Neurocomputational mechanisms underlying perception and sentience in the neocortex.

The basis for computation in the brain is the quantum threshold of "soliton," which accompanies the ion changes of the action potential, and the refractory membrane at convergences. Here, we provide a logical explanation from the action potential to a neuronal model of the coding and computation of the retina. We also explain how the visual cortex operates through quantum-phase processing. In the small-world network, parallel frequencies collide into definable patterns of distinct objects. Elsewhere, we have shown how many sensory cells are meanly sampled from a single neuron and that convergences of neurons are common. We also demonstrate, using the threshold and refractory period of a quantum-phase pulse, that action potentials diffract across a neural network due to the annulment of parallel collisions in the phase ternary computation (PTC). Thus, PTC applied to neuron convergences results in a collective mean sampled frequency and is the only mathematical solution within the constraints of the brain neural networks (BNN). In the retina and other sensory areas, we discuss how this information is initially coded and then understood in terms of network abstracts within the lateral geniculate nucleus (LGN) and visual cortex. First, by defining neural patterning within a neural network, and then in terms of contextual networks, we demonstrate that the output of frequencies from the visual cortex contains information amounting to abstract representations of objects in increasing detail. We show that nerve tracts from the LGN provide time synchronization to the neocortex (defined as the location of the combination of connections of the visual cortex, motor cortex, auditory cortex, etc.). The full image is therefore combined in the neocortex with other sensory modalities so that it receives information about the object from the eye and all the abstracts that make up the object. Spatial patterns in the visual cortex are formed from individual patterns illuminating the retina, and memory is encoded by reverberatory loops of computational action potentials (CAPs). We demonstrate that a similar process of PTC may take place in the cochlea and associated ganglia, as well as ascending information from the spinal cord, and that this function should be considered universal where convergences of neurons occur.

An overview of recent analysis and detection of acetylcholine.

Acetylcholine (ACh), the major neurotransmitter secreted by cholinergic neurons, is widely found in the peripheral and central nervous systems, and its main function is to complete the transmission of neural signals. When cholinergic neurons are impaired, the synthesis and decomposition of ACh are abnormal and the neural signalling transition is blocked. To some extent, the concentration changes of ACh reflects the occurrence and development of many kinds of nervous system diseases, such as Alzheimer's disease, Parkinson's disease, Myasthenia gravis and so on. Thus, researches of the physiological and pathological roles and the tracking of the concentration changes of ACh in vivo are significant to the prevention and treatment of these diseases. In the paper, the pathophysiological functions and the comprehensive research progress on detection methods of ACh are summarized. Specifically, the latest research and related applications of the optical and electrochemical biosensors are described, and the future development directions and challenges are prospected, which provides a reference for the detection and applications of ACh.

Progress in research of N-acetylaspartate in central nervous system / 药学学报

italic>N-Acetylaspartate (NAA) is a highly abundant brain metabolite. Nowadays, as an important marker reflecting the function of nervous system, NAA is widely used in the results analysis of nuclear magnetic resonance spectroscopy (1H MRS). NAA is synthesized in mitochondria of neurons and metabolized in oligodendrocytes. Additionally, NAA may be converted to the dipeptide N-acetylaspartylglutamate (NAAG), and catabolized into NAA and glutamate in astrocytes. NAA is related to a variety of central nervous system diseases, including Canavan disease, multiple sclerosis, depression, schizophrenia and other mental diseases. Therefore, NAA may be a biomarker of these diseases, and its related enzymes may be used as therapeutic targets for drug screening. Here, we combined the current research on the molecular mechanisms of NAA to reveal the process of NAA generation, metabolism and transport in the brain, explain the possible physiological effects of NAA and discuss its relationship with central nervous system diseases, explore the prospect of NAA in disease prediction and diagnosis, as well as the targeted treatment that may become the breakthrough of refractory diseases.