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1.
Ugeskr Laeger ; 186(11)2024 03 11.
Article in Danish | MEDLINE | ID: mdl-38533865

ABSTRACT

Congenital adrenal hyperplasia (CAH) arises from genetic enzyme defects, often in CYP21A2, causing primary adrenal insufficiency. In this case report, a man in his late 20s with lifelong CAH faced challenges in adhering to medication. Suboptimal treatment led to the development of testicular adrenal rest tumours, diagnosed by ultrasound, and hypogonadism. Enhanced adherence restored hormone levels, promoting eugonadism. Adherence plays a crucial role in diminishing tumour size and preventing complications, potentially necessitating orchiectomy in severe cases.


Subject(s)
Adrenal Hyperplasia, Congenital , Adrenal Rest Tumor , Hypogonadism , Testicular Neoplasms , Humans , Male , Adrenal Hyperplasia, Congenital/complications , Adrenal Hyperplasia, Congenital/diagnosis , Adrenal Hyperplasia, Congenital/genetics , Adrenal Rest Tumor/complications , Adrenal Rest Tumor/diagnosis , Adrenal Rest Tumor/pathology , Steroid 21-Hydroxylase , Adult
2.
Medicine (Baltimore) ; 102(49): e36061, 2023 Dec 08.
Article in English | MEDLINE | ID: mdl-38065885

ABSTRACT

RATIONALE: Congenital adrenal hyperplasia (CAH) is considered one of the most common inherited disorders. In about more than 95% of all CAH cases, the deficient enzyme is 21-hydroxylase. Infertility is an important complication of this disease, and although this topic has been studied more frequently in females, cases, and literature reviews of the causes of infertility in male patients are constantly increasing. PATIENT CONCERNS: A 28 old male with congenital adrenal hyperplasia (we assume to be a nonclassical type) presented to our institution with infertility and suspected bilateral testicular masses after 4 years of stopping dexamethasone. DIAGNOSIS: Testicular adrenal rest tumors. INTERVENTIONS: Dexamethasone was reapplied in a supraphysiologic dose (1.5 mg before bedtime) with periodic monitoring of the patient. OUTCOMES: Treatment with supraphysiologic dose of dexamethasone led to regression of these tumors and significant improvement in sperm count, resulting in being capable of having a child. LESSONS: There are many suspected causes of reduced male fertility in male CAH patients and the presence of testicular adrenal rest tumors is the main cause of infertility in this population. These benign tumors are believed to arise from ectopic adrenal cells in the testes, that grow under adrenocorticotropic hormone stimulation in poorly controlled patients. Annual scrotal ultrasound is recommended in all males with CAH for detection and treatment of these tumors as early as possible before they cause permanent damage to the seminiferous tubules and irreversible infertility.


Subject(s)
Adrenal Hyperplasia, Congenital , Adrenal Rest Tumor , Testicular Neoplasms , Humans , Male , Adrenal Hyperplasia, Congenital/complications , Adrenal Hyperplasia, Congenital/drug therapy , Adrenal Rest Tumor/complications , Adrenal Rest Tumor/drug therapy , Dexamethasone/therapeutic use , Glucocorticoids/therapeutic use , Semen , Testicular Neoplasms/complications , Testicular Neoplasms/drug therapy , Adult
3.
Saudi Med J ; 42(9): 986-993, 2021 Sep.
Article in English | MEDLINE | ID: mdl-34470837

ABSTRACT

OBJECTIVES: To identify testicular adrenal rest tumors (TARTs) prevalence among children with congenital adrenal hyperplasia (CAH) and to assess hormonal control role as a contributing factor for TART development. Testicular adrenal rest tumors are benign tumors complicating CAH. It affects adult males with CAH commonly, with a reported prevalence of 40% on average, and up to 94%. There is insufficient data regarding their prevalence in children aged above 4 years and adolescents. METHODS: This descriptive study included 21 children and adolescents with CAH (17 salt wasting type, 4 non salt wasting type) aged 4-20 years who were screened for TARTs by routine testicular ultrasonography from October 2012 to December 2020 at King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. Serum adrenocorticotropic hormone, 17-hydroxy progesterone, testosterone, dehydroepiandrosterone, and luteinizing hormone levels were measured. RESULTS: Testicular adrenal rest tumors were detected in 6 (28%) patients (median age: 12.5 years). The youngest affected child was 8 years old. All patients with TARTs were asymptomatic with impalpable testicular masses at the time of detection. Bilateral involvement was observed in 5 patients, while one patient had unilateral involvement. All patients with TARTs had poor hormonal control, and 4 patients had advanced bone age. CONCLUSION: Testicular adrenal rest tumors development has been shown to correlate with poor hormonal control. Annual screening of young children with CAH for TART development is crucial, even for asymptomatic or with impalpable testicular masses.


