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1.
Foot Ankle Int ; 45(4): 383-392, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38445607

ABSTRACT

BACKGROUND: Whether arthroscopic microfracture is effective in treating cystic osteochondral lesions of the talus (OLTs) remains controversial. In this study, outcome parameters in patients with small and shallow subchondral cysts are compared to patients without cysts with the hypothesis that equivalent outcomes may be found after primary microfracture treatment. METHODS: From 2018 to 2021, all 50 OLTs treated with arthroscopic microfracture in the authors' hospital were retrospectively reviewed for eligibility. Single unilateral symptomatic lesions were included and divided into the cyst and noncyst groups, whereas kissing lesions and arthritic lesions were excluded. Numeric rating scale (NRS) scores, American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot scores, Tegner activity level scores, Foot and Ankle Ability Measure (FAAM) scores, and magnetic resonance (MR) imaging results were used to describe outcomes. RESULTS: A total of 35 patients were included, 16 in the cyst group and 19 in the noncyst group. The patient characteristics were similar between the 2 groups (P > .05). In the cyst group the average cysts depth was 5.0 ± 1.3 mm. After a mean follow-up duration of 36.2 ± 10.2 months, no significant differences were found between the 2 groups in NRS, AOFAS, FAAM, or Tegner score improvement (P > .05). Three patients (19%) in the cyst group had no NRS score improvement. CONCLUSION: OLTs with small and shallow subchondral cysts can be treated with arthroscopic microfracture and achieve similar outcomes as noncystic lesions. A few cystic lesions may not respond to microfracture treatment. LEVEL OF EVIDENCE: Level III, retrospective comparative study.


Subject(s)
Arthroscopy , Bone Cysts , Talus , Humans , Talus/surgery , Talus/injuries , Retrospective Studies , Female , Arthroscopy/methods , Adult , Male , Bone Cysts/surgery , Bone Cysts/diagnostic imaging , Middle Aged , Magnetic Resonance Imaging , Arthroplasty, Subchondral/methods , Cartilage, Articular/surgery , Cartilage, Articular/injuries
2.
Orthop J Sports Med ; 12(2): 23259671241226719, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38343645

ABSTRACT

Background: Limited literature is available regarding the effect of subchondral cysts on the surgical outcomes for treatment of osteochondral lesion of the talus (OLT). Purpose: To conduct a systematic review and meta-analysis of studies comparing surgical outcomes between OLTs with and without cysts. Study Design: Systematic review; Level of evidence, 4. Methods: Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, the authors searched PubMed, Embase, Web of Science, and the Cochrane Library for relevant studies published up to January 7, 2023. The 4375 retrieved studies were screened, and 9 articles (level of evidence, 2-4) were included, which comprised 165 patients with OLT and subchondral cysts (cyst group) and 223 without cysts (noncyst group). After data extraction, mean differences in outcome scores (American Orthopaedic Foot and Ankle Society [AOFAS] Ankle Hindfoot Scale, visual analog scale [VAS] score for pain) and adverse events were compared between the groups. Results: Functional scores improved after surgery in both groups, with the cyst group having a significantly higher AOFAS score than the noncyst group (P = .005; I2 = 0%); subgroup analysis revealed that this difference was attributable to the size of the osteochondral lesion and the type of surgical procedure. No significant difference was found between the cyst and noncyst groups in VAS pain scores (P = .77; I2 = 0%) or postoperative adverse events (P = .35; I2 = 0%). Conclusion: The results of this review indicated that patients with subchondral cysts improved with surgical treatment of OLT. A relatively low level of evidence was available to indicate that surgical treatment for small OLTs with subchondral cysts will result in better clinical outcomes compared with OLTs without cysts.

3.
Cureus ; 16(1): e52078, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38344643

ABSTRACT

Large subchondral bone cysts in the medial talar body and dome are common and can cause persistent pain and swelling during axial loading. Open debridement and bone grafting are often necessary to treat these lesions but can require extensive soft-tissue dissection or malleolar osteotomies. A 40-year-old woman presented with ankle pain and swelling for 1 year, worsening with activity and no history of trauma. X-rays showed a cystic lesion in the medial talar dome with no joint line disruption. CT confirmed the cystic lesion without bone collapse or expansion. An anterior approach to the ankle joint was extended to access the talar neck. A window was created in the talar neck to debride and curette the medial talar dome, and the void was filled with allograft. The patient was non-weight-bearing for 6 weeks, followed by gradual weight-bearing and ankle range of motion exercises starting on postoperative day 1. The patient returned to her pre-injury status within 3 months and was asymptomatic at the 6-year follow-up, with good bone graft integration and no symptoms. This technical note presents a novel approach to lesions of the medial talar body and dome through the talar neck, avoiding the need for malleolar osteotomy or disruption to the tibiotalar joint, and resulting in good functional outcomes.

