Peptide-Alkoxyamine Drugs: An Innovative Approach to Fight Schistosomiasis: "Digging Their Graves with Their Forks".

The expansion of drug resistant parasites sheds a serious concern on several neglected parasitic diseases. Our recent results on cancer led us to envision the use of peptide-alkoxyamines as a highly selective and efficient new drug against schistosome adult worms, the etiological agents of schistosomiasis. Indeed, the peptide tag of the hybrid compounds can be hydrolyzed by worm's digestive enzymes to afford a highly labile alkoxyamine which homolyzes spontaneously and instantaneously into radicals-which are then used as a drug against Schistosome adult parasites. This approach is nicely summarized as digging their graves with their forks. Several hybrid peptide-alkoxyamines were prepared and clearly showed an activity: two of the tested compounds kill 50% of the parasites in two hours at a concentration of 100 µg/mL. Importantly, the peptide and alkoxyamine fragments that are unable to generate alkyl radicals display no activity. This strong evidence validates the proposed mechanism: a specific activation of the prodrugs by the parasite proteases leading to parasite death through in situ alkyl radical generation.

Research on domain ontology construction based on the content features of online rumors.

Online rumors are widespread and difficult to identify, which bring serious harm to society and individuals. To effectively detect and govern online rumors, it is necessary to conduct in-depth semantic analysis and understand the content features of rumors. This paper proposes a TFI domain ontology construction method, which aims to achieve semantic parsing and reasoning of the rumor text content. This paper starts from the term layer, the frame layer, and the instance layer, and based on the reuse of the top-level ontology, the extraction of core literature content features, and the discovery of new concepts in the real corpus, obtains the core classes (five parent classes and 88 subclasses) of the rumor domain ontology and defines their concept hierarchy. Object properties and data properties are designed to describe relationships between entities or their features, and the instance layer is created according to the real rumor datasets. OWL language is used to encode the ontology, Protégé is used to visualize it, and SWRL rules and pellet reasoner are used to mine and verify implicit knowledge of the ontology, and judge the category of rumor text. This paper constructs a rumor domain ontology with high consistency and reliability.

Mainstream partial Anammox for improving nitrogen removal from municipal wastewater after organic recovery via magnetic separation.

Total nitrogen (TN) removal from municipal wastewater after organic recovery is challenging because of the low ratio of chemical oxygen demand (COD) to TN. Anaerobic ammonium oxidation (Anammox) is promising because it has no organic requirement, but its performance in treating effluents following COD captured remains unclear. This study used mainstream partial Anammox to remove nitrogen from effluent following magnetic separation within a continuous-flow anoxic-oxic reactor. Compared with traditional nitrification and denitrification, partial Anammox increased TN removal efficiency by 15.0% and contributed 23.6% of TN removal. Quantitative polymerase chain reaction revealed that the copy number of the Anammox gene (hzsB) increased substantially, while those of the nitrite oxidation (nxrA) and denitrification (narG and nirS) genes decreased. High-throughput sequencing identified Candidatus Brocadia as the dominant genus of anaerobic ammonium-oxidizing bacteria. These findings demonstrate the effectiveness of mainstream partial Anammox for treating COD-captured effluents and its potential in municipal wastewater treatment.

'Rapid Counseling' with single-session therapy for patients with COVID-19: An alternative treatment before doing mental health self-care strategy with meditation.

The author suggests that mental health experts provide 'rapid counseling' as psychological help for individuals who need counseling in this COVID-19 outbreak, as one of the steps to be taken to get rid of this national and global crisis, in particular for patients with COVID-19.

Influence of painless delivery on the maternal and neonatal outcomes under the guidance of new concept of labor.

