Expression and significance of classical ACE-AngII-AT1 axis and new ACE2-Ang (1-7)-Mas axis of renin-angiotensin system in local pancreas / 临床肝胆病杂志

The renin-angiotensin system (RAS) is a classical circulating enzyme pathway that plays an important role in regulation of pancreatic function. In recent years, with deepening understanding of RAS, researchers found that RAS not only includes the classical ACE-Ang II-AT1 axis, but also includes the new ACE2-Ang (1-7)-Mas axis. Extensive studies have confirmed that the ACE2-Ang (1-7)-Mas axis can antagonize the effect of the ACE-Ang II-AT1 axis. This paper reviews the composition and function of both axes of the RAS in the local pancreas, and also presents the comparison between the two axes.