[Analysis of causes or reasons that fragment sleep and sleep disorder in pregnant and non-pregnant women] / Análisis de causas o motivos que fragmentan el sueño y los trastornos del sue-ño, en mujeres embarazadas y no embarazadas.

Introduction: During pregnancy, sleep undergoes important changes. The objective was to assess the causes or reasons that fragment sleep and sleep disorders in different women and trimesters of pregnancy, comparing them with those of non-pregnant women (NPW). Methods: Cross-sectional study. Anonymous surveys were used to evaluate reasons that fragment sleep and specific questionnaires to evaluate sleep disorders. Results: Pregnant Women (PW)= 320. 1st Trimester of pregnancy (T): n = 106, 2nd. T: n = 104, 3rd T: n = 110. MNE: n = 304. Most frequent reasons that fragmented sleep, statistically significant in PW and were: need to urinate, uncomfortable position, not being able to rotate in bed. As sleep disorders we find: nightmares 44 vs 4.9%; snoring with pauses: 31 vs 3%. Conclusion: We found that in the PW studied, most of the causes or reasons analyzed fragmented sleep; they had more sleep disorders such as nightmares, respiratory disorders and periodic leg movements, in that order, compared to the NPW who in turn, presented insomnia, excessive sleepiness and bruxism.

Introducción: Durante la gestación, el sueño sufre cambios importantes. El objetivo fue evaluar causas o motivos que fragmentan el sueño y los trastornos del sueño en diversas mujeres y trimestres de embarazo, comparándolos con los de las mujeres no embarazadas (MNE). Métodos: Estudio de corte transversal. Se utilizó encuestas anónimas, para evaluar motivos que fragmentan el sueño y cuestionarios específicos para evaluar trastornos del sueño. Resultados: Mujeres Embarazadas (ME)= 320. 1er Trimestre de embarazo (T): n = 106, 2do. T: n = 104, 3er T: n = 110. MNE: n = 304. Motivos más frecuentes que fragmentan el sueño, se presentó en ME y fueron: necesidad de orinar, posición incómoda, no poder rotar en la cama. Como trastornos del sueño encontramos: pesadillas 44 vs 4.9%; ronquidos con pausas: 31 vs 3%. Conclusión: En las mujeres embarazadas estudiadas, la mayoría de las causas o motivos analizados fragmentaron el sueño; tuvieron más desórdenes del sueño como pesadillas, trastornos respiratorios y movimientos periódicos de piernas, comparados con las no embarazadas; quienes a su vez, presentaron insomnio, somnolencia excesiva y bruxismo.

Using Prazosin to Treat Posttraumatic Stress Disorder and Associations: A Systematic Review.

OBJECTIVE: A central adrenergic hyperactivation is described in the neurobiology of posttraumatic stress disorder (PTSD) with probable variable symptomatic impact. Few studies have evaluated using the alpha-1 adrenergic antagonist prazosin for such symptoms; however, given the likely pathophysiology involved, this drug may play an important role in the pharmacological approach to PTSD. METHODS: This study assessed articles already published on the use of prazosin through a systematic review along a timeline in view of the symptomatic target of difficult access by standardized treatments. The impact of using this medication for the general symptoms of PTSD is also discussed. Several databases were searched for articles in the literature on the use of prazosin to treat PTSD. RESULTS: A total of 168 articles were found containing search terms in the title or abstract. Overall, 85 articles met the criteria described, and 48 studies were explored to conduct the present systematic review. Most articles showed some improvement after prazosin administration, especially in relation to sleep symptoms (nightmares and night waking). Only one article demonstrated no improvement after the use of this drug. More randomized studies are needed. CONCLUSION: Several clinical studies demonstrated the relevant role of prazosin for treating PTSD symptoms. Prazosin is an affordable and cost-effective pharmacological option compared to other drugs used to treat PTSD.

Longitudinal associations of nightmare frequency and nightmare distress with suicidal behavior in adolescents: mediating role of depressive symptoms.

STUDY OBJECTIVES: Nightmares are a significant risk factor of suicidal behavior. This study examined the longitudinal associations of nightmare frequency and distress with suicidal thought (ST), suicide plan (SP), and suicide attempt (SA) and mediating role of depressive symptoms in adolescents. METHODS: A total of 6,923 adolescents who participated in the 1-year follow-up of Shandong Adolescent Behavior & Health Cohort were included for the analysis. Participants completed a self-administered questionnaire to assess nightmares, sleep duration, insomnia, depressive symptoms, substance use, prior suicidal behavior, and family demographics in November-December in 2015. One year later, a follow-up survey was conducted to ask participants to report their depressive symptoms and suicidal behaviors. RESULTS: Of the sample, 26.2% reported having frequent nightmares (at least twice/month) at baseline, and 10.0%, 3.6%, and 2.7% reported having ST, SP, and SA over 1-year follow-up. The rates of subsequent ST, SP, and SA all significantly increased with baseline nightmare frequency and distress. Path analyses showed that depressive symptoms played a significant mediating role in the associations of frequent nightmares and elevated nightmare distress with ST, SP, and SA before and after adjusting for adolescent and family covariates and prior suicidal behavior. CONCLUSIONS: Suicidal risk increased with nightmare frequency and distress among adolescents. The association between nightmares and suicidal behavior was at least partially mediated by depressive symptoms. Assessing and intervening nightmares and depressive symptoms associated with nightmares may have important implications for preventing adolescent suicidal behavior.

Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series.

OBJECTIVES: Cannabidiol (CBD) is a non-psychotomimetic cannabinoid compound that is found in plants of the genus Cannabis. Preclinical research has suggested that CBD may have a beneficial effect in rodent models of post-traumatic stress disorder (PTSD). This effect is believed to be due to the action of CBD on the endocannabinoid system. CBD has seen a recent surge in research regarding its potential value in a number of neuro-psychiatric conditions. This is the first study to date examining the clinical benefit of CBD for patients with PTSD. METHODS: This retrospective case series examines the effect of oral CBD administration on symptoms of PTSD in a series of 11 adult patients at an outpatient psychiatry clinic. CBD was given on an open-label, flexible dosing regimen to patients diagnosed with PTSD by a mental health professional. Patients also received routine psychiatric care, including concurrent treatment with psychiatric medications and psychotherapy. The length of the study was 8 weeks. PTSD symptom severity was assessed every 4 weeks by patient-completed PTSD Checklist for the DSM-5 (PCL-5) questionnaires. RESULTS: From the total sample of 11 patients, 91% (n = 10) experienced a decrease in PTSD symptom severity, as evidenced by a lower PCL-5 score at 8 weeks than at their initial baseline. The mean total PCL-5 score decreased 28%, from a mean baseline score of 51.82 down to 37.14, after eight consecutive weeks of treatment with CBD. CBD was generally well tolerated, and no patients discontinued treatment due to side effects. CONCLUSIONS: Administration of oral CBD in addition to routine psychiatric care was associated with PTSD symptom reduction in adults with PTSD. CBD also appeared to offer relief in a subset of patients who reported frequent nightmares as a symptom of their PTSD. Additional clinical investigation, including double-blind, placebo-controlled trials, would be necessary to further substantiate the response to CBD that was observed in this study.

Las pesadillas como un síntoma clave para el diagnóstico de la psicopatología posaborto / Nightmares as a key symptom in diagnosing post-abortion psychopathology

Reactions to severe stress and adjustment disorders may go unnoticed if their symptoms are not related to the original traumatic situation; they may be masked by different psychosomatic complaints or mistaken for other mental disorders. If the disorder goes undiagnosed, the treatment and the psychotherapeutic approach will not be effective, resulting in chronicity and treatment resistance. Therefore, in order to achieve the desired diagnosis, besides the comprehensive assessment of disturbances, it was of great help to explore a symptom which, although frequently reported by patients, can go unnoticed in the psychopathology of these disorders: distressing dreams or nightmares. We consistently noticed that distressing dreams or nightmares in women with various affective and behavioral disorders would appear to be a premonitory symptom of the post-abortion traumatic origins of the condition and a call to consider such hypothesis. The conclusion is that nightmares are very sensitive and specific indicators of the presence of post-traumatic disorders. Therefore, in order to reach the desired efficiency in the diagnosis and treatment of post-abortion psychopathology, we postulate that, in all affective or adjustment disorders, in addition to a comprehensive assessment of their disturbances, the presence of abortion-related persistent nightmares should be taken into account or investigated, since they are often the key symptom in identifying post-abortive reactivity within the disorde

Las reacciones al estrés grave y los trastornos de adaptación pueden pasar inadvertidos, enmascarados por diferentes quejas psicosomáticas o confundidos con otras alteraciones mentales, si sus síntomas no se relacionan con el trauma que los originó. Si el trastorno queda sin diagnosticar, su tratamiento y abordaje psicoterapéutico no serán efectivos, dando lugar a la cronicidad y resistencia de la afección. Pero para llegar a dicho diagnóstico, además de la evaluación integral de las alteraciones, nos fue de gran ayuda la exploración de un síntoma que, aunque referido frecuentemente por las pacientes, puede pasar desapercibido en el conjunto psicopatológico de estos trastornos: los sueños angustiosos o pesadillas. De forma repetida fuimos comprobando que los ensueños angustiosos o pesadillas, en mujeres con diversos trastornos afectivos y conductuales, parecían ser un síntoma premonitorio del origen traumático posabortivo de la sintomatología y una llamada de alerta que obligaba a tener en cuenta dicha hipótesis, llegando finalmente a la conclusión de que las pesadillas son indicadores muy sensibles y específicos de la presencia de alteraciones postraumáticas. Por ello, para lograr la deseada eficiencia en el diagnóstico y tratamiento de la psicopatología posabortiva, postulamos que, ante todo trastorno afectivo o conductual-desadaptativo, aparte de una evaluación integral de sus alteraciones, se tenga muy en cuenta -o se investigue en su caso- la presencia de pesadillas persistentes sobre temas abortivos, por ser éstas muchas veces el síntoma clave en la identificación de la reactividad posabortiva de los trastornos

Algunas variables biológicas relacionadas con trastornos del sueño en estudiantes de primer año de medicina / Some biological variables related to sleep dysfunctions in first year medicine students

Se realizó un estudio descriptivo de 110 estudiantes de primer año de la carrera de medicina en la Facultad de Ciencias Médicas No. 2 de Santiago de Cuba, desde enero hasta julio del 2014, con el objetivo de determinar algunas variables biológicas que pudieran estar relacionadas con los principales trastornos del sueño. La información fue procesada estadísticamente, con el empleo del porcentaje como medida de resumen y la aplicación de la prueba de la Χ² para valorar la posible asociación entre variables. En la serie se obtuvo que los trastornos del sueño más frecuentes fueran el insomnio, los ronquidos y las pesadillas, con predominio en las féminas; no obstante, en la mayoría de los alumnos el electroencefalograma resultó normal.