Subject(s)
Adrenal Hyperplasia, Congenital , Adrenal Rest Tumor , Testicular Neoplasms , Adolescent , Adrenal Hyperplasia, Congenital/complications , Adrenal Hyperplasia, Congenital/epidemiology , Adrenal Rest Tumor/complications , Adrenal Rest Tumor/diagnostic imaging , Adrenal Rest Tumor/epidemiology , Adult , Child , Child, Preschool , Humans , Male , Prevalence , Testicular Neoplasms/complications , Testicular Neoplasms/epidemiology , Ultrasonography
4.
J Clin Endocrinol Metab ; 106(2): e675-e679, 2021 01 23.
Article in English | MEDLINE | ID: mdl-33245336

ABSTRACT

CONTEXT: Women with congenital adrenal hyperplasia (CAH) may present with androgen excess that is difficult to control with conventional suppressive doses of glucocorticoids. Clinical management is challenging, and the woman is at great risk of developing steroid-induced complications. PATIENTS AND METHODS: A 32-year-old woman with salt-wasting CAH due to 21-hydroxylase deficiency underwent right-sided adrenalectomy because of a large myelolipoma. Over the years, androgens became increasingly difficult to suppress on prednisolone 5 + 0 + 2.5 mg daily, and at age 39 years the left adrenal with an enlarging myelolipoma was removed. A month later serum testosterone levels had increased from 4.1 preoperatively to 18.3 nmol/L (reference 0.2-1.8 nmol/L), and adrenocorticotropin levels from 32 to 283 pmol/L (reference < 14 pmol/L). No adrenal parenchyma was visualized on computed tomography (CT). In the further search for the source of the markedly elevated testosterone, positron emission tomography (PET) was performed with 2 different tracers, 18fluorodeoxyglucose (18FDG) reflecting glucose metabolism and 11C-metomidate, an inhibitor of 11-ß-hydroxylase targeting adrenocortical tissue. RESULTS: 18FDG-PET/CT with cosyntropin stimulation showed ovarian/paraovarian hypermetabolism, suggestive of adrenal rest tumors. Further characterization with 11C-metomidate PET/CT showed uptakes localized to the ovaries/adnexa, behind the spleen, and between the right crus diaphragmaticus and inferior vena cava. CONCLUSION: Adrenal rest tumors can give rise to high androgen levels in spite of suppressive supraphysiological glucocorticoid doses. This case illustrates, for the first time, the value of 11C-metomidate PET as a sensitive method in documenting adrenal rest tumors, currently considered rare in women with CAH.


Subject(s)
Adrenal Hyperplasia, Congenital , Adrenal Rest Tumor/diagnosis , Ovarian Neoplasms/diagnosis , Retroperitoneal Neoplasms/diagnosis , Adrenal Hyperplasia, Congenital/complications , Adrenal Hyperplasia, Congenital/diagnosis , Adrenal Hyperplasia, Congenital/metabolism , Adrenal Rest Tumor/complications , Adrenal Rest Tumor/metabolism , Adult , Carbon Radioisotopes , Etomidate/analogs & derivatives , Female , Humans , Neoplasms, Multiple Primary/complications , Neoplasms, Multiple Primary/diagnosis , Neoplasms, Multiple Primary/metabolism , Ovarian Neoplasms/complications , Ovarian Neoplasms/metabolism , Positron Emission Tomography Computed Tomography/methods , Retroperitoneal Neoplasms/complications , Retroperitoneal Neoplasms/metabolism , Salts/metabolism , Sweden , Water-Electrolyte Imbalance/complications , Water-Electrolyte Imbalance/metabolism
5.
Orphanet J Rare Dis ; 14(1): 242, 2019 11 06.
Article in English | MEDLINE | ID: mdl-31694673

