High expression level of homocitrulline is correlated with seborrheic keratosis and skin aging

Abstract Backgroud Homocitrulline (Hcit), is involved in the pathological processes of some diseases. However, the role and function of Hcit (CBL) in human skin remains largely obscure. Objective To investigate the correlation of the level of Hcit in seborrheic keratosis, skin aging, and its clinical significance. Methods Immunohistochemistry was used to analyze the level of Hcit in skin lesions of seborrheic keratosis (SK), unaffected skin (distant 0.5 centimeters from SK lesion), and normal skin of healthy subjects in the control group. ELISA test was used to detect the serum level of CBL in SK patients and healthy subjects of different ages. Results Hcit was mainly localized in the nucleus of epidermal cells. In healthy control skin, the expression of Hcit increased with age and showed a positive correlation with age (the correlation coefficient was 0.806, p = 0.0002). The expressional level of Hcit in SK lesions was higher than that in healthy control skin (Z = −3.703, p = 0.0002). The serum level of CBL in healthy subjects and in SK patients increased with age (the correlation coefficient were 0.5763, p = 0.0032; 0.682, p = 0.004. respectively). The serum level of CBL in SK patients was higher than that in healthy subjects (Z = −2.19, p = 0.030). Study limitations The small serum sample size in the study. Conclusion The high expressional level of Hcit is correlated with seborrheic keratosis and skin aging. HCit may be one of the potential biomarkers of skin aging.

High expression level of homocitrulline is correlated with seborrheic keratosis and skin aging.

BACKGROUD: Homocitrulline (Hcit), is involved in the pathological processes of some diseases. However, the role and function of Hcit (CBL) in human skin remains largely obscure. OBJECTIVE: To investigate the correlation of the level of Hcit in seborrheic keratosis, skin aging, and its clinical significance. METHODS: Immunohistochemistry was used to analyze the level of Hcit in skin lesions of seborrheic keratosis (SK), unaffected skin (distant 0.5 centimeters from SK lesion), and normal skin of healthy subjects in the control group. ELISA test was used to detect the serum level of CBL in SK patients and healthy subjects of different ages. RESULTS: Hcit was mainly localized in the nucleus of epidermal cells. In healthy control skin, the expression of Hcit increased with age and showed a positive correlation with age (the correlation coefficient was 0.806, p = 0.0002). The expressional level of Hcit in SK lesions was higher than that in healthy control skin (Z = -3.703, p = 0.0002). The serum level of CBL in healthy subjects and in SK patients increased with age (the correlation coefficient were 0.5763, p = 0.0032; 0.682, p = 0.004. respectively). The serum level of CBL in SK patients was higher than that in healthy subjects (Z = -2.19, p = 0.030). STUDY LIMITATIONS: The small serum sample size in the study. CONCLUSION: The high expressional level of Hcit is correlated with seborrheic keratosis and skin aging. HCit may be one of the potential biomarkers of skin aging.

Queratosis seborreica: variante clonal. reporte de un caso / Seborrheic clonal keratosis. case report

RESUMEN Las queratosis seborreicas son tumores benignos muy frecuentes en la práctica diaria y la mayoría de los pacientes desarrollarán alguna en el transcurso de la vida. La variante clonal es una forma histopatológica rara y su importancia radica en la necesidad de realizar diagnóstico diferencial con otras patologías de mayor relevancia como carcinoma basocelular e incluso melanoma. Se presenta el caso clínico de una paciente de 76 años con una lesión histológicamente compatible con la variante clonal de la queratosis seborreica.

SUMMARY Seborrheic keratoses are benign tumors that are very common in daily dermatology practice and most patients will develop some over the course of their lives. The clonal variant is a rare histopathological form and its importance lies in the need to perform a differential diagnosis with other pathologies of greater relevance such as basal cell carcinoma and even malignant melanoma. We present the clinical case of a 76-year-old female patient with a diagnosis of clonal seborrheic keratosis.

Melanoacanthoma: a potential pitfall of reflectance confocal microscopy.