4.
Foot Ankle Int ; 44(10): 1003-1012, 2023 10.
Article in English | MEDLINE | ID: mdl-37530135

ABSTRACT

BACKGROUND: Retrograde drilling remains technically challenging, because of the difficulty of identifying the accurate location of cysts during surgery. This study's aim was to evaluate the 3-dimensional (3D) image-based surgical navigation-assisted endoscopic retrograde drilling technique for subchondral bone lesions of the talus. METHODS: From March 2017 to June 2020, a total of 21 cases with Hepple stage V subchondral bone lesions of the talus were treated with 3D image-based surgical navigation-assisted endoscopic retrograde drilling and bone graft technique. Arthroscopic views were categorized per Pritsch classifications. The correlation between the drilled tunnel with preoperative cystic lesions were assessed under postoperative computer tomographic (CT) scans. The American Orthopaedic Foot & Ankle Society (AOFAS) scores, visual analog scale (VAS) scores, and Foot and Ankle Ability Measure (FAAM) sports scales were evaluated at the preoperative and final consultation. All complications were recorded. RESULTS: On postoperative CT scans, in 20 cases (95.2%), the drilled tunnel was judged to have been in the center of previous cysts. Only 9 cases (42.9%) showed intact normal cartilage (grade 0, group A); 12 cases (57.1%) had intact, but soft, cartilage (grade I, group B). The median follow-up time was 24 (24, 30) months, and at final follow-up, there were no significant differences between the mean AOFAS and VAS scores in both groups (89.0 ± 6.4 vs 88.3 ± 7.0 and 1 vs 0.5) or postoperative FAAM sports scales (28.2 ± 2.2 vs 26.6 ± 4.9, P = .363). Two patients had revision surgery in group B. CONCLUSION: The 3D image-based surgical navigation-assisted endoscopic retrograde drilling and bone graft technique for the subchondral bone lesions of the talus in this small case series showed encouraging results. LEVEL OF EVIDENCE: Level IV, retrospective case series.


Subject(s)
Bone Diseases , Cartilage Diseases , Cartilage, Articular , Cysts , Talus , Humans , Talus/diagnostic imaging , Talus/surgery , Talus/pathology , Retrospective Studies , Arthroscopy/methods , Bone Diseases/pathology , Cartilage Diseases/pathology , Treatment Outcome , Cartilage, Articular/surgery , Magnetic Resonance Imaging
5.
J Orthop Case Rep ; 13(7): 116-120, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37521389

ABSTRACT

Introduction: Osteoarthritis is now understood to be an aberrant remodeling of the joint organ caused by wear-and-tear mechanism and by a variety of inflammatory mediators. Subchondral cysts have been one of the important radiological features of knee osteoarthritis that is not well understood. We report a case of large subchondral lytic lesion which was initially thought to be a giant cell tumor and later was identified as subchondral cyst. Case Report: A 50-year-old man presented to the outpatient department with complaints of intermittent pain and swelling over the left knee associated with difficulty in performing his daily activities Patient had undergone cerclage wiring for fracture left patella fracture 8 years back following which pain started. Radiographs showed extensive degenerative change at the knee with a large, multilocular lytic lesion in the proximal tibia. Magnetic resonance imaging showed similar features with an additional lesion in the distal femur. Core needle biopsy and histopathological examination of both lesions showed fibrocollageous tissue with bone fragments and lymphocytes. Patient was treated conservatively with analgesics and physiotherapy. He had good relief of pain and is on regular follow-up till date. Discussion: Osteoarthritis knee is the most prevalent and leading cause of pain and disability worldwide. Subchondral cysts are strongly associated with osteoarthritis. Articular cartilage damage in osteoarthritis exposes the subarticular bone to injury, particularly in the weight-bearing joints. Large cysts are a well-recognized feature of other disorders such as simple bone cyst, aneurysmal bone cyst, giant cell tumor, and osteomyelitis. As these cases are rarely reported the treatment options are not standardized. Studies had shown similar cases treated both conservatively and surgically. The occurrence of the pathological fracture in these cases is high so prophylactic surgical fixation of massive geodes is advised. We decided to treat our case conservatively with analgesics and physiotherapy. The patient has good relief of pain at present and is on regular follow-up. He has been counseled that he may need a total knee replacement in the future if pain increases in severity. Conclusion: In the presence of osteolytic lesion showing very large cyst with cortical expansion and septations in radiographs with adjacent joint arthritis, the diagnosis of subchondral cyst/Geode should be strongly considered.