ABSTRACT

PURPOSE: Testicular adrenal rests tumor (TART) is a rare kind of benign tumor in the testis. It usually occurred secondary to congenital adrenal hyperplasia (CAH), a hormonal disorder caused by hydroxylase deficiency. As the first-line examination method, ultrasound provides crucial diagnostic information for TART, although misdiagnosis to malignancy is quite common because of its rare prevalence. We aimed to summarize the sonographic manifestations of TART to improve the diagnostic accuracy and specificity. METHODS: Eight CAH patients with TART identified by ultrasound in our medical center were retrospectively reviewed. Clinical and hormonal profile, semen analysis and treatment choices were collected. Sonographic examinations were performed at the first evaluation and interpreted by experienced radiologists individually. All patients received regular follow-up, and 5 patients undertook repeated scrotal ultrasound. A literature review of TART in CAH patients was conducted, with 123 patients from 23 articles since 1990 included. RESULTS: A total of 8 patients aged between 4 to 27 years old were enrolled. 7 of 8 (87.5%) patients exhibited bilateral testicular lesions. The sizes of the testicular lesions were between 0.18 ml to 5.68 ml, and all showed a clear boundary. 10/15 (66.7%) lesions were homogenously hypoechoic, 4/15 (26.7%) were heterogeneously iso-hypoechoic, and 1/15 (6.7%) were homogenously isoechoic. 10/15 (66.7%) lesions were hyper-vascular. The longitudinal follow-up of 5 patients showed testicular lesions changed in terms of size, echogenicity, and vascularity after steroid treatment. A potential correlation may exist between ACTH levels and tumor size (p = 0.066). From the literature review, 100/123 (81%) patients got bilateral lesions, and 95% of them were located near the mediastinum. 80/103 (78%) lesions exhibited a clear boundary, and predominant lesions (74%) were hypoechogenic. Vascularity was with great diversity. Seventy-nine lesions of 44 patients were followed-up by scrotal ultrasound, among which 29 (37%) remained unchanged, 29(37%) shrank, and 21(27%) disappeared. CONCLUSIONS: Key sonographic characteristics of TART are: resembled lesions on both testes, located near the mediastinum, clear boundary, and changed in size or echogenicity after steroid treatment. These features can help radiologists to make an accurate diagnosis of TART.


Subject(s)
Adrenal Hyperplasia, Congenital/complications , Adrenal Rest Tumor/diagnostic imaging , Testicular Neoplasms/diagnostic imaging , Adolescent , Adrenal Rest Tumor/complications , Adult , Biomarkers, Tumor , Child , Child, Preschool , Humans , Male , Retrospective Studies , Testicular Neoplasms/complications , Ultrasonography , Young Adult
6.
Horm Res Paediatr ; 90(3): 161-168, 2018.
Article in English | MEDLINE | ID: mdl-30149373

ABSTRACT

BACKGROUND: Testicular adrenal rest tumors (TART) can cause infertility in congenital adrenal hyperplasia (CAH) males. AIMS: To determine TART prevalence in patients with CAH due to 21-hydroxylase deficiency (21-OHD) and evaluate possible factors associated with its development. METHODS: This is a descriptive and analytical cross-sectional study evaluating males with the classical form of 21-OHD through testicular ultrasonography and serum inhibin B dosages. Data on prescribed glucocorticoid dose and serum levels of 17- hydroxyprogesterone (17-OHP), androstenedione (Andro), ACTH, renin, and LH were obtained from medical records. RESULTS: Thirty-eight males were evaluated. The mean age on ultrasonography was 15.2 ± 6.7 (3-27) years. Nine patients (23.7%) had TART, 4 of them were prepubertal and the youngest was 5 years old. No association was found between TART and 21-OHD phenotype, glucocorticoid dose, or 17-OHP, ACTH, LH, renin, and inhibin B levels measured in the 6 preceding years. However, 50% of the patients who presented increased Andro 2 years prior to the evaluation had TART (p = 0.018, OR = 8.00 [95% CI: 1.42-44.92]), whereas in the normal Andro group only 16.7% had tumors. CONCLUSION: This study showed that TART can occur in prepubertal patients and that disease control could be a factor associated with its development. Therefore, we suggest investigating TART development early in childhood, mainly in poorly controlled 21-OHD patients.