Melanoacanthoma is a rare variant of seborrheic keratosis, which is notable for dark pigmentation and fast radial growth, making it difficult to distinguish from melanoma. Histologically, it is characterized by proliferation of keratinocytes and dendritic melanocytes. The authors report a scalp lesion, fast growing, suspected by dermoscopy and confocal microscopy examination, with dendritic cells distributed throughout the lesion. Based on these findings, it was not possible to classify this lesion as clearly benign, so it was excised. Histopathologic evaluation and immunostain were consistent with melanoacanthoma.

Melanoacanthoma: a potential pitfall of reflectance confocal microscopy

Abstract Melanoacanthoma is a rare variant of seborrheic keratosis, which is notable for dark pigmentation and fast radial growth, making it difficult to distinguish from melanoma. Histologically, it is characterized by proliferation of keratinocytes and dendritic melanocytes. The authors report a scalp lesion, fast growing, suspected by dermoscopy and confocal microscopy examination, with dendritic cells distributed throughout the lesion. Based on these findings, it was not possible to classify this lesion as clearly benign, so it was excised. Histopathologic evaluation and immunostain were consistent with melanoacanthoma.

Miscellaneous Perianal Afflictions.

This article provides an overview of hidradenitis suppurativa, lichen planus, lichen sclerosis, calcinosis cuti, pyogenic granuloma, intertrigo, and seborrheic keratosis. This article also focuses on recognition and management of these pleomorphic afflictions of the perianal region.

Signo de leser-trélat, signo paraneoplásico en cáncer de mama metastásico: presentación de caso / Leser-trélat sign: paraneoplastic sign in metastatic breast cancer, case presentation / Sinal de leser-trélat: sinal paraneoplásico em câncer de mama metastático, apresentação de caso

Resumen El signo de Leser-Trélat es una erupción súbita y de veloz crecimiento de cuantiosas queratosis seborreicas secundarias a una neoplasia interna. Estas pueden estar relacionadas con prurito y acantosis nigricans. Las neoplasias asociadas frecuentemente al signo de Leser-Trélat son los adenocarcinomas gástricos, de colon y mama, representado en menor cantidad por linfomas, carcinoma de células escamosas y malignidades hematológicas. Siendo el signo de Leser-Trélat una dermatosis paraneoplásica infrecuente, se presenta un caso de una paciente de 76 años con cáncer de mama avanzado asociado a este signo.

Abstract The Leser-Trelat sign is a sudden and rapid growth eruption of large seborrheic keratoses secondary to an internal neoplasm. These may be related to pruritus and acanthosis nigricans. The neoplasms frequently associated with the Leser-Trélat sign are gastric, colon and breast adenocarcinomas, represented to a lesser extent by lymphomas, squamous cell carcinoma and hematological malignancies. As the Leser-Trélat sign is an uncommon paraneoplastic dermatosis, a case of a 76-year-old patient with advanced breast cancer associated with this sign is presented.

Resumo O sinal de Leser-Trélat é uma erupção súbita e de veloz crescimento de múltiplas ceratoses seborreicas secundárias a uma neoplasia interna. Estas podem estar relacionadas com prurido e acantose nigricans. As neoplasias associadas frequentemente ao sinal de Leser-Trélat são os adenocarcinomas gástricos, de colón e mama, representado em menor quantidade por linfomas, carcinoma de células escamosas e malignidades hematológicas. Sendo o sinal de Leser-Trélat uma dermatose paraneoplásica infrequente, apresenta-se um caso de uma paciente de 76 anos com câncer de mama avançado associado a esse sinal.

Queratosis seborreica eruptiva y su asociación con cáncer gastrointestinal. Un estudio de casos y controles / Eruptive seborrheic keratosis and its association with gastrointestinal cancer. A case-control study