6.
J Clin Med ; 12(3)2023 Jan 19.
Article in English | MEDLINE | ID: mdl-36769464

ABSTRACT

Osteoarthritis is a degenerative joint disease affecting middle-aged and elderly patients. It mainly involves weight-bearing joints such as the hip, knee and spine as well as the basilar joint of the thumb, causing dysfunction and painful symptoms. Often, joint arthritis is accompanied by cartilage defects, joint space narrowing, osteophytes, bone sclerosis and subchondral bone cysts (SBC). The aim of the present study was to explore the pathophysiology responsible for the development of SBCs as well as the association between SBCs and disease progress, the level of clinical symptoms and their impact on postoperative outcomes and risk of possible complications following joint replacements if left untreated. A literature review on PubMed articles was conducted to retrieve and evaluate all available evidence related to the main objective mentioned above. A few theories have been put forth to explain the formation process of SBCs. These involve MMPs secretion, angiogenesis, and enhanced bone turnover as a biological response to abnormal mechanical loads causing repeated injuries on cartilage and subchondral tissue during the development of arthritis. However, the application of novel therapeutics, celecoxib-coated microspheres, local administration of IGF-1 and activated chondrocytes following surgical debridement of SBCs hinders the expansion of SBCs and prevents the progression of osteoarthritis.

7.
J Prosthodont Res ; 67(3): 392-399, 2023 Jul 31.
Article in English | MEDLINE | ID: mdl-36288977

ABSTRACT

PURPOSE: This observational study aimed to elucidate the pathophysiology of subchondral cysts (SC) in the temporomandibular joint (TMJ) and examine the results of conservative therapy administered to patients with SCs in the TMJ. METHODS: The study included 41 patients with SCs, extracted from 684 consecutive patients who underwent magnetic resonance imaging (MRI). The anatomical features of SCs and positional abnormalities of the articular disc were initially evaluated using MRI. A second MRI examination was performed for 28/41 patients at 40-107 months (mean, 66 months) after the first MRI. The joint space, anteroposterior width of the condylar head (WiC), articular eminence angle (AEA), and visual analog scale of jaw pain (VAS) were assessed alongside the MRI examinations. RESULTS: Most SCs were present in the anterosuperior and central condyle. Disc displacement was observed in 100% of 42 TMJs with SCs. Of the 29 joints in 28 patients, SCs in 19 joints resolved with time, whereas SCs in 10 joints persisted. A significant increase in the WiC and a significant decrease in AEA and VAS scores were observed on the second MRI scan. CONCLUSIONS: SCs tended to form in the anterosuperior and central parts of the condyle, where mechanical loading was likely to be applied. SCs are strongly associated with articular disc displacement. Two-thirds of SCs resolved over time, accompanied by resorption and osteophytic deformation of the condyle. SC might not be an indicator for the start of surgical treatment, and nonsurgical treatment could improve the clinical symptoms of patients with SCs.


Subject(s)
Bone Cysts , Joint Dislocations , Temporomandibular Joint Disorders , Humans , Follow-Up Studies , Cross-Sectional Studies , Mandibular Condyle/diagnostic imaging , Mandibular Condyle/pathology , Temporomandibular Joint Disorders/diagnostic imaging , Temporomandibular Joint Disorders/therapy , Temporomandibular Joint/diagnostic imaging , Magnetic Resonance Imaging/methods , Bone Cysts/diagnostic imaging , Bone Cysts/pathology , Joint Dislocations/pathology , Joint Dislocations/therapy
8.
J Equine Vet Sci ; 118: 104092, 2022 11.
Article in English | MEDLINE | ID: mdl-35940387

ABSTRACT

To date, only a few reports describe the treatment. The present report describes an extraarticular surgical approach, with the insertion of an absorbable implant, to treat a Subchondral cystic lesion (SCL) in the humeral head 3year old racing Thoroughbred & in the talus of a 11year old Arabian horse. SCLs were radiographically visible and associated with severe lameness. Scintigraphy showed focal intense radiopharmaceutical uptake in both cases, and CT scan revealed signs of osteoarthrosis associated with SCL in the talus. The use of a biocompatible, osteoinductive and osteoconductive implant allowed a reduction of the SCL radiographic appearance of at least 70% in both cases and horses returned to their previous athletic activity. The results of the present study might provide substantial information about a new surgical option to treat SCLs in the scapulohumeral and tarsocrural joints and may broaden prognosis and prolong future athletic ability of affected horses.