A descriptive study of 110 first year students of the medicine career was carried out in the Medical Sciences faculty No. 2 in Santiago de Cuba, from January to July, 2014, with the objective of determining some biological variables that could be related to the main sleep dysfunctions. The information was statistically processed, with the use of the percentage as summary measure and the chi squared test to evaluate the possible association between variables. In the series it was obtained that the most frequent sleep dysfunctions were insomnia, the snoring and nightmares, with prevalence in the females; nevertheless, in most of the students the electroencephalogram was normal.

Dream characteristics in a Brazilian sample: an online survey focusing on lucid dreaming.

During sleep, humans experience the offline images and sensations that we call dreams, which are typically emotional and lacking in rational judgment of their bizarreness. However, during lucid dreaming (LD), subjects know that they are dreaming, and may control oneiric content. Dreaming and LD features have been studied in North Americans, Europeans and Asians, but not among Brazilians, the largest population in Latin America. Here we investigated dreams and LD characteristics in a Brazilian sample (n = 3,427; median age = 25 years) through an online survey. The subjects reported recalling dreams at least once a week (76%), and that dreams typically depicted actions (93%), known people (92%), sounds/voices (78%), and colored images (76%). The oneiric content was associated with plans for the upcoming days (37%), memories of the previous day (13%), or unrelated to the dreamer (30%). Nightmares usually depicted anxiety/fear (65%), being stalked (48%), or other unpleasant sensations (47%). These data corroborate Freudian notion of day residue in dreams, and suggest that dreams and nightmares are simulations of life situations that are related to our psychobiological integrity. Regarding LD, we observed that 77% of the subjects experienced LD at least once in life (44% up to 10 episodes ever), and for 48% LD subjectively lasted less than 1 min. LD frequency correlated weakly with dream recall frequency (r = 0.20, p < 0.01), and LD control was rare (29%). LD occurrence was facilitated when subjects did not need to wake up early (38%), a situation that increases rapid eye movement sleep (REMS) duration, or when subjects were under stress (30%), which increases REMS transitions into waking. These results indicate that LD is relatively ubiquitous but rare, unstable, difficult to control, and facilitated by increases in REMS duration and transitions to wake state. Together with LD incidence in USA, Europe and Asia, our data from Latin America strengthen the notion that LD is a general phenomenon of the human species.

Tratamiento de las pesadillas en el trastorno por estrés postraumático: farmacoterapia / Pharmacological treatment of posttraumatic stress disorder nightmares

Introducción: Las pesadillas son síntomas usuales y característicos del trastorno por estrés postraumático (TEPT). Su presencia se relaciona directamente con la gravedad del trastorno, suelen tener un impacto negativo en la calidad de vida de los pacientes y, como frecuentemente se convierten en un síntoma residual y refractario, requieren especial atención y tratamiento específico. Objetivo: Revisar y actualizar los conocimientos acerca del tratamiento farmacológico de las pesadillas en el TEPT. Método: Este artículo revisa y actualiza los tratamientos disponibles para el manejo de las pesadillas en el TEPT. Conclusión: Se han realizado muy pocos estudios acerca del tratamiento farmacológico específico para las pesadillas en el TEPT. La mayoría han sido de diseño abierto o reportes de casos, las muestras han sido pequeñas, con grupos heterogéneos y algunos de los resultados han sido contradictorios. La psicoterapia adquiere entonces gran relevancia en el tratamiento de las pesadillas, pues aunque aún no hay estudios que muestren la superioridad de una modalidad sobre la otra (farmacoterapia versus psicoterapia), la experiencia clínica muestra que la combinación es importante y benéfica para los pacientes...

Introduction: Nightmares are common and characteristic symptoms of Posttraumatic Stress Disorder (PTST). Their presence is directly related with the severity of the disorder, usually having a negative impact on the patient’s quality of life. They frequently become a refractory and residual symptom, and require special attention and specific treatment. Objective: To review and update current knowledge on the pharmacological treatment available for PTSD nightmares. Conclusion: Very few studies have been done addressing the pharmacological treatment for PTSD nightmares. Most have an open design or are case reports, the samples have been small with heterogeneous groups, and some of the results have been contradictory. Psychotherapy, then, acquires great relevance in the treatment of nightmares, since although no studies exist that show the superiority of one modality over another (pharmacotherapy versus psychotherapy), clinical experience shows that the combination is beneficial for patients...