Resumen Introducción: se ha propuesto la existencia de asociación entre queratosis seborreica eruptiva y algunas neoplasias malignas. Sin embargo, la evidencia acerca de esto es pobre: tres estudios europeos de casos y controles cuyos resultados no la apoyan. El objetivo del estudio es evaluar en población colombiana la existencia o no de esta asociación. Material y métodos: estudio de 130 casos y 260 controles pareados por edad y sexo en mayores de 18 años entre pacientes con cáncer gastrointestinal o pancreatobiliar (casos) u hospitalizados por otras razones no oncológicas (controles) en el Hospital Universitario de Santander, Bucaramanga (Colombia). A todos los pacientes se les realizó examen cutáneo minucioso, incluyendo dermatoscopia, para identificar la presencia y tiempo de evolución de queratosis seborreica en zonas cubiertas por ropa. Resultados: la prevalencia de queratosis seborreica entre los casos fue 26.9% (IC95% 19.5-35.4) y de 15.4% (IC95% 11.2-20.4) entre los controles (OR 1.94, IC95% 1.17-3.19). Siete pacientes con cáncer presentaban la queratosis seborreica en los seis meses previos al diagnóstico de la neoplasia (5.3%, IC95% 2.2-10.8) frente a ninguno entre los pacientes control (0.0%, IC95% 0.0-1.4; p<0.001); tres de ellos tenían 20 o más lesiones de menos de seis meses de aparición (2.3% de los casos, IC95% 0.5-6.6) frente a ninguno entre los controles (p=0.014). Discusión: este estudio trata de subsanar las debilidades de los únicos tres estudios previos que exploran la asociación entre queratoris seborreica y cáncer mediante la rigurosa selección de pacientes, la inclusión de pacientes con cáncer de un solo sistema corporal y un proceso estricto para evaluar las lesiones cutáneas con dermatoscopia. Esto permite concluir que en pacientes colombianos con cáncer gastrointestinal hay mayor frecuencia de queratosis seborreica y de queratoris seborreica eruptiva que en personas de igual edad y sexo sin cáncer. (Acta Med Colomb 2017; 42: 224-229).

Abstract Introduction: the association between eruptive seborrhoeic keratosis and some malignant neoplasms has been proposed. However, the evidence about this is poor: three European case-control studies whose results do not support it. The objective of the study is to evaluate the existence or not of this association in the Colombian population. Material and methods: study of 130 cases and 260 matched controls for age and sex in patients over 18 years of age among patients with gastrointestinal or pancreatobiliary cancer (cases) or hospitalized for other non-oncological reasons (controls) at the University Hospital of Santander, Bucaramanga (Colombia). All patients underwent meticulous skin examination including dermatoscopy, to identify the presence and time of evolution of seborrheic keratosis in areas covered by clothing. Results: the prevalence of seborrheic keratosis among the cases was 26.9% (95% CI 19.5-35.4) and 15.4% (95% CI 11.2-20.4) among the controls (OR 1.94, 95% CI 1.17-3.19). Seven patients with cancer presented seborrheic keratosis in the six months prior to the diagnosis of neoplasia (5.3%, 95% CI 2.2-10.8) compared to none among control patients (0.0%, 95% CI 0.0-1.4, p <0.001); three of them had 20 or more lesions less than six months of onset (2.3% of cases, 95% CI 0.5-6.6) compared to none among controls (p = 0.014). Discussion: this study tries to correct the weaknesses of the only three previous studies that explore the association between seborrheic keratosis and cancer by rigorous selection of patients, the inclusion of cancer patients from a single body system and a strict process to evaluate the skin lesions with dermatoscopy. This allows concluding that in Colombian patients with gastrointestinal cancer there is a greater frequency of seborrheic keratosis and eruptive seborrheic keratosis than in people of the same age and sex without cancer. (Acta Med Colomb 2017; 42: 224-229).

Association of Dowling-Degos disease and multiple seborrheic keratosis in a "Christmas tree pattern".

Dowling-Degos disease is a rare sporadic or autosomal dominant pigmentary entity, in which clusters of papules and reticulate macules slowly develop with predominance in flexural regions. This entity is due to mutations in the keratin 5 gene, and is related with other cutaneous disorders. We report the sporadic form of Dowling-Degos disease in an elderly man with multiple seborrheic keratosis in a "Christmas tree" pattern. Worthy of note in this case study is the lesions evolved for over than 30 years. The aim is to describe the association of these keratoses with Dowling-Degos disease in a healthy man.

El signo de Leser-Trélat ¿Un predictor de neoplasias útil en clínica? / The Leser-Trélat sign A useful predictor of neoplasms in clinic?

