From Engineered Stone Slab to Silicosis: A Synthesis of Exposure Science and Medical Evidence.

Engineered stone (ES) is a popular building product, due to its architectural versatility and generally lower cost. However, the fabrication of organic resin-based ES kitchen benchtops from slabs has been associated with alarming rates of silicosis among workers. In 2024, fifteen years after the first reported ES-related cases in the world, Australia became the first country to ban the use and importation of ES. A range of interacting factors are relevant for ES-associated silicosis, including ES material composition, characteristics of dust exposure and lung cell-particle response. In turn, these are influenced by consumer demand, work practices, particle size and chemistry, dust control measures, industry regulation and worker-related characteristics. This literature review provides an evidence synthesis using a narrative approach, with the themes of product, exposure and host. Exposure pathways and pathogenesis are explored. Apart from crystalline silica content, consideration is given to non-siliceous ES components such as resins and metals that may modify chemical interactions and disease risk. Preventive effort can be aligned with each theme and associated evidence.

[Position paper on working in the intensive care unit during pregnancy : DIVI recommendations for improving the situation of pregnant employees in the ICU]. / Positionspapier zum Arbeiten in der Schwangerschaft auf der Intensivstation : DIVI-Empfehlungen zur Verbesserung der Lage von schwangeren Mitarbeiterinnen auf einer Intensivstation.

The Maternity Protection Act is intended to protect the mother and the child from hazards, excessive demands and damage to health in the workplace, and from financial disadvantages and loss of employment. However, the objectives defined by the Maternity Protection Act-the safety and health of the pregnant employee on the one hand and the prevention of disadvantages in working life on the other-are not yet adequately achieved in the intensive care unit (ICU). Implementation of the Maternity Protection Act to the benefit of all involved parties should also be promoted in the specialist areas represented by the DIVI, in particular the work of pregnant physicians and nursing staff and other working specialists (respiratory therapists, physiotherapists, speech therapists, psychotherapists, and social workers) in the ICU. The aim of this paper is to raise awareness of the need to consider each pregnant and breastfeeding staff member individually and to work together to find a personal solution for continuing to work in the ICU. Possible ways and solutions to achieve this goal are outlined and practical examples are given for implementation in everyday clinical routine. These are also based on comprehensive presentation of activities according to a traffic light color-code system for all occupational groups. Arguments against pregnant employees working in the ICU are discussed and possible solutions are presented.

[Position paper on working in the intensive care unit during pregnancy : DIVI recommendations for improving the situation of pregnant employees in the ICU]. / Positionspapier zum Arbeiten in der Schwangerschaft auf der Intensivstation : DIVI-Empfehlungen zur Verbesserung der Lage von schwangeren Mitarbeiterinnen auf einer Intensivstation.

The Maternity Protection Act is intended to protect the mother and the child from hazards, excessive demands and damage to health in the workplace, and from financial disadvantages and loss of employment. However, the objectives defined by the Maternity Protection Act-the safety and health of the pregnant employee on the one hand and the prevention of disadvantages in working life on the other-are not yet adequately achieved in the intensive care unit (ICU). Implementation of the Maternity Protection Act to the benefit of all involved parties should also be promoted in the specialist areas represented by the DIVI, in particular the work of pregnant physicians and nursing staff and other working specialists (respiratory therapists, physiotherapists, speech therapists, psychotherapists, and social workers) in the ICU. The aim of this paper is to raise awareness of the need to consider each pregnant and breastfeeding staff member individually and to work together to find a personal solution for continuing to work in the ICU. Possible ways and solutions to achieve this goal are outlined and practical examples are given for implementation in everyday clinical routine. These are also based on comprehensive presentation of activities according to a traffic light color-code system for all occupational groups. Arguments against pregnant employees working in the ICU are discussed and possible solutions are presented.