Subject(s)
Adrenal Hyperplasia, Congenital/epidemiology , Adrenal Rest Tumor/epidemiology , Testicular Neoplasms/epidemiology , Adolescent , Adrenal Hyperplasia, Congenital/complications , Adrenal Rest Tumor/complications , Adrenal Rest Tumor/pathology , Adult , Child , Child, Preschool , Cross-Sectional Studies , Humans , Male , Prevalence , Risk Factors , Testicular Neoplasms/complications , Testicular Neoplasms/pathology , Tumor Burden , Young Adult
7.
Eur J Med Genet ; 60(9): 489-493, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28676275

ABSTRACT

Congenital adrenal hyperplasia is one of the most common autosomal recessive genetic disorders. Testicular adrenal tumors are significant complications of congenital adrenal hyperplasia. We would like to present two patients of testicular adrenal rest tumors. Patient 1 24 year-old male, he was diagnosed with congenital adrenal hyperplasia at the age of 8 due to precocious puberty. He received hydro-cortisone treatment until the age of 18. Testicular mass had been detected and right radical orchiectomy had been applied 6 months ago and reported as testicular adrenal rest tumor. In scrotal ultrasound, a mixed type mass lesion (6 × 4x3 cm) covering a large part of left testis was observed. The imaging findings were consistent with adrenal rest tumor. The patient took adrenocorticotropic hormone supressive therapy with dexamethasone 0.75 mg once a day. Patient 2, 38 year-old male, he had been followed-up as adrenal insufficiency for 35 years. He underwent right orchiectomy operation due to the testicular mass in 2010 and the pathological examination revealed Leydig cell tumor. In scrotal ultrasound, small multifocal lesions were detected on the left testis and resection was done. It was reported as testicular adrenal rest tumor. He is being followed-up with glucocorticoid treatment according to androgen and adrenocorticotropic hormone levels. Early diagnosis of testicular adrenal rest tumor is significant in preventing irreversible testicular damage and infertility. In the differential diagnosis, we should keep in mind that testicular adrenal rest tumor can mimic other testicular tumors such as primary germ cell tumors.


Subject(s)
Adrenal Hyperplasia, Congenital/diagnosis , Adrenal Rest Tumor/diagnosis , Testicular Neoplasms/diagnosis , Adrenal Hyperplasia, Congenital/complications , Adrenal Hyperplasia, Congenital/drug therapy , Adrenal Hyperplasia, Congenital/surgery , Adrenal Rest Tumor/complications , Adrenal Rest Tumor/drug therapy , Adrenal Rest Tumor/surgery , Adult , Humans , Male , Testicular Neoplasms/complications , Testicular Neoplasms/drug therapy , Testicular Neoplasms/surgery
8.
Ital J Pediatr ; 41: 62, 2015 Sep 02.
Article in English | MEDLINE | ID: mdl-26329697

ABSTRACT

INTRODUCTION: The adrenocortical rest tumours are the very rare entity in the pediatric population. They are usually found along the gonadal descent paths (celiac axis, the broad ligamen, the adnexa of the testes or the spermatic cord). They have been also described to occur at rare ectopic sites like intracranial locations, placenta, kidney, pancreas and liver. CLINICAL CASE: Here we present a unusual case of an ectopic, virilising, primary adrenocortical tumour localized in the spinal region in a 8 years-old-boy. DISCUSSION: This is the first case of functional ectopic, adrenocortical tumour localized in the spinal region in a pediatric population. We discuss here the clinical presentation and the diagnostic challenges and provide the review of the literature.


Subject(s)
Adrenal Rest Tumor/complications , Adrenal Rest Tumor/diagnosis , Spinal Neoplasms/complications , Spinal Neoplasms/diagnosis , Virilism/etiology , Adrenal Rest Tumor/surgery , Child , Diagnosis, Differential , Female , Humans , Male , Spinal Neoplasms/surgery
9.
J Pediatr Endocrinol Metab ; 28(9-10): 1187-90, 2015 Sep.
Article in English | MEDLINE | ID: mdl-25879317