OBJECTIVE: To explore the possible influence of painless delivery on the maternal and neonatal outcomes under the guidance of new concept of labor. METHODS: Primiparas who received painless delivery in our hospital were selected for this retrospective clinical study. They were divided into two groups, the experimental group and the control group. The experimental group received painless delivery with the application of new labor management, while the control group received painless delivery with the application of routine labor management. The maternal and neonatal outcomes (postpartum hemorrhage, postpartum urinary retention, fetal distress and neonatal asphyxia), the duration of first and second stages of labor, the total duration of labor, medical intervention during first stage of labor such as artificial rupture of membranes or the use of oxytocin, visual analog scale (VAS) scores upon complete cervical dilation, delivery method and maternal satisfaction rate were compared between the two groups. RESULTS: Among the 208 primiparas, 112 cases were enrolled in the control group and 96 cases in the experimental group. There were no significant differences in the incidences of postpartum hemorrhage, postpartum urinary retention, fetal distress and neonatal asphyxia between the two groups (all P>0.05). The duration of first and second stages of labor and the total duration of labor in the control group were shorter than those in the experimental group (all P<0.001). The rates of artificial rupture of membranes and intravenous use of oxytocin in the control group were higher than those in the experimental group (both P<0.05). The VAS scores upon complete cervical dilation in the control group were significantly higher than those in the experimental group (P<0.05). The vaginal delivery and maternal satisfaction rates were significantly lower in the control group than in the experimental group (both P<0.05). CONCLUSION: Painless delivery under the guidance of new concept of labor has no significant influence on the maternal and neonatal outcomes. Instead, it can prolong the labor process, provide more delivery time for pregnant women, reduce the intervention measures during delivery, decrease the delivery pain and finally increase the natural delivery rate and their satisfaction with delivery, which is worth wide promotion in clinical practice.

No Arachnoid Granulations-No Problems: Number, Size, and Distribution of Arachnoid Granulations From Birth to 80 Years of Age.

Introduction: The study aims to quantify changes in the number, size, and distribution of arachnoid granulations during the human lifespan to elucidate their role in cerebrospinal fluid physiology. Material and Methods: 3T magnetic resonance imaging of the brain was performed in 120 subjects of different ages (neonate, 2 years, 10 years, 20 years, 40 years, 60 years, and 80 years) all with the normal findings of the cerebrospinal fluid system (CSF). At each age, 10 male and 10 female subjects were analyzed. Group scanned at neonatal age was re-scanned at the age of two, while all other groups were scanned once. Arachnoid granulations were analyzed on T2 coronal and axial sections. Each arachnoid granulation was described concerning size and position relative to the superior sagittal, transverse, and sigmoid sinuses and surrounding cranial bones. Results: Our study shows that 85% of neonates and 2-year-old children do not have visible arachnoid granulations in the dural sinuses and cranial bones on magnetic resonance imaging. With age, the percentage of patients with arachnoid granulations in the superior sagittal sinus increases significantly, but there is no increase in the sigmoid and transverse sinuses. However, numerous individuals in different age groups do not have arachnoid granulations in dural sinuses. Arachnoid granulations in the cranial bones are found only around the superior sagittal sinus, for the first time at the age of 10, and over time their number increases significantly. From the age of 60 onwards, arachnoid granulations were more numerous in the cranial bones than in the dural sinuses. Conclusion: The results show that the number, size, and distribution of arachnoid granulations in the superior sagittal sinus and surrounding cranial bones change significantly over a lifetime. However, numerous individuals with a completely normal CSF system do not have arachnoid granulations in the dural sinuses, which calls into question their role in CSF physiology. It can be assumed that arachnoid granulations do not play an essential role in CSF absorption as it is generally accepted. Therefore, the lack of arachnoid granulations does not appear to cause problems in intracranial fluid homeostasis.

Research on the Resilience Evaluation and Spatial Correlation of China's Sports Regional Development Under the New Concept.