Eradication without prohibition? International developments in tobacco control policies in the twenty-first century / Éradiquer sans prohiber ? Évolutions internationales des politiques publiques de contrôle du tabac au XXIe siècle

This article offers an analytical synthesis of international trends in public policies to regulate tobacco in the first quarter of the twenty-first century. It begins with a review of the densification of the repertoire of public action and the affirmation of a strategy that consists of encircling tobacco (designated as an enemy) and attacking it through a variety of material and symbolic tactics. Tobacco regulation is a constantly dynamic process, due to the intensity of the exchanges of blows between protagonists: these agonistic interactions are reflected in framing struggles that lead to a diversification of tobacco qualifications. Tobacco is thus framed as a health issue, but also as an environmental problem and a challenge for social justice. Finally, the article shows how, at the end of a quarter-century of diverse mobilizations, the gradual formulation of a paradigm shift is taking shape, in which the objective of public action is no longer simply to control tobacco, but to eliminate it as a commodity.

Cet article propose une synthèse analytique des tendances ­internationales observables dans les politiques publiques de régulation du tabac dans ce premier quart du XXIe siècle. Il revient d'abord sur la densification du répertoire d'actions publiques et l'affirmation d'une stratégie consistant à encercler le tabac (désigné comme un ennemi) et à l'attaquer par le biais de différentes tactiques matérielles et symboliques. La régulation du tabac est un processus en mouvement permanent, du fait de l'intensité des échanges de coups entre protagonistes : ces interactions agonistiques se traduisent dans des luttes de cadrage qui entraînent une diversification des qualifications du tabac, comme problème sanitaire mais aussi environnemental et social. Enfin, l'article montre comment, à l'issue de ce quart de siècle de mobilisations diverses, s'esquisse la formulation progressive d'un changement de paradigme, où l'objectif de l'action publique ne serait plus seulement le contrôle du tabac mais sa disparition comme bien courant.

Following Affirmative and Negated Rules.

Rules are often stated in a negated manner ("no trespassing") rather than in an affirmative manner ("stay in your lane"). Here, we build on classic research on negation processing and, using a finger-tracking design on a touchscreen, we show that following negated rather than affirmative rules is harder as indicated by multiple performance measures. Moreover, our results indicate that practice has a surprisingly limited effect on negated rules, which are implemented more quickly with training, but this effect comes at the expense of reduced efficiency. Only affirmative rules are thus put into action efficiently, highlighting the importance of tailoring how rules are communicated to the peculiarities of the human mind.

"It's a big added stress on top of being so ill": The challenges facing people prescribed cannabis in the UK.

BACKGROUND: This paper reports on the first qualitative study to interview people prescribed cannabis in the UK. Cannabis is a class B controlled substance under the 1971 Misuse of Drugs (MoD) Act, but a 2018 change to UK regulations provided for the prescription of cannabis for medical purposes. Relatively few people have been able to access a prescription, despite this policy change. This paper examines their experiences. METHODS: Qualitative, semi-structured interviews were conducted with 24 people with a prescription for cannabis, or their carers. Data was analysed using a reflextive thematic analysis approach. The findings are discussed using a zemiology (social harms) perspective which provides a language for critical reflection on the current cannabis policy context. RESULTS: All participants reported that cannabis had significantly improved their mental and/or physical health, across a broad range of conditions. Many had been able to reduce their use of conventional medicines and reported that cannabis had relatively few side effects. Despite the potentially life-enhancing benefits of cannabis medicine, patients in the UK face multiple barriers to access. These include a lack of funding streams, bureaucratic supply problems, and a lack of training for doctors and police. Even for the few people able to obtain a prescription, the ongoing criminalisation of cannabis in the UK contributed to their experiences of stigmatisation. This often made it difficult and anxiety-inducing to take their medicine in public spaces. CONCLUSION: The UK government's lack of implementation of medical cannabis legalisation, combined with their ongoing prohibition position, is producing multiple harms to people who need cannabis medicine. The policy context is perpetuating stigmatising attitudes to cannabis which, as we demonstrate, contribute to social harms. We make recommendations on equality of patient access, and highlight the importance of education and policy change as means of combatting stigma.

Kidney donors' interests and the prohibition on sales.

