Caracterización epidemiológica de pacientes con síndrome posterior a resección anterior baja de recto y aproximación de su relación con aspectos demográficos, patológicos y quirúrgicos, en un centro de referencia en Medellín, entre 2016-2022 / Epidemiological characterization of patients with post-low anterior rectal resection syndrome and approximation of its relationship with demographic, pathological, and surgical aspects, in a referral center in Medellin, between 2016-2022

Introducción. El cáncer colorrectal es uno de los tipos de cáncer más comunes y mortales a nivel mundial. Aunque los avances médicos han mejorado el manejo, la cirugía sigue siendo fundamental. La resección anterior baja (RAB) de recto ha ganado relevancia, a pesar de que puede llevar al síndrome de resección anterior baja de recto (LARS, por sus siglas en inglés), afectando la calidad de vida. Métodos. Estudio de corte transversal con intención analítica en un centro de referencia en Medellín, Colombia. Los pacientes con cáncer de recto sometidos a RAB entre enero de 2016 y diciembre de 2022 completaron el cuestionario LARS para evaluar disfunción intestinal. Se evaluaron factores relacionados con la presencia de LARS por medio de un análisis bivariado. Resultados. De 234 pacientes elegibles, 110 (47 %) respondieron la encuesta, predominantemente mujeres (58,2 %). La edad promedio fue 62 años. Dos tercios de los pacientes recibieron neoadyuvancia y el 69 % requirieron ileostomía. La prevalencia de LARS fue 47,3 %. El 80,9 % llevaban más de 12 meses desde la cirugía o el cierre del estoma. Factores estadísticamente significativos asociados a LARS fueron edad mayor de 65 años (p=0,03), estadío patológico avanzado (p=0,02) y requerimiento de estoma (p=0,03). Conclusiones. El LARS afecta a casi la mitad de los pacientes en diferentes etapas posquirúrgicas. El LARS scorees una herramienta práctica para evaluar la función intestinal en el seguimiento del paciente. La prevalencia y los factores de riesgo identificados contribuyen a la comprensión del impacto de la cirugía conservadora del esfínter en la calidad de vida de los pacientes.

Introduction. Colorectal cancer is one of the most common and deadly types of cancer worldwide, with a high incidence of rectal cancer. Although medical advances have improved management, surgery remains crucial. Low anterior resection of the rectum (LAR) has gained significance, despite its potential to lead to low anterior resection syndrome (LARS), affecting quality of life. Methods. A cross-sectional study with analytical intent was conducted at a referral center in Medellín, Colombia. Patients with rectal cancer who underwent LAR between January 2016 and December 2022 completed the LARS questionnaire to assess intestinal dysfunction. Factors related to the presence of LARS were analyzed using bivariate analysis. Results. Of 234 eligible patients, 110 (47%) responded, predominantly women (58.2%). The average age was 62 years. Two-thirds of patients received neoadjuvant therapy and 69% required ileostomy. The prevalence of LARS was 47.3%. 80.9% had been more than 12 months post-surgery or stoma closure. Statistically significant factors associated with LARS included age over 65 years (p=0.03), advanced pathological stage (p=0.02), and stoma requirement (p=0.03). Conclusions. LARS affects almost half of the patients in various post-surgical stages. The LARS score is a practical tool for assessing intestinal function in patient follow-up. The prevalence and risk factors identified contribute to the understanding of the impact of sphincter-conserving surgery on patients' quality of life.

Uso de stent en estenosis colorrectal benigna / Stent utilization in benign colorectal stenosis

Introducción. La estenosis colorrectal benigna hace referencia a una condición anatómica caracterizada por una disminución del diámetro de la luz intestinal distal a la válvula ileocecal, ocasionando una serie de signos y síntomas de tipo obstructivo. Es una entidad poco frecuente, secundaria en la gran mayoría de veces a la realización de anastomosis intestinales al nivel descrito. El objetivo de esta investigación fue determinar la utilidad del stentcolónico en estenosis secundaria a patología colorrectal no neoplásica. Métodos. Estudio descriptivo de una cohorte de pacientes que desarrolló estenosis colorrectal de origen benigna confirmada por colonoscopía, en 3 hospitales de alta complejidad de la ciudad de Medellín, Colombia, entre los años 2007 y 2021. Resultados. Se incluyeron 34 pacientes con diagnóstico de estenosis colorrectal de origen benigno, manejados con stents metálicos autoexpandibles. La mediana de seguimiento fue de 19 meses y se obtuvo éxito clínico en el 73,5 % de los casos. La tasa de complicación fue del 41,2 %, dada principalmente por reobstrucción y migración del stent, y en menor medida por perforación secundaria a la colocación del dispositivo. Conclusión. Los stents metálicos autoexpandibles representan una opción terapéutica en pacientes con obstrucción colorrectal, con altas tasas de mejoría clínica en pacientes con patología estenosante no maligna. Cuando la derivación por medio de estoma no es una opción, este tipo de dispositivos están asociados a altas tasas de éxito clínico y mejoría de la calidad de vida de los pacientes