Subject(s)
Bone Cysts , Horse Diseases , Talus , Horses , Animals , Talus/diagnostic imaging , Lameness, Animal/diagnosis , Horse Diseases/diagnostic imaging , Humeral Head/diagnostic imaging , Bone Cysts/diagnostic imaging , Bone Cysts/veterinary
10.
Hip Int ; 31(5): 663-668, 2021 Sep.
Article in English | MEDLINE | ID: mdl-32172601

ABSTRACT

INTRODUCTION: Osteoarthritis in dysplastic hips should develop from the lateral side of the acetabulum and the femoral head just below. However, the existence of subchondral cysts located more on the medial side contradicts the weight-loading theory. The aim of this study was to confirm the presence of medial cysts at the femoral head and to investigate the relationship between medial cysts and injuries of the ligamentum teres in hip dysplasia. METHODS: A retrospective analysis was conducted on 257 cases of hip dysplasia. All patients had x-rays and 3-dimensional computed tomographies (3D CT) preoperatively and 123 patients had magnetic resonance arthrographies. A comparison was performed between cases with and without medial cysts according to the severity of damage to the ligamentum teres, the presence of bony spurs around the fovea capitis, and the Tönnis grade. RESULTS: Medial subchondral cysts around the fovea capitis were found in 100 cases. Mild osteoarthritis (Tönnis grade 0 or 1) was present in 89% of cases in the medial cyst group. A significant difference between the groups was observed in the incidence of bony spurs around the fovea capitis (p < 0.05) and injuries of the ligamentum teres (p < 0.05). CONCLUSIONS: The formation of subchondral cysts at the medial femoral head in hip dysplasia may be related to damage in the ligamentum teres. Considering that subchondral cysts develop in early osteoarthritis, the progression of arthritis in hip dysplasia appears to correlate with damage to the ligamentum teres, as well as compressive pressure on the joint.


Subject(s)
Bone Cysts , Hip Dislocation , Acetabulum , Bone Cysts/diagnostic imaging , Bone Cysts/etiology , Femur Head/diagnostic imaging , Hip Dislocation/diagnostic imaging , Hip Dislocation/etiology , Hip Joint/diagnostic imaging , Humans , Retrospective Studies
11.
Oral Radiol ; 36(2): 156-162, 2020 04.
Article in English | MEDLINE | ID: mdl-31197739

ABSTRACT

OBJECTIVES: The present study aimed to clarify the reliabilities of four characteristic appearances, subchondral cyst, erosion, generalized sclerosis, and osteophyte, for evaluation of degenerative diseases with osseous changes in the temporomandibular joint (TMJ) using panoramic TMJ projection imaging and computed tomography (CT), and to investigate the imaging features of these modalities for subchondral cyst with reference to its magnetic resonance imaging (MRI) features. METHODS: The reliabilities (κ values) of panoramic TMJ projection and CT images were determined by three radiologists for each characteristic appearance of TMJ osseous changes in 146 condyles. The features of cyst-like areas on CT images with agreement among the three radiologists were investigated for size, location, and continuity with the joint space together with MRI signal intensity and surrounding edema-like lesions. RESULTS: Panoramic TMJ projection images showed moderate and substantial agreements for erosion and osteophyte evaluations, respectively; while CT images showed substantial agreements for subchondral cyst, erosion, and osteophyte evaluations. Cyst-like areas on CT images were predominantly located in the central parts and 69 of 86 (80.2%) areas showed no communication with the joint space. Cyst-like areas with diameters exceeding 2 mm showed high or moderate MRI signal intensities. Edema-like lesions were observed in 10 of 28 (29.4%) condyles. CONCLUSIONS: The reliabilities of panoramic TMJ projection and CT images were clarified for each characteristic appearance. The results support the bone contusion theory for the formation of subchondral cysts in the TMJ. A possible improvement in reliability is suggested relative to MRI findings.


