intervals (95 % CI) for tooth loss and periodontitis. Results: A total of 3271 cancer survivors were assessed for tooth loss status, while 1267 patients were evaluated for periodontitis status. The prevalence of any tooth loss and CDC-AAP periodontitis was 83.5 % and 47.2 %, respectively. The ROC curve showed the cut-off point of tooth loss for predicting mortality is > 5. Cancer survivors with tooth loss>5 had significantly lower bone density (1.06 vs. 1.13 g/cm2, P < 0.001), elevated C-reactive protein level (0.3 vs. 0.18 mg/dL, P < 0.001), and a trend of lower lean body mass (46.9 vs. 47.6 kg, P = 0.093). Besides, cancer survivors with severe periodontitis also exhibited elevated C-reactive protein level (0.34 vs. 0.21 mg/dL, P = 0.033). All-cause mortality significantly increased in cancer survivors with either tooth loss>5 (HR = 1.290, P = 0.001) or severe CDC-AAP periodontitis (HR = 1.682, P = 0.016) in the multivariate Cox regression analysis. Conclusion: Tooth loss and periodontitis are strong risk factors for reduced overall survival in cancer survivors. Cancer survivors should emphasize diligent oral hygiene and consistent dental check-ups to optimize long-term oral health. The causal relationship between oral health and survival rates in cancer survivors requires further validation through randomized controlled trials.

A spiking neuron model of moral judgment in trolley dilemmas.

People will make different moral judgments in similar moral dilemmas where one can act to sacrifice some number of lives to save several more. Research has shown that although people can reason that an action would save more lives, automatic processes can overwrite deliberate reasoning. Having participants imagine hypothetical moral dilemmas, researchers have discovered that factors such as action/omission, means/side-effect, and personal/impersonal can affect judgment. Joshua Greene suggests that these features do not affect people's judgment because they are morally relevant but are instead a result of the myopic nature of the automatic moral process. Greene hypothesizes that there is some myopic module or domain-general process that attaches a negative emotional response to an action when one is contemplating violent actions. In the present research a model of this myopic automatic process is paired with an analytic system to replicate deontological and utilitarian responses to moral dilemmas. Our system, MERDJ, models this in simulated spiking neurons. The system takes in representations of specific moral dilemmas as inputs and outputs judgments of appropriate or inappropriate.

Establishment and validation of a nomogram model for prediction of clinical outcomes in patients with amanita phalloides poisoning.

Amanita phalloides poisoning, renowned for its high mortality rates, is one of the most serious food safety issue in certain regions worldwide. Assessment of prognosis and development of more efficacious therapeutic strategies are critical importance for amanita phalloides poisoning patients. The aim of the study is to establish a nomogram to predict the clinical outcome of amanita phalloides poisoning patients based on the independent risk factor for prognosis. Herein, between January 2013 and September 2023, a cohort of 149 patients diagnosed with amanita phalloides poisoning was enrolled and randomly allocated into training and validation cohorts, comprising 102 and 47 patients, respectively. Multivariate logistic regression analysis was performed to identify the independent risk factors for morality of amanita phalloides poisoning patients in training cohort. Subsequently, a nomogram model was constructed to visually display the risk prediction model. The predictive accuracy of nomogram was verified by the validation cohort. The C index, the area under the receiver operating characteristic curve (AUC), and calibration plots were used to assessed the performance of nomogram. The clinical utility was evaluated by decision curve analysis (DCA). In the present study, the results showed that hepatic encephalopathy (HE), upper gastrointestinal bleeding (UGB), AST, and PT were the independent risk factors associated with the mortality of amantia phalloides poisoning patients. We constructed a new nomogram to evaluate the probability of death induced by amantia phalloides poisoning. The AUC for the prediction accuracy of the nomogram was 0.936 for the training cohort and 0.929 for the validation cohort. The calibration curves showed that the predicted probability matched the actual likelihood. The results of the DCA suggested that the nomogram has a good potential for clinical application. In summary, we developed a new nomogram to assess the probability of mortality for amanita phalloides poisoning patients. This nomogram might facilitate clinicians in making more efficacious treatment strategies for patients with amanita phalloides poisoning.

National politics ignites more talk of morality and power than local politics.