Introduction. Benign colorectal stenosis refers to an anatomical condition characterized by a decrease in the diameter of the intestinal lumen distal to the ileocecal valve, which might cause a series of obstructive signs and symptoms. It is a rare entity, caused in the vast majority of cases due to intestinal anastomosis at the described level. The purpose of this study is to determine the performance of colonic stents in the management of non-malignant colorectal strictures. Methods. Descriptive study of a cohort of patients who developed a benign colorectal stenosis confirmed by colonoscopy in three high-complexity hospitals in the city of Medellín, Colombia, between 2007 and 2021. Results. Thirty-four patients diagnosed with benign colorectal stenosis managed with self-expanding metal stents were included in the study. Median follow-up was 19 months, obtaining clinical success in 73.5% of cases, with a complication rate of 41.2%, mainly due to reobstruction and migration of the stent, and to a lesser extent due to perforation secondary to device placement.Conclusion. Self-expanding metallic stents represent a therapeutic option in patients with colorectal obstruction caused by non-malignant stenosing pathology. When diversion through a stoma is not an option, this type of device is associated with high rates of clinical success and improvement in the patients' quality of life

Correlation of endoscopic findings with suspected intestinal endometriosis in the distal sigmoid and rectum as observed on transrectal ultrasonography

Introduction: Colonoscopy enables detailed endoscopic evaluation of the interior of the colon. Changes observed via colonoscopy may be subtle or pronounced and can sometimes mimic those of other diseases, such as deep intestinal endometriosis. The diagnosis of endometriosis in the distal sigmoid and rectum by colonoscopy has been described in previous case reports. Objective: We aimed to correlate the endoscopic changes found in the distal sigmoid and rectum with the presence of endometrial deposits confirmed by transrectal ultrasound (TRUS). Methods: We included 50 female patients referred to the endoscopy department at our institution for colonoscopy, rectosigmoidoscopy, or TRUS, who exhibited one or more symptoms associated with endometriosis. Results: The colonoscopic findings were normal in 36 patients but showed alterations in 14 patients. Among the latter, TRUS revealed involvement of the sigmoid and/or rectal wall in 11 patients. Conclusions: The endoscopic changes in the distal sigmoid or rectum described in this study were strongly associated with endometrial deposits confirmed using TRUS. (AU)

Diseño de un protocolo de intervenciones de enfermería para personas con enfermedades anorrectales que requieren cirugía ambulatoria / Design of a Protocol for Nursing Interventions for People with Anorectal Diseases Requiring Ambulatory Surgery

Introducción: Las intervenciones de enfermería son tratamientos basados en el conocimiento y juicio clínico que realizan estos profesionales. En la cirugía ambulatoria de enfermedades anorrectales se constata variabilidad en la elección correcta de estas intervenciones y falta de sustitución de personal calificado para realizarla. Objetivo: Diseñar un protocolo de intervenciones de enfermería para personas con enfermedades anorrectales que requieren cirugía ambulatoria. Métodos: Estudio de desarrollo, descriptivo transversal, contextualizado en hospitales de la provincia Camagüey con servicios de Cirugía Ambulatoria, desde enero de 2018 hasta septiembre de 2021. Fueron seleccionados los especialistas para elaborar la propuesta. En una primera reunión se siguieron las recomendaciones de las Guías de elaboración de protocolos basados en la evidencia, se identificaron intervenciones de enfermería por lluvia de ideas. En una segunda reunión se registraron las sugerencias y se presentó el protocolo. Resultados: Se seleccionaron siete especialistas competentes. La primera versión del protocolo quedó diseñada con el consenso del 100 por ciento de los especialistas. El protocolo contempla 14 ítems, las intervenciones de enfermería se presentan con códigos numéricos, denominación y definición, así como las actividades para ejecutarlas en cada etapa que comprende el período perioperatorio. Se selecciona el nivel de evidencia correspondiente a cada intervención de enfermería. Conclusiones: Se diseñó un protocolo de intervenciones de enfermería para personas con enfermedades anorrectales que requieren cirugía ambulatoria, basado en el consenso de especialistas, donde se describen las intervenciones de enfermería a ejecutar en cada etapa del período perioperatorio, de forma ordenada y justificadas con el nivel de evidencia correspondiente(AU)