Subject(s)
Bone Cysts , Osteophyte , Temporomandibular Joint Disorders , Bone Cysts/diagnostic imaging , Humans , Osteophyte/diagnostic imaging , Reproducibility of Results , Temporomandibular Joint , Temporomandibular Joint Disorders/diagnostic imaging
13.
Rheumatology (Oxford) ; 58(4): 588-599, 2019 04 01.
Article in English | MEDLINE | ID: mdl-29982826

ABSTRACT

OBJECTIVES: Detailed knowledge of the sequential cell and tissue responses following haemarthrosis is important for a deep understanding of the pathological process initiated upon extensive bleeding into the joint causing haemophilic arthropathy (HA). The underlying pathobiology driving haemarthrosis towards HA has been difficult to establish in detail, although animal models have shed light on some processes. Previous studies have focused on a single or a few distant time points and often only characterizing one tissue type of the joint. The objective of this study was, therefore, to carefully map early onset of synovitis and HA following induced haemarthrosis. METHODS: One hundred and thirty haemophilia A rats were subjected to induced haemarthrosis or a sham procedure in full anaesthesia and euthanized from 30 min to 7 days after the procedure. Pathological changes of the joints were visualized using micro-computed tomography, histology and immunohistochemistry. RESULTS: Synovitis developed within 24 h and was dominated by myeloid cell infiltrations. Cartilage and bone pathology were evident as early as 48-96 h after haemarthrosis, and the pathology rapidly progressed with extensive periosteal bone formation and formation of subchondral cysts. CONCLUSION: Fast, extensive and simultaneous cartilage and bone degeneration developed shortly after haemarthrosis, as shown by the detailed mapping of the early pathogenesis of HA. The almost immediate loss of cartilage and the pathological bone turnover suggest a direct influence of blood on these processes and are unlikely to be attributed simply to an indirect effect of inflammation.


Subject(s)
Bone and Bones/physiopathology , Cartilage/physiopathology , Hemarthrosis/physiopathology , Hemophilia A/complications , Synovitis/physiopathology , Animals , Bone Remodeling , Disease Models, Animal , Hemarthrosis/etiology , Inflammation , Rats , Synovitis/etiology , X-Ray Microtomography
14.
Surg Pathol Clin ; 10(3): 731-748, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28797511

ABSTRACT

A number of nonneoplastic conditions can mimic tumors of bone. Some of the more common mimics of primary bone tumors include infectious, inflammatory, periosteal, and degenerative joint disease-associated lesions that produce tumorlike bone surface-based or intraosseous lesions. This article considers a spectrum of reactive and nonreactive processes including stress fracture, subchondral cysts, osteonecrosis, heterotopic ossification, osteomyelitis, sarcoidosis, and amyloidoma that can present in such a way that they are mistaken for a tumor arising primary in bone.


Subject(s)
Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Bone Cysts/diagnostic imaging , Bone Cysts/pathology , Bone Diseases/diagnostic imaging , Bone Diseases/pathology , Diagnosis, Differential , Fractures, Bone/diagnostic imaging , Fractures, Bone/pathology , Humans , Ossification, Heterotopic/diagnostic imaging , Ossification, Heterotopic/pathology , Osteomyelitis/diagnostic imaging , Osteomyelitis/pathology , Osteonecrosis/diagnostic imaging , Osteonecrosis/pathology
15.
J Foot Ankle Surg ; 55(5): 1003-6, 2016.
Article in English | MEDLINE | ID: mdl-27432027

ABSTRACT

The aim of the present study was to clinically evaluate whether the presence of subchondral cysts had an effect on the treatment results of autologous osteochondral graft transfer in osteochondral lesions of the talus. Patients were enrolled in the present study according to the inclusion criteria. In the evaluation, we divided the patients into 2 groups according to presence (n = 13 patients) or absence (n = 15 patients) of a subchondral cyst. The mean age, body mass index, follow-up period, and lesion size in each group were measured and compared, and no statistically significant differences were found between the 2 groups (p > .05). The clinical assessment was performed using the American Orthopaedic Foot and Ankle Society Hindfoot scoring system, visual analog scale, and International Knee Society scoring system. No statistically significant difference was found between the pre- and postoperative scores of the 2 patient groups (p > .05). The successful results in both groups after a 2-year follow-up period have demonstrated that treatment of osteochondral lesions of the talus with osteochondral graft transfer is a safe method that can be performed independently of the presence of a subchondral cyst.