I shall argue, first, that potential kidney donors may be subject to harmful pressure to donate. This pressure may take almost any form; people have diverse interests, and anything that could set them back may qualify as pressure. Given features of the context-the high stakes, the involvement of family, and the social meaning of donation-such pressure may be especially harmful. This problem is less tractable than the more familiar worry that pressure may compromise consent. Screening may ensure donors validly consent, but it provides no protection against harmful pressure. I shall argue, second, that the use of such pressure is the predictable consequence of the prohibition on kidney sales. Potential donors have something-a transplantable kidney-that is both valuable and scarce. Many of them, informed about donation, decide against it. Those in need of a transplant may seek to persuade the unwilling. Given the prohibition, the donation cannot be made more attractive in absolute terms by, say, the addition of money. However, it can be made more attractive in relative terms. If declining the option is made worse, then, by comparison, accepting it is made better. The application of harmful pressure has the desired effect. With so much at stake, and no good alternatives, its use is predictable. I conclude that potential donors' interests should figure more prominently in the discussion of transplant policy. Those who defend the prohibition have made virtually no attempt to account for its impact on that group.

The Prohibition of Suicide and Its Theological Rationale in Catholic Moral and Canonical Tradition: Origins and Development.

This paper analyzes the nuances of the Roman Catholic Church's opposition to suicide. First, we analyze biblical suicide cases, showing that these were not usually met with clear condemnation. Next, we show the development of the Roman Catholic Church's moral teachings, with special attention to Augustine. The canon law of the Middle Ages still made some distinctions regarding motivation, but at this point, Roman Catholic funerals started to be refused to those having committed suicide as discouragement to others. This was maintained by the Council of Trent. In the twentieth century, the Roman Catholic Church followed modern psychiatry in attributing suicide to mental illness, and the ban on Roman Catholic funerals was lifted. Currently, the Roman Catholic Church tries to discourage suicide while accompanying people in need.

Effects of grazing prohibition on nirK- and nirS-type denitrifier communities in salt marshes.

Introduction: Grazing prohibition is an effective management practice to restore salt marsh functioning. However, the effects of grazing exclusion on denitrifying microbial communities and their controlling factors in salt marshes remain unclear. Methods: In this study, we surveyed soil physicochemical properties and above- and below-ground biomass and using quantitative polymerase chain reaction and Illumina MiSeq high-throughput sequencing technology to determine the relative abundance, composition, and diversity of nitrite reductase nirS- and nirK-type denitrifying bacterial communities associated with grazing prohibition treatments and elevations. Results: The abundance of nirS-type denitrifiers increased with grazing prohibition time, whereas the abundance of nirK-type denitrifiers remained unaltered. Moreover, nirS-type denitrifiers were more abundant and diverse than nirK-type denitrifiers in all treatments. Grazing prohibition significantly altered the operational taxonomic unit richness, abundance-based coverage estimator, and Chao1 indices of the nirS-type denitrifying bacterial communities, whereas it only minimally affected the structure of the nirK-type denitrifying bacterial community. Discussion: The results imply that the nirS community, rather than nirK, should be the first candidate for use as an indicator in the process of salt marsh restoration after grazing prohibition. Substances of concern, total nitrogen, and salinity were the key environmental factors affecting the abundance and community composition of nirS and nirK denitrifiers. The findings of this study provide novel insights into the influence of the length of grazing prohibition and elevation on nirS- and nirK-type denitrifying bacterial community composition in salt marshes.

Practical benzylation of N,N-substituted ethanolamines related to chemical warfare agents for analysis and detection by electron ionization gas chromatography-mass spectrometry.

The benzylation of three low molecular weight N,N-disubstituted ethanolamines related to chemical warfare agents (CWAs) to furnish derivatives with improved gas chromatography-mass spectrometry (GC-MS) profiles is described. Due to their low molecular weight and polar nature, N,N-disubstituted ethanolamines are notoriously difficult to detect by routine GC-MS analyses during Organisation for the Prohibition of Chemical Weapons (OPCW) proficiency tests (PTs), particularly in scenarios when they are present at low levels (~1-10 ppm) amidst more abundant interferences. Our studies revealed that the optimal derivatization conditions involved the treatment of the ethanolamine with benzyl bromide in the presence of an inorganic base (e.g., Na2 CO3 ) in dichloromethane at 55°C for 2 h. This optimized set of conditions was then successfully applied to the derivatization of N,N-dimethylethanolamine, N,N-diethylethanolamine and N,N-diisopropylethanolamine present separately at 1 and 10 µg/mL concentrations in a glycerol-rich matrix sample featured in the 48th OPCW PT. The benzylated derivatives of the three ethanolamines possessed retention times long enough to clear the massive glycerol-containing matrix interferences. The protocol herein is introduced as an alternative method for derivatization of these CWA and pharmaceutically important species and should find broad applicability in laboratories where routine forensic analysis is carried out.