Introduction: Nursing interventions are treatments based on the knowledge and clinical judgment performed by these professionals. In ambulatory surgery for anorectal diseases, there is variability in the correct choice of these interventions and lack of substitution of qualified personnel to perform them. Objective: To design a protocol of nursing interventions for people with anorectal diseases requiring ambulatory surgery. Methods: Development study, descriptive transversal, contextualized in hospitals in Camagüey province with Ambulatory Surgery services, from January 2018 to September 2021. Specialists were selected to elaborate the proposal. In a first meeting, the recommendations of the Guidelines for the elaboration of evidence-based protocols were followed, nursing interventions were identified by brainstorming. In a second meeting, suggestions were recorded and the protocol was presented. Results: Seven competent specialists were selected. The first version of the protocol was designed with the consensus of 100.00 percent of the specialists. The protocol contemplates 14 items, the nursing interventions are presented with numerical codes, denomination and definition, as well as the activities to execute them in each stage comprising the perioperative period. The level of evidence corresponding to each nursing intervention is selected. Conclusions: A protocol of nursing interventions for people with anorectal diseases requiring ambulatory surgery was designed, based on the consensus of specialists, where the nursing interventions to be executed in each stage of the perioperative period are described, in an orderly manner and justified with the corresponding level of evidence(AU)

Beneficios sociales del protocolo de intervenciones de enfermería a pacientes con cirugía ambulatoria de enfermedades anorrectales

RESUMEN El presente estudio pretende demostrar los beneficios sociales de un protocolo de intervenciones de enfermería a pacientes con cirugía ambulatoria de enfermedades anorrectales. Se realizó una revisión bibliográfica sistemática para hacer un análisis crítico reflexivo del contenido de artículos originales y de revisión publicados entre 2015 y 2021 en español, portugués e inglés. La búsqueda fue realizada en las bases de datos Medline, Pubmed y SciELO de enero a junio de 2021, en función de los presupuestos teóricos de una investigación realizada en el salón ambulatorio del Hospital Universitario Provincial Manuel Ascunce Domenech. Se constató la importancia de los protocolos de atención, ya que son de relevancia, para que cada profesional socio sanitario asuma que su participación es vital para el bienestar de la persona.

ABSTRACT This research aims to demonstrate the social benefits of a nursing intervention protocol for patients with outpatient surgery for anorectal diseases. A systematic bibliographic review was carried out to make a reflexive critical analysis of the content of original and review articles published between 2015 and 2021 in Spanish, Portuguese and English. The search was carried out in the Medline, Pubmed and SciELO databases from January to June 2021, based on the theoretical assumptions of an investigation carried out in the outpatient operating room of the provincial university hospital "Manuel Ascunce Domenech". The importance of care protocols was confirmed, since they are relevant, so that each socio-health professional has in his actions the certainty that his intervention is vital for the well-being of the person.

Úlcera rectal solitaria como simulador de cáncer colorrectal y enfermedad de Crohn: reporte de caso / Solitary rectal ulcer simulating colorectal cancer and Crohn's disease: Case report

Resumen La úlcera rectal solitaria es una patología poco frecuente de naturaleza benigna que debe diferenciarse de otras entidades en su presentación inicial, con mecanismos fisiopatológicos definidos y con sintomatología variada. Se presenta el caso de una paciente de 31 años sin antecedentes de importancia, que consultó a nuestra institución por un cuadro de 3 años de sangrado rectal asociado con episodios de diarrea, manejada con múltiples diagnósticos.

Abstract Solitary rectal ulcer is a rare condition of benign nature that must be differentiated from other disorders with defined pathophysiological mechanisms and varied symptoms. The following is the case of a 31-year-old female patient with no relevant history, who consulted our institution due to symptoms of rectal bleeding associated with episodes of diarrhea for three years, who received multiple diagnoses.

Anorectal diseases in patients with Antiphospholipid syndrome: a cross-sectional study.