In order to fully implement the new development concept, bring into full play the potential of sports development, and maintain the resilience of China's sports development. This paper studies the resilience evaluation and spatial correlation of Chinese sports development under the new development concept. First, we constructed Resilience Evaluation Indexes System for Sports Development in China based on the analysis of the resilience features of sports development and the DPSIR model, which is from the five aspects of "driving force - pressure - state - influence - response." Second, used Coefficient of Variation and Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) Method to measure the resilience level of sports development in 31 provinces in China from 2013 to 2017. Then, we introduced the obstacle degree model to identify the obstacle factors that hinder the resilience of Chinese sports development in different periods. Finally, we used the global and local Moran indexes to analyze the spatial correlation of China sports regional development. The results showed that: (1) overall, the development level of sports resilience in 31 provinces in China showed an upward trend from 2013 to 2017, while some provinces showed obvious fluctuations. (2) The obstacles to the development of sports resilience in China mainly include sports scientific research equipment, the number of national fitness monitoring stations, the number of national fitness centers, the full-time equivalent of (R&D) personnel, and the number of sports scientific research projects. The response subsystem is the main obstacle factor that affects the improvement of the resilience level of sports development in China. (3) There is a positive spatial autocorrelation between the resilience level of sports development and regional spatial distribution, and the correlation shows a weakening trend, and the internal difference is significant. Finally, we concluded that we must take the new development philosophy as the guiding principle. First, we should stick to innovation-driven development to fully upgrade the resilience of China's sports development. Second, we should adhere to the principle of coordinated development to promote the overall and balanced development of sports. Lastly, we should promote shared development so as to deliver benefits for all in an equal way.

New Concept of Power Generation Using TEGs: Thermal Modeling, Parametric Analysis, and Case Study.

In this manuscript, an innovative concept of producing power from a thermoelectric generator (TEG) is evaluated. This concept takes advantage of using the exhaust airflow of all-air heating, ventilating, and air-conditioning (HVAC) systems, and sun irradiation. For the first step, a parametric analysis of power generation from TEGs for different practical configurations is performed. Based on the results of the parametric analysis, recommendations associated with practical applications are presented. Therefore, a one-dimensional steady-state solution for the heat diffusion equation is considered with various boundary conditions (representing applied configurations). It is revealed that the most promising configuration corresponds to the TEG module exposed to a hot fluid at one face and a cold fluid at the other face. Then, based on the parametric analysis, the innovative concept is recognized and analyzed using appropriate thermal modeling. It is shown that for solar radiation of 2000 W/m2 and a space cooling load of 20 kW, a 40 × 40 cm2 flat plate is capable of generating 3.8 W of electrical power. Finally, an economic study shows that this system saves about $6 monthly with a 3-year payback period at 2000 W/m2 solar radiation. Environmentally, the system is also capable of reducing about 1 ton of CO2 emissions yearly.

Essential concepts are missing: Foreign DNA in food invades the organisms' cells and can lead to stochastic epigenetic alterations with a wide range of possible pathogenetic consequences.

In this article, a new concept for general pathogenesis has been proposed. Advances in molecular genetics have led to the realization that essential concepts in the framework of molecular biology are still missing. Clinical medicine is plagued by similar shortcomings: The questioning of current paradigms could open new vistas and invite challenging approaches. This article presents an unconventional idea. Foreign DNA which is regularly ingested with the essential food supply is not completely degraded. Small quantities of fragmented DNA rather persist transiently in the gastro-intestinal tract of mice and can be traced to various organ systems, except for cells in the germ line. Foreign DNA entering and persisting in mammalian cells can stochastically lead to genome-wide alterations of transcriptional and CpG DNA methylation profiles. In the course of food-ingested DNA invading somatic cells, completely new cell types can be generated which might be involved in the causation of common ailments. Projects emanating from this perception merit critical analysis and rigorous pursuit.

A new concept of advanced management of hazardous waste in the Republic of Korea.