Politics and the media in the United States are increasingly nationalized, and this changes how we talk about politics. Instead of reading the local news and discussing local events, people are more often consuming national media and discussing national issues. Unlike local politics, which can rely on shared concrete knowledge about the region, national politics must coordinate large groups of people with little in common. To provide this coordination, we find that national-level political discussions rely upon different themes than local-level discussions, using more abstract, moralized, and power-centric language. The higher prevalence of abstract, moralized, and power-centric language in national vs. local politics was found in political speeches, politician Tweets, and Reddit discussions. These national-level linguistic features lead to broader engagement with political messages, but they also foster more anger and negativity. These findings suggest that the nationalization of politics and the media may contribute to rising partisan animosity.

What do children value more in a collaborator-Problem-solving capacity or fair sharing?

Collaboration requires individuals to find partners who are adept at problem-solving and act fairly when sharing the spoils of joint labor. Given that individuals might vary along both dimensions, it can create a dilemma with the challenging decision of whether to prioritize a potential partner's capacity to perform a task or the partner's level of fairness in sharing obtained resources. Here we tested whether young children can solve this dilemma when two potential partners have opposing qualities: One partner is high in the capacity to solve a problem but less likely to share fairly, whereas the other partner is lower in capacity but fair. In two studies with a total of N = 188 children aged 4 to 6 years, we found that children adjust their decisions based on the social context and the perceived difficulty of the collaborative task: Children show an overall preference for fair partners when collaborating in an easy task, but they choose partners high in problem-solving capacity and low in fairness when collaborating in a more difficult task. These results show that already young children can evaluate others along two dimensions and make trade-offs between capacity and fairness when deciding what is more relevant for a given situation.

Understanding empathy and De Waal's contribution within the fields of social neurosciences.

This review delves into the remarkable career and scientific contributions of Frans de Waal, a renowned figure in the field of ethology, primatology with important implications for the field of social neurosciences. Rooted in the Dutch tradition of ethology, influenced by luminaries like Niko Tinbergen and Jan Van Hooff, De Waal's career began with groundbreaking research on chimpanzees, which questioned long-held beliefs about dominance and aggression in animal behavior. His work, epitomized in his influential books, such as "Chimpanzee Politics", "The ape and the sushi master", "The age of empathy", not only revolutionized scientific thinking but also ignited discussions about empathy, morality, and complex cognitive functions in animals. De Waal's interdisciplinary approach extended to neuroscience, particularly in understanding empathy, contributing to the development of an original model: the Perception-Action Model (PAM). The fundamental concept of PAM is that even the most intricate forms of empathy stem from basic neural mechanisms of action-perception, such as mirror neurons. Some behavioral phenomena like motor mimicry and emotional contagion arise from a direct neuroanatomical network activity where sensory information about others' emotional states triggers corresponding behavioral responses. Intriguingly, even the most intricate forms of empathy such as concern, consolation and targeted helping, may have evolved from basic neural mechanisms of action-perception.Through these investigations and theoretical explorations, he advocated for a bottom-up approach to comprehending the cognitive abilities of animals. This approach challenged conventional anthropocentric perspectives and underscored the interconnected emotional and cognitive terrain shared among humans and other species. Beyond academia, De Waal's work has profound implications for how we perceive and interact with animals. By debunking notions of human exceptionalism, he highlights the rich tapestry of emotions that bind all living beings. Through his efforts, De Waal has not only advanced our scientific understanding of animal minds but also fostered a more profound appreciation for the depth of emotional connections across species.

Selective cultural adoption: The roles of warmth, competence, morality and perceived indispensability in majority-group acculturation.

Psychological research has begun considering the dynamics involved in majority-group acculturation, which is the extent to which cultural majority groups adopt the culture of immigrants and minority groups. However, previous research has predominantly concentrated on reactions to 'immigrants' or 'minority groups' as a homogenous entity, overlooking the nuanced perceptions and varied valuations attributed to different groups. Recognizing the heterogeneity among immigrant and minority groups, the present work investigated the influence of several perceived characteristics of immigrant and minority groups on majority-group members' adoption of their cultures. Specifically, in three pre-registered studies-one correlational (Nparticipants = 201, Ntrials = 2814) and two within-subjects experimental (Nparticipants = 144 and 146, Ntrials = 720 and 730) designs with close to politically representative samples from the U.K. and U.S.  -majority-group members were more willing to adopt immigrant and minority-group cultures that they perceived as warm, competent and moral because these perceptions made immigrants and minority groups seem indispensable to the identity and economy of the mainstream society. Our studies highlight the importance of considering the differentiated acculturation that majority-group members have to various groups within the same national context. We discuss the societal and cultural repercussions of this selective uptake of other cultures.

