1.
Allergy
; 41(1): 71-4, 1986 Jan.
Article
in English
| MEDLINE
| ID: mdl-2421600
ABSTRACT
The site of antagonistic action on allergen-induced early skin reactions by the beta 2-agonist terbutaline was studied by light microscopy in 10 atopic subjects. Pretreatment with 1 microgram terbutaline intradermally 5 min prior to challenge with horse dander allergen produced an approximate inhibition of 85 and 55% of flare and wheal responses respectively (P less than 0.001). Biopsy specimens obtained from skin sites injected with allergen alone showed a reduced number of remaining stainable mast cells as compared to sites injected with terbutaline prior to allergen (P less than 0.05, Sign test). The data support the concept of in vivo inhibition of the mast cell mediator release reaction in atopic skin by terbutaline.
Subject(s)
Adrenergic beta-Agonists , Allergens , Asthma/immunology , Hypersensitivity, Immediate/pathology , Intradermal Tests , Mast Cells/metabolism , Rhinitis/immunology , Skin Tests , Terbutaline , Adrenergic beta-Agonists/administration & dosage , Adrenergic beta-Agonists/pharmacology , Adult , Allergens/administration & dosage , Allergens/antagonists & inhibitors , Asthma/pathology , Biopsy , Female , Histamine Release/drug effects , Humans , Male , Mast Cells/drug effects , Rhinitis/pathology , Skin/pathology , Terbutaline/administration & dosage , Terbutaline/pharmacology
2.
J Allergy
; 46(1): 1-11, 1970 Jul.
Article
in English
| MEDLINE
| ID: mdl-4393190
Subject(s)
Allergens/antagonists & inhibitors , Bronchial Diseases/prevention & control , Chromones/therapeutic use , Dyspnea/prevention & control , Promethazine/therapeutic use , Adolescent , Adult , Bronchodilator Agents/therapeutic use , Child , Dyspnea/etiology , Female , Histamine H1 Antagonists/therapeutic use , Humans , Male , Middle Aged
3.
Acta Allergol
; 23(3): 287-96, 1968 Sep.
Article
in English
| MEDLINE
| ID: mdl-4179760
Subject(s)
Asthma/drug therapy , Heparin/pharmacology , Histamine Release/drug effects , Allergens/antagonists & inhibitors , Amine Oxidase (Copper-Containing)/blood , Blood Platelets/drug effects , Complement Inactivator Proteins , Epinephrine/pharmacology , Female , Heparin/therapeutic use , Histamine/blood , Humans , Hypersensitivity, Immediate/drug therapy , Male , Mast Cells/metabolism , Phagocytosis/drug effects , Pinocytosis/drug effects , Respiratory Function Tests , Serotonin Antagonists
4.
Z Haut Geschlechtskr
; 42(10): 345-8, 1967 May 15.
Article
in German
| MEDLINE
| ID: mdl-4969336