ABSTRACT
Objective: To observe the effect of Xuebijing Injection on the expression of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in patients with severe pneumonia. Methods: Totally 100 patients with severe pneumonia were randomly assigned to the conventional treatment group (n = 50) and Xuebijing treatment group (n = 50). Each group was given conventional treatment, while in the Xuebijing treatment group, Xuebijing Injection was additionally given for consecutive 7 d. Ten healthy people were chosen as normal control group. The changes of patients' body temperature, white blood cell count, C-reactive protein, arterial oxygenation, and oxygenation index in two groups were compared. The expression levels of IL-6 and TNF-α were detected by ELISA method at different time points. Results: In conventional treatment group and Xuebijing treatment group, the patients' body temperature, white blood cell count, C-reactive protein, arterial oxygenation, and oxygenation index were significantly improved after treatment (P < 0.01). Compared with conventional treatment group, in Xuebijing treatment group, these indicators were significantly improved after treatment (P < 0.05 or 0.01). Compared with normal control group, in conventional treatment group and Xuebijing treatment group, the expression levels of IL-6 and TNF-α were significantly higher. Compared with the conventional treatment group, in Xuebijing treatment group, the expression levels of IL-6 and TNF-α had no significant difference before the treatment. On days 3 and 7 after Xuebijing administration, the expression levels of IL-6 and TNF-α decreased than those before the treatment. The expression levels of IL-6 and TNF-α in Xuebijing treatment group significantly decreased than those in the conventional treatment group. Conclusion: Xuebijing Injection can reduce the levels of IL-6 and TNF-α in patients with severe pneumonia, thus this agent has certain auxiliary therapeutic effect in the treatment of patients with severe pneumonia.
ABSTRACT
Post-stroke depression (PSD) referred to the onset of depression after being diagnosed with post-stroke. It was a secondary disease, mainly including depression, little words, sleep disorders, anorexia, absence of interest, undynamic, passiveness, misfitting rehabilitation and so on. It was not only a psychological and physiological disease, but also delay the function recovery of damaged nerves, influence the patient’s quality of life, and increase the rate of disability and mortality. It was essential to research and develop effective and safe treatment medication. This paper reviewed the current situation and developing prospects of western medicine, Chinese medicinal, treatment of integrated traditional Chinese medicine and western medicine in PSD treatment.