Propósito: el signo de Leser-Trélat conjuga la presencia simultánea de queratosis seborreica eruptiva con una neoplasia maligna, pero existen publicaciones de pacientes con queratosis con o sin la neoplasia. Se buscó establecer si hay evidencia sobre esta asociación para considerar la potencialidad de la aparición de tales lesiones dermatológicas como un hallazgo precoz de neoplasias malignas. Fuente de datos: revisión sistemática de la literatura ubicada en Medline, Cochrane, Lilacs, Scholar Gloogle e Imbiomed. Selección de estudios: se evaluaron todos los artículos afines a queratosis seborreica eruptiva y cáncer, sin límite en edad, sexo, tipo de artículo o idioma. Extracción de datos: se leyeron de 668 resúmenes y se revisaron 120 artículos completos, 66 utilizados en este informe. Resultados: la evidencia que apoya la asociación entre queratosis seborreica súbita y cáncer es pobre: sólo existen cuatro estudios de casos y controles cuyos resultados no apoyan esta asociación. Conclusiones: la gran mayoría de las publicaciones son producto del hallazgo al azar de las dos entidades y no producto de la búsqueda sistemática de una de ellas cuando aparece la otra, lo que refleja una especie de sesgo de selección a la hora de publicar dichos casos.

Purpose: the sign of Leser-Trélat conjugates the simultaneous presence of eruptive seborrheic keratoses with a malignancy, but there are reports of patients with keratosis with or without neoplasia. The establishment of whether there is evidence for this association to consider the potential for the occurrence of such skin lesions as an early finding of malignant neoplasms was sought. Data Sources: a systematic review of the literature located on Medline, Cochrane, Lilacs, Schoolar Google and Imbiomed. Study Selection: all articles related to eruptive seborrheic keratosis and cancer, with no limit on age, sex, type of article or language were evaluated. Data Extraction: 668 abstracts were read and 120 full articles were reviewed, 66 used in this report. Results: the evidence supporting the association between sudden seborrheic keratosis and cancer is poor: there are only four case-control studies whose results do not support this association. Conclusions: the vast majority of publications are the product of chance finding of the two entities and not the result of a systematic search of one of them when the other appears, reflecting a kind of selection bias in publishing such cases.

Queratosis seborreica: análisis clínico e histopatológico de 5.093 biopsias / Seborrheic keratosis: clinical and histopathological analysis of 5.093 biopsies

Introducción: La presencia de queratosis seborreica (QS) es un frecuente motivo de consulta dermatológica por parte de los pacientes que la padecen. Objetivos: Describir la clínica y epidemiología de los pacientes con queratosis seborreica. Analizar edad y sexo, localización anatómica, variantes histológicas, lesiones adyacentes. Material y Método: Estudio descriptivo retrospectivo de 5.093 biopsias con diagnóstico clínico o histológico de QS entre enero de 2001 a diciembre de 2005. Se evaluaron sexo, edad apellidos del paciente, localización anatómica variante histológica y lesiones. Resultados: De un total de 54.320 biopsias recibidas, 4,515 corresponden a QS confirmada por histología 53% en mujeres y 47% en varones, siendo más frecuentes en áreas fotoexpuestas. La variable histológica más habitual es la queratosis seborreica común. Conclusión: La distribución por grupos de edad en relación al sexo es similar. En este estudio la QS fue más frecuente en el sexo femenino. La mayoría de las QS se encuentran en zonas 100% fotoexpuestas.

Introduction: The presence of seborrheic keratosis (SK) is a frequent cause of dermatological consultation. Objectives: Describe the clinical epidemiology of patients with seborrheic keratosis. Analyzing age and sex, anatomic location, histological variants and adjacent lesions. Material and Method: A retrospective descriptive study of 5,093 biopsies with clinical or histological diagnosis of SK from January 2010 to December 2005. We assessed gender, age, surname, anatomic location histological variants and injuries. Results: Of 54,320 biopsies received, 4,5 1 5 are SK histologically confirmed, 53% in females and 47% in men, being more common in sun-exposed areas. The mast frequent histological variable is common seborrheic keratosis. Conclusion: Distribution by age groups in relation to gender is similar. In this study, SK was more common in females, Most SK are located in 100% sun-exposed areas.