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Acta Physiol Pharmacol Bulg ; 6(1): 48-52, 1980.
Article in English | MEDLINE | ID: mdl-6996423

ABSTRACT

It is established that the hexobarbital oxidase activity of 12,000 g rat liver supernatant does not change when examined at the 2nd h after whole body irradiation (700 R) but increases at longer postexposure periods (72 hours). Intraperitoneal injection of phenobarbital in daily doses of 80 mg/kg body wt for three days increases the hexobarbital oxidase activity of non-irradiated rats, the effect being much stronger in phenobarbital-treated rats at the 2nd h of postirradiation. The possible mechanisms of these effects are discussed, as well as their correlation with the increased lipid peroxidation and their significance for the radiation effect on the drug action.


Subject(s)
Alcohol Oxidoreductases/radiation effects , Liver/radiation effects , Aminopyrine N-Demethylase/radiation effects , Animals , Enzyme Induction/drug effects , Hexobarbital/radiation effects , Lipid Peroxides/metabolism , Liver/enzymology , Male , Phenobarbital/pharmacology , Rats , X-Rays
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