Subject(s)
Adenosarcoma/diagnosis , Endometrial Neoplasms/pathology , Polyps/pathology , Uterine Neoplasms/diagnosis , Adenosarcoma/pathology , Adenosarcoma/surgery , Adenosarcoma/ultrastructure , Adult , Diagnosis, Differential , Endometrial Neoplasms/diagnosis , Endometrial Neoplasms/surgery , Endometrial Neoplasms/ultrastructure , Endometrium/pathology , Endometrium/ultrastructure , Female , Humans , Mixed Tumor, Mullerian/diagnosis , Mixed Tumor, Mullerian/ultrastructure , Polyps/diagnosis , Polyps/surgery , Polyps/ultrastructure , Stromal Cells/pathology , Tomography, X-Ray Computed , Uterine Neoplasms/pathology , Uterine Neoplasms/surgery , Uterine Neoplasms/ultrastructureSubject(s)
Golgi Apparatus/pathology , Neoplasms/pathology , Organelles/pathology , Organelles/ultrastructure , Abdominal Neoplasms/pathology , Abdominal Neoplasms/ultrastructure , Adenosarcoma/pathology , Adenosarcoma/ultrastructure , Bronchial Neoplasms/pathology , Bronchial Neoplasms/ultrastructure , Gastrointestinal Neoplasms/pathology , Gastrointestinal Neoplasms/ultrastructure , Golgi Apparatus/ultrastructure , Leiomyosarcoma/pathology , Leiomyosarcoma/ultrastructure , Lung Neoplasms/pathology , Lung Neoplasms/ultrastructure , Neoplasms/ultrastructureABSTRACT
Four cases of Mullerian adenosarcoma were studied by light and electron microscopy and immunohistochemistry. All 4 cases showed the histologic characteristics of adenosarcoma with benign endometrial glands and a malignant stroma. Ultrastructurally, the epithelial component in all cases had the appearance of proliferative endometrial glands, and the malignant mesenchymal cells showed features of endometrial stroma. A distinct basal lamina separating glands from stroma was present. In addition, 2 of the cases showed extensive smooth muscle differentiation which was associated with sarcomatous overgrowth. The smooth muscle features were confirmed by immunohistochemistry. Multiple theories of the histogenesis of this tumor are discussed.
Subject(s)
Adenosarcoma/ultrastructure , Muscle, Smooth/ultrastructure , Uterine Neoplasms/ultrastructure , Adult , Aged , Aged, 80 and over , Cell Differentiation , Female , Humans , Middle Aged , Mixed Tumor, Mullerian/ultrastructureABSTRACT
Adenocarcinoma of the middle ear is seldom encountered in clinical practice. In the past 20 years, nearly 20 cases of primary adenocarcinoma of the middle ear have been reported, and most cases of these tumors have been described without histologic presentation. To our knowledge, only one case of adenocarcinoma originating in the postoperative middle ear has been reported. We describe a case of primary poorly differentiated adenocarcinoma in the middle ear which was surgically treated for chronic otitis media 50 years ago. Planning diagnostic and therapeutic procedures in connection with middle ear tumors is also discussed.