BACKGROUND: Hemorrhoid disease (HD) is one of the most common gastrointestinal complaints worldwide, affecting 4.4% of the general population in the United States. Since antiphospholipid syndrome (APS) may lead to intra-abdominal thrombosis, one may expect that this condition can impact the risk for HD development. Additionally, as APS patients are more prone to thrombosis and treatment with anticoagulants may increase risk of bleeding, one may also infer that rates of HD complications may be higher in this scenario. Nevertheless, no data in these regards have been published until now. The objective of the present study is to evaluate frequency of HD and describe its complications rates in antiphospholipid syndrome APS patients. METHODS: We consecutively invited patients who fulfilled APS criteria to undergo proctological examination. After examination, patients were divided in two groups, based on the presence of HD, and compared regarding different clinical manifestations and antiphospholipid profile. We performed the analysis of the data, using chi-square and Mann Whitney U when applicable and considering a significance level of 0.05. Multivariate regression analysis included age and variables with p < 0.10 in the bivariate analysis. RESULTS: Forty-one APS patients agreed to undergo proctological examination. All were female and overall median age was 43 (36-49). Seventeen (41.4%) patients were diagnosed with HD, with the following frequency distribution: 7 internal (41.2%), 4 external (23.5%) and 5 mixed hemorrhoids (29.4%). Of the internal hemorrhoids, 5 patients were classified as grade I (71.4%), 1 grade II (14.3%), and 1 grade IV (14.3%). Prior gestation (p = 0.067) and constipation (p = 0.067) correlated with a higher frequency of HD. In multivariate analysis, constipation remained as an important risk factor (OR 3.92,CI95% 1.03-14.2,p = 0.037). Five out of 17 patients (29.4%) reported anal bleeding, but it did not correlate with warfarin dose (p = 0.949). Surgical treatment was indicated for 10 patients (58.8%). Other anorectal findings were anal fissure, plicoma, condyloma and one chlamydial retitis. CONCLUSION: We found an unexpected high frequency of hemorrhoids in APS patients, with a great proportion requiring surgical treatment.

Anorectal diseases in patients with Antiphospholipid syndrome: a cross-sectional study

Abstract Background: Hemorrhoid disease (HD) is one of the most common gastrointestinal complaints worldwide, affecting 4.4% of the general population in the United States. Since antiphospholipid syndrome (APS) may lead to intra-abdominal thrombosis, one may expect that this condition can impact the risk for HD development. Additionally, as APS patients are more prone to thrombosis and treatment with anticoagulants may increase risk of bleeding, one may also infer that rates of HD complications may be higher in this scenario. Nevertheless, no data in these regards have been published until now. The objective of the present study is to evaluate frequency of HD and describe its complications rates in antiphospholipid syndrome APS patients. Methods: We consecutively invited patients who fulfilled APS criteria to undergo proctological examination. After examination, patients were divided in two groups, based on the presence of HD, and compared regarding different clinical manifestations and antiphospholipid profile. We performed the analysis of the data, using chi-square and Mann Whitney U when applicable and considering a significance level of 0.05. Multivariate regression analysis included age and variables with p < 0.10 in the bivariate analysis. Results: Forty-one APS patients agreed to undergo proctological examination. All were female and overall median age was 43 (36-49). Seventeen (41.4%) patients were diagnosed with HD, with the following frequency distribution: 7 internal (41.2%), 4 external (23.5%) and 5 mixed hemorrhoids (29.4%). Of the internal hemorrhoids, 5 patients were classified as grade I (71.4%), 1 grade II (14.3%), and 1 grade IV (14.3%). Prior gestation ( p = 0.067) and constipation ( p = 0.067) correlated with a higher frequency of HD. In multivariate analysis, constipation remained as an important risk factor (OR 3.92,CI95% 1.03-14.2, p = 0.037). Five out of 17 patients (29.4%) reported anal bleeding, but it did not correlate with warfarin dose ( p = 0.949). Surgical treatment was indicated for 10 patients (58.8%). Other anorectal findings were anal fissure, plicoma, condyloma and one chlamydial retitis. Conclusion: We found an unexpected high frequency of hemorrhoids in APS patients, with a great proportion requiring surgical treatment.(AU)

Anoplastia com plicoma sentinela para o tratamento de fissura anal crônica / Anoplasty with skin tag flap for the treatment of chronic anal fissure