ABSTRACT

OBJECTIVE: The nicotinamide nucleotide transhydrogenase (NNT) enzyme is the main generator of nicotinamide adenine dinucleotide phosphate-oxidase in the mitochondrion. Mutations of the NNT gene have been recently implicated in familial glucocorticoid deficiency. We describe the long-term clinical course of a NNT-deficient 20-year-old patient with combined adrenal failure who had developed a testicular adrenal rest tumor and precocious puberty. METHODS: The patient's medical records were reviewed. Whole-exome sequencing was performed on DNA obtained from the patient and family members. RESULTS: The patient experienced Addisonian crisis at 10 months of age. Enlarged testicular volume and precocious puberty, accompanied by increased testosterone levels, were noted at 6 years. Testicular biopsy revealed a adrenal rest tumor, which regressed after intensification of glucocorticoid treatment. Genetic studies disclosed a c.1163A>C, p.Tyr388Ser substitution on the NNT gene. This mutation is predicted to be damaging to NNT function. CONCLUSION: We demonstrated for the first time that the clinical spectrum of NNT deficiency may consist of mineralocorticoid deficiency and testicular involvement as well.


Subject(s)
Adrenal Insufficiency/complications , Adrenal Rest Tumor/complications , NADP Transhydrogenases/deficiency , Testicular Neoplasms/complications , Adrenal Insufficiency/drug therapy , Adrenal Insufficiency/pathology , Adrenal Rest Tumor/drug therapy , Adrenal Rest Tumor/pathology , Glucocorticoids/therapeutic use , Humans , Male , Testicular Neoplasms/drug therapy , Testicular Neoplasms/pathology , Young Adult
10.
J Clin Endocrinol Metab ; 100(3): E524-30, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25485724

ABSTRACT

CONTEXT: Testicular adrenal rest tumors (TART) are one of the major long term complications in patients with congenital adrenal hyperplasia. Although several adrenal-like properties have been assigned to these benign lesions, the etiology has not been confirmed yet. OBJECTIVE: The aim of this study was to describe TART in more detail by analyzing several (steroidogenic) characteristics that may be classified as adrenal cortex or Leydig cell specific. METHODS: Gene expression analysis by qPCR was performed for 14 genes in TART tissue (n = 12) and compared with the expression in healthy control fibroblasts (nonsteroidogenic control). In addition, a comparison was made with the expression levels in testis tissue (n = 9) and adrenal tissue (n = 13). RESULTS: Nearly all genes were highly expressed in TART tissue, including all genes that encode the key steroidogenic enzymes. TART expression levels are in the majority almost identical to those found in adrenal tissue. The expression of adrenal cortex specific genes (CYP11B1, CYP11B2, and MC2R) in both TART and adrenal tissue is approximately 1000-10 000 times higher compared to that in testes samples. In addition, the Leydig cell markers INSL3 and HSD17B3 were not only found in testes, but also in TART, both at significantly higher levels than in the adrenal (p < 0.01). CONCLUSION: Our study shows for the first time that TART have multiple steroidogenic properties, which include not only the expression of adrenal cortex but also of Leydig cell markers. Therefore, the origin of these tumors might be a more totipotent embryonic cell type.


Subject(s)
Adrenal Cortex/pathology , Adrenal Hyperplasia, Congenital/genetics , Adrenal Rest Tumor/genetics , Adrenal Rest Tumor/pathology , Leydig Cells/pathology , Testicular Neoplasms/genetics , Adrenal Cortex/metabolism , Adrenal Hyperplasia, Congenital/complications , Adrenal Hyperplasia, Congenital/pathology , Adrenal Rest Tumor/complications , Adult , Gene Expression Regulation, Neoplastic , Humans , Leydig Cells/metabolism , Male , Testicular Neoplasms/complications , Testicular Neoplasms/pathology , Transcriptome
11.
Med Ultrason ; 16(4): 383-5, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25463895

ABSTRACT

Benign intratesticular lesions are rare; thus, radiological diagnosis is important to avoid unnecessary surgical intervention. Testicular adrenal rest tumors (TART) are the nodular testicular lesions deriving from the adrenal remnant tissue reported in patients with congenital adrenal hyperplasia. We present ultrasonographic (US) and magnetic resonance imaging (MRI) findings of intratesticular adrenal rests in a 16-year-old patient with 11 ß hydroxilase deficiency. Scrotal ultrasonography demonstrated bilateral heterogenous hypoechoic lesions located around mediastinum testis and highly vascularized on powerDoppler US. On MRI the lesions were hyperintense on T1-weighted and hypointense on T2-weighted images and enhanced brightly on post-contrast images.


