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BACKGROUND: Dipeptidyl peptidase-4 (DPP4) is associated with cognitive dysfunction in patients with type 2 diabetes. AIM: To assess a possible relationship between serum DPP4 and cognitive function in perinatal pregnant women with gestational diabetes mellitus (GDM). METHODS: The study subjects were divided into three groups: GDM group (n = 81), healthy pregnant (HP) group (n = 85), and control group (n = 51). The Montreal Cognitive Assessment (MoCA) was used to assess the cognitive status of each group. Venous blood samples were collected to measure blood lipids, glycated hemoglobin, and glucose levels. For each participant, a 3-mL blood sample was collected and centrifuged, and the serum was collected. Blood samples were stored at -80 â, and DPP4, interleukin-6 (IL-6), and 8-iso-prostaglandin F2α (8-iso-PGF2α), and brain-derived neurotrophic factor (BDNF) were detected using ELISA. RESULTS: The MoCA scores in the GDM and HP groups were significantly different from those in the control group in terms of visuospatial/executive function and attention (P < 0.05); however, the scores were not significantly different between the GDM and HP groups (P > 0.05). In terms of language, the GDM group had significantly different scores from those in the other two groups (P < 0.05). In terms of memory, a significant difference was found between the HP and control groups (P < 0.05), as well as between the GDM and HP groups. The levels of DPP4, IL-6, and 8-iso-PGF2α in the GDM group were significantly higher than those in the HP and control groups (P < 0.05); however, the differences between these levels in the HP and control groups were not significant (P > 0.05). The level of BDNF in the GDM group was significantly lower than that in the HP and control groups (P < 0.05), although the difference in this level between the HP and control groups was not significant (P > 0.05). CONCLUSION: Cognitive dysfunction in perinatal pregnant women with GDM mainly manifested as memory loss, which might be associated with elevated DPP4 levels.
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Objective To investigate the effects of perinatal maternal infection of hepatitis B virus on neonatal umbilical cord blood immune factor and lymphocyte subsets,and to provide a theoretical basis for the prevention of neonatal hepatitis B.Methods A total of 110 cases of neonatus in Pengzhou People's Hospital from June 2015 to June 2016 were selected and divided into the observation group and the control group according to whether the pregnant women were infected with hepatitis B virus in perinatal period or not,each group had 55 cases.Neonatus umbilical cord blood were taken to detected serum immune globulin A (IgA),G(IgG),M(IgM) and lymphocyte subsets CD3+,CD4+,CD8+,CD19+,and the two groups' neonatal hepatitis B infection,lung infection,the incidence of jaundice and survival were compared.Results The observation group's neonatal IgA and IgM were respectively(0.46±0.12) and (0.68±0.23)g/L,which were significantly higher than those of the control group[(0.21±0.08),(0.68 ± 0.23)g/L],the differences had statistical significance(P＜0.05).There were no statistical significance in IgG level between the two groups(P＞0.05).The observation group's CD4+/CD8+,CD3+,CD4+ were significantly higher than those of the control group,CD19+ was significantly lower than that of the control group,the differences had statistical significance (P＜ 0.05).There was no statistical significance in CD8+ (P＞0.05).The observation group's neonatus survival rate was 96.36 ％,which was lower than that of the control group(100.00 ％),but the difference had no statistical significance(P＞0.05).The observation group's hepatitis B infection rate,pulmonary infection rate,incidence of jaundice were 41.82 ％,29.10 ％,10.10 ％,which were significantly higher than those of the control group(9.10 ％,7.27 ％,0.00 ％),the difference had statistical significance(P＜0.05).Conclusion Perinatal pregnant women infected with hepatitis B virus could sharply increase the level of IgA and IgG,increase the CD3+,CD4+,CD4+/CD8+,reduce the proportion of CD19+,affect neonatus immune function,and are more susceptible to viral infection.
ABSTRACT
Objective To investigate the effects of perinatal maternal infection of hepatitis B virus on neonatal umbilical cord blood immune factor and lymphocyte subsets,and to provide a theoretical basis for the prevention of neonatal hepatitis B.Methods A total of 110 cases of neonatus in Pengzhou People's Hospital from June 2015 to June 2016 were selected and divided into the observation group and the control group according to whether the pregnant women were infected with hepatitis B virus in perinatal period or not,each group had 55 cases.Neonatus umbilical cord blood were taken to detected serum immune globulin A (IgA),G(IgG),M(IgM) and lymphocyte subsets CD3+,CD4+,CD8+,CD19+,and the two groups' neonatal hepatitis B infection,lung infection,the incidence of jaundice and survival were compared.Results The observation group's neonatal IgA and IgM were respectively(0.46±0.12) and (0.68±0.23)g/L,which were significantly higher than those of the control group[(0.21±0.08),(0.68 ± 0.23)g/L],the differences had statistical significance(P＜0.05).There were no statistical significance in IgG level between the two groups(P＞0.05).The observation group's CD4+/CD8+,CD3+,CD4+ were significantly higher than those of the control group,CD19+ was significantly lower than that of the control group,the differences had statistical significance (P＜ 0.05).There was no statistical significance in CD8+ (P＞0.05).The observation group's neonatus survival rate was 96.36 ％,which was lower than that of the control group(100.00 ％),but the difference had no statistical significance(P＞0.05).The observation group's hepatitis B infection rate,pulmonary infection rate,incidence of jaundice were 41.82 ％,29.10 ％,10.10 ％,which were significantly higher than those of the control group(9.10 ％,7.27 ％,0.00 ％),the difference had statistical significance(P＜0.05).Conclusion Perinatal pregnant women infected with hepatitis B virus could sharply increase the level of IgA and IgG,increase the CD3+,CD4+,CD4+/CD8+,reduce the proportion of CD19+,affect neonatus immune function,and are more susceptible to viral infection.
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Objective To provide evidences which are for clinicians to formulate effective prevention and treatment measures by analyzing the perinatal pregnant women vaginal group B streptococcus (GBS)infection and adverse pregnancy outcomes. Methods From January 2013 to February 2015,the vaginal secretions were sampled from 795 cases of perinatal pregnant women for culture identification of GBS,the final results were statistical analyzed.Results In the 795 pregnant women ca-ses,there were 256 GBS carriers cases,the carrier rate was 32.2%.There was statistically significance (χ2 = 19.095,P <0.01)between less than 30 years old group (28.9%)and greater than or equal to 30 years old group (42.3%).The differ-ent incidence rate of clinical symptoms between GBS negative cases and GBS positive cases (18.8% vs 8.0%)was also had statistically significance (χ2 =39.514,P <0.01).The antimicrobial resistant rates of ten kinds of antibacterial drugs (vanco-mycin,linezolid,penicillin,ampicillin,ceftriaxone,nitrofurantoin,levofloxacin,clindamycin,erythromycin and tetracycline) was 0,0,0.6%,3.1%,6.6%,9.6%,21.9%,23.8%,29.9% and 58.1% respectively.The positive rate of D-bacteriostatic ring experiment was 23.9%.Conclusion The carrier rate of perinatal pregnant women GBS was higher in this region,and the elderly were easier to be infected.Perinatal pregnant women infected with GBS to vancomycin and rina thiazole amine and penicillin and ampicillin and ceftriaxone and with nitrofurantoin because of the sensitive rate is high.