In order to activate the recycling of hazardous wastes, the hazardous characteristics of wastes should be removed or stabilized. However, most recyclers in recycling companies do not understand how to remove the hazardous characteristics in wastes with the proper technology. The aim of a new form of advanced management of hazardous waste is to inform recyclers and operators in industries about hazardous characteristics and the treatment methods required for all management processes, from waste generation to final treatment. In a new method of advanced management of hazardous wastes, chemicals in the waste should be initially examined at the generation source in each industry to create a chemical catalogue. Since hazardous characteristics can be determined by a chemical catalogue obtained from the waste, the hazardous characteristics of wastes can be established and considered when choosing the proper treatment method. Then, the categories of waste treatment methods for each hazardous characteristic can be introduced for generators to treat hazardous wastes properly. Therefore, it is possible to create a link between the source and the final treatment of hazardous wastes using a new concept of industry (In), waste (W), hazardous chemicals and their hazardous characteristics (Ha) and treatment methods (T). This new concept of the "InWhat" system, which includes all management processes in Korea, from waste generation to final treatment, will be proposed as a tool in the advanced management of hazardous wastes.

Injury effect of navy new concept weaponry on combatants and its medical prevention / 第二军医大学学报

New concept weaponry have much greater damage effects than traditional weaponry, not only destroying military equipment and communication systems, but also severely injurying combatants. Typical new concept weaponry, including shipborne laser weapons, electromagnetic pulse weapons and infrasonic weapons, holds destructive power by special light, sound, or electromagnetic wave. This paper expounds the injury effects of new concept weapons on combatants and its medical protection measures, so as to provide reference for the health service support under the condition of new concept weapons.

[New-concept animal vaccines emerging in recent years].

Animal infectious diseases pose a serious and continuing threat to the animal health and cause huge economic losses throughout the world. Vaccination is one of the most effective solutions to prevent and control animal infectious diseases. With the development of biotechnologies and the need for disease prevention and control, the focus of vaccine research has been shifted to the development of safe, efficient, broad-spectrum, low-dose and marker vaccines. Novel vaccines capable of inducing high levels of both humoral and cellular immune responses are promising to provide more efficient protection against animal infectious diseases. This minireview summarizes the development, applications, advantages and disadvantages of new-concept animal vaccines emerging in recent years, including mucosal vaccines, long-acting and fast-acting vaccines, chimeric vaccines, nanoparticle vaccines, and so on. Furthermore, we discuss future directions of the vaccines, in order to provide new insights for animal vaccine development.

[New method for evaluating pharmacodynamics of traditional Chinese medicine compounds based on its moderate regulation and principle of balanced adjustment of immunity under pan-immunomic].

For the basic research on the traditional Chinese medicine(TCM), objective syndrome of traditional Chinese medicine and evaluation criteria of traditional Chinese medicine compounds are hardly to break though. While, the modern immunology points out that the body is a counterbalance state and immune imbalance is the root of sickness. The thinking mode of treating diseases in traditional Chinese medicine is also "balance", considering disease is the result of bias which present the imbalance of "Yin counters Yang", "exterior counters interior", "cold counters heat" and "weak counters strong". The Chinese herbal compound formula preparation was applied on disease therapy based on theory of Chinese medicine, which was confirmed by long period clinical application. It is composed of multi-compounds and has the characteristic of multi-targeting. Integrative medicine has spawned pan-immunomics, and the evaluation of immune function (immune balance) has become an important basis for diagnosis and treatment models of integrative medicine. In addition, balance is the core idea of whole-systemic conception of traditional Chinese medicine. Therefore, we speculate that immune balance under pan-immunomic can bridge the traditional Chinese medicine and modern integrative medicine and is the important basis for objective syndrome of traditional Chinese medicine and evaluation criteria of traditional Chinese medicine compounds. According to the bridging theory, we attempt to utilize informatics and statistical methods to construct an evaluation system for pharmacodynamics of traditional Chinese medicine based on its moderate regulation and the balanced adjustment of immunity under pan-immunomic, which further reveal the scientific essence of the whole-systemic view of traditional Chinese medicine. This research brings out a new valuable strategy and provides a theoretical basis for accelerating the transformation of traditional Chinese medicine, especially the exploitation of Chinese herbal compound formula, and constructing the new drug innovation and review system for traditional Chinese medicine. Besides as a reference for traditional Chinese medicine objective syndrome and pharmacodynamics of traditional Chinese medicine compounds, the evaluation system can screen the immunity of sub-health population also. With the continuous accumulation of clinical sample and data, the evaluation system will be more accurate and intelligent.