RESUMO Objetivo: avaliar os resultados de longo prazo da correção de fissuras anais crônicas em pacientes sem hipertonia anal usando a técnica de anoplastia com o plicoma sentinela. Métodos: estudo prospectivo de pacientes com fissura anal crônica refratários ao tratamento conservador e sem hipertonia anal, submetidos à operação de anoplastia com utilização do plicoma anal para cobrir a área cruenta. Foi confirmada a ausência de hipertonia anal através do toque retal e da eletromanometria. Foi aplicado um questionário de dor visual e o escore de incontinência fecal da Cleveland Clinic, antes e após a cirurgia. Resultados: quinze pacientes com fissura anal crônica foram acompanhados por um período médio de 29 meses (12 a 56). A média de idade foi 41 anos (29 a 69) e a duração dos sintomas variou entre seis meses e cinco anos. A cicatrização ocorreu entre três e seis semanas para 13 pacientes (86,7%). Os outros dois pacientes foram submetidos a desbridamento e nova anoplastia, com sucesso. Em nenhum paciente ocorreu necrose do plicoma ou estenose anal. O escore de incontinência anal não se alterou após o procedimento e todos os pacientes referiram melhora da dor. Após 12 meses de seguimento, nenhum paciente apresentou recorrência ou incontinência anal e 93,3% (14/15) dos pacientes responderam estar muito satisfeitos. Conclusão: fissurectomia e anoplastia com o uso do plicoma sentinela é uma técnica segura que resulta em melhora da dor sem alterações da continência fecal e com altas taxas de satisfação.

ABSTRACT Objective: to evaluate the long-term results of the correction of chronic anal fissures (CAF) in patients without anal hypertonia using the technique of anoplasty with skin tag flap. Methods: we conducted a prospective study of CAF patients refractory to conservative treatment without anal hypertonia, subjected to anoplasty with the use of anal plicoma to cover the bloody area. We confirmed the absence of anal hypertonia through rectal exam and electromanometry. We applied a visual pain questionnaire and the Cleveland Clinic fecal incontinence score before and after surgery. Results: we followed 15 patients with chronic anal fissure for a mean period of 29 months (12-56). The mean age was 41 years (29-69) and the duration of symptoms ranged from six months to five years. Healing occurred between three and six weeks for 13 patients (86.7%). The other two patients underwent debridement and new anoplasty successfully. No plicoma necrosis or anal stenosis occurred in any patient. The anal incontinence score did not change after the procedure, and all patients reported reduced pain. After 12 months of follow-up, none of the patients presented recurrence or anal incontinence, and 93.3% (14/15) of the patients were very satisfied. Conclusion: fissurectomy and anoplasty with the use of sentinel plie is a safe technique that results in improvement in pain without change of fecal continence and with high satisfaction rates.

Continence changes following transanal endoscopic microsurgery result from the impact on rectal capacity: clinical and functional evaluation before and after surgical treatment / Alterações da continência após microcirurgia endoscópica transanal resultam do impacto sobre a capacidade retal: avaliação clínica e funcional antes e após tratamento cirúrgico

ABSTRACT Introduction: Described in 1983 and with a stable clinical application, the impact of Transanal Endoscopic Microsurgery on anorectal function remains unknown. The objectives of the present study were to evaluate the impact of Transanal Endoscopic Microsurgery on anorectal function according to clinical (Wexner score) and functional (anorectal manometry) evaluations before and after surgery. Method: Prospectively, 23 consecutive patients with rectal lesions were operated using TEO® equipment (Karl Storz, Tuttlingen, Germany). For all patients, the value of Wexner score was obtained before and after surgery (7, 30 and 90 days) and anorectal electromanometry was performed before surgery, and also postoperatively (30 and 90 days). Results: Fourteen patients were men. The mean age was 53.7 (24-81) years. The mean distance from the lesion to the pectineal line was 7 (2-15) cm. The histopathologic analysis revealed adenoma in 14 (61%); neuroendocrine tumor in 5 (21.7%); invasive carcinoma in 3 (13%); and hyperplastic polyp in 1 (4.3%) case. The mean duration of postoperative follow-up was 5 (3-7) months. Wexner score was significantly lower at 30 days compared to 7 days (Wilcoxon; p = 0.03). Rectal capacity was significantly lower 30 days after surgery and recovered at 90 days of surgery (ANOVA; p = 0.04). Conclusions: After Transanal Endoscopic Microsurgery, a modest impact on anorectal function can be observed. The transient impairment results from loss of rectal capacity and not from impairment of the anal sphincters, being completely resolved 90 days after surgery.