Subject(s)
Adrenal Hyperplasia, Congenital/complications , Adrenal Rest Tumor/diagnosis , Magnetic Resonance Imaging/methods , Testicular Neoplasms/diagnosis , Ultrasonography, Doppler/methods , Adolescent , Adrenal Rest Tumor/complications , Humans , Male , Testicular Neoplasms/complications , Testis/diagnostic imaging , Testis/pathology
15.
Eur J Endocrinol ; 170(4): K11-7, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24394723

ABSTRACT

CONTEXT: Classical congenital adrenal hyperplasia (CAH), a genetic disorder characterized by 21-hydroxylase deficiency, impairs male fertility, if insufficiently treated. PATIENT: A 30-year-old male was referred to our clinic for endocrine and fertility assessment after undergoing unilateral orchiectomy for a suspected testicular tumor. Histopathological evaluation of the removed testis revealed atrophy and testicular adrenal rest tumors (TARTs) and raised the suspicion of underlying CAH. The remaining testis was also atrophic (5 ml) with minor TARTs. Serum 17-hydroxyprogesterone levels were elevated, cortisol levels were at the lower limit of normal range, and gonadotropins at prepubertal levels, but serum testosterone levels were within the normal adult range. Semen analysis revealed azoospermia. CAH was confirmed by a homozygous mutation g.655A/C>G (IVS2-13A/C>G) in CYP21A2. Hydrocortisone (24 mg/m(2)) administered to suppress ACTH and adrenal androgen overproduction unmasked deficient testicular testosterone production. As azoospermia persisted due to sustained hypogonadotropic hypogonadism, a combined s.c. gonadotropin replacement with human chorionic gonadotropin (hCG) (1500 IU twice weekly) and FSH (human menopausal gondadotropin (hMG) 150 IU three times weekly) was initiated. RESULTS: Normalization of testosterone levels and a stable low sperm concentration (0.5 mill/ml) with good sperm motility (85% A+B progressive) were achieved within 21 months of treatment. Despite persisting TARTs, while receiving treatment, the patient successfully impregnated his wife twice, the latter impregnation leading to the birth of a healthy girl. CONCLUSIONS: TARTs in unrecognized (simple virilizing) CAH may lead to unnecessary orchiectomy. In hypogonadotropic, azoospermic CAH, a combined treatment with oral corticosteroids and subcutaneously administered hCG and FSH can successfully restore testicular testosterone production and fertility, even if only one hypoplastic and atrophic testis with adrenal rest tumors is present.


Subject(s)
Adrenal Hyperplasia, Congenital/complications , Adrenal Rest Tumor/surgery , Azoospermia/drug therapy , Chorionic Gonadotropin/therapeutic use , Hormone Replacement Therapy/methods , Menotropins/therapeutic use , Reproductive Control Agents/therapeutic use , Testicular Neoplasms/surgery , Adrenal Rest Tumor/complications , Adult , Azoospermia/etiology , Humans , Hypogonadism , Male , Orchiectomy , Testicular Neoplasms/complications
16.
Ann Endocrinol (Paris) ; 73(6): 515-22, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23131470

ABSTRACT

OBJECTIVES: Several cases of testicular adrenal rest tumours have been reported in men with congenital adrenal hyperplasia (CAH) due to the classical form of 21-hydroxylase deficiency but the prevalence has not been established. The aims of this report were to evaluate the frequency of testicular adrenal rest tissue in this population in a retrospective multicentre study involving eight endocrinology centres, and to determine whether treatment or genetic background had an impact on the occurrence of adrenal rest tissue. MATERIAL AND METHODS: Testicular adrenal rest tissue (TART) was sought clinically and with ultrasound examination in forty-five males with CAH due to the classical form of 21-hydroxylase deficiency. When the diagnosis of testicular adrenal rest tumours was sought, good observance of treatment was judged on biological concentrations of 17-hydroxyprogesterone (17OHP), delta4-androstenedione, active renin and testosterone. The results of affected and non-affected subjects were compared. RESULTS: TART was detected in none of the 18 subjects aged 1 to 15years but was detected in 14 of the 27 subjects aged more than 15years. Five patients with an abnormal echography result had no clinical signs. Therapeutic control evaluated at diagnosis of TART seemed less effective when diagnosis was made in patients with adrenal rest tissue compared to TART-free subjects. Various genotypes were observed in patients with or without TART. CONCLUSION: Due to the high prevalence of TART in classical CAH and the delayed clinical diagnosis, testicular ultrasonography must be performed before puberty and thereafter regularly during adulthood even if the clinical examination is normal.


