1.
Biochim Biophys Acta
; 1768(4): 756-71, 2007 Apr.
Article
in English
| MEDLINE
| ID: mdl-17141178
ABSTRACT
The realization that there existed a G-protein coupled signal transduction mechanism developed gradually and was initially the result of an ill fated quest for uncovering the mechanism of action of insulin, followed by a refocused research in many laboratories, including mine, on how GTP acted to increase hormonal stimulation of adenylyl cyclase. Independent research into how light-activated rhodopsin triggers a response in photoreceptor cells of the retina and the attendant biochemical studies joined midway and, without the left hand knowing well what the right hand was doing, preceded classical G protein research in identifying the molecular players responsible for signal transduction by G proteins.
Subject(s)
Heterotrimeric GTP-Binding Proteins/history , Adenylyl Cyclases/drug effects , Adenylyl Cyclases/history , Adenylyl Cyclases/metabolism , Animals , Binding Sites , Cholera Toxin/history , Cholera Toxin/metabolism , GTP Phosphohydrolases/metabolism , GTP-Binding Protein alpha Subunits, Gi-Go/history , GTP-Binding Protein alpha Subunits, Gi-Go/metabolism , GTP-Binding Protein alpha Subunits, Gs/history , GTP-Binding Protein alpha Subunits, Gs/metabolism , Guanine Nucleotides/history , Guanine Nucleotides/metabolism , Heterotrimeric GTP-Binding Proteins/genetics , Heterotrimeric GTP-Binding Proteins/metabolism , History, 20th Century , History, 21st Century , Pertussis Toxin/history , Pertussis Toxin/metabolism
2.
J Am Soc Nephrol
; 8(10): 1608-17, 1997 Oct.
Article
in English
| MEDLINE
| ID: mdl-9335391