In utero and childhood exposure to alcohol and old age mortality: Evidence from the temperance movement in the US.

Previous research suggests the relevance of in-utero insults and early-life circumstances for a wide array of life cycle outcomes. This research note joins this strand of studies by exploring the long-run mortality effects of in-utero and early-life exposure to alcohol accessibility. In so doing, we take advantage of the prohibition movement during the early part of the twentieth century that generated quasi-natural reductions in alcohol consumption. We use Social Security Administration Death Master Files linked to the full-count 1940 census and compare the longevity of male individuals exposed to the prohibition during in-utero and early childhood (1900-1930) as a result of statewide and federal alcohol ban to those wet counties after the law change to before. The results suggest an intent-to-treat effect of 0.17 years higher longevity as a result of prohibition. A back-of-an-envelope calculation suggests a minimum treatment-on-treated effect of 1.7 years impact. Furthermore, we show that these effects are not driven by other county-level demographic and socioeconomic changes, endogenous selection of births, and preexisting trends in the outcome. Our findings contribute to the growing body of research that explores the in-utero and childhood circumstances on long-term health outcomes.

Nine Insights From 10 Years of Legal Cannabis for Nonmedical Purposes.

Whereas the 20th century could be largely characterized as the age of cannabis prohibition, the 21st century may ultimately be known as the era of cannabis legalization. Although several countries and subnational jurisdictions have relaxed laws to allow cannabis to be used for medical purposes, the policy landscape shifted dramatically in 2012 when voters in Colorado and Washington passed ballot initiatives to allow cannabis to be sold to adults for nonmedical purposes. Since then, Canada, Uruguay, and Malta have legalized nonmedical cannabis, and >47% of the US population live in states that have passed laws allowing commercial production and for-profit retail sales. Some countries are now implementing pilot programs for legal supply (eg, the Netherlands, Switzerland), and others are seriously contemplating changing their laws (eg, Germany, Mexico). This commentary offers 9 insights from the first 10 years of legal cannabis for nonmedical purposes, with the goal of informing policy discussions in places considering, implementing, or revising their approach to cannabis legalization: (1) cannabis prices are declining in places with commercial regimes and this matters for several outcomes; (2) noncommercial models are being implemented and seriously considered in some places; (3) policy discussions about cannabis taxes are evolving; (4) the number of cannabis products available in commercial regimes is proliferating; (5) emerging research on higher potency cannabis products raises some public health concerns, but there is still a lot to learn; (6) social equity is playing a larger role in many legalization debates; (7) it takes time to move consumers to the legal market; (8) data collection about cannabis consumption is getting better, but there is much work to do; and (9) ongoing methodological advances should improve our understanding of cannabis policy changes.

[The pharmacy tourism. Part II. The prohibitions, limitations and risks at importation of medications by natural persons in the Russian Federation].

The study of peculiarities of handling medications as goods for personal use by natural persons is quite actual in view of complexity of normative legal regulation of procedure under study. The actuality of study is also confirmed by rapidly growing rate of medical tourism and pharmacy tourism (as its part) as dynamically developing economy branch. Within the framework of research study the analysis was applied to procedure of handling medications by natural persons and to present prohibitions, limitations and risks as well. The occurrence of last ones is capable to be resulted in administrative or criminal responsibility. In case of handling medications by natural persons difficulties with identifying particular rules are conditioned by the fact that they are included both in international (Eurasian Economic Union) and national (Russian Federation) normative legal acts. Furthermore, regular alterations of customs legislation sometimes significantly affect customs administration that requires additional research studies to provide clarity of understanding measures of customs regulation. The article presents analysis of normative legal base of the Russian Federation and the Eurasian Economic Union that regulates import of medications as goods for personal use by individuals, prohibitions and limitations concerning medications handled by natural persons. The consequences of risks in case of non-compliance with prohibitions and limitations are marked. The conclusions on study results are formulated.