Subject(s)
Adrenal Hyperplasia, Congenital/epidemiology , Adrenal Rest Tumor/epidemiology , Testicular Neoplasms/epidemiology , Adolescent , Adrenal Hyperplasia, Congenital/complications , Adrenal Hyperplasia, Congenital/diagnostic imaging , Adrenal Rest Tumor/complications , Adrenal Rest Tumor/diagnostic imaging , Adult , Child , Child, Preschool , France/epidemiology , Humans , Male , Prevalence , Retrospective Studies , Semen Analysis , Testicular Neoplasms/complications , Testicular Neoplasms/diagnostic imaging , Ultrasonography , Young Adult
17.
Curr Opin Endocrinol Diabetes Obes ; 19(6): 489-96, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23108200

ABSTRACT

PURPOSE OF REVIEW: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is one of the most common autosomal recessive disorders. In the past, pregnancy was considered to be unlikely for women with CAH, particularly the classical forms. The purpose of this review is to provide current information regarding the pathophysiology of CAH, factors relevant for female and male fertility, and recommendations for management during pregnancy. RECENT FINDINGS: Individuals with CAH, both female and male, have reduced fertility. For women, chronic anovulation, elevated progestin levels, and aberrant endometrial implantation have been identified as reasons for the subfertility. Testicular adrenal rest tumors, oligospermia, and hypogonadotropic hypogonadism are frequently associated with subfertility in men with all forms of CAH. SUMMARY: Adequate suppression of progesterone appears to be an essential aspect of preconception management for women. Most importantly, treatment needs to be individualized. Awareness of these factors and appropriate therapeutic interventions can lead to successful outcome defined as a healthy live born infant.


Subject(s)
Adrenal Hyperplasia, Congenital/drug therapy , Adrenal Rest Tumor/drug therapy , Infertility/therapy , Precision Medicine , Pregnancy Complications/drug therapy , Reproductive Health , Reproductive Techniques, Assisted , Adolescent , Adrenal Hyperplasia, Congenital/complications , Adrenal Hyperplasia, Congenital/genetics , Adrenal Rest Tumor/complications , Adrenal Rest Tumor/genetics , Adult , Female , Humans , Infant, Newborn , Infertility/etiology , Male , Pregnancy , Pregnancy Complications/genetics , Pregnancy Complications, Neoplastic/drug therapy , Pregnancy Outcome , Steroid 21-Hydroxylase/genetics
18.
J Clin Res Pediatr Endocrinol ; 4(2): 94-100, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22672867

ABSTRACT

OBJECTIVE: Early diagnosis and treatment of testicular adrenal rest tumors (TART) is important for gonadal functions and fertility protection in boys with congenital adrenal hyperplasia (CAH). In this descriptive study, we investigated the prevalence of TART in boys with 21-hydroxylase deficient (21OHD) CAH followed in our pediatric endocrine clinic. METHODS: The study group consisted of 14 male patients with a mean age of 9.6 ± 5.1 (range: 0.8-18.3) years. Six (42.9%) of the 14 patients were diagnosed as having salt-wasting type (SW) and eight (57.1%) patients - as having the simple virilizing (SV) form of 21OHD. Mean age at diagnosis was 2.9 ± 2.7 (range: 0.03-6.3) years. Two different radiologists performed scrotal ultrasonography. Chronological age, bone age, and anthropometric measurements were evaluated. Serum adrenocorticotropic hormone (ACTH), 17-alpha-hydroxyprogesterone (17OHP) and androstenedione levels were also evaluated in all patients during the follow-up period. RESULTS: Scrotal ultrasonography revealed bilateral TART in two patients (14.3%) and testicular microlithiasis (TM) in four patients (28.6%). One patient had both TART and TM bilaterally. During the follow-up period, the mean serum adrenocorticotropic hormone, 17OHP and androstenedione levels in the total group of patients were 130.0 ± 179.1 pg/mL (21.7-726.5), 5.8 ± 3.3 ng/mL (0.8-11.4) and 4.3 ± 4.1 (0.2-11.0) ng/mL, respectively. CONCLUSIONS: Microlithiasis or TART may be frequently encountered during the follow-up of patients with CAH. In order to prevent late complications including infertility, we suggest that ultrasonographic evaluations be performed yearly in all male CAH patients.


