[The role of endogenous K+ in realizing the protective action of M-cholinolytics in chlorophos poisoning]. / Rol' éndogennogo K+ v osushchestvlenii zashchitnogo deistviia M-kholinolitikov pri otravlenii khlorofosom.

The protective effect of M-cholinolytics during the poisoning of mice with chlorophos or exogenous acetylcholine is characterized by certain specific features. An attempt to reproduce the cholinolytic effect during poisoning by organophosphorus compounds was successful in case where the intoxication by a direct cholinomimetic was carried out in the presence of KCl solution or where the animals' poisoning was preceded by administration of voltage-dependent K+ channel blockers. The conclusion is made that the increased concentration of extracellular K+ occurring as the result of poisoning with organophosphorus compounds may play a role in the mechanism of the protective action of M-cholinolytics in chlorophos poisoning.

[Relationship between the choline-blocking and protective actions of m-cholinolytics in chlorophos poisoning]. / Sviaz' mezhdu kholinoblokiruiushchim i zashchitnym deistviem m-kholinolitikov pri otravlenii khlorofosom.

It was established in experiments on mice that the protective effect of metacine and atropine iodomethylate during chlorophos and acetylcholine intoxication is directly proportional to the peripheral m-cholinolytic activity of the drugs. The protective effect of the doses of metacine and atropine iodomethylate equieffective by the choline-blocking effect was equal during acetylcholine intoxication but differed during chlorophos intoxication. Atropine iodomethylate exhibited a stronger selective peripheral m-cholinolytic action than metacine.