Linking obsessions to morality: A cross-cultural study among Turkish and Belgian university students.

The present study examines the links between different types of morality and obsessions in university students from Leuven, Belgium (N = 252) and Istanbul, Turkey (N = 301) using validated scales for morality and obsessions. Belgium and Turkey were chosen as two exemplar cultural contexts expected, and in the current study found, to differ in the relative levels of individualizing and binding morality. We hypothesized that obsessions involving potential harm (e.g., aggressive obsessions) are cross-culturally associated with individualizing morals, and obsessions indicating impurity (e.g., contamination) are cross-culturally associated with binding morals. Moreover, we expected that cultural differences in the frequency of obsessions could be linked to differences in culturally prevalent moralities. As predicted, contamination obsessions were cross-culturally linked to binding morals. Also, the frequency of contamination obsessions was higher in the Turkish sample compared to the Belgian, which was predicted by higher levels of binding morals in Turkey. Doubts were cross-culturally endorsed at similar rates and were associated with individualizing morals. Aggressive obsessions were relatively more frequent in the Belgian compared to the Turkish sample, however-unexpectedly-these intrusions were not positively linked to either type of morality, neither in Belgium nor in Turkey. Taken together, these findings provide initial support for the role of morality in obsessive-compulsive disorder (OCD), at least for certain types of obsessions (contamination and doubts), as well as suggest that some differences in the moral foundations may play a role in explaining the prevalence of certain obsessions (i.e., contamination).

From Non-Traditional Sexual Behavior to Non-Legitimate Victims: Moral Virtue, Victim Blame, and Helping Intentions Toward a Woman Victim of Image-Based Sexual Abuse.

Image-based sexual abuse represents an increasingly common form of gender-based violence, consisting of the act of non-consensually capturing, distributing, or threatening to distribute sexually explicit material depicting another person. The purpose of the present study was to investigate how women victims' noncompliance with traditional female sexuality influences bystanders' perceptions of the phenomenon. Specifically, we experimentally examined whether a woman's sexual agency (high vs. low) and the length (steady vs. transient) of the relationship with the perpetrator affected her moral evaluation, victim blaming, and participants' willingness to support her. A sample of 597 adults (65.7% women, Mage = 31.29 years) took part in the study. The findings indicated that while a transient (vs. steady) relationship with the perpetrator significantly lowered the woman's perceived moral virtue and increased the extent to which she was blamed for the incident, a high (vs. low) woman's sexual agency decreased participants' helping intentions towards her. Additionally, results showed that men were less likely than women to attribute moral virtue and help the victim. Lastly, through the mediation of moral virtue and victim blaming, the length of the relationship indirectly influenced participants' helping intentions.

Modular morals: Mapping the organization of the moral brain.

Is morality the product of multiple domain-specific psychological mechanisms, or one domain-general mechanism? Previous research suggests that morality consists of a range of solutions to the problems of cooperation recurrent in human social life. This theory of 'morality as cooperation' suggests that there are (at least) seven specific moral domains: family values, group loyalty, reciprocity, heroism, deference, fairness and property rights. However, it is unclear how these types of morality are implemented at the neuroanatomical level. The possibilities are that morality is (1) the product of multiple distinct domain-specific adaptations for cooperation, (2) the product of a single domain-general adaptation which learns a range of moral rules, or (3) the product of some combination of domain-specific and domain-general adaptations. To distinguish between these possibilities, we first conducted an anatomical likelihood estimation meta-analysis of previous studies investigating the relationship between these seven moral domains and neuroanatomy. This meta-analysis provided evidence for a combination of specific and general adaptations. Next, we investigated the relationship between the seven types of morality - as measured by the Morality as Cooperation Questionnaire (Relevance) - and grey matter volume in a large neuroimaging (n = 607) sample. No associations between moral values and grey matter volume survived whole-brain exploratory testing. We conclude that whatever combination of mechanisms are responsible for morality, either they are not neuroanatomically localised, or else their localisation is not manifested in grey matter volume. Future research should employ phylogenetically informed a priori predictions, as well as alternative measures of morality and of brain function.