RESUMO Introdução: Descrita em 1983 e de sólida aplicação clínica, o impacto da Microcirurgia Endoscópica Transanal sobre a função anorretal permanece pouco conhecido. Os objetivos do presente estudo foram avaliar o impacto da Microcirurgia Endoscópica Transanal na função anorretal conforme avaliações clínica (Wexner score) e funcional (manometria anorretal) antes e após a cirurgia. Método: Prospectivamente, 23 pacientes consecutivos com lesões retais foram operados com o uso do equipamento TEO® (Karl Storz, Tuttlingen, Alemanha). Para todos os pacientes, o valor do escore de Wexner foi obtido antes e após a cirurgia (7, 30 e 90 dias) e a eletromanometria anorretal foi realizada antes da cirurgia e também no pós-operatório (30 e 90 dias). Resultados: Quatorze pacientes eram homens. A idade média foi 53,7 (24-81) anos. A distância média da lesão à linha pectínea foi de 7 (2-15) cm. A histopatológica revelou adenoma em 14 (61%), tumor neuroendócrino em 5 (21,7%); carcinoma invasivo em 3 (13%) e pólipo hiperplásico em 1 (4,3%) caso. A duração média do seguimento pós-operatório foi de 5 (3-7) meses. O escore de Wexner foi significativamente menor aos 30 dias em comparação com 7 dias (Wilcoxon; p = 0,03). A capacidade retal foi significativamente menor aos 30 dias após a cirurgia e recuperada aos 90 dias após a cirurgia (ANOVA; p = 0,04). Conclusões: Após Microcirurgia Endoscópica Transanal, um impacto modesto na função anorretal pode ser observado. O comprometimento transitório resulta de perda de capacidade retal e não por comprometimento dos esfíncteres anais cessando completamente 90 dias após a cirurgia.

Advantages of the robotic approach to deep infiltrating rectal endometriosis: because less is more.

For symptomatic deep infiltrating endometriosis, surgery is often required to achieve symptom relief and restore fertility. A minimally invasive approach using laparoscopy is considered the gold standard. However, specific limitations of the laparoscopic approach deep in the pelvis keep challenging even surgeons with a solid experience with minimally invasive techniques. Robotic surgery has the potential to compensate for technical drawbacks inherent in conventional laparoscopic surgery, such as limited degree of freedom, two-dimensional vision, and the fulcrum effect. In the present report, we aim at demonstrating the central role of robotic surgery for deep infiltrating endometriosis, with special emphasis in the ability to practice organ (rectal) preservation. A 45-year-old white female with a 4-month history of chronic pelvic pain, dyschezia, and dysmenorrhea, refractory to hormonal therapy was referred to our unit. MRI findings were diagnostic of deep infiltrating endometriosis (retrocervical and rectovaginal) extending to the anterior rectal serosal layer (partial-thickness rectal invasion). Using a fully robotic approach, appropriate dissection of the rectovaginal septum and of the extraperitoneal rectum followed by complete excision of the endometriotic rectal nodule with organ (rectal) preservation was undertaken. It is our belief that using a robotic approach, the potential to boost rectal preservation might be established. Moreover, it is possible that in many cases, a robotic operation may allow the surgeon to perform the intervention with greater accuracy and comfort. As a result, more patients with deep infiltrating endometriosis may benefit from rectal sparing procedures.

Manometric analysis of the influence of rectal content on anal pressures in chronically constipated patients / Análise manométrica da influência do conteúdo retal nas pressões anais em pacientes cronicamente constipados

OBJECTIVE: The aim of our study was to analyze whether the presence of content in the rectum influences the anorectal manometry examination results in chronically constipated patients. METHODS: We evaluated 38 chronically constipated patients, 36 women and 2 men, with an average age of 53.55 years of age, all with a score above 10 on the Agachan Constipation Scoring System. All the patients underwent rectal preparation and then had the anorectal manometry examination without rectal content and after 5 min had it with a rectal balloon inflated with 200 ml of air in the rectum. STATISTICAL ANALYSIS: The statistical parametric paired-t test was applied in order to verify the difference in response between the groups after an intervention, adopting a significant level of 5% (p < 0.05). RESULTS: The anal pressure was analyzed from the standard anal manometry examination and we found a statistically significant influence on the manometric results for the patients' average resting pressures, absolute average contractions, average contractions, evacuations, and sustained contractions in the functional anal canals. CONCLUSION: The presence of rectal content influences the manometric values of average resting pressure, average absolute contraction, average contraction, evacuation, and average sustained contractions in the functional anal canal in the group of chronically constipated patients. (AU)