Subject(s)
Bone Cysts/surgery , Bone Transplantation/methods , Osteochondritis Dissecans/surgery , Talus/surgery , Adolescent , Adult , Bone Cysts/diagnostic imaging , Bone Transplantation/rehabilitation , Cohort Studies , Female , Follow-Up Studies , Graft Survival , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Osteochondritis Dissecans/diagnostic imaging , Pain/physiopathology , Pain/surgery , Pain Measurement , Postoperative Care/methods , Retrospective Studies , Risk Assessment , Splints , Statistics, Nonparametric , Talus/diagnostic imaging , Transplantation, Autologous , Treatment Outcome , Young Adult
16.
Am J Sports Med ; 43(8): 1951-6, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25989800

ABSTRACT

BACKGROUND: Although various treatment modalities for an osteochondral lesion of the talus (OLT) with a subchondral cyst have been recommended previously, the primary treatment methods for such conditions have yet to be conclusively determined. Moreover, few comprehensive studies have compared the outcomes of cases where patients were treated with microfracture for OLT with and without subchondral cysts. PURPOSE: To evaluate the clinical outcomes after arthroscopic microfractures performed as a primary treatment for OLT with a subchondral cyst. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: The study cohort consisted of 102 patients (102 ankles) who underwent arthroscopic microfracture for small to midsized OLT. The ankles were divided into a cyst group (45 ankles) and a noncyst group (57 ankles).The American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot scale, visual analog scale (VAS), and Ankle Activity Score (AAS) were used to compare the clinical outcomes between the groups over a mean follow-up period of 48 months. RESULTS: The mean AOFAS ankle-hindfoot scores were 64.8 in the cyst group and 66.2 in the noncyst group preoperatively. These improved to 91.8 and 91.3, respectively, at the final follow-up. The mean VAS scores were 7.5 in the cyst group and 7.3 in the noncyst group preoperatively; these improved to 2.3 and 2.2, respectively, at the final follow-up. The mean AAS in the cyst group and the noncyst group improved from 2.7 and 2.6 preoperatively to 6.7 and 6.5 at the final follow-up, respectively. In terms of radiographic stage improvements, the cyst group showed no change in 18 ankles (40%) and showed improvements of 1 grade in 13 ankles (28.9%), 2 grades in 9 ankles (20%), 3 grades in 3 ankles (6.7%), and 4 grades in 2 ankles (4.4%). The noncyst group showed no change in 17 ankles (29.8%) and showed improvements of 1 grade in 11 ankles (19.3%), 2 grades in 11 ankles (19.3%), 3 grades in 14 ankles (24.6%), and 4 grades in 4 ankles (7.0%). No significant differences were found between the groups in terms of the AOFAS score, VAS score, AAS, or radiographic stage improvements. CONCLUSION: OLT with and without subchondral cysts treated with arthroscopic microfracture showed similarly good clinical results. The study results suggest that microfracture could be a primary treatment strategy for treating small to midsized OLT regardless of the existence of subchondral cysts.


Subject(s)
Ankle Joint/surgery , Arthroscopy/methods , Bone Cysts/complications , Cartilage, Articular/pathology , Cartilage, Articular/surgery , Talus/pathology , Talus/surgery , Adult , Ankle Joint/physiopathology , Cohort Studies , Female , Humans , Male , Middle Aged , Pain Measurement , Visual Analog Scale , Young Adult
17.
Bone ; 66: 140-5, 2014 Sep.
Article in English | MEDLINE | ID: mdl-24925444

ABSTRACT

INTRODUCTION: Subchondral cysts are deeply related to the pathogenesis of osteoarthritis (OA), but the factors contributing to cyst formation are not well known. A three-dimensional analysis of subchondral cysts at the micro-structural level was conducted using a high-resolution peripheral quantitative CT (HR-pQCT), and their relationships with cartilage attrition and subchondral bone microstructure were investigated. METHODS: Femoral heads extracted from ten female patients with hip OA were scanned using an HR-pQCT at a voxel size of 41µm. The volume fractions, numbers, and sizes of the cysts were measured in the subchondral bone region under the area of cartilage loss. Furthermore, the areas of cartilage loss, as well as the microstructure of the subchondral bones, were also measured, and their correlations with the cysts were analyzed. RESULTS: The volume fractions of cysts within subchondral bone regions varied from 2% to 33%, the numbers of cysts varied from 6 to 87, and the sizes varied from 1mm(3) to 657mm(3). There was a positive correlation between the number of cysts and bone volume (r>0.8, p<0.01). CONCLUSION: The degree of cyst formation showed a wide distribution in number and volume, and there was a close relationship between multiple cyst formation and bone sclerosis, which might be caused by reactive bone formation that occurred around each cyst.


