ABSTRACT
Side effects of hysterosalpingography with Dimer-X, Hexabrix, Vasurix polyvidone and Endografine in 142 consecutive patients, receiving one of the four tested media were evaluated from replies to postal questionnaires. The Dimer-X group had a higher incidence of nausea and dizziness. The Endografine group had a higher incidence of abdominal pain. These differences occur especially in the age groups under 30 years. Hexabrix and Vasurix polyvidone are considered the best contrast media for hysterosalpingography and perhaps because of its low toxicity Hexabrix should be preferred.
Subject(s)
Contrast Media/adverse effects , Hysterosalpingography/adverse effects , Abdomen , Acetrizoic Acid/adverse effects , Adult , Diatrizoate/adverse effects , Female , Humans , Hysterosalpingography/methods , Iothalamic Acid/adverse effects , Iothalamic Acid/analogs & derivatives , Ioxaglic Acid , Meglumine/adverse effects , Nausea/chemically induced , Pain/chemically induced , Pain/etiology , Triiodobenzoic Acids/adverse effectsSubject(s)
Angiography/adverse effects , Contrast Media/adverse effects , Urography/adverse effects , Acetrizoic Acid/adverse effects , Cardiovascular System/drug effects , Diatrizoate/adverse effects , Drug Hypersensitivity/etiology , Erythrocytes/drug effects , Histamine Release , Humans , Iothalamate Meglumine/adverse effects , Iothalamate Meglumine/analogs & derivatives , Iothalamic Acid/adverse effects , Iothalamic Acid/analogs & derivatives , Water-Electrolyte Imbalance/chemically inducedABSTRACT
An allergic, immunologic mechanism for certain adverse reactions to radiocontrast agents has been postulated on the basis of clinical and theoretical considerations. One obstacle to the acceptance of this allergic theory has been the inability to demonstrate significant antibodies with specificity for these agents. In our studies, rabbits were immunized with 4 analogues of radiocontrast agents which induced IgG or IgE antibodies specific for the contrast media analogues. Then, to determine if antibodies to contrast agents were present in man a prospective, one-year surveillance of radiocontrast agent reactions was undertaken. Sera from 27 patients suffering severe reactions and 37 control subjects were analyzed by radioimmunoassay for antibodies reactive with radiocontrast media. Binding of radiolabeled contrast media was significantly elevated (p less than 0.01) by the serum globulin fraction of the patients suffering severe reactions. Demonstration of this antibody activity, although not proof of cause and effect between the presence of antibody activity and clinical symptoms, nonetheless adds support to the hypothesis that some adverse reactions to radiocontrast agents are due to antibodies.
Subject(s)
Antibodies/analysis , Contrast Media/adverse effects , Acetrizoic Acid/adverse effects , Adolescent , Adult , Aged , Animals , California , Child , Diatrizoate/adverse effects , Female , Haptens , Humans , Immunoglobulin E/analysis , Immunoglobulin G/analysis , Iodipamide/adverse effects , Iothalamic Acid/adverse effects , Male , Middle Aged , Prospective Studies , RabbitsABSTRACT
Thrombophlebitis similar to that which is frequently observed following i.v. injection of irritative drugs in clinical treatment has been successfully reproduced in experimental animals by utilizing a newly devised technique. Thrombophlebitis at a high rate resulted within a few days by allowing the sample to remain in the sealed section of the V. retroauricularis in rabbits for 3 min after injection. The effects of several drug preparations on the thrombus as well as on the inflammation formed by means of this technique were examined, and the results were in good parallel with clinical cases reported in medical literature. Histopathologically, it was observed that each thrombus was formed by the irritative effect of drugs on the portion on the veneous wall damaged when needles had been inserted.