Subject(s)
Adrenal Hyperplasia, Congenital/diagnosis , Adrenal Rest Tumor/diagnosis , Testicular Neoplasms/diagnosis , 17-alpha-Hydroxyprogesterone/blood , Adolescent , Adrenal Hyperplasia, Congenital/complications , Adrenal Hyperplasia, Congenital/drug therapy , Adrenal Rest Tumor/complications , Adrenal Rest Tumor/drug therapy , Adrenocorticotropic Hormone/blood , Age Determination by Skeleton , Androstenedione/blood , Child , Child, Preschool , Follow-Up Studies , Humans , Male , Scrotum/diagnostic imaging , Steroid 21-Hydroxylase/metabolism , Testicular Neoplasms/complications , Testicular Neoplasms/drug therapy , Treatment Outcome , Ultrasonography/methods
19.
Ann Clin Biochem ; 49(Pt 5): 497-9, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22734073

ABSTRACT

Primary testicular failure is characterized by low serum testosterone with appropriately high serum gonadotrophins, that is hypergonadotrophic hypogonadism. We report on a 27-year-old man with congenital adrenal hyperplasia (CAH) and infertility due to testicular adrenal rest rumours (TART) resulting in primary testicular failure but presenting with azoospermia, elevated serum testosterone and very low serum gonadotrophins. Hypergonadotrophic hypogonadism was unmasked by increasing glucocorticoid dosage. It is important to recognise the limitations of follicle-stimulating hormone, luteinising hormone and testosterone in assessing testicular function in men with CAH. Abnormal semen analysis may be the best indicator of testicular dysfunction in men with CAH.


Subject(s)
Adrenal Rest Tumor/complications , Adrenal Rest Tumor/pathology , Hypogonadism/etiology , Hypogonadism/pathology , Adrenal Rest Tumor/drug therapy , Adult , Congenital Abnormalities , Follicle Stimulating Hormone/blood , Glucocorticoids/therapeutic use , Humans , Infertility/etiology , Luteinizing Hormone/blood , Male , Semen Analysis , Testosterone/blood
20.
Ginekol Pol ; 83(9): 700-2, 2012 Sep.
Article in English | MEDLINE | ID: mdl-23342900

ABSTRACT

Since testes and adrenal cortex derive from the same urogenital ridge, adrenal tissue with descending gonads may migrate in early embryonic period. Although most often ectopic tissue undergoes atrophy in some cases, when adrenocorticotrophic (ACTH) overstimulation occurs, the adrenal remnants in the testes may become hypertrophic and form testicular adrenal rest tumors (TARTs). The growth of TARTs in the testes leads to obstruction of the seminiferous tubules which can mechanically impair the function of the gonads and cause irreversible azoospermia. We describe a patient suffering since neonatal period from congenital adrenal hyperplasia (CAH), disorder with defected pathway of cortisol production, which leads to increased ACTH production and to overstimulation of adrenal cortex. He had very poor disease control and therefore in late puberty he was diagnosed with TARTs. At the age of 19.5 he was diagnosed with azoospermia, most likely caused by TARTs. It is the first evidence of TARTs in Polish literature. Although not many cases have been published so far the incidence of TARTs seems to be highly underdiagnosed, so it seems reasonable to consider the disease in differential diagnosis of male infertility.


Subject(s)
Adrenal Hyperplasia, Congenital/complications , Adrenal Rest Tumor/complications , Azoospermia/diagnosis , Azoospermia/etiology , Testicular Neoplasms/complications , Adrenal Hyperplasia, Congenital/diagnostic imaging , Adrenal Rest Tumor/diagnostic imaging , Humans , Male , Poland , Testicular Neoplasms/diagnostic imaging , Testis/diagnostic imaging , Ultrasonography , Young Adult
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