Subject(s)
Bone Cysts/diagnostic imaging , Imaging, Three-Dimensional , Osteoarthritis, Hip/diagnostic imaging , Tomography, X-Ray Computed , Aged , Aged, 80 and over , Bone Cysts/pathology , Bone and Bones/diagnostic imaging , Bone and Bones/pathology , Cartilage/diagnostic imaging , Cartilage/pathology , Female , Femur Head/diagnostic imaging , Femur Head/pathology , Humans , Middle Aged , Organ Size , Osteoarthritis, Hip/pathology
18.
Osteoarthritis Cartilage ; 21(11): 1685-92, 2013 Nov.
Article in English | MEDLINE | ID: mdl-23948977

ABSTRACT

OBJECTIVE: To evaluate the relationship of hip radiographic osteoarthritis (ROA) and MRI findings of cartilage lesions, labral tears, bone marrow edema-like lesions (BMELs) and subchondral cysts with self-reported and physical function. DESIGN: Eighty five subjects were classified as controls (n = 55, Kellgren-Lawrence (KL) 0, 1) or having mild-moderate ROA (n = 30, KL 2, 3). T2 weighted MRI images at 3-T were graded for presence of cartilage lesions, labral tears, BMELs and subchondral cysts. Posterior wall sign, cross-over sign, center-edge angle and alpha angle were also recorded. Function was assessed using Hip dysfunction and Osteoarthritis Outcome Score (HOOS), Timed-Up and Go (TUG) test and Y-Balance Test (YBT). Analysis compared function between subjects with and without ROA and those with and without femoral or acetabular cartilage lesions, adjusted for age. Non-parametric correlations were used to assess the relationship between radiographic scores, MRI scores and function. RESULTS: Subjects with acetabular cartilage lesions had worse HOOS (Difference = 5-10%, P = 0.036-0.004), but not TUG or YBT, scores. Acetabular cartilage lesions, BMELs and subchondral cysts were associated with worse HOOS scores (ρ = 0.23-0.37, P = 0.041-0.001). Differences in function between subjects with and without ROA or femoral cartilage lesions were not significant. Other radiologic findings were not associated with function. CONCLUSIONS: Acetabular cartilage defects, but not femoral cartilage defects or ROA, were associated with greater self-reported pain and disability. BMELs and subchondral cysts were related to greater hip related self-reported pain and disability. None of the radiographic or MRI features was related to physical function.


Subject(s)
Cartilage, Articular/injuries , Osteoarthritis, Hip/complications , Pain/etiology , Adult , Aged , Bone Cysts/diagnosis , Bone Cysts/etiology , Bone Marrow Diseases/diagnosis , Bone Marrow Diseases/etiology , Cartilage, Articular/pathology , Case-Control Studies , Exercise Test/methods , Female , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Osteoarthritis, Hip/diagnostic imaging , Osteoarthritis, Hip/physiopathology , Pain Measurement/methods , Radiography , Self Report , Severity of Illness Index
19.
Ces med. vet. zootec ; 6(2): 109-117, jul.-dic. 2011. ilus, tab, graf
Article in Spanish | LILACS | ID: lil-648243

ABSTRACT

Se reporta el caso de una paciente equina, evaluada por Especial•Vet práctica privada, la cual presentaba alexamen clínico ortopédico un grado de claudicación II/V en ambos miembros posteriores (según clasificaciónde la AAEP), la cual no presento mejoría después de realizar un tratamiento médico de tipo parenteral confenilbutazona. Posteriormente se realizó un nuevo examen clínico ortopédico en el cual se realizó bloqueoanestésico perineural abaxial en ambos miembros posteriores encontrando una mejoría del 90% con respectoal grado de claudicación inicial. Se realizó evaluación radiológica digital, con las siguientes proyecciones:dorso plantar y lateromedial en las cuales se evidenció un área radiolúcida circunscrita a nivel del terciodistal de la primera falange, con comunicación a la articulación interfalángica proximal en ambos miembros posteriores, seguidamente se realizó evaluación ultrasonográfica en la cual se observa un área anecóica y lafalta de continuidad de la superficie ósea a nivel de la articulación interfalángica proximal de ambos miembrosposteriores. Estableciendo de esta forma como diagnóstico definitivo quiste subcondral a nivel del tercio distalde la primera falange, con comunicación a la articulación interfalángica proximal. Se realizó infiltración conacetato de triamcinolona, betametasona y ácido hialurónico a nivel intrarticular; antibioterapia de maneraprofiláctica al procedimiento, descanso en pesebrera por 4 semanas y reincorporación al ejercicio de maneraprogresiva, suministro de complementos condroprotectores de manera enteral (Flexequin® 40 gr/día VO yCortaflex® 20 ml/día VO). Al momento de la publicación de este artículo, la paciente no presenta ningún gradode claudicación y se encuentra realizando un trabajo físico y atlético normal.