Changes in hazardous drinking pre, during and post 70-day alcohol sales ban during COVID-19 pandemic in Botswana.

BACKGROUND: Absolute alcohol sales bans instituted in countries like Botswana provide a rare opportunity for a quasi-natural experiment on how such strict policies influence users' behaviours during the COVID pandemic and beyond. From March 2020 to September 2021, Botswana banned the sales of alcohol on four separate occasions spanning a cumulative 225 days. We studied changes in retrospectively recalled hazardous drinking following the longest and last alcohol sales ban in Botswana. METHODS: This online cross-sectional study, carried out following a 70-day alcohol sales ban in 2021, comprised a convenience sample of 1326 adults who completed the AUDIT-C and had to recall their alcohol use during three points: pre alcohol sale ban (before 28th June 2021), during alcohol sales ban (28th June 2021 to 5th September 2021), and post alcohol sales ban (after 5th September 2021). RESULTS: The prevalence of hazardous drinking (defined by an AUDIT-C score of 3 or 4 for females and males, respectively) prior, during and post the alcohol sales ban was 52.6% (95%CI=49.8-55.3), 33.9% (95%CI=31.3-36.5), and 43.1% (95%CI=40.4-45.8), respectively. CONCLUSION: The findings from this study showed that reduced alcohol availability by way of the fourth alcohol sales ban was associated with reductions in self-reported hazardous drinking, albeit at a lesser degree compared to during an earlier sales ban.

Do patron bans affect subsequent behaviour? An examination of pre- and post-ban offending for barring notice and prohibition order recipients in Western Australia.

INTRODUCTION: To explore whether receipt of either of two patron banning provisions currently used in Western Australia-in response to alcohol-related disorderly and anti-social behaviour-is associated with changes to subsequent offending. METHOD: Western Australia Police de-identified the offender records and associated data for 3440 individuals who had received one or more police-imposed barring notice/s between 2011 and 2020, and 319 individuals who had received one or more prohibition orders between 2013 and 2020. The number of offences recorded for each recipient before and after the first notice/order were examined to understand the potential effect of both provisions upon subsequent offending. RESULTS: The low number of repeat barring notices (5% of the total) and prohibition orders (1% of the total) points to their general success. Analysis of offending records before and after receipt/expiry of either provision indicates that both have a generally positive effect on subsequent behaviours. For all barring notice recipients, 52% recorded no further offences and for all prohibition order recipients, 58% recorded no further offences. There was a less positive effect for the sub-set of multiple ban recipients and prolific offenders. DISCUSSION AND CONCLUSIONS: Barring notices and prohibition orders appear to have a generally positive effect on subsequent behaviours for the majority of recipients. More targeted interventions are recommended for repeat offenders, for whom patron banning provisions have a more limited effect.

Monks: A Population at Risk for Liver Fluke and Skin-Penetrating Helminths.

Monks cannot cook received raw meat dishes and should walk barefoot while working. This population lacks both a survey of parasitic infection and a proper prevention and control policy. Five hundred and fourteen monks from the Ubolratana, Ban Haet, and Ban Phai Districts of Kh on Kaen Province were enrolled in this study. A stool container and questionnaire were collected from each study participant. Stool samples were processed by formalin ethyl acetate concentration and agar plate culture techniques. We then analyzed the results and risk factors to demonstrate associations. The prevalence of overall parasites, liver flukes, and skin-penetrating helminths were 28.8%, 11.1%, and 19.3%, respectively. Raw fish dish offerings were associated with opisthorchiasis (ORcrude 3.32; 95% CI 1.53-7.20). The risk factors for skin-penetrating helminths were older age (ORcrude 5.02; 95% CI 2.2-11.17), being a long-term ordinate (ORcrude 3.28; 95% CI 1.15-9.34), smoking (ORcrude 2.03; 95% CI 1.23-3.36), and chronic kidney disease with other underlying disease (ORcrude 20.7; 95% CI 2.54-190.1). The protective factors for skin-penetrating helminths were secular education above primary education (ORcrude 0.41; 95% CI 0.25-0.65) and having received health education about parasitic infection (ORcrude 0.47; 95% CI 0.28-0.80). Wearing shoes at times other than alms work does not show a protective effect against skin-penetrating helminths (ORcrude 0.86; 95% CI 0.51-1.46). These findings support the recommendation for a strict Rule of Discipline regarding raw meat ingestion and allowing shoes to be worn for protection against skin-penetrating helminths in high-risk situations.