OBJETIVO: O objetivo deste estudo foi analisar se a presença de conteúdo no reto influencia os resultados do exame de manometria anorretal em pacientes cronicamente constipados. MÉTODOS: Foram avaliados 38 pacientes cronicamente constipados, 36 mulheres e dois homens, com média de 53,55 anos de idade, todos com pontuação acima de 10 no Agachan Constipation Scoring System. Todos os pacientes foram submetidos a preparo retal e, em seguida, passaram por um exame de manometria anorretal sem conteúdo retal e, depois de transcorridos cinco minutos, um novo exame foi realizado, agora com um balão retal inflado com 200 ml de ar no reto. ANÁLISE ESTATÍSTICA: Na análise estatística, foi aplicado o teste t paramétrico, com a finalidade de verificar a diferença, em termos de resposta, entre os grupos após uma intervenção. Para tanto, foi adotado um nível de significância de 5% (P < 0,05). RESULTADOS: A pressão anal foi analisada com base no exame de manometria anal de rotina; em nossos pacientes, foi observada influência estatisticamente significativa nos resultados manométricos para as pressões médias em repouso, contrações médias absolutas, contrações médias, evacuações e contrações sustentadas nos canais anais funcionais. CONCLUSÃO: A presença de conteúdo retal influencia os valores manométricos da pressão média em repouso, contração absoluta média, contração média, evacuação, e contrações sustentadas médias no canal anal funcional no grupo de pacientes cronicamente constipados. (AU)

Expressão de mediadores neurotróficos e pró-inflamatórios na endometriose de reto e sigmoide / Expression of neurotrophic and inflammatory mediators in rectosigmoid endometriosis

OBJETIVO: Avaliar a expressão de mediadores neurotróficos (NGF, NPY E VIP) e pró-inflamatórios (TNF-α) em fragmentos de reto e sigmoide comprometidos por endometriose. MÉTODOS: Foram selecionadas 24 pacientes submetidas ao tratamento cirúrgico de endometriose de reto e sigmoide com técnica de ressecção segmentar, seguido de anastomose mecânica término-terminal, com grampeador circular, no período de janeiro de 2005 a dezembro de 2007. Neste estudo incluímos mulheres no menacme que se submeteram a tratamento cirúrgico por endometriose profunda infiltrativa com acometimento do reto e sigmoide, atingindo o nível da camada muscular, submucosa ou mucosa. Para o grupo de estudo foram utilizados 24 fragmentos de reto e sigmoide com endometriose confirmada histologicamente, sendo um fragmento de cada uma das 24 pacientes selecionadas. Para o grupo controle, utilizou-se um fragmento da margem distal da ressecção, denominado anel de anastomose, de cada uma das 24 pacientes selecionadas e incluídas no estudo. As amostras foram agrupadas em blocos de Tissue Micro Array (TMA) e submetidas à reação imunoistoquímica para avaliar a expressão do fator de necrose tumoral alfa (TNF-α), do fator de crescimento neural (NGF), do neuropeptídeo Y (NPY) e do peptídeo intestinal vasoativo P (VIP), e posterior análise semiquantitativa da imunomarcação por meio da leitura da densidade ótica relativa (DO). RESULTADOS: Observou-se maior densidade ótica relativa da imunomarcação para TNF-α e NGF no grupo de estudo (amostras com endometriose intestinal), DO= 0,01, respectivamente, para as duas proteínas (p<0,05), em relação aos controles sem endometriose. Não houve diferença estatística na densidade ótica da imunomarcação do NPY e VIP. CONCLUSÃO: Identificou-se o aumento da imunomarcação dos anticorpos TNF-α e NGF em fragmentos de reto e sigmoide comprometidos por endometriose em relação aos controles livres da doença. Não identificamos diferença estatística na imunomarcação das proteínas NPY e VIP.

PURPOSE: To evaluate the expression of neurotrophic (NGF, NPY and VIP) and pro-inflammatory (TNF-α) mediators in the rectum and sigmoid fragments compromised by endometriosis. METHODS: Twenty-four patients were selected to undergo surgical treatment of endometriosis of the rectum and sigmoid colon with a segmental resection technique, followed by end-to-end anastomosis with a circular stapler from January 2005 to December 2007. The study included premenopausal women who underwent surgical treatment for deep endometriosis infiltrating the rectum with involvement of the rectum and sigmoid, reaching the level of the muscle layer, submucosa or mucosa. Twenty-four rectum and sigmoid fragments with histologically confirmed endometriosis, one from each of the 24 selected patients, were used for the study group. For the control group, we used a fragment of the distal resection margin called anastomosis ring from each of the 24 patients enrolled in the study. Samples were grouped into Tissue Micro Array (TMA) blocks and subjected to immunohistochemistry to evaluate the expression of tumor necrosis factor alpha (TNF-α), nerve growth factor (NGF), neuropeptide Y (NPY) and P vasoactive intestinal peptide (VIP), followed by semiquantitative analysis of immunostaining by reading the relative optical density (OD). RESULTS: There was higher optical density relative to TNF-α immunostaining and NGF in the study group (samples with intestinal endometriosis), DO=0.01, for the two proteins, respectively (p<0.05), compared to controls without endometriosis. There was no statistically significant difference in the optical density of immunostaining of NPY and VIP. CONCLUSION: We identified increased immunostaining of TNF-α antibodies and fragments of NGF in the rectum and sigmoid compromised by endometriosis compared to disease-free controls. We did not identify any statistical difference in immunostaining of NPY and VIP proteins.