We report the case of an equine patient, assessed by Especial Vet private practice, whose orthopedic clinicalexamination showed a degree of lameness II / V in both hind limbs (according to AAEP classification), whichdemonstrated no improvement after medical treatment with parenteral phenylbutazone. Subsequently a neworthopedic clinical examination was performed in which an abaxial, perineural anesthetic block was applied to both hind legs, which produced 90% improvement compared to the initial degree of lameness. Digital radiographicevaluation was performed with the following results: dorsal-plantar and lateral-medial images which showeda circumscribed, radiolucent area at the level of the distal third of the first phalanx, with communication to theproximal interphalangeal joint on both hind limbs. Following, an ultrasound evaluation was carried out in whichthere was an anechoic area and lack of continuity of the bone surface at the proximal interphalangeal joint of bothhind limbs. These findings established a definitive diagnosis of a subchondral bone cyst at the distal third of the firstphalanx, with communication to the proximal interphalangeal joint. Intra-articular infiltration was performed with triamcinolone acetonide, betamethasone and hyaluronic acid; antibiotics as prophylaxis, rest in a stable for 4 weekswith a gradual return to exercise, and provision of enteral, chondroprotective supplements (p.o. Flexequin ® 40 gr/day and p.o. Cortaflex ® 20ml/day). At the time of publication of this article, the patient does not present any degreeof lameness and is performing normal athletic and physical activity.


Relatamos um caso de um paciente eqüino, avaliado pela prática privada Especial Vet, cujo exame clínicoortopédico mostrou um grau de claudicação II / V em ambos os membros posteriores (de acordo com aclassificação do AAEP), o qual não demonstrou melhora após o tratamento médico com fenilbutazona parenteral.Após a aplicação de um bloqueio anestésico perineural abaxial em ambas as pernas traseiras, foi realizadoum novo exame clínico ortopédico, mostrando uma melhora de 90% em comparação com o grau inicial declaudicação. Realizou-se também uma avaliação radiográfica digital obtendo-se os seguintes resultados: imagensdorso-plantar e latero-medial que mostrou uma área radiolúcida circunscrita ao nível do terço distal da primeirafalange, com comunicação para a articulação interfalângica proximal em ambos os membros posteriores. E após,a realização de um ultra-som, verificou-se que houve uma área anecóica e falta de continuidade da superfície óssea ao nível da articulação interfalângica proximal dos dois membros posteriores. Desta forma estabeleceu umdiagnóstico definitivo de um cisto ósseo subcondral no terço distal da primeira falange, com comunicação para aarticulação interfalângica proximal. Uma infiltração intra-articular foi realizada com acetato de triamcinolona,betametasona e ácido hialurônico; antibióticos como profilaxia, um descanso em estábulo durante 4 semanas, com um retorno gradual aos exercícios, e administração de suplementos condroprotetores de maneira enteral(Flexequin® 40 gr/día VO e Cortaflex® 20 ml/día VO). No momento da publicação deste artigo, o paciente nãoapresenta qualquer grau de claudicação e está realizando atividades atléticas e físicas normais.


Subject(s)
Animals , Lameness, Animal/therapy , Clinical Diagnosis/veterinary , Phenylbutazone/therapeutic use , Lameness, Animal , Bone Cysts/veterinary , Therapeutics/instrumentation , Therapeutics/veterinary
20.
Article in Korean | WPRIM (Western Pacific) | ID: wpr-651833

ABSTRACT

Subchondral cyst is a benign cystic lesion, and it is often found in patients with rheumatoid arthritis or osteoarthritis. However, its occurrence in those joints without preexisted disease is rare. Furthermore, there has been no report in the medical literature regarding pathologic fracture in the bony plate of a subchondral cyst at the superior acetabulum. We report here on a case of the 44-year-old woman for whom a pathologic fracture was found in the bony plate of a subchondral cyst at the superior acetabulum.


Subject(s)
Adult , Female , Humans , Acetabulum , Arthritis, Rheumatoid , Bone Cysts , Fractures, Spontaneous , Joints , Osteoarthritis
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