[The 10th Annual Meeting of the Japanese Society for Pharmaceutical Palliative Care and Sciences].

　The 10th Annual Meeting of the Japanese Society for Pharmaceutical Palliative Care and Sciences was held at Act City Hamamatsu, Japan, with a total of 2634 participants in attendance. The theme of the meeting was realized through a number of new concepts, such as a debate symposium, information sessions, nurses' workshops, and so on. The results obtained from the participation questionnaire (n=438), which were aggregated up to 1 month following the end of this year's meeting, revealed that 89% of the participants at considered it to have been appealing. In particular, 63% of the participants favored the adoption of a debate symposium whereby it was possible to ask and respond to questions in real time. In the free comments section of the questionnaire, the participants expressed how they felt the debate symposium made it easy to give their opinions, and that this element might be further developed in the future. They also stated that they found the introduction of the Clica system effective in terms of making the annual meeting an active learning place. One issue that was highlighted concerned the observation that the hall used to host the symposium was designed as a concert venue, which meant it was highly shielded from the outside environment, in addition to access to the internet being blocked. I hope that many of the projects from this Annual Meeting will serve to guide the future style of the Society's Annual Meetings.

New-concept animal vaccines emerging in recent years / 生物工程学报

Animal infectious diseases pose a serious and continuing threat to the animal health and cause huge economic losses throughout the world. Vaccination is one of the most effective solutions to prevent and control animal infectious diseases. With the development of biotechnologies and the need for disease prevention and control, the focus of vaccine research has been shifted to the development of safe, efficient, broad-spectrum, low-dose and marker vaccines. Novel vaccines capable of inducing high levels of both humoral and cellular immune responses are promising to provide more efficient protection against animal infectious diseases. This minireview summarizes the development, applications, advantages and disadvantages of new-concept animal vaccines emerging in recent years, including mucosal vaccines, long-acting and fast-acting vaccines, chimeric vaccines, nanoparticle vaccines, and so on. Furthermore, we discuss future directions of the vaccines, in order to provide new insights for animal vaccine development.

New method for evaluating pharmacodynamics of traditional Chinese medicine compounds based on its moderate regulation and principle of balanced adjustment of immunity under pan-immunomic / 中国中药杂志

For the basic research on the traditional Chinese medicine(TCM), objective syndrome of traditional Chinese medicine and evaluation criteria of traditional Chinese medicine compounds are hardly to break though. While, the modern immunology points out that the body is a counterbalance state and immune imbalance is the root of sickness. The thinking mode of treating diseases in traditional Chinese medicine is also "balance", considering disease is the result of bias which present the imbalance of "Yin counters Yang", "exterior counters interior", "cold counters heat" and "weak counters strong". The Chinese herbal compound formula preparation was applied on disease therapy based on theory of Chinese medicine, which was confirmed by long period clinical application. It is composed of multi-compounds and has the characteristic of multi-targeting. Integrative medicine has spawned pan-immunomics, and the evaluation of immune function (immune balance) has become an important basis for diagnosis and treatment models of integrative medicine. In addition, balance is the core idea of whole-systemic conception of traditional Chinese medicine. Therefore, we speculate that immune balance under pan-immunomic can bridge the traditional Chinese medicine and modern integrative medicine and is the important basis for objective syndrome of traditional Chinese medicine and evaluation criteria of traditional Chinese medicine compounds. According to the bridging theory, we attempt to utilize informatics and statistical methods to construct an evaluation system for pharmacodynamics of traditional Chinese medicine based on its moderate regulation and the balanced adjustment of immunity under pan-immunomic, which further reveal the scientific essence of the whole-systemic view of traditional Chinese medicine. This research brings out a new valuable strategy and provides a theoretical basis for accelerating the transformation of traditional Chinese medicine, especially the exploitation of Chinese herbal compound formula, and constructing the new drug innovation and review system for traditional Chinese medicine. Besides as a reference for traditional Chinese medicine objective syndrome and pharmacodynamics of traditional Chinese medicine compounds, the evaluation system can screen the immunity of sub-health population also. With the continuous accumulation of clinical sample and data, the evaluation system will be more accurate and intelligent.