Adenocarcinoma colorretal com células em anel de sinete em criança: relato de caso / Colorectal adenocarcinoma with signet-ring cells in children: case report

Adenocarcinoma colorretal com células em anel de sinete é uma variante do adenocarcinoma mucinoso. Esse tipo de neoplasia é comum em pacientes com idade avançada, sendo raro em crianças, sendo geralmente diagnosticado em estágios avançados. Apresenta pior prognóstico e baixa taxa de sobrevida em cinco anos. O diagnóstico é realizado por exame anatomopatológico associado a exames de imagem e quadro clínico evolutivo. Apresenta-se e discute-se um caso de adenocarcinoma colorretal com células em anel de sinete em um paciente de 14 anos.

Colorectal Adenocarcinoma with signet-ring cells is a mucinous variant of adenocarcinoma. This type of neoplasm is common in patients with advanced age, being sufficiently uncommon in children and diagnosied in advanced periods of training already, presenting one worse prognostic and supervened tax of below five year. The diagnostic is carried through anatomy-pathological examination, associate the image examinations and picture physician-evolution. We present and we argue a case report of colorectal adenocarcinoma with signet-ring cells in a patient of fourteen years.

Associação de lesões anorretais em portadoras de infecção genital por HPV e neoplasia cérvico-uterina / Association between anorectal lesions in women with genital HPV infection and cervical-uterine neoplasia

OBJETIVOS: Diagnosticar a presença do HPV anorretal em portadoras dessa afecção no trato genital inferior, através do exame coloproctológico com anuscopia de alta resolução. MÉTODOS: Estudo observacional e transversal realizado através de um protocolo de pesquisa, no Hospital Universitário da UFAL de Fevereiro a Julho de 2008, analisando 57 mulheres com diagnóstico prévio de infecção genital por HPV submetendo-as a uma avaliação através da anuscopia de alta resolução. RESULTADOS: A idade média variou de 31,2 anos, seis pacientes eram gestantes, 59,6 por cento cursaram apenas o 1º grau, 73,7 por cento tinham união estável; A idade média de menarca foi 12,6 anos e a sexarca de 17 anos. Em relação ao número de parceiros sexuais, 33,3 por cento tiveram 2 a 3 parceiros; 68,6 por cento apresentaram lesão intraepitelial genital de baixo grau (LGSIL), CONCLUSÕES: 89,5 por cento não apresentavam lesões e 10,5 por cento apresentavam através da anuscopia de alta resolução(AAR) lesões sub-clínicas perianal, vulvar e vaginal. É possível e viável ao especialista incorporar o exame de anuscopia de alta resolução para diagnóstico de HPV ano-retal na forma subclínica à sua rotina, já que é de simples execução, barato e a doença acomete pacientes sem lesões visíveis ao exame proctológico.

AIM: To diagnose the presence of anorectal HPV in women with lower genital tract lesions, through rectal examination with High Resolution Anuscopy. METHODS: Observational, transversal study conducted by a research protocol in the Hospital Universitário Prof. Alberto Antunes (HUPAA/UFAL) from February to July 2008, examining 57 women with a previous diagnosis of genital HPV infection by subjecting them to an assessment by High Resolution Anuscopy. RESULTS: The mean age ranged from 31.2 years, six patients were pregnant women, 59.6 percent had finished elementary school, 73.7 percent were in a stable union with a partner, the average age of menarche was 12.6 years and 17 years for the first intercourse. Regarding the number of sexual partners, 33.3 percent had 2 to 3 partners, 68.6 percent had low grade squamous intraepithelial lesion (LGSIL), CONCLUSIONS: 89,5 percent had no lesions and 10,5 percent had subclinical perianal, vulvar and vaginal lesions. It is possible and feasible to the professionals incorporate the High Resolution Anuscopy for diagnosis of HPV in anorectal subclinical lesions to their routine, it is simple,inexpensive and mainly because the disease affects patients with no visible lesions to the anorectal examination.