ABSTRACT
Altogether 82 breast cancer patients were investigated to determine a possibility of the use of parasternal lymphoscintigraphy with colloid finely divided radiopharmaceuticals 99mTc and 198Au to form individual irradiation fields; 43 patients with fibroadenomatosis were taken as controls. Variants of the localization of parasternal lymph nodes were defined, standard and "optimum" (individual) parasternal irradiation field values were compared. 54.9% of the patients were shown to be in need of correction by increasing a standard irradiation field (5 cm wide).
Subject(s)
Adenofibroma/diagnostic imaging , Breast Neoplasms/diagnostic imaging , Lymph Nodes/diagnostic imaging , Patient Care Planning/methods , Adenofibroma/radiotherapy , Adult , Aged , Breast Neoplasms/radiotherapy , Female , Gold Colloid, Radioactive , Humans , Lymphatic Metastasis , Middle Aged , Organotechnetium Compounds , Radionuclide Imaging , Sternum , Technetium Tc 99m Aggregated AlbuminABSTRACT
Levels of cAMP and cGMP were higher in breast cancer tissue as compared with benign tumors. Large-fraction irradiation was followed by a decrease in cGMP concentration matched by a rise in cAMP/cGMP ratio in cases of radiosensitive tumors. Small-fraction treatment did not affect cyclic nucleotide levels. Radiotherapy was followed by a decrease in initially raised blood plasma cyclic nucleotide concentration.