Establishment of Modern Basic Theory of Traditional Chinese Medicine, Part Ⅰ New Concept:Theoretical Premise, Reveal Connotation of Concept Towards Modern Science / 世界科学技术-中医药现代化

Editor's Notes: The basic theory of traditional Chinese medicine is the theoretical foundation of Chinese medicine , modernization of Chinese medicine needs of the modern theory of Chinese medicine urgently . However , it is always the important issues about how modern Chinese medicine theory should be created , and what kind of theory should have been established concerned and explored by domestic and foreign counterparts in tradi-tional Chinese medicine . To lead the development of modern Chinese medicine theory , Modern Basic Theory of Traditional Chinese Medicine series of symposiums are set up specially in the current Review column, and discussed thoroughly and systematically using three consecutive pats respectively. Among them, part I contains 3 articles about new concepts, new theories, new disciplines; part II contains 5 articles about new ideas, new norms, how to clear concept, how to verify hypotheses, why to evaluate theory; part III contains 12 articles about concept of wholism updating, treatment based on syndrome differentiation development, viscera-state doc-trine innovation, pathogeny, etiology, pathogenesis, prevention, principle of treatment, knowledge structure, cogni-tion structure , monographic study , 5-year outlook . Published article on this issue is the first one belong to new concept of part I. In this paper, we want to describe the denotation and connotation of the new concept of the modern basic theory of traditional Chinese medicine from three aspects of a concept: a label , a theoretical definition , and an operational definition learning from the international academic understanding of scientific concepts, demonstrate the necessity of theoretical premise to the research and establishment of the modern basic theory of traditional Chinese medicine and the need to build on , illustrate the inevitable trend toward modern science . The whole article contains profound meaning and a certain breakthrough and innovation. We are expected to cause concerns and discusses of experts and scholars through this article .

Study on development strategy of medical and biological techniques correlating with medical protection against New Concept Weapons / 第三军医大学学报

Objective To evaluate the key role of development of medical and biological techniques correlating with medical protection against New Concept Weapons(NCWs) and put forward a development strategy in medical protection against NCWs. Methods Data on the present medical techniques protecting against NCWs were obtained by tracing references. On the basis of analyzing and studying the obtained data, an evaluation was made by consulting experts, system analysis, scientific selection, clustering analysis and policy analysis. Results The correlation coefficients correlation, indexes and scores in the present progress of 36 techniques were determined. Furthermore, the evaluation was made. Conclusion Different developing strategy should be taken in accordance with the important and the present research on medical and biological techniques correlating with medical protection against NCWs. This study will give us some advice on protecting against NCWs in medicine.

A BRIEF INQUIRY INTO HIGHTECH WEAPON INJURIES / 解放军医学杂志

Solving the problem of weapon injuries is of primary importance in military medical research. This article aims at presenting an inquiry into hightech weapon injuries in terms of the following: (1)classify hightech weapons into special, hightech conventional and new concept weapons, and expound their characteristics; (2)demonstrate from different angles the pressing necessity to step up researches on special (nuclear, chemical and biological) weapons; (3)discuss the types and injurious effects (high speed projectiles, war heads with numerous shrapnels and cluster bomb, multiple killing factors and high casualty inflicting power) of the everlastingly emerging hightech conventional weapons, and multiple injuries, and combined injuries produced thereby; (4)probe into new concept weapons, mainly the beamed (laser, microwave and infrasound) and non lethal weapon injuries; (5)bring up the question of confrontation of hightech weapons′ in the space in the future; (6)explore the tactics in four levels to confront hightech weapons, and research on medical protection against hightech weapon injuries in terms of basic sciences, medical logistics, and medical equipments.