1.
Acta Microbiol Acad Sci Hung
; 22(2): 145-52, 1975.
Article
in English
| MEDLINE
| ID: mdl-1168398
ABSTRACT
In studying the transformation of diazepam (7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one) by fungi isolated from soil. N1-demethylation and cleavage of the diazepine ring were observed. Three metabolites: 7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 2-acetamido-2"-benzoyl-4"-chloroacetanilide and 2-acetamido-2"-benzoyl-4"-chloro-N-methylacetanilide were isolated and identified.
Subject(s)
Diazepam/metabolism , Fungi/metabolism , Soil Microbiology , Acetanilides/analogs & derivatives , Acetanilides/biosynthesis , Aspergillus/metabolism , Benzodiazepinones/biosynthesis , Biodegradation, Environmental , Chemical Phenomena , Chemistry , Chromatography, Thin Layer , Fermentation , Hydrolysis , Mass Spectrometry , Mitosporic Fungi/metabolism , Mucorales/metabolism , Penicillium/metabolism , Rhizopus/metabolism , Spectrophotometry, Infrared
2.
J Med Chem
; 16(10): 1106-12, 1973 Oct.
Article
in English
| MEDLINE
| ID: mdl-4201421
