Comparison of the levels of the serotonin metabolite, 5-hydroxyindole acetic acid, in cerebrospinal fluid from patients with and without premature ejaculation / Comparación de los niveles de ácido 5-hidroxindolacético, metabolito de la serotonina, en el líquido cefalorraquídeo de pacientes con y sin eyaculación precoz

Introduction: Premature ejaculation (PE) is a significant problem as it can cause a loss of sexual self-confidence and a significant deterioration in quality of life. The frequency of PE varies between 9% and 27%. In the current study, we aimed to compare the levels of the serotonin metabolite 5HIAA (5 hydroxyindole acetic acid) in the cerebrospinal fluid (CSF) of patients with and without PE according to IELT (intravaginal ejaculation latency time) in order to investigate the relationship of PE with CSF 5HIAA levels. Materials and methods: A total of 60 male patients were included in the study who were planning to undergo surgery under spinal anesthesia, 30 in the patient (PE) group (all of the included patients had an IELT of <1min) and 30 in the control group (patients had an IELT of > 1 min). Levels of CSF 5HIAA were measured. Results: There was a significant negative correlation between IELT and the 5HIAA variables in all patients (r = -0.322, p = 0.012). Although the average 5HIAA levels (nmol/L) were higher in the patient group (86.80 ± 28.33) than in the control group (76.44 ± 35.91), this difference was not significant (p = 0.22). Discussion: Results of the current study bring new and different perspectives to the explanation of PE pathophysiology. There is a need for more specific and genetic studies to determine the best treatment for this common disorder

Introducción: La eyaculación precoz (EP) es un problema importante, ya que puede provocar una pérdida de confianza sexual en uno mismo y un deterioro considerable de la calidad de vida. La frecuencia de EP varía entre el 9 y el 27%. En este estudio, nuestro objetivo fue comparar los niveles del ácido 5-hidroxindolacético (5-HIAA), metabolito de la serotonina, en el líquido cefalorraquídeo (LCR) de pacientes con y sin EP según el tiempo de latencia eyaculatoria intravaginal (TLEI) para analizar la relación de la EP con los niveles de 5-HIAA en el LCR. Materiales y métodos: Se incluyeron en el estudio un total de 60 pacientes de sexo masculino que tenían prevista cirugía con anestesia intradural, 30 en el grupo de pacientes con EP (todos los pacientes incluidos tenían un TLEI < 1 min) y 30 en el grupo de control (los pacientes tenían un TLEI > 1 min). Se midieron los niveles de 5-HIAA en el LCR. Resultados: Hubo una correlación negativa importante entre las variables TLEI y 5-HIAA en todos los pacientes (r = -0,322; p = 0,012). Aunque los niveles medios de 5-HIAA (nmol/l) fueron más elevados en el grupo de pacientes (86,80 ± 28,33) que en el grupo de control (76,44 ± 35,91), esta diferencia no fue considerable (p = 0,22). Discusión: Los resultados del presente estudio aportaron nuevas y diferentes perspectivas a la explicación de la fisiopatología de la EP. Es necesario realizar más estudios específicos y genéticos para establecer el mejor tratamiento de este trastorno frecuente

High-resolution nuclear magnetic resonance spectroscopic study of metabolites in the cerebrospinal fluid of patients with cervical myelopathy and lumbar radiculopathy.

There have been few reports describing substances related to oxidative and intermediary metabolism in the cerebrospinal fluid (CSF) in patients with spinal degenerative disorders. This study investigated whether the concentrations of metabolites in the CSF differed between patients with spinal degenerative disorders and controls, and whether the concentrations of these metabolites correlated with the severity of symptoms. CSF samples were obtained from 30 patients with cervical myelopathy (Group M), 30 patients with lumbar radiculopathy (Group R), and 10 volunteers (control). Metabolites in these CSF samples were measured by nuclear magnetic resonance spectroscopy. There were no differences in the concentrations of lactate, alanine, acetate, glutamate, pyruvate, or citrate between Groups M and R, between Group M and the control, or between Group R and the control. In Group M, neither symptom duration nor the Japanese Orthopaedic Association score correlated with the concentration of any metabolite. In Group R, the symptom duration positively correlated with the concentration of lactate, glutamate, and citrate in CSF. The duration of nerve root block showed a negative correlation with the concentrations of acetate in CSF of the patients in Group R. In patients with lumbar radiculopathy, there is a possibility of increased aerobic metabolic activity or decreased gluconeogenic activity in patients with shorter symptom duration, and increased aerobic metabolic activity in patients with severe inflammation around a nerve root.