ABSTRACT
Neonatal adenovirus infection is infrequent, but in most cases the outcome of the infection is fatal. In this case report we describe the hospital course of a 3 day old newborn patient presenting with bloody stools and thrombocytopenia that remained clinically stable and had a benign course following Adenovirus 40/41 infection detected in stool. Neonatal adenovirus infection should be considered in the differential diagnosis of neonatal sepsis and pneumonia but also in patients that present with hematochezia, thrombocytopenia and/or other less specific signs and symptoms of viral illness.
Subject(s)
Adenoviridae Infections/congenital , Ampicillin/therapeutic use , Anti-Bacterial Agents/therapeutic use , Gastrointestinal Hemorrhage/microbiology , Gentamicins/therapeutic use , Thrombocytopenia/microbiology , Adenoviridae Infections/drug therapy , Adenoviridae Infections/microbiology , Female , Gastrointestinal Hemorrhage/drug therapy , Humans , Infant, Newborn , Pregnancy , Thrombocytopenia/drug therapy , Treatment OutcomeABSTRACT
Five hysterectomy-derived colostrum-deprived pigs housed in individual cages with positive ventilation developed severe skin cyanosis and edema of the subcutaneous tissues in the submandibular, thoracic, and abdominal regions. The 5 pigs were killed 7 to 10 days after birth. Eosinophilic intranuclear inclusion bodies were found in endothelial cells of capillary and small blood vessels throughout the body. Ultrastructurally, nuclei of these affected endothelial cells contained small crystalline arrays of virus particles, which were considered to belong to the adenovirus-like group from their size and structure. The present results indicated that the porcine adenovirus-like agent might also have the ability to produce transplacental infection.