Impact of three years of prohibition on extent and pattern of alcohol use in Bihar: Observations and insights from the National Family Health Survey.

Bihar Excise (Amendment) Act, 2016 was promulgated in the state and a complete prohibition on alcohol was declared within the state of Bihar. We aimed to assess the impact of the prohibition on extent and pattern of alcohol use in the state of Bihar using the National Family Health Survey data. We also compared the data from Bihar with the data for the whole country, its neighbouring states and the state of Gujarat. There was a 41.78% reduction in the proportion of men who reported alcohol use in Bihar. Among those who reported alcohol use proportion of those who used 'almost every day' reduced by 29.72%. There was a 69.56% reduction in the proportion of women in Bihar who reported alcohol use. There was a significant increase in proportion of men reporting use of tadi madi and country liquor. Since the prohibition of alcohol in the state of Bihar there has been a reduction in self-reported alcohol use among men and women. However, alcohol use continues to be reported in the state even after the prohibition. There are states in the country that have similar extent of alcohol use as compared to Bihar, despite lack of prohibition. This warrants a relook at the policy to address what the prohibition could not achieve.

Decriminalisation and smart regulation of psychoactive substances: a modern alternative to prohibition.

Prohibition has been the globally dominant concept for the regulation and control of psychoactive substances for nearly 70 years. Its effectiveness and legitimacy as a sustainable solution to the problems associated with the existence of psychoactive substances in society has been repeatedly questioned. It is based on the normative assumption that the use of psychoactive substances for other than therapeutic purposes is not allowed, and non-medical supply should be severely punished. This precludes the use of the full range of regulatory, public health, prevention, and harm reduction strategies, reduces well-being, and increases harms for the human-rights, health, and social cohesion. It is time to replace the prohibitionist paradigm with modern regulation that considers the different harms and risks of psychoactive substances, but also the benefits of psychoactive substances for mental health and well-being, lifestyle, and socialisation. This new paradigm (the so-called 'smart regulation') should accept non-medical use of psychoactive substances, apply criminal law as an exceptional tool to regulate human behaviour, regulate the availability of substances according to their harmfulness, regulate the risk profile of the product, strictly regulate marketing and advertising, protect minors and 'others' from the use and supply of psychoactive substances, protect the legal market from the supply of substances from the illegal market, and use economic instruments to regulate demand and to subsidise prevention and treatment.

[Policy Analysis in Plastic Pollution Governance and Recommendations in China].

Plastic pollution is a global concern and an issue in environmental governance. Based on the updated "Plastic Prohibition/Restriction Order" issued recently in China, the present study systematically reviewed the implementation effectiveness of the "Plastic Prohibition/Restriction Order" since 2007. Furthermore, we summarized plastics in China and plastic waste management progress policies. Additionally, three deficiencies of the updated "Plastic Prohibition/Restriction Order" were discussed:policy formulation, implementation, and supervision. Some positive recommendations were provided based on the available reports, such as integrating plastic pollution into national basic laws and regulation systems, building a network platform for public attendance, and coordinating the publicity of the "Plastic prohibition/Restriction Order" with the public interest. Besides these measurements, some points about plastic waste management in the future were also highlighted, such as the "blind area" in small retail stores, the rational sharing of environmental protection responsibility, new materials and processes, and recycling and disposal systems for plastic wastes. Most importantly, the present study could provide ideas for policy-makers to address plastic pollution at its sources.