ABSTRACT
Although adenovirus type 3 is a common pathogen of pediatric infection, there have been few reports on encephalitis and encephalopathy caused by this virus. We report two cases, one of acute encephalitis and another of transient encephalopathy, associated with adenovirus type 3 infection. Case 1, an 11-year-old boy with unconsciousness and convulsions, was diagnosed as having acute encephalitis because adenovirus type 3 was isolated from the cerebrospinal fluid. Case 2, a 3-year-old boy with intermittent excitement and hallucinations, was diagnosed as having transient encephalopathy. MRI, EEG, and cerebrospinal fluid studies were normal. Our cases and previously reported cases exhibit a wide clinico-pathological spectrum of the central nervous system involvement by adenovirus type 3.
Subject(s)
Adenovirus Infections, Human/diagnosis , Encephalitis, Viral/diagnosis , Acute Disease , Adenoviridae/isolation & purification , Adenovirus Infections, Human/physiopathology , Adenovirus Infections, Human/psychology , Adenovirus Infections, Human/therapy , Child , Child, Preschool , Diagnostic Imaging , Encephalitis, Viral/physiopathology , Encephalitis, Viral/psychology , Encephalitis, Viral/therapy , Humans , Male , PrognosisABSTRACT
The author describes the phenomenon of somatopsychic synergy as a variant of combination of somatic pathology in the form of adenovirus and coccal infections with subclinical affective syndromes of cyclothymic and schizophrenic nature which is exactly opposite to the synergy of somatic and psychic diseases denoted as "somatopsychic antagonism". In practice somatopsychic synergy is assessed as a complicated form disguising some subdepressive states. The main clinical criteria for the recognition of these states from the internist's view-point have been formulated.
Subject(s)
Psychophysiologic Disorders , Adenovirus Infections, Human/complications , Adenovirus Infections, Human/psychology , Adolescent , Adult , Female , Humans , Male , Middle Aged , Psychophysiologic Disorders/complications , Psychophysiologic Disorders/diagnosisABSTRACT
Forty-nine children who had a virus infection of the central nervous system (CNS) when under 1 year of age were studied. One child had died during the initial illness and three of the survivors were severely disabled. The other survivors, more than 5 years after the initial illness, were all attending normal schools. These 45 children, together with 45 matched controls, were examined. We confirm the findings of other studies that virus infections of the CNS in infancy may cause severe disabilities in some cases, and may depress intellectual abilities in others, even though they appear to have recovered fully. Many of the children who had a virus infection of the CNS in infancy had adverse birth and social histories and so were exceptionally vulnerable, but these factors did not account fully for the findings, and when their influence was included in the analysis, the index children still had a mean performance IQ (WISC) 6 points lower than the control children (P less than 0.05), whereas there was less than 1 point difference between the verbal IQs. Attention is drawn to the problem of virus infections in neonatal units.
